Abcd2 (ATP binding cassette subfamily D member 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Abcd2 (ATP binding cassette subfamily D member 2) Rattus norvegicus
Symbol: Abcd2
Name: ATP binding cassette subfamily D member 2
RGD ID: 69244
Description: Enables protein heterodimerization activity and protein homodimerization activity. Involved in very long-chain fatty acid catabolic process. Located in peroxisomal membrane. Orthologous to human ABCD2 (ATP binding cassette subfamily D member 2); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adrenoleukodystrophy-related protein; ALDR; ATP-binding cassette sub-family D member 2; ATP-binding cassette, sub-family D (ALD), member 2; ATP-binding cassette, subfamily D (ALD), member 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   WIST/Nhg  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27122,263,034 - 122,311,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7122,263,032 - 122,311,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7124,054,640 - 124,103,336 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07126,280,755 - 126,329,211 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07126,207,915 - 126,256,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07132,294,564 - 132,343,169 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7132,294,562 - 132,343,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07131,968,475 - 132,017,044 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47129,542,758 - 129,591,363 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17129,577,902 - 129,626,508 (-)NCBI
Celera7118,713,620 - 118,762,172 (-)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
clothianidin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
delta-tocotrienol  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (EXP)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
furan  (EXP)
gentamycin  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
ketoconazole  (EXP)
lipopolysaccharide  (ISO)
maneb  (ISO)
methimazole  (EXP)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)


References - curated
# Reference Title Reference Citation
1. Rat adrenoleukodystrophy-related (ALDR) gene: full-length cDNA sequence and new insight in expression. Albet S, etal., Biochim Biophys Acta 2001 Jan 26;1517(2):257-69.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers. Geillon F, etal., J Biol Chem. 2014 Aug 29;289(35):24511-20. doi: 10.1074/jbc.M114.575506. Epub 2014 Jul 20.
4. Peroxisomal ATP-binding cassette transporters form mainly tetramers. Geillon F, etal., J Biol Chem. 2017 Apr 28;292(17):6965-6977. doi: 10.1074/jbc.M116.772806. Epub 2017 Mar 3.
5. Substrate specificity overlap and interaction between adrenoleukodystrophy protein (ALDP/ABCD1) and adrenoleukodystrophy-related protein (ALDRP/ABCD2). Genin EC, etal., J Biol Chem. 2011 Mar 11;286(10):8075-8084. doi: 10.1074/jbc.M110.211912. Epub 2011 Jan 5.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A Thyroid Hormone-Based Strategy for Correcting the Biochemical Abnormality in X-Linked Adrenoleukodystrophy. Hartley MD, etal., Endocrinology. 2017 May 1;158(5):1328-1338. doi: 10.1210/en.2016-1842.
8. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
9. A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern. Lombard-Platet G, etal., Proc Natl Acad Sci U S A 1996 Feb 6;93(3):1265-9.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10196381   PMID:10329405   PMID:15489218   PMID:16412981   PMID:16854843   PMID:17686565   PMID:18614015   PMID:18624909   PMID:18723473   PMID:18854420   PMID:21145416   PMID:23012479  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27122,263,034 - 122,311,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7122,263,032 - 122,311,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7124,054,640 - 124,103,336 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07126,280,755 - 126,329,211 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07126,207,915 - 126,256,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07132,294,564 - 132,343,169 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7132,294,562 - 132,343,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07131,968,475 - 132,017,044 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47129,542,758 - 129,591,363 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17129,577,902 - 129,626,508 (-)NCBI
Celera7118,713,620 - 118,762,172 (-)NCBICelera
Cytogenetic Map7q35NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381239,531,025 - 39,619,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1239,550,033 - 39,619,803 (-)EnsemblGRCh38hg38GRCh38
GRCh371239,943,835 - 40,013,605 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,232,813 - 38,300,237 (-)NCBINCBI36Build 36hg18NCBI36
Build 341238,232,813 - 38,300,237NCBI
Celera1238,749,047 - 38,818,059 (-)NCBICelera
Cytogenetic Map12q12ENTREZGENE
HuRef1236,971,383 - 37,040,198 (-)NCBIHuRef
CHM1_11239,911,021 - 39,979,850 (-)NCBICHM1_1
T2T-CHM13v2.01239,480,907 - 39,601,214 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391591,029,874 - 91,076,013 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1591,030,074 - 91,076,002 (-)EnsemblGRCm39 Ensembl
GRCm381591,145,871 - 91,192,007 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1591,145,871 - 91,191,799 (-)EnsemblGRCm38mm10GRCm38
MGSCv371590,976,302 - 91,022,238 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361590,973,638 - 91,019,574 (-)NCBIMGSCv36mm8
Celera1593,253,156 - 93,299,066 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1546.0NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955505721,222 - 798,470 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955505717,800 - 769,702 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11254,522,683 - 54,598,358 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01249,082,122 - 49,158,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11249,941,914 - 50,011,140 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1249,941,914 - 50,011,140 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12714,015,093 - 14,084,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2714,015,091 - 14,163,312 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2732,351,661 - 32,426,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02714,182,734 - 14,251,081 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2714,187,982 - 14,251,183 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12713,992,155 - 14,060,013 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02714,030,140 - 14,098,038 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02732,500,349 - 32,568,488 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494574,459,561 - 74,544,026 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366071,292,888 - 1,343,334 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366071,292,964 - 1,345,671 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl571,122,325 - 71,180,723 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1571,123,187 - 71,180,758 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2573,679,380 - 73,746,350 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11135,818,451 - 35,884,696 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037210,906,997 - 210,973,843 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624778847,879 - 909,727 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624778854,297 - 912,498 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Abcd2
497 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:380
Count of miRNA genes:221
Interacting mature miRNAs:282
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27122,265,140 - 122,265,344 (+)MAPPERmRatBN7.2
Rnor_6.07132,296,671 - 132,296,874NCBIRnor6.0
Rnor_5.07131,970,582 - 131,970,785UniSTSRnor5.0
RGSC_v3.47129,544,865 - 129,545,068UniSTSRGSC3.4
Celera7118,715,727 - 118,715,930UniSTS
Cytogenetic Map7q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27122,264,137 - 122,264,325 (+)MAPPERmRatBN7.2
Rnor_6.07132,295,668 - 132,295,855NCBIRnor6.0
Rnor_5.07131,969,579 - 131,969,766UniSTSRnor5.0
RGSC_v3.47129,543,862 - 129,544,049UniSTSRGSC3.4
Celera7118,714,724 - 118,714,911UniSTS
RH 3.4 Map7974.4UniSTS
Cytogenetic Map7q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27122,310,975 - 122,311,096 (+)MAPPERmRatBN7.2
Rnor_6.07132,342,503 - 132,342,623NCBIRnor6.0
Rnor_5.07132,016,378 - 132,016,498UniSTSRnor5.0
RGSC_v3.47129,590,697 - 129,590,817UniSTSRGSC3.4
Celera7118,761,506 - 118,761,626UniSTS
RH 3.4 Map7976.1UniSTS
Cytogenetic Map7q35UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27122,266,067 - 122,266,256 (+)MAPPERmRatBN7.2
Rnor_6.07132,297,598 - 132,297,786NCBIRnor6.0
Rnor_5.07131,971,509 - 131,971,697UniSTSRnor5.0
RGSC_v3.47129,545,792 - 129,545,980UniSTSRGSC3.4
Celera7118,716,654 - 118,716,842UniSTS
RH 3.4 Map7976.5UniSTS
Cytogenetic Map7q35UniSTS

Related Rat Strains
The following Strains have been annotated to Abcd2


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 15 11 2 11 1 57 5 2
Low 3 41 41 29 17 29 8 10 17 30 36 9 8
Below cutoff 2 1 1 1 5


RefSeq Acc Id: ENSRNOT00000021064   ⟹   ENSRNOP00000021064
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7122,263,032 - 122,311,642 (-)Ensembl
Rnor_6.0 Ensembl7132,294,562 - 132,343,169 (-)Ensembl
RefSeq Acc Id: NM_033352   ⟹   NP_203503
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.27122,263,034 - 122,311,642 (-)NCBI
Rnor_6.07132,294,564 - 132,343,169 (-)NCBI
Rnor_5.07131,968,475 - 132,017,044 (-)NCBI
RGSC_v3.47129,542,758 - 129,591,363 (-)RGD
Celera7118,713,620 - 118,762,172 (-)RGD
Protein Sequences
Protein RefSeqs NP_203503 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF22142 (Get FASTA)   NCBI Sequence Viewer  
  EDL76598 (Get FASTA)   NCBI Sequence Viewer  
  Q9QY44 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_203503   ⟸   NM_033352
- UniProtKB: Q9QY44 (UniProtKB/Swiss-Prot),   G3V7Z6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021064   ⟸   ENSRNOT00000021064
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QY44-F1-model_v2 AlphaFold Q9QY44 1-741 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69244 AgrOrtholog
BioCyc Gene G2FUF-32405 BioCyc
Ensembl Genes ENSRNOG00000015538 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000021064 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021064 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:84356 UniProtKB/Swiss-Prot
  PTHR11384:SF24 UniProtKB/Swiss-Prot
Pfam ABC_membrane_2 UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PhenoGen Abcd2 PhenoGen
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
TIGR TC216684
UniProt ABCD2_RAT UniProtKB/Swiss-Prot
UniProt Secondary G3V7Z6 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcd2  ATP binding cassette subfamily D member 2  Abcd2  ATP-binding cassette, subfamily D (ALD), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcd2  ATP-binding cassette, subfamily D (ALD), member 2  Abcd2  ATP-binding cassette, sub-family D (ALD), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Abcd2  ATP-binding cassette, sub-family D (ALD), member 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to peroxisomal membrane 68735
gene_disease associated with the development of X-linked adrenoleukodystrophy (X-ALD), an inherited demyelinating disorder 68735
gene_drugs induced by fenofibrate in adult liver but is not induced in suckling rats  
gene_expression expressed in high levels in the brain and liver before the weaning stage and drops to low levels in the adult stage 68735
gene_expression RNA levels increased gradually and reached a maximum level in the adult rat brain, expression levels higher in the liver for adult females 68735
gene_function peroxisomal ABC half-transporter 68735
gene_homology has 97% amino acid homology and 93% nucleotide identities to mouse orthologue 68735
gene_homology has 92% for amino acids and 87% for nucleotide identities to human orthologue 68735
gene_process responsible for peroxisomal B-oxidation impairement leading to accumulation of very long-chain fatty acids 68735
gene_product member of the ATP-binding cassette (ABC) transporter superfamily 68735
gene_protein 741 amino acid 68735
gene_transcript transcripts of 3.0 kb and 5.5 kb are detected  
gene_transcript 5.5 kb 68735
gene_transcript contains polyadenylation sites and alternative usage generates 3.0 and 5.5 kb transcripts and the 3 UTR contains two main functional consensus polyadenylation signals (AATAAA) at +2822 and +5315 68735