GLUCAGON SIGNALING PATHWAY (PW:0000676)

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Description

In the pancreatic alpha cells of the islets of Langerhans, glucagon is processed from the precursor proglucagon by the prohormone convertase 2 (PC-2). In the intestinal L cells and brainstem neurons, prohormone convertase 1 (PC-1) processes the same precursor molecule into several peptides distinct from glucagon, including the glucagon-like peptides (GLP) 1 and 2. The resulting peptides bind to cognate G-protein coupled receptors (GPCR) to elicit distinct responses. When the levels of circulatin

Pathway Diagram:

Ariadne Genomics Inc. expression of gluconeogenic genes gluconeogenesis pathway glycogen degradation pathway glycogen biosynthetic pathway glycolysis pathway protein kinase A (PKA) signaling pathway G protein mediated signaling pathway via Galphas family Adcy6 Adcy5 protein kinase A (PKA) signaling pathway --+> expression of gluconeogenic genes reduced F2, 6P levels protein kinase A (PKA) signaling pathway --+> gluconeogenesis pathway protein kinase A (PKA) signaling pathway ---| glycolysis pathway ATP ---> cAMP Gnas --+> Adcy6 Gnas --+> Adcy5 cAMP --+> protein kinase A (PKA) signaling pathway cAMP ATP Gnas Gcg Gcgr ---- Gnas Gcg ---- Gcgr protein kinase A (PKA) signaling pathway --+> glycogen degradation pathway protein kinase A (PKA) signaling pathway ---| glycogen biosynthetic pathway Gcgr
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Genes in Pathway:

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glucagon signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcy5 adenylate cyclase 5 JBrowse link 11 68,695,839 68,842,452 RGD:2315004
RGD:2315006
G Adcy6 adenylate cyclase 6 JBrowse link 7 140,270,678 140,291,722 RGD:2315004
RGD:2315006
G Gcg glucagon JBrowse link 3 48,442,635 48,451,650 RGD:2315015
G Gcgr glucagon receptor JBrowse link 10 109,707,863 109,716,253 RGD:1625210
RGD:2315004
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:1625210
RGD:2315004

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Pathwaygluconeogenesis pathway
Pathwayglycogen biosynthetic pathway
Pathwayglycolysis pathway
Pathwayglycogen degradation pathway
PathwayG protein mediated signaling via Galphas familyBased on sequence similarity, the Galpha genes have been grouped into four classes. Effectors of activated Galphas are adenylyl cyclases that catalyzed the formation of cAMP
Small MoleculecAMPcAMP binding to the PKA complex leads to dissociation of the catalytic subunits
Pathwayprotein kinase A (PKA) signaling pathwayProtein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the second messenger cAMP signal

Pathway Gene Annotations

Disease Annotations Associated with Genes in the glucagon signaling pathway
Disease TermsGene Symbols
Aberrant Crypt FociGcg
acromegalyGnas
ACTH-Independent Macronodular Adrenal Hyperplasia 1Gcgr , Gnas
ACTH-secreting pituitary adenomaGnas
adrenal carcinomaGnas
Adrenal Gland NeoplasmsGnas
adrenocortical carcinomaGnas
Albright's hereditary osteodystrophyGnas
Alzheimer's diseaseGcg , Gnas
Animal Mammary NeoplasmsAdcy5
AnorexiaGcg
autistic disorderGcg
B-Cell Chronic Lymphocytic LeukemiaGnas
Birth WeightAdcy5
brachydactylyGnas
BradycardiaGcg
breast cancerGnas
Breast NeoplasmsGnas
Cafe-au-Lait SpotsGnas
cancerGnas
carcinomaAdcy5
cardiomyopathyAdcy5
CatalepsyGcg
cholangiocarcinomaGnas
Cognitive DysfunctionGnas
colitisGcg
Colonic NeoplasmsGcg
Colorectal NeoplasmsGnas
ComaGcg
congestive heart failureGcg
constipationGcg
Cushing syndromeGnas
Diabetes Mellitus, Experimental Gcg
disease of cellular proliferationGnas
DysarthriaAdcy5
endocrine system diseaseGnas
Familial Dyskinesia with Facial MyokymiaAdcy5
familial hyperlipidemiaGcg
FibrosisAdcy5
GallstonesGnas
gastric adenocarcinomaGnas
genetic diseaseAdcy5 , Gnas
growth hormone secreting pituitary adenomaGnas
head and neck squamous cell carcinomaGnas
heart diseaseGcg
hemorrhagic diseaseGnas
hepatocellular carcinomaGnas
hyperglycemiaGcg
hyperinsulinismGcg
HyperkinesisGcg
hypertensionAdcy5 , Gcg , Gnas
HypocalcemiaGnas
HypotensionGcg
Hypotension, OrthostaticGnas
HypothermiaGcg
HypoxiaGnas
Insulin ResistanceGnas
intellectual disabilityGnas
Lethal Congenital Contracture Syndrome 8Adcy6
liver cancerGnas
lung adenocarcinomaGnas
Mammary Neoplasms, ExperimentalAdcy5
McCune Albright syndromeGnas
melanomaGnas
Metabolic Bone DiseasesGnas
Multiple AbnormalitiesAdcy5 , Gnas
Myocardial Reperfusion InjuryGcg
neuroblastomaGnas
Neurodevelopmental DisordersAdcy5
obesityGcg , Gnas
Ossification, HeterotopicGnas
osteoporosisAdcy5
pancreatic adenocarcinomaGnas
pancreatic cancerGnas
Parasitic Liver DiseasesGnas
Parkinson's diseaseAdcy5
Parkinsonian DisordersAdcy5
PITUITARY ADENOMA 3, MULTIPLE TYPESGnas
Pituitary NeoplasmsGnas
pituitary-dependent Cushing's diseaseGnas
PoisoningGcg
polycystic ovary syndromeGnas
Precocious PubertyGnas
prediabetes syndromeGcg
primary hyperaldosteronismGnas
Progressive Osseous HeteroplasiaGnas
Prolonged Bleeding Time, Brachydactyly, and Mental RetardationGnas
pseudohypoaldosteronismGnas
pseudohypoparathyroidismGnas
Pseudohypoparathyroidism Type 1CGnas
pseudohypoparathyroidism type IBGnas
pseudopseudohypoparathyroidismGnas
Respiration DisordersGnas
schizophreniaGnas
sex cord-gonadal stromal tumorGnas
Smith-Magenis syndromeGcgr
SpasmGcg
stomach diseaseGcg
TachycardiaGcg , Gnas
Tachycardia, SinusGcg
TetanyGnas
type 2 diabetes mellitusAdcy5 , Gcg , Gcgr
ureteral obstructionAdcy6
Uterine Cervical NeoplasmsGnas
vascular diseaseGcg
Ventricular Dysfunction, LeftAdcy5
withdrawal disorderGnas
Pathway Annotations Associated with Genes in the glucagon signaling pathway

References Associated with the glucagon signaling pathway:

Ontology Path Diagram:

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