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Gene: Slc45a4 (solute carrier family 45, member 4) Rattus norvegicus
Analyze
Symbol:
Slc45a4
Name:
solute carrier family 45, member 4
RGD ID:
1309971
Description:
Predicted to have sucrose:proton symporter activity. Predicted to be involved in sucrose transport. Predicted to localize to membrane. Orthologous to human SLC45A4 (solute carrier family 45 member 4); INTERACTS WITH bisphenol A; C60 fullerene; dibutyl phthalate.
Type:
protein-coding
RefSeq Status:
MODEL
Also known as:
LOC315054; RGD1309971; similar to KIAA1126 protein; solute carrier family 45 member 4
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SLC45A4 (solute carrier family 45 member 4) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Slc45a4 (solute carrier family 45, member 4) HGNC
Treefam, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Pan paniscus (bonobo/pygmy chimpanzee):
SLC45A4 (solute carrier family 45 member 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SLC45A4 (solute carrier family 45 member 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Slc45a4 (solute carrier family 45 member 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SLC45A4 (solute carrier family 45 member 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
SLC45A4 (solute carrier family 45 member 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Slc45a4 (solute carrier family 45 member 4) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Slc45a4 (solute carrier family 45, member 4)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Homo sapiens (human):
SLC45A4 (solute carrier family 45 member 4)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
slc45a4 (solute carrier family 45 member 4)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
Slc45-1
Alliance
DIOPT (Ensembl Compara|PANTHER|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 114,817,817 - 114,888,998 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 114,821,971 - 114,848,414 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 7 114,741,753 - 114,812,934 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 111,283,726 - 111,311,116 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 111,317,959 - 111,345,614 (-) NCBI Celera 7 101,886,429 - 101,957,293 (-) NCBI Celera Cytogenetic Map 7 q34 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
17beta-estradiol multiple interactions ISO RGD:1607016 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of SLC45A4 mRNA CTD PMID:30165855 2,3',4,4',5-Pentachlorobiphenyl decreases expression ISO RGD:1320603 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1320603 6480464 Tetrachlorodibenzodioxin affects the expression of SLC45A4 mRNA CTD PMID:21570461 3-Iodothyronamine affects uptake ISO RGD:1607016 6480464 SLC45A4 mRNA affects the uptake of 3-iodothyronamine CTD PMID:19074582 4-hydroxyphenyl retinamide decreases expression ISO RGD:1320603 6480464 Fenretinide results in decreased expression of SLC45A4 mRNA CTD PMID:28973697 aflatoxin B1 increases methylation ISO RGD:1607016 6480464 Aflatoxin B1 results in increased methylation of SLC45A4 gene CTD PMID:27153756 aflatoxin B1 decreases methylation ISO RGD:1607016 6480464 Aflatoxin B1 results in decreased methylation of SLC45A4 intron CTD PMID:30157460 antirheumatic drug decreases expression ISO RGD:1607016 6480464 Antirheumatic Agents results in decreased expression of SLC45A4 mRNA CTD PMID:24449571 arsane affects methylation ISO RGD:1607016 6480464 Arsenic affects the methylation of SLC45A4 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1607016 6480464 Arsenic affects the methylation of SLC45A4 gene CTD PMID:25304211 arsenous acid multiple interactions ISO RGD:1607016 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SLC45A4 protein] CTD PMID:26598702 benzo[a]pyrene increases expression ISO RGD:1320603 6480464 Benzoapyrene results in increased expression of SLC45A4 mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1607016 6480464 Benzoapyrene affects the methylation of SLC45A4 5' UTR CTD PMID:27901495 benzo[a]pyrene increases methylation ISO RGD:1607016 6480464 Benzoapyrene results in increased methylation of SLC45A4 promoter CTD PMID:27901495 benzo[a]pyrene multiple interactions ISO RGD:1320603 6480464 [Benzoapyrene co-treated with benzaanthracene co-treated with benzobfluoranthene co-treated with chrysene] results in decreased expression of SLC45A4 mRNA CTD PMID:27858113 benzo[a]pyrene decreases expression ISO RGD:1607016 6480464 Benzoapyrene results in decreased expression of SLC45A4 mRNA CTD PMID:22178795 benzo[a]pyrene decreases expression ISO RGD:1320603 6480464 Benzoapyrene results in decreased expression of SLC45A4 mRNA CTD PMID:21569818 , PMID:22228805 benzo[b]fluoranthene decreases expression ISO RGD:1320603 6480464 benzobfluoranthene results in decreased expression of SLC45A4 mRNA CTD PMID:26377693 benzo[b]fluoranthene multiple interactions ISO RGD:1320603 6480464 [Benzoapyrene co-treated with benzaanthracene co-treated with benzobfluoranthene co-treated with chrysene] results in decreased expression of SLC45A4 mRNA CTD PMID:27858113 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SLC45A4 mRNA CTD PMID:25181051 , PMID:30816183 butanal decreases expression ISO RGD:1607016 6480464 butyraldehyde results in decreased expression of SLC45A4 mRNA CTD PMID:26079696 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of SLC45A4 mRNA CTD PMID:19167457 carbon nanotube decreases expression ISO RGD:1320603 6480464 Nanotubes, Carbon results in decreased expression of SLC45A4 mRNA CTD PMID:25554681 chrysene multiple interactions ISO RGD:1320603 6480464 [Benzoapyrene co-treated with benzaanthracene co-treated with benzobfluoranthene co-treated with chrysene] results in decreased expression of SLC45A4 mRNA CTD PMID:27858113 cisplatin multiple interactions ISO RGD:1607016 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of SLC45A4 mRNA CTD PMID:27392435 cyclosporin A decreases methylation ISO RGD:1607016 6480464 Cyclosporine results in decreased methylation of SLC45A4 promoter CTD PMID:27989131 diarsenic trioxide multiple interactions ISO RGD:1607016 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to SLC45A4 protein] CTD PMID:26598702 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SLC45A4 mRNA CTD PMID:21266533 diclofenac decreases expression ISO RGD:1320603 6480464 Diclofenac results in decreased expression of SLC45A4 mRNA CTD PMID:26934552 ethanol affects splicing ISO RGD:1320603 6480464 Ethanol affects the splicing of SLC45A4 mRNA CTD PMID:30319688 folic acid decreases expression ISO RGD:1320603 6480464 Folic Acid results in decreased expression of SLC45A4 mRNA CTD PMID:25629700 folic acid decreases expression ISO RGD:1607016 6480464 Folic Acid results in decreased expression of SLC45A4 mRNA CTD PMID:21867686 hydrogen peroxide multiple interactions ISO RGD:1607016 6480464 SLC45A4 protein promotes the reaction [Paraquat results in increased chemical synthesis of Hydrogen Peroxide] CTD PMID:29058724 ketamine increases expression EXP 6480464 Ketamine results in increased expression of SLC45A4 mRNA CTD PMID:20080153 paracetamol affects expression ISO RGD:1607016 6480464 Acetaminophen affects the expression of SLC45A4 mRNA CTD PMID:25458485 paraquat multiple interactions ISO RGD:1607016 6480464 SLC45A4 protein promotes the reaction [Paraquat results in increased chemical synthesis of Hydrogen Peroxide] CTD PMID:29058724 paraquat increases response to substance ISO RGD:1607016 6480464 SLC45A4 protein results in increased susceptibility to Paraquat CTD PMID:29058724 pentachlorophenol increases expression ISO RGD:1320603 6480464 Pentachlorophenol results in increased expression of SLC45A4 mRNA CTD PMID:23892564 pirinixic acid increases expression ISO RGD:1320603 6480464 pirinixic acid results in increased expression of SLC45A4 mRNA CTD PMID:18301758 serpentine asbestos increases expression ISO RGD:1607016 6480464 Asbestos, Serpentine results in increased expression of SLC45A4 mRNA CTD PMID:21148743 sodium arsenite multiple interactions ISO RGD:1607016 6480464 sodium arsenite results in increased expression of and affects the splicing of SLC45A4 mRNA CTD PMID:25879800 sodium arsenite decreases expression ISO RGD:1607016 6480464 sodium arsenite results in decreased expression of SLC45A4 mRNA CTD PMID:29301061 tetraphene multiple interactions ISO RGD:1320603 6480464 [Benzoapyrene co-treated with benzaanthracene co-treated with benzobfluoranthene co-treated with chrysene] results in decreased expression of SLC45A4 mRNA CTD PMID:27858113 titanium dioxide decreases expression ISO RGD:1320603 6480464 titanium dioxide results in decreased expression of SLC45A4 mRNA CTD PMID:23409001 titanium dioxide increases expression ISO RGD:1320603 6480464 titanium dioxide results in increased expression of SLC45A4 mRNA CTD PMID:29264374 trichostatin A affects expression ISO RGD:1607016 6480464 trichostatin A affects the expression of SLC45A4 mRNA CTD PMID:28542535 tungsten decreases expression ISO RGD:1320603 6480464 Tungsten results in decreased expression of SLC45A4 mRNA CTD PMID:30912803 valproic acid affects expression ISO RGD:1320603 6480464 Valproic Acid affects the expression of SLC45A4 mRNA CTD PMID:17963808 valproic acid increases expression ISO RGD:1607016 6480464 Valproic Acid results in increased expression of SLC45A4 mRNA CTD PMID:23179753 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of SLC45A4 mRNA CTD PMID:20566332
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
2316947 Rf58 Renal function QTL 58 7.8 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) 7 55072862 123602998 Rat 2316952 Pur22 Proteinuria QTL 22 5.2 urine protein amount (VT:0005160) urine protein level (CMO:0000591) 7 55072862 123602998 Rat 2316955 Stl24 Serum triglyceride level QTL 24 7.1 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 7 55072862 123602998 Rat 631687 Hcas1 Hepatocarcinoma susceptibility QTL 1 3.9 0.001 liver integrity trait (VT:0010547) liver tumorous lesion volume to total liver volume ratio (CMO:0001082) 7 100160423 140335001 Rat 2317052 Aia17 Adjuvant induced arthritis QTL 17 2.13 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 7 91018361 136018361 Rat 1298528 Bp169 Blood pressure QTL 169 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 70421228 115421228 Rat 731174 Uae23 Urinary albumin excretion QTL 23 2.4 0.0042 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 7 114825174 145729302 Rat 631504 Cm27 Cardiac mass QTL 27 3.45 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) 7 50704769 128085642 Rat 631529 Tls2 T-lymphoma susceptibility QTL 2 0 0.001 thymus integrity trait (VT:0010555) percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911) 7 88365265 119318087 Rat 634331 Pia17 Pristane induced arthritis QTL 17 4.7 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) 7 81645773 140745067 Rat 7411654 Foco25 Food consumption QTL 25 9.3 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 7 85595369 130595369 Rat 7411607 Foco15 Food consumption QTL 15 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 7 85595369 130595369 Rat 1300179 Kidm5 Kidney mass QTL 5 3.51 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 7 51251919 145729302 Rat 1358361 Sradr5 Stress Responsive Adrenal Weight QTL 5 5.55 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 7 51251919 118477612 Rat 1331728 Bp214 Blood pressure QTL 214 2.825 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 88365265 134673427 Rat 1331731 Bp216 Blood pressure QTL 216 2.851 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 111519266 143965591 Rat 1331746 Kidm9 Kidney mass QTL 9 3.934 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) 7 88365265 121986709 Rat 1331768 Kidm10 Kidney mass QTL 10 4.62096 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 7 88365265 133365265 Rat 1357336 Gluco6 Glucose level QTL 6 3.4 blood glucose amount (VT:0000188) serum glucose level (CMO:0000543) 7 103867802 126080176 Rat 1357338 Stl17 Serum triglyceride level QTL 17 3.23 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 7 77428234 122421148 Rat 1549899 Stresp8 Stress response QTL 8 4.37 0.0008 stress-related behavior trait (VT:0010451) defensive burying duration (CMO:0001961) 7 100192194 145192194 Rat 1558655 Swd4 Spike wave discharge measurement QTL 4 3.68 0.0002 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge severity grade (CMO:0001988) 7 96630946 141630946 Rat 1358891 Bp265 Blood pressure QTL 265 2.21 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 91832949 145158140 Rat 1358914 Bp266 Blood pressure QTL 266 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 91832949 145158140 Rat 61357 Bp38 Blood pressure QTL 38 1.6 0.052 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 48118835 128611831 Rat 70173 Niddm19 Non-insulin dependent diabetes mellitus QTL 19 4.33 0.00005 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 7 71448715 145729302 Rat 71114 Niddm14 Non-insulin dependent diabetes mellitus QTL 14 4.5 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 7 93726906 138726906 Rat 70159 Bp61 Blood pressure QTL 61 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 112429186 126525386 Rat 2298475 Eau6 Experimental allergic uveoretinitis QTL 6 0.0029 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) 7 93726906 138726906 Rat 2299163 Iddm34 Insulin dependent diabetes mellitus QTL 34 2.71 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) 7 100028953 145729302 Rat 731176 Glom5 Glomerulus QTL 5 2.5 0.0035 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) 7 106564316 145729302 Rat 2313102 Bmd79 Bone mineral density QTL 79 2.3 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 7 103815550 126525386 Rat 631540 Bw9 Body weight QTL 9 4.5 body mass (VT:0001259) body weight (CMO:0000012) 7 77428105 127748511 Rat 634336 Anxrr17 Anxiety related response QTL 17 3.66 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 7 2920071 124838025 Rat 61397 Bw17 Body weight QTL 17 6.3 body mass (VT:0001259) body weight (CMO:0000012) 7 102588256 116249643 Rat
