Prickle1 (prickle planar cell polarity protein 1) - Rat Genome Database

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Gene: Prickle1 (prickle planar cell polarity protein 1) Rattus norvegicus
Analyze
Symbol: Prickle1
Name: prickle planar cell polarity protein 1
RGD ID: 735090
Description: Predicted to enable zinc ion binding activity. Involved in protein import into nucleus. Predicted to be located in cytosol and nuclear membrane. Predicted to be part of proteasome complex. Predicted to be active in several cellular components, including cell trailing edge; glutamatergic synapse; and postsynaptic density. Used to study temporal lobe epilepsy. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; Wnt signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: prickle homolog 1; prickle homolog 1 (Drosophila); prickle-like 1; prickle-like 1 (Drosophila); prickle-like protein 1; REST/NRSF-interacting lim domain protein; REST/NRSF-interacting LIM domain protein 1; Rilp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87126,518,587 - 126,614,581 (-)NCBIGRCr8
mRatBN7.27124,639,142 - 124,735,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7124,639,142 - 124,658,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7126,413,839 - 126,432,848 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07128,639,712 - 128,658,721 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07128,561,664 - 128,580,709 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07134,702,964 - 134,799,437 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7134,702,964 - 134,722,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07134,370,195 - 134,466,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47131,967,220 - 131,986,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17132,044,813 - 132,052,370 (-)NCBI
Celera7121,036,572 - 121,055,537 (-)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flusilazole  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
isobutanol  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
Monobutylphthalate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trametinib  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (IEA,ISO)
anterior visceral endoderm cell migration  (IEA,ISO)
aorta development  (IEA,ISO)
apoptotic process  (IEA,ISO)
axonogenesis  (IEA,ISO)
basement membrane organization  (IEA,ISO)
bone mineralization  (IEA,ISO)
cardiac muscle cell development  (IEA,ISO)
cell migration  (IEA,ISO)
cell-cell adhesion  (IEA,ISO)
cilium assembly  (IEA,ISO)
cilium organization  (IEA,ISO)
cornea development in camera-type eye  (IEA,ISO)
coronary vasculature development  (IEA,ISO)
cytoskeleton organization  (IEA,ISO)
cytoskeleton-dependent intracellular transport  (IEA,ISO)
dendrite development  (IEA,ISO)
embryonic brain development  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
embryonic nail plate morphogenesis  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IEA,ISO)
establishment of bipolar cell polarity involved in cell morphogenesis  (IEA,ISO)
establishment of cell polarity  (IEA,ISO)
establishment of protein localization  (IEA,ISO)
establishment or maintenance of cell polarity  (IEA,ISO)
extracellular matrix assembly  (IEA,ISO)
eyelid development in camera-type eye  (IEA,ISO)
face morphogenesis  (IEA,ISO)
focal adhesion disassembly  (IEA,ISO)
gene expression  (IEA,ISO)
heart development  (IEA,ISO)
limb development  (IEA,ISO)
limb morphogenesis  (IEA,ISO)
maintenance of postsynaptic density structure  (IEA,ISO)
mesenchyme development  (IEA,ISO)
mitotic spindle assembly  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle cell myoblast differentiation  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
neural tube closure  (IEA,ISO)
neuron projection development  (IEA,ISO)
neuron projection extension  (IEA,ISO)
neuron projection morphogenesis  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
polarized secretion of basement membrane proteins in epithelium  (IEA,ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein ubiquitination  (IEA,ISO)
post-anal tail morphogenesis  (IEA,ISO)
primitive streak formation  (IEA,ISO)
programmed cell death  (IEA,ISO)
protein import into nucleus  (IDA,IEA,ISO)
regulation of postsynaptic density assembly  (IEA,ISO)
renal tubule development  (IEA,ISO)
response to electrical stimulus  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
tear secretion  (IEA,ISO)
tissue development  (IEA,ISO)
tissue homeostasis  (IEA,ISO)
vesicle-mediated transport  (IEA,ISO)
Wnt signaling pathway  (IEA,ISO)
Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)

Cellular Component
cell trailing edge  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
endomembrane system  (IEA)
glutamatergic synapse  (IEA,ISO)
membrane  (IEA,ISO)
nuclear membrane  (IEA,ISO)
nucleus  (IEA,ISO)
postsynaptic density  (IEA,ISO)
proteasome complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Planar cell polarity signaling in vertebrates. Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32.
2. Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. McClelland S, etal., Ann Neurol. 2011 Sep;70(3):454-64. doi: 10.1002/ana.22479.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor. Shimojo M and Hersh LB, Mol Cell Biol 2003 Dec;23(24):9025-31.
Additional References at PubMed
PMID:16417580   PMID:17030191   PMID:17173866   PMID:18922795   PMID:21199191   PMID:21901791   PMID:22333836   PMID:24312498   PMID:25807483  


Genomics

Comparative Map Data
Prickle1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87126,518,587 - 126,614,581 (-)NCBIGRCr8
mRatBN7.27124,639,142 - 124,735,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7124,639,142 - 124,658,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7126,413,839 - 126,432,848 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07128,639,712 - 128,658,721 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07128,561,664 - 128,580,709 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07134,702,964 - 134,799,437 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7134,702,964 - 134,722,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07134,370,195 - 134,466,674 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47131,967,220 - 131,986,187 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17132,044,813 - 132,052,370 (-)NCBI
Celera7121,036,572 - 121,055,537 (-)NCBICelera
Cytogenetic Map7q35NCBI
PRICKLE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381242,456,757 - 42,589,746 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1242,456,757 - 42,590,355 (-)EnsemblGRCh38hg38GRCh38
GRCh371242,850,559 - 42,983,548 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361241,139,341 - 41,269,745 (-)NCBINCBI36Build 36hg18NCBI36
Build 341241,139,340 - 41,269,745NCBI
Celera1241,653,996 - 41,785,497 (-)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1239,878,936 - 40,010,599 (-)NCBIHuRef
CHM1_11242,818,791 - 42,950,331 (-)NCBICHM1_1
T2T-CHM13v2.01242,414,615 - 42,547,546 (-)NCBIT2T-CHM13v2.0
Prickle1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391593,396,992 - 93,494,147 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1593,396,995 - 93,493,772 (-)EnsemblGRCm39 Ensembl
GRCm381593,499,111 - 93,596,266 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1593,499,114 - 93,595,891 (-)EnsemblGRCm38mm10GRCm38
MGSCv371593,329,545 - 93,426,322 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361593,327,294 - 93,424,071 (-)NCBIMGSCv36mm8
Celera1595,647,051 - 95,744,081 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1547.69NCBI
Prickle1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555001,897,912 - 1,990,875 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555001,897,899 - 1,990,791 (-)NCBIChiLan1.0ChiLan1.0
PRICKLE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21051,569,777 - 51,704,514 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11251,566,578 - 51,699,232 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01246,127,673 - 46,262,333 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11247,100,352 - 47,126,116 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1247,100,393 - 47,126,102 (+)Ensemblpanpan1.1panPan2
PRICKLE1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12711,327,086 - 11,437,799 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2711,426,647 - 11,437,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2734,864,577 - 34,975,269 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02711,522,959 - 11,634,418 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2711,559,081 - 11,634,108 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12711,336,611 - 11,448,200 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02711,366,003 - 11,477,284 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02735,111,079 - 35,222,648 (-)NCBIUU_Cfam_GSD_1.0
Prickle1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494571,894,685 - 71,999,671 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365121,163,615 - 1,270,255 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365121,165,159 - 1,270,138 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRICKLE1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl573,707,050 - 73,826,430 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1573,707,026 - 73,826,529 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2576,446,397 - 76,452,034 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRICKLE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11138,696,771 - 38,819,324 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1138,694,602 - 38,718,519 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037207,742,821 - 207,865,507 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prickle1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481610,164,666 - 10,184,994 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481610,087,866 - 10,185,004 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prickle1
560 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:129
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000036750
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
AW215793  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27124,639,256 - 124,639,384 (+)MAPPERmRatBN7.2
Rnor_6.07134,703,079 - 134,703,206NCBIRnor6.0
Rnor_5.07134,370,310 - 134,370,437UniSTSRnor5.0
RGSC_v3.47131,967,335 - 131,967,462UniSTSRGSC3.4
Celera7121,036,687 - 121,036,814UniSTS
Cytogenetic Map7q35UniSTS
BE114974  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27124,696,400 - 124,696,573 (+)MAPPERmRatBN7.2
Rnor_6.07134,760,686 - 134,760,858NCBIRnor6.0
Rnor_5.07134,427,917 - 134,428,089UniSTSRnor5.0
RGSC_v3.47132,024,474 - 132,024,646UniSTSRGSC3.4
Celera7121,093,972 - 121,094,144UniSTS
RH 3.4 Map71020.7UniSTS
Cytogenetic Map7q35UniSTS
RH143298  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27124,639,200 - 124,639,308 (+)MAPPERmRatBN7.2
Rnor_6.07134,703,023 - 134,703,130NCBIRnor6.0
Rnor_5.07134,370,254 - 134,370,361UniSTSRnor5.0
RGSC_v3.47131,967,279 - 131,967,386UniSTSRGSC3.4
Celera7121,036,631 - 121,036,738UniSTS
RH 3.4 Map71017.7UniSTS
Cytogenetic Map7q35UniSTS
BE099414  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27124,701,708 - 124,701,907 (+)MAPPERmRatBN7.2
Rnor_6.07134,766,005 - 134,766,203NCBIRnor6.0
Rnor_5.07134,433,236 - 134,433,434UniSTSRnor5.0
RGSC_v3.47132,029,782 - 132,029,980UniSTSRGSC3.4
Celera7121,099,284 - 121,099,482UniSTS
RH 3.4 Map71019.8UniSTS
Cytogenetic Map7q35UniSTS
RH138805  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map71045.0UniSTS
Cytogenetic Map7q35UniSTS
MARC_13855-13856:1032800061:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27124,640,929 - 124,641,338 (+)MAPPERmRatBN7.2
Rnor_6.07134,704,752 - 134,705,160NCBIRnor6.0
Rnor_5.07134,371,983 - 134,372,391UniSTSRnor5.0
RGSC_v3.47131,969,008 - 131,969,416UniSTSRGSC3.4
Celera7121,038,360 - 121,038,768UniSTS
Cytogenetic Map7q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000036750   ⟹   ENSRNOP00000031476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7124,639,142 - 124,658,113 (-)Ensembl
Rnor_6.0 Ensembl7134,702,964 - 134,722,215 (-)Ensembl
RefSeq Acc Id: NM_199396   ⟹   NP_955428
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87126,518,587 - 126,537,554 (-)NCBI
mRatBN7.27124,639,142 - 124,658,113 (-)NCBI
Rnor_6.07134,702,964 - 134,722,215 (-)NCBI
Rnor_5.07134,370,195 - 134,466,674 (-)NCBI
RGSC_v3.47131,967,220 - 131,986,187 (-)RGD
Celera7121,036,572 - 121,055,537 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242213   ⟹   XP_006242275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87126,518,602 - 126,614,581 (-)NCBI
mRatBN7.27124,639,154 - 124,735,027 (-)NCBI
Rnor_6.07134,702,976 - 134,799,437 (-)NCBI
Rnor_5.07134,370,195 - 134,466,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242215   ⟹   XP_006242277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87126,518,602 - 126,552,435 (-)NCBI
mRatBN7.27124,639,154 - 124,673,059 (-)NCBI
Rnor_6.07134,702,976 - 134,737,149 (-)NCBI
Rnor_5.07134,370,195 - 134,466,674 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063263654   ⟹   XP_063119724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87126,518,602 - 126,614,470 (-)NCBI
RefSeq Acc Id: XM_063263655   ⟹   XP_063119725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87126,518,602 - 126,614,470 (-)NCBI
RefSeq Acc Id: NP_955428   ⟸   NM_199396
- UniProtKB: Q71QF9 (UniProtKB/Swiss-Prot),   G3V8Z4 (UniProtKB/TrEMBL),   A6K7T7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242275   ⟸   XM_006242213
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006242277   ⟸   XM_006242215
- Peptide Label: isoform X1
- UniProtKB: Q71QF9 (UniProtKB/Swiss-Prot),   G3V8Z4 (UniProtKB/TrEMBL),   A6K7T7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031476   ⟸   ENSRNOT00000036750
RefSeq Acc Id: XP_063119724   ⟸   XM_063263654
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119725   ⟸   XM_063263655
- Peptide Label: isoform X1
Protein Domains
LIM zinc-binding   PET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q71QF9-F1-model_v2 AlphaFold Q71QF9 1-831 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735090 AgrOrtholog
BioCyc Gene G2FUF-32329 BioCyc
Ensembl Genes ENSRNOG00000022772 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036750 ENTREZGENE
  ENSRNOT00000036750.5 UniProtKB/TrEMBL
  ENSRNOT00000120709 ENTREZGENE
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LIM2_prickle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM3_prickle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PET_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PET_prickle UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pk/Esn/Tes UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:315259 UniProtKB/TrEMBL
NCBI Gene 315259 ENTREZGENE
PANTHER LIM DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRICKLE-LIKE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prickle1 PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PET UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022772 RatGTEx
SMART LIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6K7T7 ENTREZGENE, UniProtKB/TrEMBL
  G3V8Z4 ENTREZGENE, UniProtKB/TrEMBL
  PRIC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Prickle1  prickle planar cell polarity protein 1  Prickle1  prickle homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-30 Prickle1  prickle homolog 1  Prickle1  prickle homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Prickle1  prickle homolog 1 (Drosophila)  Prickle1  prickle-like 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Prickle1  prickle-like 1 (Drosophila)      Symbol and Name status set to approved 1299863 APPROVED