Rbx1 (ring-box 1) - Rat Genome Database

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Gene: Rbx1 (ring-box 1) Rattus norvegicus
Analyze
Symbol: Rbx1
Name: ring-box 1
RGD ID: 1308453
Description: Predicted to enable several functions, including cullin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein metabolic process; and protein modification by small protein conjugation. Predicted to act upstream of or within protein K48-linked ubiquitination; protein catabolic process; and protein monoubiquitination. Part of VCB complex. Orthologous to human RBX1 (ring-box 1); PARTICIPATES IN hypoxia inducible factor pathway; neddylation pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase RBX1; LOC300084; MGC116275; ring-box 1, E3 ubiquitin protein ligase; ring-box 1-like; RING-box protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27112,976,863 - 113,001,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,990,835 - 113,001,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7114,753,189 - 114,763,404 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07116,976,687 - 116,986,902 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07116,946,098 - 116,956,313 (+)NCBIRnor_WKY
Rnor_6.07122,700,849 - 122,710,907 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,700,854 - 122,709,935 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07122,677,395 - 122,687,076 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47119,794,976 - 119,805,104 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17119,828,667 - 119,836,146 (+)NCBI
Celera7109,310,166 - 109,320,235 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
all-trans-retinoic acid  (ISO)
antimycin A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calycosin  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
deguelin  (ISO)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dinophysistoxin 1  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
ferroheme b  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
heme b  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
maneb  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pinosylvin  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pyrimidifen  (ISO)
sertraline  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
solanesol  (ISO)
sulindac  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
thifluzamide  (ISO)
trans-pinosylvin  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
3. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Kamura T, etal., Genes Dev. 2004 Dec 15;18(24):3055-65.
4. Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. Kamura T, etal., J Biol Chem. 2001 Aug 10;276(32):29748-53. Epub 2001 May 30.
5. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Kamura T, etal., Science. 1999 Apr 23;284(5414):657-61.
6. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
7. Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex. Megumi Y, etal., Genes Cells. 2005 Jul;10(7):679-91.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. Ohh M, etal., EMBO Rep. 2002 Feb;3(2):177-82. Epub 2002 Jan 29.
10. Nedd8 on cullin: building an expressway to protein destruction. Pan ZQ, etal., Oncogene. 2004 Mar 15;23(11):1985-97.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
16. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Zheng N, etal., Nature. 2002 Apr 18;416(6882):703-9.
Additional References at PubMed
PMID:10230407   PMID:11956208   PMID:12140560   PMID:12477932   PMID:12732143   PMID:14528312   PMID:14739464   PMID:15103331   PMID:15983046   PMID:16880526   PMID:17085480   PMID:17543862  
PMID:17636018   PMID:18498745   PMID:18794347   PMID:19028597   PMID:19250909   PMID:20129063   PMID:20223979   PMID:20389280   PMID:21343341   PMID:21572392   PMID:22358839   PMID:22405651  
PMID:23263282   PMID:25585578   PMID:29593216  


Genomics

Comparative Map Data
Rbx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27112,976,863 - 113,001,051 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,990,835 - 113,001,051 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7114,753,189 - 114,763,404 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07116,976,687 - 116,986,902 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07116,946,098 - 116,956,313 (+)NCBIRnor_WKY
Rnor_6.07122,700,849 - 122,710,907 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,700,854 - 122,709,935 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07122,677,395 - 122,687,076 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47119,794,976 - 119,805,104 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17119,828,667 - 119,836,146 (+)NCBI
Celera7109,310,166 - 109,320,235 (+)NCBICelera
Cytogenetic Map7q34NCBI
RBX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,951,378 - 40,973,309 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2240,951,347 - 40,973,309 (+)EnsemblGRCh38hg38GRCh38
GRCh372241,347,382 - 41,369,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,677,331 - 39,698,614 (+)NCBINCBI36Build 36hg18NCBI36
Build 342239,671,884 - 39,693,168NCBI
Celera2225,151,059 - 25,172,347 (+)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,308,951 - 24,330,592 (+)NCBIHuRef
CHM1_12241,306,113 - 41,327,855 (+)NCBICHM1_1
T2T-CHM13v2.02241,423,571 - 41,445,506 (+)NCBIT2T-CHM13v2.0
Rbx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,350,517 - 81,360,570 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,350,497 - 81,360,570 (+)EnsemblGRCm39 Ensembl
GRCm381581,466,316 - 81,476,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,466,296 - 81,476,369 (+)EnsemblGRCm38mm10GRCm38
MGSCv371581,296,746 - 81,306,799 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361581,293,628 - 81,303,619 (+)NCBIMGSCv36mm8
Celera1583,584,172 - 83,594,608 (+)NCBICelera
Cytogenetic Map15E1NCBI
Rbx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,579,759 - 26,592,980 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541326,579,759 - 26,592,980 (+)NCBIChiLan1.0ChiLan1.0
RBX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12239,941,405 - 39,962,175 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2239,941,405 - 39,962,175 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02221,845,351 - 21,866,627 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RBX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,265,733 - 24,280,253 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,266,408 - 24,280,235 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1024,200,859 - 24,214,782 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01025,014,111 - 25,028,037 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1025,013,516 - 25,028,019 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,729,691 - 24,743,612 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,050,324 - 25,064,237 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01025,224,699 - 25,238,847 (-)NCBIUU_Cfam_GSD_1.0
Rbx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,861,902 - 7,880,482 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492873,576 - 890,835 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936492872,316 - 890,860 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,500,490 - 7,515,370 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.157,500,492 - 7,515,388 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RBX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,500,361 - 23,521,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1923,500,356 - 23,522,723 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045101,955,371 - 101,977,480 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247527,546,959 - 7,560,668 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247527,547,702 - 7,560,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbx1
110 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:140
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000025979
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat

Markers in Region
RH135115  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07122,710,269 - 122,710,460NCBIRnor6.0
RH 3.4 Map7882.2UniSTS
Cytogenetic Map7q34UniSTS
RH137490  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,996,536 - 112,996,742 (+)MAPPERmRatBN7.2
Rnor_6.07122,706,572 - 122,706,777NCBIRnor6.0
Rnor_5.07122,682,583 - 122,682,788UniSTSRnor5.0
RGSC_v3.47119,799,479 - 119,799,684UniSTSRGSC3.4
Celera7109,315,848 - 109,316,053UniSTS
Cytogenetic Map7q34UniSTS
RH131226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27113,000,747 - 113,000,930 (+)MAPPERmRatBN7.2
Rnor_6.07122,710,604 - 122,710,786NCBIRnor6.0
Rnor_5.07122,686,773 - 122,686,955UniSTSRnor5.0
RGSC_v3.47119,804,801 - 119,804,983UniSTSRGSC3.4
Celera7109,319,932 - 109,320,114UniSTS
RH 3.4 Map7878.9UniSTS
Cytogenetic Map7q34UniSTS
RH142947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,992,368 - 112,992,491 (+)MAPPERmRatBN7.2
Rnor_6.07122,702,383 - 122,702,505NCBIRnor6.0
Rnor_5.07122,678,929 - 122,679,051UniSTSRnor5.0
Celera7109,311,700 - 109,311,822UniSTS
RH 3.4 Map7880.6UniSTS
Cytogenetic Map7q34UniSTS
RH137754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,991,861 - 112,992,039 (+)MAPPERmRatBN7.2
Rnor_6.07122,701,876 - 122,702,053NCBIRnor6.0
Rnor_5.07122,678,422 - 122,678,599UniSTSRnor5.0
Celera7109,311,193 - 109,311,370UniSTS
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086603   ⟹   ENSRNOP00000069049
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,990,835 - 113,001,051 (+)Ensembl
Rnor_6.0 Ensembl7122,700,854 - 122,709,935 (+)Ensembl
RefSeq Acc Id: NM_001034135   ⟹   NP_001029307
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27112,990,835 - 113,001,051 (+)NCBI
Rnor_6.07122,700,849 - 122,710,907 (+)NCBI
Rnor_5.07122,677,395 - 122,687,076 (+)NCBI
RGSC_v3.47119,794,976 - 119,805,104 (+)RGD
Celera7109,310,166 - 109,320,235 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078841   ⟹   XP_038934769
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27112,976,863 - 113,001,051 (+)NCBI
RefSeq Acc Id: XM_039078842   ⟹   XP_038934770
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27112,990,797 - 113,001,051 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001029307   ⟸   NM_001034135
- UniProtKB: Q498D8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069049   ⟸   ENSRNOT00000086603
RefSeq Acc Id: XP_038934769   ⟸   XM_039078841
- Peptide Label: isoform X1
- UniProtKB: Q498D8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934770   ⟸   XM_039078842
- Peptide Label: isoform X2
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q498D8-F1-model_v2 AlphaFold Q498D8 1-108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695511
Promoter ID:EPDNEW_R6036
Type:multiple initiation site
Name:Rbx1_1
Description:ring-box 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07122,700,840 - 122,700,900EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308453 AgrOrtholog
BioCyc Gene G2FUF-32677 BioCyc
Ensembl Genes ENSRNOG00000058914 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069049 ENTREZGENE
  ENSRNOP00000069049.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000086603 ENTREZGENE
  ENSRNOT00000086603.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7444286 IMAGE-MGC_LOAD
InterPro Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_H2 UniProtKB/TrEMBL
KEGG Report rno:300084 UniProtKB/TrEMBL
MGC_CLONE MGC:116275 IMAGE-MGC_LOAD
NCBI Gene 300084 ENTREZGENE
Pfam zf-rbx1 UniProtKB/TrEMBL
PhenoGen Rbx1 PhenoGen
PROSITE ZF_RING_2 UniProtKB/TrEMBL
UniProt A0A0G2JUC8_RAT UniProtKB/TrEMBL
  Q498D8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Rbx1  ring-box 1  Rbx1  ring-box 1, E3 ubiquitin protein ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Rbx1  ring-box 1, E3 ubiquitin protein ligase  LOC100363742  ring-box 1-like  Data Merged 1643240 APPROVED
2012-10-10 Rbx1  ring-box 1, E3 ubiquitin protein ligase  Rbx1  ring-box 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100363742  ring-box 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Rbx1  ring-box 1  Rbx1_predicted  ring-box 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Rbx1_predicted  ring-box 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED