Advanced Search (OLGA)

Gene: Parvb (parvin, beta) Rattus norvegicus

Analyze

Symbol:

Parvb

Name:

parvin, beta

RGD ID:

1311485

Description:

Predicted to enable actin binding activity. Predicted to be involved in several processes, including establishment or maintenance of cell polarity regulating cell shape; lamellipodium assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Orthologous to human PARVB (parvin beta); PARTICIPATES IN integrin mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

beta-parvin; LOC362973

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PARVB (parvin beta)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Parvb (parvin, beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Parvb (parvin beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PARVB (parvin beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PARVB (parvin beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101965678 (beta-parvin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PARVB (parvin beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PARVB (parvin beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Parvb (parvin beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PARVB (parvin beta)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Parvb (parvin, beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	parvb (parvin, beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pat-6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	parvin	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	parvb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,240,238 - 117,325,744 (+)	NCBI		GRCr8
mRatBN7.2	7	115,360,254 - 115,445,767 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,360,261 - 115,445,766 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	117,108,064 - 117,193,472 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,333,790 - 119,419,192 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,303,246 - 119,388,648 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	125,189,827 - 125,275,977 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	125,189,827 - 125,277,689 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	63,181,011 - 63,268,380 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	122,223,325 - 122,310,356 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	122,235,509 - 122,344,586 (+)	NCBI
Celera	7	111,665,408 - 111,748,729 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Phelan-McDermid syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

cantharidin (ISO)

CGP 52608 (ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

dextran sulfate (ISO)

dibutyl phthalate (EXP)

fenvalerate (EXP)

formaldehyde (ISO)

FR900359 (ISO)

gentamycin (EXP)

hypochlorous acid (ISO)

lovastatin (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N,N-diethyl-m-toluamide (EXP)

nitrates (ISO)

ozone (ISO)

permethrin (EXP)

rotenone (EXP,ISO)

selenomethionine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

temozolomide (ISO)

tetrachloromethane (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

valdecoxib (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IBA,IEA,ISO)

cell adhesion (IEA)

cell projection assembly (IEA,ISO)

establishment or maintenance of cell polarity regulating cell shape (IBA,IEA,ISO)

lamellipodium assembly (IBA,IEA,ISO)

substrate adhesion-dependent cell spreading (IBA)

Cellular Component

actin cytoskeleton (IBA,IEA,ISO)

cytoplasm (IBA)

cytoskeleton (IEA)

focal adhesion (IBA,IEA,ISO)

lamellipodium (IBA,IEA,ISO)

plasma membrane (IEA,ISO)

Molecular Function

actin binding (IBA,IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

integrin mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ILK, PINCH and parvin: the tIPP of integrin signalling.	Legate KR, etal., Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31.
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15005707	PMID:18325335	PMID:22869380	PMID:30515554

Genomics

Comparative Map Data

Parvb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,240,238 - 117,325,744 (+)	NCBI		GRCr8
mRatBN7.2	7	115,360,254 - 115,445,767 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,360,261 - 115,445,766 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	117,108,064 - 117,193,472 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,333,790 - 119,419,192 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,303,246 - 119,388,648 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	125,189,827 - 125,275,977 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	125,189,827 - 125,277,689 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	63,181,011 - 63,268,380 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	122,223,325 - 122,310,356 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	122,235,509 - 122,344,586 (+)	NCBI
Celera	7	111,665,408 - 111,748,729 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

PARVB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	43,999,211 - 44,172,939 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	43,999,211 - 44,172,939 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	44,395,091 - 44,568,819 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	42,726,506 - 42,896,439 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	42,745,068 - 42,890,002	NCBI
Celera	22	28,306,774 - 28,479,077 (+)	NCBI		Celera
Cytogenetic Map	22	q13.31	NCBI
HuRef	22	27,348,952 - 27,516,946 (+)	NCBI		HuRef
CHM1_1	22	44,353,851 - 44,522,290 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	44,483,004 - 44,656,061 (+)	NCBI		T2T-CHM13v2.0

Parvb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	84,116,244 - 84,199,890 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	84,116,244 - 84,199,889 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	84,232,043 - 84,315,689 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	84,232,043 - 84,315,688 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	84,062,473 - 84,146,039 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	84,059,809 - 84,143,375 (+)	NCBI		MGSCv36	mm8
MGSCv36	15	85,033,050 - 85,115,036 (+)	NCBI		MGSCv36	mm8
Celera	15	86,363,102 - 86,447,450 (+)	NCBI		Celera
Cytogenetic Map	15	E2	NCBI
cM Map	15	39.78	NCBI

Parvb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	28,961,804 - 29,020,430 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	28,962,614 - 29,020,430 (+)	NCBI	ChiLan1.0	ChiLan1.0

PARVB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	53,853,333 - 53,998,127 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	56,545,823 - 56,693,918 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	24,913,710 - 25,061,603 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	43,107,009 - 43,245,932 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	43,079,786 - 43,245,932 (+)	Ensembl	panpan1.1		panPan2

PARVB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	21,549,654 - 21,629,771 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	21,551,998 - 21,640,781 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	21,492,217 - 21,589,726 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	22,300,594 - 22,397,773 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	22,299,169 - 22,397,976 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	22,019,817 - 22,117,314 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	22,340,152 - 22,437,648 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	22,513,879 - 22,611,416 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101965678
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	5,222,742 - 5,258,715 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	1,721,452 - 1,756,997 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	1,721,452 - 1,757,423 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PARVB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	4,906,685 - 5,015,441 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	4,906,667 - 5,015,494 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	2,124,672 - 2,160,970 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PARVB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	26,536,346 - 26,672,740 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	26,606,974 - 26,672,190 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	98,764,422 - 98,868,527 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Parvb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	5,039,037 - 5,121,116 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	5,039,180 - 5,121,056 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Parvb
399 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	114
Count of miRNA genes:	86
Interacting mature miRNAs:	100
Transcripts:	ENSRNOT00000015665
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134780	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000080152 ⟹ ENSRNOP00000075605

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	115,360,263 - 115,445,009 (+)	Ensembl
Rnor_6.0 Ensembl	7	125,189,827 - 125,275,977 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082805 ⟹ ENSRNOP00000074569

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	115,360,283 - 115,445,766 (+)	Ensembl
Rnor_6.0 Ensembl	7	125,189,837 - 125,277,689 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109026 ⟹ ENSRNOP00000096268

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	115,380,687 - 115,445,009 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111995 ⟹ ENSRNOP00000080773

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	115,385,172 - 115,445,009 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000113705 ⟹ ENSRNOP00000076480

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	115,360,261 - 115,445,009 (+)	Ensembl

RefSeq Acc Id:

NM_001134780 ⟹ NP_001128252

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	117,240,238 - 117,324,083 (+)	NCBI
mRatBN7.2	7	115,360,254 - 115,444,105 (+)	NCBI
Rnor_6.0	7	125,189,827 - 125,275,977 (+)	NCBI
Rnor_5.0	7	63,181,011 - 63,268,380 (+)	NCBI
RGSC_v3.4	7	122,223,325 - 122,310,356 (+)	RGD
Celera	7	111,665,408 - 111,748,729 (+)	RGD

Sequence:

show sequence

GGCCGGCGGTGGGTGGTGCGCACTCGCTTATGTCCTCCGCGCTACCACGATCGCCCACCCCGCG
GGCCCCCAAGATGAAGAAGGACGAGTCTTTCTTGGGCAAGTTGGGCGGCACACTGGCAAGGAAG
AAGAAGACCAGGGAGGTGACCGACTTGCAGGAAGAAGGCAAGAGCGCCATCAATTCTCCAATGG
CCCCGGCTTTGGTGGACATTCACCCTGAAGACACCCAGCTAGAGGAGAATGAGGAGCGCACCAT
GATCGATCCCACCTCTAGAGAAGACCCCAAGTTCAAGGAGTTGGTCAAGGTGCTTCTGGACTGG
ATCAACGACGTGCTGGCAGAGGAGCGCATCATTGTGAAGCAGCTGGAGGAGGACCTGTACGATG
GCCAGGTGCTACAGAAACTTCTGGAAAAGCTGGCACACTGCAAGCTGAATGTGGCAGAGGTGAC
GCAGTCTGAGATCGGGCAGAAGCAGAAGTTGCAGACAGTTCTGGAAGCCGTGCAAGACCTGCTC
CGGCCCCACGGCTGGCCGCTGCGTTGGAATGTGGACTCTATCCACGGGAAGAACCTGGTGTCCA
TTCTGCACCTCCTCGTCTCCCTGGCCATGCACTTCAGGGCCCCCATCCACCTTCCTGAACACGT
CACCGTGCAGGTGGTGGTCGTCCGGAAGCGGGAAGGCCTGCTGCACTCCAGCCACATCTCAGAG
GAGCTGACCACGACCACAGAGATCATGATGGGCCGGTTTGAGCGGGATGCCTTCGACACGCTCT
TCGACCACGCGCCGGACAAGCTCAACCTTGTGAAGAAGTCTCTCATCACGTTTGTGAACAAACA
CCTGAACAAGCTAAACTTGGAGGTCACTGACCTGGAGACCCAGTTTGCAGATGGTGTGTACCTG
GTTCTACTCCTGGGCCTCCTTGAAGACTACTTTGTCCCCCTCCACAACTTCTACCTGACTCCTG
ACAGCTTTGACCAGAAGGTGCACAACGTGGCCTTTGCCTTTGAACTGATGCTGGACGGGGGACT
CAAGAAGCCCAAGGCACGCCCTGAAGACGTCGTGAACTTGGACCTCAAGTCCACTCTGCGGGTC
CTTTACACACTGTTCACCAAGTACAAGGACGTCGAGTGACAGAGCAGCCGGTTCTTCAGGGACA
AGTTTTAGACAAGAAAAAAATGGTCGTGTCCATCCACAGTCCCTGATTTCCCAGGAACCGTCTC
CTCAGGGAGGCCTCAGGCTTCCCAGGTCTAGCTGTGTAATGCCTCTGCTCTCTGCTCCCTGCCT
GGTTTGGTTTTAAACCCTTTTCCCTTGTGGTTCCCTAGCTGATTAGATCATTGAGAACTTGGTG
CTTCAAACACCCACTCCAGTTTGAGGCCTCACTTCCTCTTTTTCTCTGCCTCCCCTGAAGATGA
AAGAGAACAAAGGCCCAGCCTAGCCCTCAGCTGGAAAGGGCTGTCCACCTGTGCTCCAACCCAC
GGAGCAATTACAGCAACAGCCCTGGCTCCAGGGACTCCGCCCCATTTGTCCTCAGGAATCCCCT
GGGCTGGGCTCTCCCTGGAAGCAGGGTCTCGCCTCAGTAAAAAGATCCTCTCGGGTTTTTTTCT
TTCCTGAATCTCAGAAGATTTAGACTCCTGACATGTGTCTCCACCCCCATCCTGTCTTGCGGTT
TGCTGATTTTTAACTGACCTTTTACATGAACTCTCAGGACCCAGAATGCCTTGGGGCCCCAGGG
CAGCTTGTACAAGGGCATGTCTGGGTCTCTTGCTGGCTCTGAACATGCAGCTTGAGCCGGCTCG
GAGTTGGAACCTTCCATCTCTGAGGCCCTGTTAGGGAATGGATACATTTTTAGAGACTTTACAA
GAGGGAGGGAATCCATTATGAGGGCTGCCTGACCACAGGCTACCGGCAGCCAGAATTACAGAGG
CGTGCGTCTGGCAGCTCTGGAGGCTGAGAGTAGGAGACAGAGGTGCTGGCAGGTTGCCTCTCTC
TGCCTTCACACCA

hide sequence

RefSeq Acc Id:

XM_039079610 ⟹ XP_038935538

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	117,265,152 - 117,325,744 (+)	NCBI
mRatBN7.2	7	115,385,279 - 115,445,767 (+)	NCBI

RefSeq Acc Id:

XM_039079611 ⟹ XP_038935539

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	117,265,034 - 117,325,744 (+)	NCBI
mRatBN7.2	7	115,385,104 - 115,445,767 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001128252	(Get FASTA)	NCBI Sequence Viewer
	XP_038935538	(Get FASTA)	NCBI Sequence Viewer
	XP_038935539	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66826	(Get FASTA)	NCBI Sequence Viewer
	EDM15606	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074569
	ENSRNOP00000074569.2
	ENSRNOP00000075605
	ENSRNOP00000075605.1
	ENSRNOP00000076480.1
	ENSRNOP00000080773.1
	ENSRNOP00000096268
	ENSRNOP00000096268.1

RefSeq Acc Id:

NP_001128252 ⟸ NM_001134780

- UniProtKB:

A0A0G2KB09 (UniProtKB/TrEMBL), A0A8I5Y6N4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSALPRSPTPRAPKMKKDESFLGKLGGTLARKKKTREVTDLQEEGKSAINSPMAPALVDIHPE
DTQLEENEERTMIDPTSREDPKFKELVKVLLDWINDVLAEERIIVKQLEEDLYDGQVLQKLLEK
LAHCKLNVAEVTQSEIGQKQKLQTVLEAVQDLLRPHGWPLRWNVDSIHGKNLVSILHLLVSLAM
HFRAPIHLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEIMMGRFERDAFDTLFDHAPDKLNL
VKKSLITFVNKHLNKLNLEVTDLETQFADGVYLVLLLGLLEDYFVPLHNFYLTPDSFDQKVHNV
AFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYTLFTKYKDVE

hide sequence

Ensembl Acc Id:

ENSRNOP00000074569 ⟸ ENSRNOT00000082805

Ensembl Acc Id:

ENSRNOP00000075605 ⟸ ENSRNOT00000080152

RefSeq Acc Id:	XP_038935539 ⟸ XM_039079611
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6AS53 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038935538 ⟸ XM_039079610
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZR23 (UniProtKB/TrEMBL), A0A8I6AS53 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000096268 ⟸ ENSRNOT00000109026

Ensembl Acc Id:

ENSRNOP00000080773 ⟸ ENSRNOT00000111995

Ensembl Acc Id:

ENSRNOP00000076480 ⟸ ENSRNOT00000113705

Protein Domains

Calponin-homology (CH)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZKG5-F1-model_v2	AlphaFold	D3ZKG5	1-365	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695565

Promoter ID:

EPDNEW_R6081

Type:

initiation region

Name:

Parvb_1

Description:

parvin, beta

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	125,189,846 - 125,189,906	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311485	AgrOrtholog
BioCyc Gene	G2FUF-32580	BioCyc
Ensembl Genes	ENSRNOG00000055305	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000080152	ENTREZGENE
	ENSRNOT00000080152.2	UniProtKB/TrEMBL
	ENSRNOT00000082805	ENTREZGENE
	ENSRNOT00000082805.2	UniProtKB/TrEMBL
	ENSRNOT00000109026	ENTREZGENE
	ENSRNOT00000109026.1	UniProtKB/TrEMBL
	ENSRNOT00000111995.1	UniProtKB/TrEMBL
	ENSRNOT00000113705.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.10	UniProtKB/TrEMBL
InterPro	Calponin-like_dom_sf	UniProtKB/TrEMBL
	Calponin_act-bd	UniProtKB/TrEMBL
	Parvin	UniProtKB/TrEMBL
KEGG Report	rno:362973	UniProtKB/TrEMBL
NCBI Gene	362973	ENTREZGENE
PANTHER	BETA-PARVIN	UniProtKB/TrEMBL
	PTHR12114	UniProtKB/TrEMBL
Pfam	PF00307	UniProtKB/TrEMBL
PhenoGen	Parvb	PhenoGen
PIRSF	Parvin	UniProtKB/TrEMBL
PROSITE	PS50021	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000055305	RatGTEx
SMART	SM00033	UniProtKB/TrEMBL
Superfamily-SCOP	Calponin-homology	UniProtKB/TrEMBL
UniProt	A0A0G2KB09	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5Y6N4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZR23	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AS53	ENTREZGENE, UniProtKB/TrEMBL
	B2RYL9_RAT	UniProtKB/TrEMBL
	D3ZKG5_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Parvb	parvin, beta	Parvb_predicted	parvin, beta (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Parvb_predicted	parvin, beta (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

RGD Manual Annotations