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VASOPRESSIN SIGNALING PATHWAY (PW:0000491)

View Ontology Report

Description

Vasopressin (Avp) acts as an antidiuretic hormone and as a neuromodulator and neurotransmitter. Avp exerts its actions by binding to two receptor types, G-protein coupled receptors coupling to particular G alpha subunits of heterotrimeric G proteins. Avp plays important roles in the cardiovascular and autonomic function by signaling via receptor type 1a (Avpr1a). The receptor couples to Gq alpha subunit leading to stimulation of phospholipase C beta isoforms, subsequent generation of seco

Pathway Diagram:

Ariadne Genomics Inc. vasopressin signaling pathway via receptor type 2 G protein mediated signaling pathway via Galphas family vasopressin signaling pathway via receptor type 1 G protein mediated signaling pathway via Galphaq family protein kinase A (PKA) signaling pathway Avpr1a Avpr2 vasoconstriction autonomic functions protein kinase A (PKA) signaling pathway --+> Aqp2 expression Avp Aqp2 expression ---> water reabsorption Aqp2 translocation ---> water reabsorption protein kinase A (PKA) signaling pathway --+> Aqp2 translocation Aqp2 expression Aqp2 translocation Avpr2 --+> protein kinase A (PKA) signaling pathway Avpr1a --+> vasoconstriction Avp ---- Avpr2 Avp ---- Avpr1a water reabsorption second messengers generation [Ca] elevation behavioral effects
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Genes in Pathway:


show annotations for term's descendants           Sort by:
vasopressin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy6 adenylate cyclase 6 IMP
IDA
ISO
RGD PMID:18971210 PMID:15579502 PMID:18431594 RGD:2312654, RGD:2313211, RGD:2312656 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Akap7 A-kinase anchoring protein 7 IDA
ISO
RGD PMID:15037626 PMID:18431594 RGD:1303982, RGD:2312656 NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797
JBrowse link
G Aqp2 aquaporin 2 IDA
TAS
IMP
RGD PMID:15037626 PMID:18431594 PMID:15579502 PMID:18971210 RGD:1303982, RGD:2312656, RGD:2313211, RGD:2312654 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Avp arginine vasopressin TAS
ISO
IMP
RGD PMID:12942143 PMID:18431594 PMID:14624682 PMID:18299204 RGD:1358326, RGD:2312656, RGD:1579891, RGD:2301920 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpr1a arginine vasopressin receptor 1A TAS
ISO
RGD PMID:12942143 PMID:14624682 RGD:1358326, RGD:1579891 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO
TAS
IDA
RGD PMID:14624682 PMID:7624319 PMID:19047484 RGD:1579891, RGD:61542, RGD:2312649 NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792
JBrowse link
G Avpr2 arginine vasopressin receptor 2 TAS
ISO
IMP
RGD PMID:11882591 PMID:18431594 PMID:14624682 PMID:18971210 RGD:628560, RGD:2312656, RGD:1579891, RGD:2312654 NCBI chr  X:151,633,501...151,636,155
Ensembl chr  X:151,633,522...151,635,989
JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:14624682 RGD:1579891 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:14624682 RGD:1579891 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gnas GNAS complex locus IMP
ISO
IDA
RGD PMID:18971210 PMID:18431594 PMID:15579502 PMID:14624682 RGD:2312654, RGD:2312656, RGD:2313211, RGD:1579891 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Myo5b myosin Vb IMP
TAS
RGD PMID:17156409 PMID:18431594 RGD:2312655, RGD:2312656 NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745
JBrowse link
G Pde4d phosphodiesterase 4D ISO RGD PMID:18431594 RGD:2312656 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO RGD PMID:17156409 PMID:18431594 RGD:2312655, RGD:2312656 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
JBrowse link
G Rab11fip2 RAB11 family interacting protein 2 ISO RGD PMID:17156409 PMID:18431594 RGD:2312655, RGD:2312656 NCBI chr 1:258,950,535...259,094,555
Ensembl chr 1:258,923,873...259,093,752
JBrowse link
G Sipa1 signal-induced proliferation-associated 1 ISO RGD PMID:18431594 RGD:2312656 NCBI chr 1:202,938,532...202,950,672
Ensembl chr 1:202,938,580...202,950,591
JBrowse link
G Snap23 synaptosome associated protein 23 TAS RGD PMID:18431594 RGD:2312656 NCBI chr 3:107,514,088...107,546,177
Ensembl chr 3:107,514,131...107,544,320
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 ISO RGD PMID:18431594 RGD:2312656 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
JBrowse link
vasopressin signaling pathway via receptor type 1 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin ISO RGD PMID:14624682 RGD:1579891 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpr1a arginine vasopressin receptor 1A ISO RGD PMID:14624682 RGD:1579891 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:14624682 RGD:1579891 NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792
JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:14624682 RGD:1579891 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:14624682 RGD:1579891 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
vasopressin signaling pathway via receptor type 2 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy2 adenylate cyclase 2 ISO SMPDB SMP:00322 NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236
JBrowse link
G Adcy3 adenylate cyclase 3 IEA KEGG rno:04962 NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686
JBrowse link
G Adcy6 adenylate cyclase 6 ISO
IDA
IMP
IEA
KEGG
RGD
PMID:18431594 PMID:15579502 PMID:18971210 rno:04962, RGD:2312656, RGD:2313211, RGD:2312654 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adcy9 adenylate cyclase 9 IEA KEGG rno:04962 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
JBrowse link
G Akap7 A-kinase anchoring protein 7 ISO
IDA
RGD PMID:18431594 PMID:15037626 RGD:2312656, RGD:1303982 NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797
JBrowse link
G Aqp2 aquaporin 2 TAS
IDA
IMP
IEA
KEGG
RGD
PMID:18431594 PMID:15579502 PMID:18971210 PMID:15037626 rno:04962, RGD:2312656, RGD:2313211, RGD:2312654, RGD:1303982 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) IEA KEGG rno:04962 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
JBrowse link
G Aqp4 aquaporin 4 IEA KEGG rno:04962 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha IEA KEGG rno:04962 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta IEA KEGG rno:04962 NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
JBrowse link
G Avp arginine vasopressin TAS
ISO
IEA
KEGG
RGD
PMID:18431594 PMID:14624682 rno:04962, RGD:2312656, RGD:1579891 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpr2 arginine vasopressin receptor 2 TAS
ISO
IMP
IEA
KEGG
SMPDB
RGD
PMID:18431594 PMID:14624682 PMID:18971210 SMP:00322 rno:04962, RGD:2312656, RGD:1579891, RGD:2312654 NCBI chr  X:151,633,501...151,636,155
Ensembl chr  X:151,633,522...151,635,989
JBrowse link
G Creb1 cAMP responsive element binding protein 1 IEA KEGG rno:04962 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 IEA KEGG rno:04962 NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 IEA KEGG rno:04962 NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 IEA KEGG rno:04962 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048
JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 IEA KEGG rno:04962 NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932
JBrowse link
G Dctn1 dynactin subunit 1 IEA KEGG rno:04962 NCBI chr 4:115,671,024...115,703,824
Ensembl chr 4:115,661,638...115,703,815
JBrowse link
G Dctn2 dynactin subunit 2 IEA KEGG rno:04962 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543
JBrowse link
G Dctn4 dynactin subunit 4 IEA KEGG rno:04962 NCBI chr18:53,982,355...54,009,409
Ensembl chr18:53,982,358...54,009,399
JBrowse link
G Dctn5 dynactin subunit 5 IEA KEGG rno:04962 NCBI chr 1:176,689,176...176,705,907
Ensembl chr 1:176,689,156...176,705,906
JBrowse link
G Dctn6 dynactin subunit 6 IEA KEGG rno:04962 NCBI chr16:58,077,595...58,096,604
Ensembl chr16:58,077,585...58,096,968
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 IEA KEGG rno:04962 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 IEA KEGG rno:04962 NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149
JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 IEA KEGG rno:04962 NCBI chr 3:56,033,882...56,085,080
Ensembl chr 3:56,033,917...56,085,080
JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 IEA KEGG rno:04962 NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 IEA KEGG rno:04962 NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670
JBrowse link
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 IEA KEGG rno:04962 NCBI chr 8:4,189,067...4,412,183
Ensembl chr 8:4,189,257...4,412,183
JBrowse link
G Dync2li1 dynein cytoplasmic 2 light intermediate chain 1 IEA KEGG rno:04962 NCBI chr 6:9,992,537...10,025,355
Ensembl chr 6:9,992,541...10,025,336
JBrowse link
G Dynll1 dynein light chain LC8-type 1 IEA KEGG rno:04962 NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741
JBrowse link
G Dynll2 dynein light chain LC8-type 2 IEA KEGG rno:04962 NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805
JBrowse link
G Fshr follicle stimulating hormone receptor ISO SMPDB SMP:00322 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Gnas GNAS complex locus ISO
IDA
IMP
IEA
KEGG
SMPDB
RGD
PMID:18431594 PMID:14624682 PMID:15579502 PMID:18971210 SMP:00322 rno:04962, RGD:2312656, RGD:1579891, RGD:2313211, RGD:2312654 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnb1 G protein subunit beta 1 ISO SMPDB SMP:00322 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
JBrowse link
G Gng12 G protein subunit gamma 12 ISO SMPDB SMP:00322 NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
JBrowse link
G Myo5b myosin Vb TAS RGD PMID:18431594 RGD:2312656 NCBI chr18:68,038,759...68,341,568
Ensembl chr18:68,038,759...68,338,745
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase IEA KEGG rno:04962 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
JBrowse link
G Pde4d phosphodiesterase 4D ISO RGD PMID:18431594 RGD:2312656 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha IEA KEGG rno:04962 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta IEA
ISO
KEGG
SMPDB
SMP:00322 rno:04962 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Prkx protein kinase cAMP-dependent X-linked catalytic subunit IEA KEGG rno:04962 NCBI chr  X:41,823,349...41,866,844
Ensembl chr  X:41,823,355...41,866,669
JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO
IEA
KEGG
RGD
PMID:18431594 rno:04962, RGD:2312656 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
JBrowse link
G Rab11b RAB11B, member RAS oncogene family IEA KEGG rno:04962 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593
JBrowse link
G Rab11fip2 RAB11 family interacting protein 2 ISO RGD PMID:18431594 RGD:2312656 NCBI chr 1:258,950,535...259,094,555
Ensembl chr 1:258,923,873...259,093,752
JBrowse link
G Rab5a RAB5A, member RAS oncogene family IEA KEGG rno:04962 NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873
JBrowse link
G Rab5b RAB5B, member RAS oncogene family IEA KEGG rno:04962 NCBI chr 7:1,109,449...1,128,348
Ensembl chr 7:1,109,454...1,128,268
JBrowse link
G Rab5c RAB5C, member RAS oncogene family IEA KEGG rno:04962 NCBI chr10:85,642,553...85,666,142
Ensembl chr10:85,642,809...85,666,103
JBrowse link
G Sipa1 signal-induced proliferation-associated 1 ISO RGD PMID:18431594 RGD:2312656 NCBI chr 1:202,938,532...202,950,672
Ensembl chr 1:202,938,580...202,950,591
JBrowse link
G Snap23 synaptosome associated protein 23 TAS RGD PMID:18431594 RGD:2312656 NCBI chr 3:107,514,088...107,546,177
Ensembl chr 3:107,514,131...107,544,320
JBrowse link
G Stx4 syntaxin 4 IEA KEGG rno:04962 NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 ISO
IEA
KEGG
RGD
PMID:18431594 rno:04962, RGD:2312656 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwayprotein kinase A (PKA) signaling pathwayprotein kinase A (PKA) signaling pathway
Pathwayvasopressin signaling pathway via receptor type 2vasopressin signaling pathway via receptor type 2

Pathway Gene Annotations

Disease Annotations Associated with Genes in the vasopressin signaling pathway
Disease TermsGene Symbols
acrodysostosisPde4d
Acrodysostosis 2, with or without Hormone ResistancePde4d
acromegalyGnas
ACTH-independent macronodular adrenal hyperplasiaGnas
ACTH-independent macronodular adrenal hyperplasia 1Gnas
ACTH-secreting pituitary adenomaAvpr1b
acute kidney failureAvp , Avpr1a
Adrenal Gland NeoplasmsGnas
adrenocortical carcinomaGnas
adrenoleukodystrophyAvpr2
Aicardi-Goutieres Syndrome 3Sipa1
Albright's hereditary osteodystrophyGnas
AlbuminuriaGnaq
alcohol dependenceAvpr1b
Alzheimer's diseaseGnas
amnestic disorderAvp
amphetamine abuseMyo5b , Pde4d
amyotrophic lateral sclerosis type 8Gnas
Angina PectorisAvp
anxiety disorderAvpr1b
asthmaPde4d
autism spectrum disorderAvpr1a , Avpr1b
autistic disorderAvp , Avpr1a , Avpr1b , Avpr2
autosomal dominant hypocalcemia 2Gna11
B-Cell Chronic Lymphocytic LeukemiaGnas
Bardet-Biedl syndromeSipa1
Barth syndromeAvpr2
bipolar disorderAvpr1b
blood coagulation diseaseGnaq
Bloom syndromeRab11a , Snap23
brachydactylyGnas
brain edemaAvpr1a
Brain InjuriesAvpr1a , Pde4d
Breast NeoplasmsGnas
Cafe-au-Lait SpotsGnas
Cardiac ArrhythmiasAvp
CardiomegalyAvpr1a , Gnaq
cardiomyopathyAqp2 , Avp , Avpr2
Cardiovascular AbnormalitiesGnaq
cerebral creatine deficiency syndrome 1Avpr2
ChloracneRab11a
cholangiocarcinomaGnas
Chromosome Xq28 Duplication SyndromeAvpr2
chronic myeloid leukemiaSipa1
CLOVES syndromeGna11
colorectal cancerRab11a , Snap23
Colorectal NeoplasmsGnas
common variable immunodeficiencyVamp2
congenital adrenal hyperplasiaAvpr1a , Avpr2
congenital heart diseaseGna11 , Gnaq
congestive heart failureAvp , Avpr2 , Gnaq
Craniofacial AbnormalitiesGna11 , Gnaq
Crohn's diseaseMyo5b
Cushing SyndromeAvpr1b , Gnas
DehydrationAvp
depressive disorderAvpr1b , Pde4d
diabetes insipidusAqp2 , Avp
diabetic ketoacidosisAqp2
Diabetic NephropathiesAqp2
Diamond-Blackfan anemiaVamp2
diarrheaMyo5b
dilated cardiomyopathyGnaq
disease of cellular proliferationGnas
Drug OverdoseAvp
Duane retraction syndromeGnas
dyskeratosis congenitaAvpr2 , Vamp2
DysmenorrheaAvp
Emery-Dreifuss muscular dystrophyAvpr2
endocrine system diseaseGnas
esophageal atresiaPde4d , Sipa1
Experimental Diabetes MellitusAqp2 , Avp
Experimental Liver CirrhosisSnap23
familial adult myoclonic epilepsy 5Avpr1b
familial hypocalciuric hypercalcemia 2Gna11
familial multiple nevi flammeiGna11 , Gnaq
favismAvpr2
Febrile SeizuresAvp
focal segmental glomerulosclerosisGnaq
GallstonesGnas
gastric adenocarcinomaGnas
Gastrointestinal HemorrhageAvp
gastrointestinal stromal tumorAvpr1b
genetic diseaseAdcy6 , Aqp2 , Avp , Avpr2 , Gna11 , Gnaq , Gnas , Myo5b , Pde4d , Vamp2
glycogen storage disease VSipa1
Growth DisordersAvpr2
growth hormone secreting pituitary adenomaGnas
head and neck squamous cell carcinomaGnas
HemorrhageAvpr1a
hemorrhagic diseaseGnas
hepatocellular carcinomaGnas
hereditary spastic paraplegia 4Gnas
Heterotopic OssificationGnas
high grade gliomaSipa1
Huntington's disease-like 1Avp
hydronephrosisAqp2
HyperalgesiaAvp
hyperglycemiaAvp
hypertensionAqp2 , Avp , Avpr1a , Avpr2 , Gnas
Hypokalemic Periodic Paralysis, Type 1Avpr1b
HyponatremiaAvp
HypotensionAvp
HypoxiaGnas
immunodeficiency 33Avpr2
inappropriate ADH syndromeAvp
inflammatory bowel disease 1Myo5b
inherited metabolic disorderMyo5b
Inosine Triphosphatase DeficiencyAvp
Insulin ResistanceGnas
intellectual disabilityGnas , Myo5b , Pde4d , Rab11a , Sipa1
intestinal diseaseMyo5b
ischemiaAvp
Kabuki syndromeAdcy6
Klippel-Trenaunay syndromeGnaq
Lethal Congenital Contracture Syndrome 8Adcy6
Li-Fraumeni syndromeVamp2
Liver NeoplasmsMyo5b
lung adenocarcinomaGnas
lung non-small cell carcinomaGnaq
lung small cell carcinomaAvp
McCune Albright syndromeGnas
melanomaGna11 , Gnaq , Gnas , Sipa1
Memory DisordersAvp
Metabolic Bone DiseasesGnas
microcephalyRab11a
microvillus inclusion diseaseMyo5b
mood disorderAvpr1b
myocardial infarctionAvpr1a
Myocardial IschemiaSnap23
nemaline myopathy 6Rab11a
nephrogenic diabetes insipidusAqp2 , Avpr2
nephrogenic diabetes insipidus type 2Aqp2
nephrogenic syndrome of inappropriate antidiuresisAvpr2
Neu-Laxova syndrome 2Gnaq
neuroblastomaGnas
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND AUTISTIC FEATURES WITH OR WITHOUT HYPERKINETIC MOVEMENTSVamp2
Neurodevelopmental DisordersGna11 , Pde4d , Vamp2
neurohypophyseal diabetes insipidusAvp
neuronal ceroid lipofuscinosisRab11a
obesityGnas
OliguriaAvpr2
Orthostatic HypotensionGnas
PainAvp
pancreatic adenocarcinomaGnas
pancreatic cancerGnas
pantothenate kinase-associated neurodegenerationAvp
paraplegiaAvpr2
Parasitic Liver DiseasesGnas
parathyroid carcinomaAvpr1b
periventricular nodular heterotopiaAvpr2
pituitary adenomaAvpr1b
pituitary adenoma 3Gnas
Pituitary NeoplasmsGnas
polycystic kidney diseaseGnas
polycystic ovary syndromeGnas
PolyuriaAqp2 , Avp
Port-Wine StainGnaq
portal hypertensionAvp , Avpr1a
Precocious PubertyGnas
primary hyperaldosteronismGnas
primary microcephalyRab11a
Progressive Familial Intrahepatic Cholestasis 10Myo5b
progressive myoclonus epilepsy 9Gna11
progressive osseous heteroplasiaGnas
Prostatic NeoplasmsPde4d
pseudohypoaldosteronismGnas
pseudohypoparathyroidismGnas
pseudohypoparathyroidism type IBGnas
Pseudohypoparathyroidism Type ICGnas
pseudopseudohypoparathyroidismGnas
psychotic disorderAvp
RASopathyGna11
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsSipa1
renovascular hypertensionAvpr1a
Respiration DisordersGnas
schizophreniaAvp , Avpr1a , Gnas
severe congenital encephalopathy due to MECP2 mutationAvpr2
sex cord-gonadal stromal tumorGnas
ShockAvp
Shy-Drager SyndromeAvp
skin melanomaGna11 , Gnas
Spinal Cord InjuriesPde4d
SplenomegalyAvpr2
StrokeAvp , Pde4d
Sturge-Weber syndromeGnaq
substance-related disorderAkap7
syndromic X-linked intellectual disability Lubs typeAvpr2
TachycardiaGnas
temporal lobe epilepsyAvp
transient cerebral ischemiaPde4d
type 1 diabetes mellitusAvp
type 2 diabetes mellitusAvp
ureteral obstructionAdcy6 , Avpr2
Uterine Cervical NeoplasmsGnas
uveal melanomaGna11 , Gnaq
vascular dementiaAvp
very long chain acyl-CoA dehydrogenase deficiencyVamp2
withdrawal disorderAvp , Gnas
X-linked monogenic diseaseAvpr2
X-linked nephrogenic diabetes insipidusAqp2 , Avpr2
Pathway Annotations Associated with Genes in the vasopressin signaling pathway
Pathway TermsGene Symbols
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein familyGna11 , Gnaq
adenine phoshoribosyltransferase deficiency pathwayPde4d
adenosine monophosphate deaminase deficiency pathwayPde4d
adenosine signaling pathwayGnas
adenylosuccinate lyase deficiency pathwayPde4d
AICA-ribosuria pathwayPde4d
Alzheimer's disease pathwayGnaq
amiloride pharmacodynamics pathwayAqp2
angiotensin II signaling pathway via AT1 receptorGna11 , Gnaq
autophagy pathwayRab11a
azathioprine pharmacodynamics pathwayPde4d
bendroflumethiazide pharmacodynamics pathwayAqp2
bile acid transport pathwayAdcy6 , Gnas
bumetanide pharmacodynamics pathwayAqp2
calcium/calcium-mediated signaling pathwayAvpr1a , Avpr1b , Gna11 , Gnaq , Gnas
Chagas disease pathwayGna11 , Gnaq , Gnas
chemokine mediated signaling pathwayAdcy6
chlorothiazide pharmacodynamics pathwayAqp2
chlorthalidone pharmacodynamics pathwayAqp2
cilostazol pharmacodynamics pathwayPde4d
corticotropin-releasing hormone signaling pathwayGnas
cystinuria pathwayAqp2
dilated cardiomyopathy pathwayAdcy6 , Gnas
dipyridamole pharmacodyamics pathwayPde4d
dopamine signaling pathway via D1 family of receptorsGnas
eicosanoid signaling pathwayGna11 , Gnaq , Rab11a
endocytosis pathwayRab11a , Rab11fip2
endothelin signaling pathwayAdcy6 , Gna11 , Gnaq
Entamoebiasis pathwayGna11 , Gnaq , Gnas
epinephrine signaling pathway via adrenergic receptor betaGnas
eplerenone pharmacodynamics pathwayAqp2
etacrynic acid pharmacodynamics pathwayAqp2
follicle-stimulating hormone signaling pathwayGnas
furosemide pharmacodynamics pathwayAqp2
G protein mediated signaling pathway via Galphaq familyAvpr1a , Avpr1b , Gna11 , Gnaq
G protein mediated signaling pathway via Galphas familyAdcy6 , Avpr1b , Avpr2 , Gnas
glucagon signaling pathwayAdcy6 , Gnas
glutamate signaling pathwayAdcy6 , Gnaq , Gnas
gonadotropin-releasing hormone signaling pathwayAdcy6 , Gna11 , Gnaq , Gnas
Hartnup disease pathwayAqp2
histamine signaling pathway, immunologicalGnas
Huntington's disease pathwayGnaq
hydrochlorothiazide pharmacodynamics pathwayAqp2
hydroflumethiazide pharmacodynamics pathwayAqp2
iminoglycinuria pathwayAqp2
insulin responsive facilitative sugar transporter mediated glucose transport pathwayMyo5b , Rab11a , Snap23 , Vamp2
insulin secretion pathwayVamp2
Kelley-Seegmiller syndrome pathwayPde4d
Lesch-Nyhan syndrome pathwayPde4d
long term depressionGna11 , Gnaq , Gnas
long term potentiationGnaq
luteinizing hormone signaling pathwayGnas
lysinuric protein intolerance pathwayAqp2
melanocortin system pathwayGnas
mercaptopurine pharmacodynamics pathwayPde4d
metolazone pharmacodynamics pathwayAqp2
molybdenum cofactor deficiency pathwayPde4d
Notch signaling pathwayRab11a
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1Gnaq
orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2Gnaq
oxytocin signaling pathwayGna11 , Gnaq
platelet-derived growth factor signaling pathwaySipa1
prostaglandin D2 signaling pathwayGnas
prostaglandin I2 signaling pathwayGnas
protein kinase A (PKA) signaling pathwayAdcy6 , Akap7 , Pde4d
purine metabolic pathwayAdcy6 , Pde4d
purine nucleoside phosphorylase deficiency pathwayPde4d
Rab family mediated signaling pathwayRab11a
serotonin signaling pathway via receptors engaging G alphas protein familyGnas
sleeping sickness pathwayGnaq
sphingosine 1-phosphate signaling pathwayGna11 , Gnaq
spironolactone pharmacodynamics pathwayAqp2
tioguanine pharmacodynamics pathwayPde4d
torasemide pharmacodynamics pathwayAqp2
triamterene pharmacodynamics pathwayAqp2
trichlormethiazide pharmacodynamics pathwayAqp2
vasopressin signaling pathwayAdcy6 , Akap7 , Aqp2 , Avp , Avpr1a , Avpr1b , Avpr2 , Gna11 , Gnaq , Gnas , Myo5b , Pde4d , Rab11a , Rab11fip2 , Sipa1 , Snap23 , Vamp2
vasopressin signaling pathway via receptor type 1Avp , Avpr1a , Avpr1b , Gna11 , Gnaq
vasopressin signaling pathway via receptor type 2Adcy6 , Akap7 , Aqp2 , Avp , Avpr2 , Gnas , Myo5b , Pde4d , Rab11a , Rab11fip2 , Sipa1 , Snap23 , Vamp2
water transport pathwayAqp2
xanthinuria type I pathwayPde4d
xanthinuria pathwayPde4d
xanthinuria type II pathwayPde4d
Phenotype Annotations Associated with Genes in the vasopressin signaling pathway
Phenotype TermsGene Symbols
polyuriaAvp

References Associated with the vasopressin signaling pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: