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View Ontology Report


Protein kinase A (PKA) signaling is a widely used intracellular pathway and the major route for channeling the second messenger cAMP signal. Ligand activated G-protein coupled receptors that transduce the signal via the Gs alpha subunit of the heterotrimeric G protein lead to activation of the adenylyl cyclase enzymes (AC) that catalyze the formation of cAMP from ATP. GTP-bound Gs binds to AC and increases the affinity between the C1 and C2 cytoplasmic domains whose interface constitutes t

Pathway Diagram:

Elsevier Inc. GPCRs upstream PKA Gnas ---- GPCRs upstream PKA Gnas AC members G protein mediated signaling pathway via Galphas family Pka complex ---> cytoskeleton dynamics ATP ---> cAMP nuclear dynamics cytoskeleton dynamics Pka complex Gnas --+> AC members cAMP --+> Pka complex regulation of ion channels cardiovascular function Pka complex ---> gene expression Akaps Pdes cAMP ATP metabolism exocytosis gene expression Pka complex ---> nuclear dynamics Pdes ---| cAMP regulation of neuroreceptors Pka complex ---> metabolism Pka complex ---> regulation of neuroreceptors Pka complex ---> cardiovascular function Pka complex ---> regulation of ion channels Pka complex ---> exocytosis

Genes in Pathway:

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protein kinase A (PKA) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 ISO RGD PMID:18948702 RGD:2312469 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Adcy10 adenylate cyclase 10 ISO RGD PMID:18948702 RGD:2312469 NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951
JBrowse link
G Adcy2 adenylate cyclase 2 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 1:34,375,639...34,822,237
Ensembl chr 1:34,375,895...34,822,236
JBrowse link
G Adcy3 adenylate cyclase 3 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686
JBrowse link
G Adcy4 adenylate cyclase 4 ISO RGD PMID:18948702 RGD:2312469 NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108
JBrowse link
G Adcy5 adenylate cyclase 5 ISO RGD PMID:18948702 RGD:2312469 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Adcy6 adenylate cyclase 6 ISO
RGD PMID:18948702 PMID:15579502 RGD:2312469, RGD:2313211 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adcy7 adenylate cyclase 7 ISO RGD PMID:18948702 RGD:2312469 NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311
JBrowse link
G Adcy8 adenylate cyclase 8 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
JBrowse link
G Adcy9 adenylate cyclase 9 ISO RGD PMID:18948702 RGD:2312469 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
JBrowse link
G Akap1 A-kinase anchoring protein 1 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896
JBrowse link
G Akap10 A-kinase anchoring protein 10 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr10:46,545,464...46,608,768
Ensembl chr10:46,551,532...46,608,769
JBrowse link
G Akap11 A-kinase anchoring protein 11 ISO
RGD PMID:14715913 PMID:19319965 PMID:18385542 RGD:2312475, RGD:2312477, RGD:2312637 NCBI chr15:53,911,635...53,956,138
Ensembl chr15:53,911,657...53,941,605
JBrowse link
G Akap12 A-kinase anchoring protein 12 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
JBrowse link
G Akap13 A-kinase anchoring protein 13 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646
JBrowse link
G Akap14 A-kinase anchoring protein 14 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr  X:116,395,512...116,410,697
Ensembl chr  X:116,395,516...116,410,697
JBrowse link
G Akap2 A-kinase anchoring protein 2 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 5:72,536,986...72,648,524
Ensembl chr 5:72,181,718...72,648,524
JBrowse link
G Akap3 A-kinase anchoring protein 3 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 4:159,688,049...159,714,067
Ensembl chr 4:159,699,289...159,713,903
JBrowse link
G Akap4 A-kinase anchoring protein 4 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr  X:15,435,391...15,445,684
Ensembl chr  X:15,435,410...15,445,684
JBrowse link
G Akap5 A-kinase anchoring protein 5 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
JBrowse link
G Akap6 A-kinase anchoring protein 6 ISO
RGD PMID:14715913 PMID:19319965 PMID:11296225 RGD:2312475, RGD:2312477, RGD:68716 NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738
JBrowse link
G Akap7 A-kinase anchoring protein 7 ISO
RGD PMID:14715913 PMID:19319965 PMID:17901878 RGD:2312475, RGD:2312477, RGD:2312630 NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797
JBrowse link
G Akap8 A-kinase anchoring protein 8 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 7:11,316,224...11,332,523
Ensembl chr 7:11,316,228...11,332,399
JBrowse link
G Akap9 A-kinase anchoring protein 9 ISO RGD PMID:14715913 PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:15911134 RGD:5131271 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
JBrowse link
G Ezr ezrin ISO RGD PMID:14715913 RGD:2312475 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G Pde10a phosphodiesterase 10A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pde11a phosphodiesterase 11A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158
JBrowse link
G Pde1a phosphodiesterase 1A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
JBrowse link
G Pde1b phosphodiesterase 1B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
JBrowse link
G Pde1c phosphodiesterase 1C ISO RGD PMID:17376027 RGD:2312479 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219
JBrowse link
G Pde2a phosphodiesterase 2A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
JBrowse link
G Pde3a phosphodiesterase 3A ISO RGD PMID:17376027 PMID:17376027 RGD:2312479, RGD:2312479 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274
JBrowse link
G Pde3b phosphodiesterase 3B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334
JBrowse link
G Pde4a phosphodiesterase 4A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pde4b phosphodiesterase 4B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pde4c phosphodiesterase 4C ISO RGD PMID:17376027 RGD:2312479 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640
JBrowse link
G Pde4d phosphodiesterase 4D ISO
RGD PMID:17376027 PMID:11296225 RGD:2312479, RGD:68716 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Pde7a phosphodiesterase 7A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
JBrowse link
G Pde7b phosphodiesterase 7B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900
JBrowse link
G Pde8a phosphodiesterase 8A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
JBrowse link
G Pde8b phosphodiesterase 8B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO RGD PMID:14715913 RGD:2312475 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta ISO RGD PMID:14715913 RGD:2312475 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO RGD PMID:14715913 RGD:2312475 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041
JBrowse link
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta ISO RGD PMID:14715913 RGD:2312475 NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942
JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha ISO RGD PMID:14715913 RGD:2312475 NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta ISO RGD PMID:14715913 RGD:2312475 NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassAkapsA Kinase Anchoring Protein family members
Functional ClassACadenylyl (adenylate) cyclase family members
Functional ClassPdesphosphopdiesterase family members
ComplexPka complexthe regulatory and catalytic subunits of serine/threonine protein kinase A (PKA) complex

Pathway Gene Annotations

Disease Annotations Associated with Genes in the protein kinase A (PKA) signaling pathway
Disease TermsGene Symbols
3-methylglutaconic aciduria type 7bPde2a
3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndromeEzr
acrodysostosisPde4d , Prkar1a
Acrodysostosis 1, with or without Hormone ResistancePrkar1a
Acrodysostosis 2, with or without Hormone ResistancePde4d
ACTH-independent macronodular adrenal hyperplasia 1Prkaca
Acute Lung InjuryAkap12
acute myeloid leukemiaAdcy7 , Pde4b
acute promyelocytic leukemiaPrkar1a
Adrenal Cortex NeoplasmsPrkar1a
adrenal cortical adenomaPrkaca , Prkacb
Adrenal Gland NeoplasmsPrkaca
Aicardi-Goutieres Syndrome 1Prkar2a
alcohol use disorderPde4b
Alzheimer's diseaseAkap5 , Pde2a
amelogenesis imperfecta type 1GPrkar1a
amphetamine abusePde4b , Pde4d
Animal Mammary NeoplasmsAdcy5 , Ezr
anorexia nervosaAkap6
anxiety disorderCrhr2
apparent mineralocorticoid excess syndromePrkar1a
arrhythmogenic right ventricular cardiomyopathyAkap9
arrhythmogenic right ventricular dysplasia 10Prkar1a
Arsenic PoisoningAkap9 , Pde4b
asthmaAdcy2 , Crhr2 , Pde4b , Pde4d
atrial fibrillationAkap6 , Akap9
autistic disorderAkap10 , Akap14 , Akap4 , Pde4a , Pde4b
autosomal dominant nonsyndromic deafnessPde1c
autosomal dominant nonsyndromic deafness 74Pde1c
autosomal recessive nonsyndromic deafness 44Adcy1
Bardet-Biedl syndrome 16Pde11a
basal ganglia diseasePde8b
biliary tract benign neoplasmPrkacb
bipolar disorderAdcy2 , Akap11 , Pde4b
Birth WeightAdcy5
Bloom syndromeAkap13 , Pde8a
Brain InjuriesPde4d
brain ischemiaAkap1 , Akap12 , Prkaca , Prkacb
Brain-Lung-Thyroid SyndromeAdcy4 , Akap6
Breast NeoplasmsAkap12 , Pde2a
Brugada syndrome 1Akap9
carcinomaAdcy5 , Ezr
cardiac arrestAkap9
Cardiac ArrhythmiasAkap9
Cardioacrofacial Dysplasia 1Prkaca
Cardioacrofacial Dysplasia 2Prkacb
CardiomegalyAdcy10 , Akap5
cardiomyopathyAdcy5 , Akap9 , Pde2a
Carney complexPrkar1a
catecholaminergic polymorphic ventricular tachycardiaAkap9
cerebral cavernous malformationAkap9
Charcot-Marie-Tooth disease type 2Crhr2
cholangiocarcinomaPrkaca , Prkacb
choreatic diseasePde2a
chronic kidney diseaseAkap12
Cocaine-Related DisordersCrhr2
Coffin-Siris syndrome 6Pde4d
colorectal cancerAkap13 , Akap9 , Pde8a
colorectal carcinomaAkap12
congenital adrenal hyperplasiaPde8b , Prkar1a
congenital disorder of glycosylation type IImAkap4
congenital heart diseaseAdcy9
congestive heart failureAkap6 , Akap9 , Prkaca , Prkar2a , Prkar2b
COVID-19Akap12 , Akap5
Cushing SyndromePrkacb , Prkar1a
Danon diseaseAkap14
depressive disorderCrhr2 , Pde4d
developmental coordination disorderAkap5
Developmental DisabilitiesPde10a
diabetic angiopathyAdcy3 , Adcy8
dilated cardiomyopathyAkap9
distal muscular dystrophy 4Adcy5
Duchenne muscular dystrophyAkap6
Dyskinesia with Orofacial InvolvementAdcy5
Dyskinesia with Orofacial Involvement, Autosomal DominantAdcy5
Dyskinesia with Orofacial Involvement, Autosomal RecessiveAdcy5
Ehlers-Danlos syndrome kyphoscoliotic type 2Crhr2
episodic ataxia type 1Akap3
esophageal atresiaPde4d
Esophageal NeoplasmsAkap13
Experimental Autoimmune EncephalomyelitisAkap12
Experimental Diabetes MellitusPde3a
Experimental Liver CirrhosisEzr
Experimental Mammary NeoplasmsAdcy5 , Ezr
Familial Atrial MyxomaPrkar1a
familial Behcet-like autoinflammatory syndromePde7b
familial hypocalciuric hypercalcemiaAdcy5
Familial Thoracic Aortic Aneurysm 7Adcy5
Familial Ventricular TachycardiaAkap9
Fetal HypoxiaCrhr2
fibrolamellar carcinomaPrkaca
functional colonic diseaseCrhr2
gastrointestinal stromal tumorAdcy10
genetic diseaseAdcy1 , Adcy10 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9 , Akap1 , Akap10 , Akap11 , Akap12 , Akap13 , Akap14 , Akap2 , Akap3 , Akap4 , Akap5 , Akap6 , Akap7 , Akap8 , Akap9 , Crhr2 , Ezr , Pde10a , Pde11a , Pde1a , Pde1b , Pde1c , Pde2a , Pde3a , Pde3b , Pde4a , Pde4b , Pde4c , Pde4d , Pde7a , Pde7b , Pde8a , Pde8b , Prkaca , Prkacb , Prkar1a , Prkar1b , Prkar2a , Prkar2b
granulosa cell tumorPrkar2b
Greig cephalopolysyndactyly syndromeAdcy9
Hereditary Neoplastic SyndromesPrkar1a
Hermansky-Pudlak syndrome 2Pde8b
Hypercalciuria, Absorptive, 2Adcy10
HyperkinesisAdcy1 , Adcy8
Hyperphosphatemic Familial Tumoral Calcinosis 1Akap3
hypertensionAdcy5 , Crhr2 , Prkar1b
hypertension and brachydactyly syndromePde3a
hypertrophic cardiomyopathyAkap6 , Akap9
Hypoglossal Nerve InjuriesPrkaca , Prkacb
idiopathic generalized epilepsyAdcy9
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndromeAkap4
immunodeficiency 25Adcy10
immunodeficiency 27APde7b
Infantile-Onset Limb and Orofacial DyskinesiaPde10a
Insulin ResistancePrkar1a
intellectual disabilityAkap6 , Pde2a , Pde3b , Pde4b , Pde4d
irritable bowel syndromeCrhr2
Joubert syndromeAkap1
juvenile myelomonocytic leukemiaAkap12
juvenile rheumatoid arthritisAdcy7
Kohlschutter-Tonz syndromeAdcy9
language disorderAdcy5
learning disabilityPde1b
Left Ventricular HypertrophyCrhr2 , Pde1a , Pde2a , Pde3a
Lethal Congenital Contracture Syndrome 8Adcy6
liver cirrhosisAkap12
long QT syndromeAkap8 , Akap9
long QT syndrome 1Akap9
long QT syndrome 11Akap9
long QT syndrome 2Akap9
lung diseaseCrhr2
lung small cell carcinomaAdcy1
lymphoproliferative syndrome 2Akap3
lysinuric protein intoleranceAdcy4
major depressive disorderAdcy3
male infertilityAdcy10 , Akap4
Meckel Syndrome 9Akap10
Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1Pde4c
Memory DisordersAkap5
mixed fibrolamellar hepatocellular carcinomaPrkaca
mood disorderAdcy8 , Adcy9
morbid obesityAdcy3
Mouth NeoplasmsAkap11
Muscle HypotoniaPde10a , Pde2a
Muscle RigidityPde8b
muscular atrophyCrhr2 , Prkar1a
myocardial infarctionPde3a
Myocardial IschemiaPde4b
Neoplasm MetastasisEzr
nephronophthisis 14Adcy7
Nerve DegenerationPde8b
neural tube defectPrkar1a
neurodegeneration with brain iron accumulation 5Akap4
neurodegenerative diseasePde8b
Neurodevelopmental DisordersAdcy5 , Adcy9 , Pde4d , Pde8b , Prkaca , Prkar1b
non-alcoholic fatty liver diseasePrkaca
obesityAdcy3 , Akap1 , Pde3a , Prkar1a , Prkar2b
Optic Nerve InjuriesAdcy10
ovary epithelial cancerAkap6
parathyroid carcinomaAdcy10
Parkinson's diseaseAdcy5
pleomorphic xanthoastrocytomaAdcy1 , Akap9 , Crhr2 , Pde1c , Prkar2b
Pneumococcal PneumoniaCrhr2
polycystic ovary syndromePde3b
Potocki-Lupski syndromeAkap10
primary ciliary dyskinesiaPrkar1b
primary ciliary dyskinesia 18Prkar1b
primary ciliary dyskinesia 32Ezr
Primary Lymphedema with MyelodysplasiaAdcy5
primary pigmented nodular adrenocortical diseasePrkar1a
Primary Pigmented Nodular Adrenocortical Disease, 1Prkar1a
Primary Pigmented Nodular Adrenocortical Disease, 2Pde11a
Primary Pigmented Nodular Adrenocortical Disease, 3Pde8b
Primary Pigmented Nodular Adrenocortical Disease, 4Prkaca
Progressive Microcephaly with Seizures and Cerebral and Cerebellar AtrophyPrkar2a
prostate cancerAkap1 , Akap2 , Pde1c , Pde3a , Pde7b
Prostatic NeoplasmsAkap13 , Ezr , Pde4d , Prkacb
pulmonary hypertensionPde3a
renal cell carcinomaAkap13
restrictive cardiomyopathyAkap9
Romano-Ward SyndromeAkap9
Rubinstein-Taybi syndromeAdcy9
schizophreniaAdcy7 , Akap11 , Pde11a , Pde4b
sciatic neuropathyAkap12
short-rib thoracic dysplasia 9 with or without polydactylyAdcy9
skin diseaseAkap9 , Pde4b
Specific Granule DeficiencyAdcy4
Spermatogenic Failure 82Akap3
split hand-foot malformation 5Pde11a
Stocco Dos Santos type X-linked intellectual disabilityAkap4
Striatal Degeneration, Autosomal DominantPde8b
Striatal Degeneration, Autosomal Dominant 1Pde8b
Striatal Degeneration, Autosomal Dominant 2Pde10a
StrokePde3a , Pde4d
substance-related disorderAkap7 , Pde1c
Sudden Cardiac DeathAkap9
sudden infant death syndromeAkap10
syndromic X-linked intellectual disability 14Akap14
syndromic X-linked intellectual disability Cabezas typeAkap14
syndromic X-linked intellectual disability Lubs typeAkap14 , Akap4
Tatton-Brown-Rahman syndromeAdcy3
thyroid gland follicular carcinomaPrkar1a
transient cerebral ischemiaPde4d
traumatic brain injuryPde10a
type 2 diabetes mellitusAdcy5
ulcerative colitisAdcy7
ureteral obstructionAdcy6
Usher Syndrome Type 4Prkar1a
Ventricular Dysfunction, LeftAdcy5
Ventricular FibrillationAkap9
Ventricular TachycardiaAkap9
visual epilepsyPde4a
Weight GainAkap2
withdrawal disorderAdcy1 , Adcy8
Wolff-Parkinson-White syndromeAkap9
X-linked epilepsy with variable learning disabilities and behavior disordersAkap4
X-linked severe congenital neutropeniaAkap4
Pathway Annotations Associated with Genes in the protein kinase A (PKA) signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayPrkaca , Prkar1a
adenine phoshoribosyltransferase deficiency pathwayAdcy10 , Pde10a , Pde4d
adenosine monophosphate deaminase deficiency pathwayAdcy10 , Pde10a , Pde4d
adenosine signaling pathwayAdcy2 , Prkacb
adenylosuccinate lyase deficiency pathwayAdcy10 , Pde10a , Pde4d
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayPrkaca , Prkar1a
AICA-ribosuria pathwayAdcy10 , Pde10a , Pde4d
amiodarone pharmacodynamics pathwayPrkaca , Prkar1a
amlodipine pharmacodynamics pathwayPrkaca , Prkar1a
apoptotic cell death pathwayPrkaca , Prkacb , Prkar1a , Prkar2a , Prkar2b
atenolol pharmacodynamics pathwayPrkaca , Prkar1a
azathioprine pharmacodynamics pathwayAdcy10 , Pde10a , Pde4d
betaxolol pharmacodynamics pathwayPrkaca , Prkar1a
bile acid transport pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9 , Prkaca , Prkacb
bisoprolol pharmacodynamics pathwayPrkaca , Prkar1a
bupranolol drug pathwayPrkaca , Prkar1a
bupranolol pharmacodynamics pathwayPrkaca , Prkar1a
calcium/calcium-mediated signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy7 , Adcy8 , Adcy9 , Pde1a , Pde1b , Pde1c , Prkaca , Prkacb
carvedilol pharmacodynamics pathwayPrkaca , Prkar1a
Chagas disease pathwayAdcy1
chemokine mediated signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9 , Prkaca , Prkacb
cilostazol pharmacodynamics pathwayPde4d
corticotropin-releasing hormone signaling pathwayCrhr2
dilated cardiomyopathy pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9 , Prkaca , Prkacb
diltiazem pharmacodynamics pathwayPrkaca , Prkar1a
dipyridamole pharmacodyamics pathwayPde4d
disopyramide pharmacodynamics pathwayPrkaca , Prkar1a
dobutamine pharmacodynamics pathwayPrkaca , Prkar1a
dopamine signaling pathwayPrkaca , Prkacb
dopamine signaling pathway via D1 family of receptorsAdcy2 , Adcy5 , Prkacb
dopamine signaling pathway via D2 family of receptorsAdcy5
eicosanoid signaling pathwayPrkaca
endothelin signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9
Entamoebiasis pathwayAdcy1 , Prkaca , Prkacb
esmolol pharmacodynamics pathwayPrkaca , Prkar1a
FasL mediated signaling pathwayEzr
flecainde pharmacodynamics pathwayPrkaca , Prkar1a
follicle-stimulating hormone signaling pathwayAdcy2 , Prkacb
fosphenytoin pharmacodynamics pathwayPrkaca , Prkar1a
G protein mediated signaling pathway via Galphai familyAdcy5
G protein mediated signaling pathway via Galphas familyAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9 , Crhr2
glucagon signaling pathwayAdcy5 , Adcy6
glutamate signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9 , Prkaca , Prkacb
gonadotropin-releasing hormone signaling pathwayAdcy1 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9 , Prkaca , Prkacb
granulocyte-macrophage colony-stimulating factor signaling pathwayPrkaca , Prkacb
Hedgehog signaling pathwayPrkaca , Prkacb
histamine signaling pathway, immunologicalAdcy2 , Prkacb
ibutilide pharmacodynamics pathwayPrkaca , Prkar1a
insulin signaling pathwayPde3a , Pde3b , Prkaca , Prkacb , Prkar1a , Prkar2a , Prkar2b
interleukin-3 signaling pathwayPrkaca , Prkacb
isoprenaline pharmacodynamics pathwayPrkaca , Prkar1a
isradipine pharmacodynamics pathwayPrkaca , Prkar1a
Kelley-Seegmiller syndrome pathwayAdcy10 , Pde10a , Pde4d
Lesch-Nyhan syndrome pathwayAdcy10 , Pde10a , Pde4d
levobunolol pharmacodynamics pathwayPrkaca , Prkar1a
lidocaine pharmacodynamics pathwayPrkaca , Prkar1a
long term potentiationAdcy1 , Adcy8 , Prkaca , Prkacb
luteinizing hormone signaling pathwayAdcy2 , Prkacb
melanocortin system pathwayAdcy2 , Prkacb
mercaptopurine pharmacodynamics pathwayAdcy10 , Pde10a , Pde4d
metoprolol pharmacodynamics pathwayPrkaca , Prkar1a
mexiletine pharmacodynamics pathwayPrkaca , Prkar1a
mitogen activated protein kinase signaling pathwayPrkaca , Prkacb
molybdenum cofactor deficiency pathwayAdcy10 , Pde10a , Pde4d
nadolol pharmacodynamics pathwayPrkaca , Prkar1a
nebivolol pharmacodynamics pathwayPrkaca , Prkar1a
nifedipine pharmacodynamics pathwayPrkaca , Prkar1a
nimodipine pharmacodynamics pathwayPrkaca , Prkar1a
nisoldipine pharmacodynamics pathwayPrkaca , Prkar1a
nitrendipine pharmacodynamics pathwayPrkaca , Prkar1a
parathyroid hormone signaling pathwayEzr
penbutolol pharmacodynamics pathwayPrkaca , Prkar1a
phenytoin pharmacodynamics pathwayPrkaca , Prkar1a
phosphatidylinositol 3-kinase-Akt signaling pathwayPrkaca
pindolol pharmacodynamics pathwayPrkaca , Prkar1a
prion disease pathwayPrkaca , Prkacb
procainamide pharmacodynamics pathwayPrkaca , Prkar1a
propranolol pharmacodynamics pathwayPrkaca , Prkar1a
prostaglandin D2 signaling pathwayAdcy2 , Prkacb
prostaglandin I2 signaling pathwayAdcy2 , Prkacb
protein kinase A (PKA) signaling pathwayAdcy1 , Adcy10 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9 , Akap1 , Akap10 , Akap11 , Akap12 , Akap13 , Akap14 , Akap2 , Akap3 , Akap4 , Akap5 , Akap6 , Akap7 , Akap8 , Akap9 , Crhr2 , Ezr , Pde10a , Pde11a , Pde1a , Pde1b , Pde1c , Pde2a , Pde3a , Pde3b , Pde4a , Pde4b , Pde4c , Pde4d , Pde7a , Pde7b , Pde8a , Pde8b , Prkaca , Prkacb , Prkar1a , Prkar1b , Prkar2a , Prkar2b
purine metabolic pathwayAdcy1 , Adcy10 , Adcy2 , Adcy3 , Adcy4 , Adcy5 , Adcy6 , Adcy7 , Adcy8 , Adcy9 , Pde10a , Pde11a , Pde1a , Pde1b , Pde1c , Pde2a , Pde3a , Pde3b , Pde4a , Pde4b , Pde4c , Pde4d , Pde7a , Pde7b , Pde8a , Pde8b
purine nucleoside phosphorylase deficiency pathwayAdcy10 , Pde10a , Pde4d
quinidine pharmacodynamics pathwayPrkaca , Prkar1a
serotonin signaling pathway via receptors engaging G alphas protein familyAdcy2 , Prkacb
sotalol pharmacodynamics pathwayPrkaca , Prkar1a
syndecan signaling pathwayEzr , Prkaca
timolol pharmacodynamics pathwayPrkaca , Prkar1a
tioguanine pharmacodynamics pathwayAdcy10 , Pde10a , Pde4d
vascular endothelial growth factor signaling pathwayAkap1 , Prkaca
vasopressin signaling pathwayAdcy6 , Akap7 , Pde4d
vasopressin signaling pathway via receptor type 2Adcy2 , Adcy3 , Adcy6 , Adcy9 , Akap7 , Pde4d , Prkaca , Prkacb
verapamil pharmacodynamics pathwayPrkaca , Prkar1a
Wnt signaling pathwayPrkaca , Prkacb
xanthinuria type I pathwayAdcy10 , Pde10a , Pde4d
xanthinuria pathwayAdcy10 , Pde10a , Pde4d
xanthinuria type II pathwayAdcy10 , Pde10a , Pde4d
Phenotype Annotations Associated with Genes in the protein kinase A (PKA) signaling pathway

References Associated with the protein kinase A (PKA) signaling pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: