Xrcc6 (X-ray repair cross complementing 6)

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Gene: Xrcc6 (X-ray repair cross complementing 6) Rattus norvegicus

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Symbol:

Xrcc6

Name:

X-ray repair cross complementing 6

RGD ID:

2643

Description:

Contributes to double-stranded DNA binding activity. Involved in cellular hyperosmotic salinity response and cellular response to X-ray. Part of protein-containing complex. Orthologous to human XRCC6 (X-ray repair cross complementing 6); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; 7,12-dimethyltetraphene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

G22p1; Ku70; Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa); Kup70; thyroid autoantigen; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	115,423,026 - 115,443,884 (+)	NCBI		GRCr8
mRatBN7.2	7	113,542,992 - 113,563,762 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	113,543,057 - 113,563,762 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	115,299,552 - 115,320,274 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	117,523,052 - 117,543,774 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	117,492,491 - 117,513,218 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	123,259,881 - 123,280,613 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	123,259,761 - 123,280,612 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	123,244,581 - 123,265,278 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	120,401,944 - 120,422,923 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	120,436,196 - 120,457,039 (+)	NCBI
Celera	7	109,858,919 - 109,879,605 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

Animal Disease Models (ISO)

basal cell carcinoma (ISO)

common variable immunodeficiency 4 (ISO)

lung adenocarcinoma (ISO)

squamous cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

(R,R,R)-alpha-tocopherol (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,2'-dithiodiethanol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3'-diindolylmethane (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

7,12-dimethyltetraphene (EXP,ISO)

acrolein (ISO)

acrylonitrile (EXP)

aldehydo-D-glucose (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

biphenyl-4-amine (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bupivacaine (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumarin (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

curcumin (ISO)

cyclophosphamide (ISO)

D-glucose (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

doxorubicin (EXP,ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenthion (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

glucose (ISO)

idarubicin (ISO)

ivermectin (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

melatonin (ISO)

methyl methanesulfonate (ISO)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (ISO)

ochratoxin A (EXP)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

phosphoramide mustard (EXP)

potassium bromate (ISO)

resveratrol (EXP,ISO)

rotenone (EXP)

sodium arsenite (ISO)

sulindac sulfide (ISO)

tamoxifen (EXP)

terbufos (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

vitamin E (ISO)

vorinostat (ISO)

wortmannin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (ISO)

cellular hyperosmotic salinity response (IDA)

cellular response to gamma radiation (ISO)

cellular response to X-ray (IDA)

DNA damage response (ISO)

DNA duplex unwinding (IEA)

double-strand break repair (ISO,TAS)

double-strand break repair via classical nonhomologous end joining (ISO)

double-strand break repair via nonhomologous end joining (IBA,ISO)

negative regulation of DNA-templated transcription (ISO)

neurogenesis (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of lymphocyte differentiation (ISO)

positive regulation of neurogenesis (ISO)

positive regulation of protein kinase activity (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of smooth muscle cell proliferation (ISO)

response to ionizing radiation (ISO)

telomere maintenance (IBA)

V(D)J recombination (ISO)

Cellular Component

cytoplasm (ISO)

DNA-dependent protein kinase complex (ISO)

DNA-dependent protein kinase-DNA ligase 4 complex (ISO)

Ku70:Ku80 complex (IBA,ISO)

nonhomologous end joining complex (ISO)

nucleolus (ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

protein-containing complex (IDA,ISO)

protein-DNA complex (ISO)

transcription regulator complex (ISO)

Molecular Function

5'-deoxyribose-5-phosphate lyase activity (ISO)

ATP binding (IEA)

ATP hydrolysis activity (ISO)

ATP-dependent activity, acting on DNA (ISO)

cyclin binding (ISO)

damaged DNA binding (IEA)

DNA end binding (ISO)

DNA helicase activity (ISO)

double-stranded DNA binding (IBA,IDA,ISO)

double-stranded telomeric DNA binding (ISO)

protein binding (IPI,ISO)

protein-containing complex binding (ISO)

scaffold protein binding (ISO)

telomeric DNA binding (IBA)

transcription cis-regulatory region binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

non-homologous end joining pathway of double-strand break repair (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Autoantigen Ku in the brain. Developmentally regulated expression and subcellular localization.	Bakalkin G, etal., Neuroreport. 1998 Jun 22;9(9):2147-51.
2.	Hypertonic treatment inhibits radiation-induced nuclear translocation of the Ku proteins G22p1 (Ku70) and Xrcc5 (Ku80) in rat fibroblasts.	Endoh D, etal., Radiat Res. 2001 Feb;155(2):320-7.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.	Hammer F, etal., Endocrinology 2004 Feb;145(2):901-12. Epub 2003 Oct 23.
6.	Immunolocalization of Ku-proteins (p80/p70): localization of p70 to nucleoli and periphery of both interphase nuclei and metaphase chromosomes.	Higashiura M, etal., Exp Cell Res. 1992 Aug;201(2):444-51.
7.	Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.	Jin S and Weaver DT, EMBO J. 1997 Nov 17;16(22):6874-85. doi: 10.1093/emboj/16.22.6874.
8.	The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.	Lieber MR Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Deficiency in nuclear accumulation of G22p1 and Xrcc5 proteins in hyper-radiosensitive Long-Evans Cinnamon (LEC) rat cells after X irradiation.	Okui T, etal., Radiat Res 2002 May;157(5):553-61.
11.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
12.	Expression and heterodimer-binding activity of Ku70 and Ku80 in human non-melanoma skin cancer.	Parrella P, etal., J Clin Pathol. 2006 Nov;59(11):1181-5. Epub 2006 Feb 23.
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8621488	PMID:10409678	PMID:10716994	PMID:10783163	PMID:11751629	PMID:12145306	PMID:12377759	PMID:12604618	PMID:15159402	PMID:15979950	PMID:18162465	PMID:18378183
PMID:18809223	PMID:19121380	PMID:19135898	PMID:19723106	PMID:19946888	PMID:20150414	PMID:20383123	PMID:21568942	PMID:22019940	PMID:22504299	PMID:22658674	PMID:22681889
PMID:24095731	PMID:25852083	PMID:25941166	PMID:26359349	PMID:27621182	PMID:27829214	PMID:28712728

Genomics

Comparative Map Data

Xrcc6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	115,423,026 - 115,443,884 (+)	NCBI		GRCr8
mRatBN7.2	7	113,542,992 - 113,563,762 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	113,543,057 - 113,563,762 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	115,299,552 - 115,320,274 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	117,523,052 - 117,543,774 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	117,492,491 - 117,513,218 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	123,259,881 - 123,280,613 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	123,259,761 - 123,280,612 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	123,244,581 - 123,265,278 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	120,401,944 - 120,422,923 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	120,436,196 - 120,457,039 (+)	NCBI
Celera	7	109,858,919 - 109,879,605 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

XRCC6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	41,621,295 - 41,664,041 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	41,621,163 - 41,664,048 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	42,017,299 - 42,060,045 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	40,347,241 - 40,389,998 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	40,341,794 - 40,384,552	NCBI
Celera	22	25,823,724 - 25,866,486 (+)	NCBI		Celera
Cytogenetic Map	22	q13.2	NCBI
HuRef	22	24,982,897 - 25,025,516 (+)	NCBI		HuRef
CHM1_1	22	41,977,343 - 42,020,083 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	42,100,225 - 42,143,017 (+)	NCBI		T2T-CHM13v2.0

Xrcc6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	81,868,805 - 81,924,286 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	81,872,036 - 81,924,286 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	81,987,833 - 82,040,085 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	81,987,835 - 82,040,085 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	81,846,799 - 81,870,514 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	81,843,555 - 81,867,327 (+)	NCBI		MGSCv36	mm8
Celera	15	84,138,425 - 84,161,793 (+)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	38.33	NCBI

Xrcc6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	27,135,805 - 27,159,750 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	27,135,785 - 27,158,344 (+)	NCBI	ChiLan1.0	ChiLan1.0

XRCC6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	51,452,534 - 51,493,784 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	54,151,029 - 54,193,092 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	22,516,281 - 22,557,379 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	40,626,191 - 40,643,540 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	40,603,038 - 40,643,314 (+)	Ensembl	panpan1.1		panPan2

XRCC6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	23,637,905 - 23,661,618 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	23,638,237 - 23,661,480 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	23,571,669 - 23,594,987 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	24,383,246 - 24,406,874 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	24,382,986 - 24,406,763 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	24,100,152 - 24,123,487 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	24,421,552 - 24,445,083 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	24,595,424 - 24,619,012 (-)	NCBI		UU_Cfam_GSD_1.0

Xrcc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	7,293,429 - 7,315,475 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	300,057 - 325,845 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	303,843 - 325,812 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

XRCC6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	6,903,495 - 6,929,052 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	6,903,496 - 6,929,162 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	4,274,586 - 4,300,429 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

XRCC6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	24,160,459 - 24,204,237 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	24,160,483 - 24,206,320 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	101,209,345 - 101,253,933 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Xrcc6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	6,979,271 - 7,010,787 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	6,987,456 - 7,010,834 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Xrcc6
128 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	105
Count of miRNA genes:	75
Interacting mature miRNAs:	79
Transcripts:	ENSRNOT00000008819, ENSRNOT00000066849
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Markers in Region

RH131971

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	113,563,535 - 113,563,743 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	123,280,387 - 123,280,594	NCBI	Rnor6.0
Rnor_5.0	7	123,265,052 - 123,265,259	UniSTS	Rnor5.0
RGSC_v3.4	7	120,422,697 - 120,422,904	UniSTS	RGSC3.4
Celera	16	17,241,644 - 17,241,851	UniSTS
Celera	7	109,879,379 - 109,879,586	UniSTS
RH 3.4 Map	7	893.1	UniSTS
Cytogenetic Map	7	q34	UniSTS

AI230026

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	113,559,122 - 113,559,330 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	123,275,974 - 123,276,181	NCBI	Rnor6.0
Rnor_5.0	7	123,260,639 - 123,260,846	UniSTS	Rnor5.0
RGSC_v3.4	7	120,418,284 - 120,418,491	UniSTS	RGSC3.4
Celera	7	109,874,966 - 109,875,173	UniSTS
RH 3.4 Map	7	889.2	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_139080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB066102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC128377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000008819 ⟹ ENSRNOP00000008819

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	113,544,966 - 113,563,762 (+)	Ensembl
Rnor_6.0 Ensembl	7	123,259,761 - 123,280,612 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000066849 ⟹ ENSRNOP00000061920

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	113,543,057 - 113,563,607 (+)	Ensembl
Rnor_6.0 Ensembl	7	123,260,607 - 123,280,510 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105863 ⟹ ENSRNOP00000081965

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	113,547,679 - 113,563,762 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108388 ⟹ ENSRNOP00000082673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	113,543,121 - 113,563,760 (+)	Ensembl

RefSeq Acc Id:

NM_139080 ⟹ NP_620780

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	115,423,184 - 115,443,884 (+)	NCBI
mRatBN7.2	7	113,543,057 - 113,563,762 (+)	NCBI
Rnor_6.0	7	123,259,892 - 123,280,613 (+)	NCBI
Rnor_5.0	7	123,244,581 - 123,265,278 (+)	NCBI
RGSC_v3.4	7	120,401,944 - 120,422,923 (+)	RGD
Celera	7	109,858,919 - 109,879,605 (+)	RGD

Sequence:

show sequence

GAGACCTGGAGCCCGCGTGGAAGTGGCGCCCACCCTCTTCTGTCCCAGTGGCGCTCTCGCCTCC
GGCTAAGTGACCAAACAAACATGTCAGAGTGGGAATCCTACTACAAAACTGAGGGTGAGGAAGA
GGAAGAGGAGGAGCAGAGCCCTGACACAAATGGAGAATATAAATATTCAGGAAGAGATAGTTTG
ATTTTTCTGGTTGACGCCTCCAGGGCTATGTTTGAATCTCAGGGTGAAGACGAGCTCACACCTT
TTGATATGAGCATCCAGTGTATCCAGAGTGTGTACACCAGTAAGATCATAAGCAGCGATCGGGA
TCTCTTGGCAGTGGTGTTCTATGGTACCGAGAAAGACAAAAATTCAGTGAACTTCAAAAGTATT
TATGTCTTACAAGATCTGGATAACCCAGGAGCTAAACGAGTGTTAGAGCTTGACCGCTTTAAGG
GACAACAGGGGAAAAAACATTTCCGAGACACAATTGGCCATGGGTCTGACTACTCTTTGAGTGA
AGTGCTCTGGGTCTGTGCCAACCTCTTCAGCGACGTCCAGTTCAAGATGAGTCATAAGAGGATC
ATGCTATTCACCAATGAAGATGACCCCCATGGTAATGACAGTGCCAAAGCCAGCCGGGCCAGGA
CCAAAGCCAGCGATCTGCGGGACACTGGGATCTTCCTCGACTTGATGCACCTGAAGAAGCGAGG
GGGCTTTGACGTGTCCTTGTTCTACAGAGACATCATCAGCATCGCTGAGGATGAGGACCTCGGG
GTTCACTTTGAGGAGTCAAGCAAGCTGGAAGACCTGCTAAGGAAGGTTCGAGCCAAGGAGACCA
AAAAGCGAGTGCTGTCCAGGTTAAAGTTTAAGCTCGGCAAAGACGTAGCACTCATGGTGGGCGT
TTATAACTTGGTCCAGAAAGCTAACAAGCCTTTTCCAGTGAGGCTGTATCGAGAAACAAACGAA
CCAGTGAAAACTAAGACAAGGACTTTTAATGTAAACACAGGCAGTCTGCTCCTGCCCAGTGATA
CCAAGCGGTCTCTGACTTTTGGGACGCGTCAGATTGTGCTGGAGAAAGAGGAAACAGAGGAGCT
GAAGCGGTTTGATGAGCCAGGTTTGATTCTCATGGGCTTTAAGCCCATGGTAATGCTGAAGAAC
CACCACTACCTGAGGCCCTCTCTGTTCCTGTACCCAGAGGAGTCCTTGGTCAACGGGAGCTCAA
CCTTGTTCAGCGCCCTGCTCACCAAGTGTGTGGAGAAGGAGGTCATAGCAGTGTGTAGATACAC
AGCCCGAAAGAATGTCTCCCCTTATTTTGTGGCTTTGGTGCCACAGGAAGAGGAGCTAGATGAT
CAGAACATTCAGGTGACTCCCGCAGGCTTCCAGCTTGTCTTCCTCCCTTACGCCGATGACAAGC
GGAAGGTGCCCTTTACGGAGAAGGTGATGGCCAACCCGGAACAGATAGACAAGATGAAGGCCAT
TGTTCAAAAGCTCCGCTTTACATACAGGAGCGACAGTTTCGAGAACCCAGTGCTGCAGCAGCAC
TTCCGGAACCTGGAGGCCCTAGCTTTGGACATGATGGAGTCGGAGCAAGTGGTAGATCTGACAC
TGCCCAAGGTTGAAGCCATAAAGAAAAGACTGGGCTCCCTGGCAGATGAGTTTAAAGAACTTGT
CTACCCTCCAGGTTATAATCCTGAGGGAAAAATTGCCAAGAGAAAAGCAGACAATGAAGGTTCT
GCAAGTAAAAAGCCCAAGGTAGAGTTATCAGAAGAGGAGCTGAAGGACCTTTTTGCCAAGGGCA
CACTGGGCAAGCTCACTGTGCCTGCACTGAGGGACATCTGCAAGGCCTATGGGCTAAAGAGTGG
ACCGAAGAAGCAGGAACTACTCGAGGCTCTCAGCAGACACTTGGAGAAGAACTGACTAATGATC
ACACGCCCAGCCACCTTCCACACTGCAGTCAGGCCAAGCTAGGTGTTAGCTACAGAGAGCCACC
TAACAGAAAATGCAAGACCTTCACCATGGAGTGCTGCCCTCCCACCTCACTGTGCCTTACTCTG
TGAATAAAGAGCTCTAACTTTA

hide sequence

RefSeq Acc Id:

XM_008765671 ⟹ XP_008763893

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	115,423,026 - 115,443,884 (+)	NCBI
mRatBN7.2	7	113,542,992 - 113,563,762 (+)	NCBI
Rnor_6.0	7	123,259,881 - 123,280,613 (+)	NCBI

Sequence:

show sequence

TGATTGGACGAGAGACCTGGAGCCCGCGTGGAAGTGGCGCCCACCCTCTTCTGTCCCAGTGGCG
CTCTCGCCTCCGGCTAAGTGACCAAACAAACATGTCAGAGTGGGAATCCTACTACAAAACTGAG
GGTGAGGAAGAGGAAGAGGAGGAGCAGAGCCCTGACACAAATGGAGAATATAAATATTCAGGAA
GAGATAGTTTGATTTTTCTGGTTGACGCCTCCAGGGCTATGTTTGAATCTCAGGGTGAAGACGA
GCTCACACCTTTTGATATGAGCATCCAGTGTATCCAGAGTGTGTACACCAGTAAGATCATAAGC
AGCGATCGGGATCTCTTGGCAGTGGTGTTCTATGGTACCGAGAAAGACAAAAATTCAGTGAACT
TCAAAAGTATTTATGTCTTACAAGATCTGGATAACCCAGGAGCTAAACGAGTGTTAGAGCTTGA
CCGCTTTAAGGGACAACAGGGGAAAAAACATTTCCGAGACACAATTGGCCATGGGTCTGACTAC
TCTTTGAGTGAAGTGCTCTGGGTCTGTGCCAACCTCTTCAGCGACGTCCAGTTCAAGATGAGTC
ATAAGAGGATCATGCTATTCACCAATGAAGATGACCCCCATGGTAATGACAGTGCCAAAGCCAG
CCGGGCCAGGACCAAAGCCAGCGATCTGCGGGACACTGGGATCTTCCTCGACTTGATGCACCTG
AAGAAGCGAGGGGGCTTTGACGTGTCCTTGTTCTACAGAGACATCATCAGCATCGCTGAGGATG
AGGACCTCGGGGTTCACTTTGAGGAGTCAAGCAAGCTGGAAGACCTGCTAAGGAAGGTTCGAGC
CAAGGAGACCAAAAAGCGAGTGCTGTCCAGGTTAAAGTTTAAGCTCGGCAAAGACGTAGCACTC
ATGGTGGGCGTTTATAACTTGGTCCAGAAAGCTAACAAGCCTTTTCCAGTGAGGCTGTATCGAG
AAACAAACGAACCAGTGAAAACTAAGACAAGGACTTTTAATGTAAACACAGGCAGTCTGCTCCT
GCCCAGTGATACCAAGCGGTCTCTGACTTTTGGGACGCGTCAGATTGTGCTGGAGAAAGAGGAA
ACAGAGGAGCTGAAGCGGTTTGATGAGCCAGGTTTGATTCTCATGGGCTTTAAGCCCATGGTAA
TGCTGAAGAACCACCACTACCTGAGGCCCTCTCTGTTCCTGTACCCAGAGGAGTCCTTGGTCAA
CGGCTTCCAGCTTGTCTTCCTCCCTTACGCCGATGACAAGCGGAAGGTGCCCTTTACGGAGAAG
GTGATGGCCAACCCGGAACAGATAGACAAGATGAAGGCCATTGTTCAAAAGCTCCGCTTTACAT
ACAGGAGCGACAGTTTCGAGAACCCAGTGCTGCAGCAGCACTTCCGGAACCTGGAGGCCCTAGC
TTTGGACATGATGGAGTCGGAGCAAGTGGTAGATCTGACACTGCCCAAGGTTGAAGCCATAAAG
AAAAGACTGGGCTCCCTGGCAGATGAGTTTAAAGAACTTGTCTACCCTCCAGGTTATAATCCTG
AGGGAAAAATTGCCAAGAGAAAAGCAGACAATGAAGGTTCTGCAAGTAAAAAGCCCAAGGTAGA
GTTATCAGAAGAGGAGCTGAAGGACCTTTTTGCCAAGGGCACACTGGGCAAGCTCACTGTGCCT
GCACTGAGGGACATCTGCAAGGCCTATGGGCTAAAGAGTGGACCGAAGAAGCAGGAACTACTCG
AGGCTCTCAGCAGACACTTGGAGAAGAACTGACTAATGATCACACGCCCAGCCACCTTCCACAC
TGCAGTCAGGCCAAGCTAGGTGTTAGCTACAGAGAGCCACCTAACAGAAAATGCAAGACCTTCA
CCATGGAGTGCTGCCCTCCCACCTCACTGTGCCTTACTCTGTGAATAAAGAGCTCTAACTTTA

hide sequence

RefSeq Acc Id:

XM_063263006 ⟹ XP_063119076

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	115,423,026 - 115,440,329 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_620780	(Get FASTA)	NCBI Sequence Viewer
	XP_008763893	(Get FASTA)	NCBI Sequence Viewer
	XP_063119076	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78718	(Get FASTA)	NCBI Sequence Viewer
	BAB83858	(Get FASTA)	NCBI Sequence Viewer
	EDM15680	(Get FASTA)	NCBI Sequence Viewer
	EDM15681	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008819.5
	ENSRNOP00000061920.1
	ENSRNOP00000081965.1
	ENSRNOP00000082673.1

RefSeq Acc Id:

NP_620780 ⟸ NM_139080

- UniProtKB:

Q6AZ64 (UniProtKB/TrEMBL), E9PT85 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSEWESYYKTEGEEEEEEEQSPDTNGEYKYSGRDSLIFLVDASRAMFESQGEDELTPFDMSIQC
IQSVYTSKIISSDRDLLAVVFYGTEKDKNSVNFKSIYVLQDLDNPGAKRVLELDRFKGQQGKKH
FRDTIGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDDPHGNDSAKASRARTKASDLR
DTGIFLDLMHLKKRGGFDVSLFYRDIISIAEDEDLGVHFEESSKLEDLLRKVRAKETKKRVLSR
LKFKLGKDVALMVGVYNLVQKANKPFPVRLYRETNEPVKTKTRTFNVNTGSLLLPSDTKRSLTF
GTRQIVLEKEETEELKRFDEPGLILMGFKPMVMLKNHHYLRPSLFLYPEESLVNGSSTLFSALL
TKCVEKEVIAVCRYTARKNVSPYFVALVPQEEELDDQNIQVTPAGFQLVFLPYADDKRKVPFTE
KVMANPEQIDKMKAIVQKLRFTYRSDSFENPVLQQHFRNLEALALDMMESEQVVDLTLPKVEAI
KKRLGSLADEFKELVYPPGYNPEGKIAKRKADNEGSASKKPKVELSEEELKDLFAKGTLGKLTV
PALRDICKAYGLKSGPKKQELLEALSRHLEKN

hide sequence

RefSeq Acc Id:	XP_008763893 ⟸ XM_008765671
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZXI9 (UniProtKB/TrEMBL), E9PT85 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSEWESYYKTEGEEEEEEEQSPDTNGEYKYSGRDSLIFLVDASRAMFESQGEDELTPFDMSIQC IQSVYTSKIISSDRDLLAVVFYGTEKDKNSVNFKSIYVLQDLDNPGAKRVLELDRFKGQQGKKH FRDTIGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDDPHGNDSAKASRARTKASDLR DTGIFLDLMHLKKRGGFDVSLFYRDIISIAEDEDLGVHFEESSKLEDLLRKVRAKETKKRVLSR LKFKLGKDVALMVGVYNLVQKANKPFPVRLYRETNEPVKTKTRTFNVNTGSLLLPSDTKRSLTF GTRQIVLEKEETEELKRFDEPGLILMGFKPMVMLKNHHYLRPSLFLYPEESLVNGFQLVFLPYA DDKRKVPFTEKVMANPEQIDKMKAIVQKLRFTYRSDSFENPVLQQHFRNLEALALDMMESEQVV DLTLPKVEAIKKRLGSLADEFKELVYPPGYNPEGKIAKRKADNEGSASKKPKVELSEEELKDLF AKGTLGKLTVPALRDICKAYGLKSGPKKQELLEALSRHLEKN hide sequence

Ensembl Acc Id:

ENSRNOP00000008819 ⟸ ENSRNOT00000008819

Ensembl Acc Id:

ENSRNOP00000061920 ⟸ ENSRNOT00000066849

Ensembl Acc Id:

ENSRNOP00000081965 ⟸ ENSRNOT00000105863

Ensembl Acc Id:

ENSRNOP00000082673 ⟸ ENSRNOT00000108388

RefSeq Acc Id:	XP_063119076 ⟸ XM_063263006
- Peptide Label:	isoform X2

Protein Domains

SAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PT85-F1-model_v2	AlphaFold	E9PT85	1-609	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695525

Promoter ID:

EPDNEW_R6049

Type:

multiple initiation site

Name:

Xrcc6_1

Description:

X-ray repair cross complementing 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	123,259,938 - 123,259,998	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2643	AgrOrtholog
BioCyc Gene	G2FUF-32648	BioCyc
Ensembl Genes	ENSRNOG00000006392	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008819.8	UniProtKB/TrEMBL
	ENSRNOT00000066849.2	UniProtKB/TrEMBL
	ENSRNOT00000105863.1	UniProtKB/TrEMBL
	ENSRNOT00000108388.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1600.10	UniProtKB/TrEMBL
	1.10.720.30	UniProtKB/TrEMBL
	2.40.290.10	UniProtKB/TrEMBL
	3.40.50.410	UniProtKB/TrEMBL
	4.10.970.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7115290	IMAGE-MGC_LOAD
InterPro	DNA_helicase_ATP-dep_Ku	UniProtKB/TrEMBL
	DNA_helicase_ATP-dep_Ku70	UniProtKB/TrEMBL
	Ku70_bridge/pillars_dom	UniProtKB/TrEMBL
	KU70_core_dom	UniProtKB/TrEMBL
	Ku_C	UniProtKB/TrEMBL
	Ku_N	UniProtKB/TrEMBL
	SAP_DNA-bd	UniProtKB/TrEMBL
	SAP_dom_sf	UniProtKB/TrEMBL
	SPOC-like	UniProtKB/TrEMBL
	vWFA_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:25019	UniProtKB/TrEMBL
MGC_CLONE	MGC:93146	IMAGE-MGC_LOAD
NCBI Gene	25019	ENTREZGENE
PANTHER	KU AUTOANTIGEN DNA HELICASE	UniProtKB/TrEMBL
	X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6	UniProtKB/TrEMBL
Pfam	Ku_C	UniProtKB/TrEMBL
	Ku_N	UniProtKB/TrEMBL
	PF02735	UniProtKB/TrEMBL
	SAP	UniProtKB/TrEMBL
PhenoGen	Xrcc6	PhenoGen
PIRSF	Ku70	UniProtKB/TrEMBL
PROSITE	SAP	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006392	RatGTEx
SMART	Ku78	UniProtKB/TrEMBL
	SAP	UniProtKB/TrEMBL
Superfamily-SCOP	SPOC-like	UniProtKB/TrEMBL
	SSF53300	UniProtKB/TrEMBL
	SSF68906	UniProtKB/TrEMBL
UniProt	A0A8I5ZSS0_RAT	UniProtKB/TrEMBL
	A0A8I5ZXI9	ENTREZGENE, UniProtKB/TrEMBL
	A6HT42_RAT	UniProtKB/TrEMBL
	E9PT85	ENTREZGENE, UniProtKB/TrEMBL
	F7EV16_RAT	UniProtKB/TrEMBL
	Q6AZ64	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-08	Xrcc6	X-ray repair cross complementing 6	Xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6	G22p1	thyroid autoantigen	Symbol and Name updated	1299863	APPROVED
2002-11-06	G22p1	thyroid autoantigen		Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa)	Name updated	625702	APPROVED
2002-06-10	G22p1	Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa)			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)