Xrcc5 (X-ray repair cross complementing 5) - Rat Genome Database

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Gene: Xrcc5 (X-ray repair cross complementing 5) Rattus norvegicus
Analyze
Symbol: Xrcc5
Name: X-ray repair cross complementing 5
RGD ID: 3976
Description: Contributes to double-stranded DNA binding activity. Involved in several processes, including cellular hyperosmotic salinity response; cellular response to X-ray; and cellular response to fatty acid. Located in cytoplasm and nucleus. Part of protein-containing complex. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple myeloma; and rectum cancer. Orthologous to human XRCC5 (X-ray repair cross complementing 5); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 2,6-dinitrotoluene; 3-chloropropane-1,2-diol; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ku autoantigen, 80kD); Ku80; Kup80; X-ray repair complementing defective repair in Chinese hamster cells 5; X-ray repair cross complementation (double-strand-break rejoining; X-ray repair cross complementation (double-strand-break rejoining, Ku autoantigen, 80kD); X-ray repair cross-complementing protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2973,955,220 - 74,044,020 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl973,955,216 - 74,044,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx982,419,375 - 82,508,055 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0987,548,243 - 87,636,932 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0985,935,851 - 86,024,584 (+)NCBIRnor_WKY
Rnor_6.0979,659,275 - 79,748,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl979,659,251 - 79,748,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0979,432,205 - 79,520,611 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4971,472,459 - 71,581,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1971,619,440 - 71,728,918 (+)NCBI
Celera971,352,925 - 71,440,328 (+)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2'-dithiodiethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-1,8-naphthalimide  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
biphenyl-4-amine  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
curcumin  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
etoposide  (ISO)
fenofibrate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nitrogen mustard  (ISO)
ozone  (ISO)
p-anisidine  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP)
prochloraz  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium fluoride  (ISO)
sulindac  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Autoantigen Ku in the brain. Developmentally regulated expression and subcellular localization. Bakalkin G, etal., Neuroreport. 1998 Jun 22;9(9):2147-51.
2. Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro. Benadiba M, etal., IUBMB Life. 2009 Mar;61(3):244-51.
3. Hypertonic treatment inhibits radiation-induced nuclear translocation of the Ku proteins G22p1 (Ku70) and Xrcc5 (Ku80) in rat fibroblasts. Endoh D, etal., Radiat Res. 2001 Feb;155(2):320-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Hammer F, etal., Endocrinology 2004 Feb;145(2):901-12. Epub 2003 Oct 23.
7. Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myeloma. Hayden PJ, etal., Hum Mol Genet. 2007 Dec 15;16(24):3117-27. Epub 2007 Sep 26.
8. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Hersh CP, etal., Am J Respir Crit Care Med. 2010 Sep 1;182(5):605-13. doi: 10.1164/rccm.200910-1586OC. Epub 2010 May 12.
9. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Lieber MR Annu Rev Biochem. 2010;79:181-211. doi: 10.1146/annurev.biochem.052308.093131.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome. Naccarati A, etal., Oncotarget. 2016 Apr 26;7(17):23156-69. doi: 10.18632/oncotarget.6804.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Effect of fenofibrate on oxidative DNA damage and on gene expression related to cell proliferation and apoptosis in rats. Nishimura J, etal., Toxicol Sci. 2007 May;97(1):44-54. Epub 2007 Jan 29.
14. Deficiency in nuclear accumulation of G22p1 and Xrcc5 proteins in hyper-radiosensitive Long-Evans Cinnamon (LEC) rat cells after X irradiation. Okui T, etal., Radiat Res 2002 May;157(5):553-61.
15. Expression and heterodimer-binding activity of Ku70 and Ku80 in human non-melanoma skin cancer. Parrella P, etal., J Clin Pathol. 2006 Nov;59(11):1181-5. Epub 2006 Feb 23.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8621488   PMID:10409678   PMID:10535943   PMID:10716994   PMID:10783163   PMID:12377759   PMID:12531011   PMID:12604618   PMID:14704337   PMID:17010969   PMID:17554309   PMID:18809223  
PMID:19135898   PMID:19188702   PMID:19549901   PMID:19581589   PMID:19946888   PMID:20383123   PMID:20439489   PMID:22266820   PMID:22504299   PMID:22658674   PMID:22681889   PMID:24095731  
PMID:25852083   PMID:25941166   PMID:26321753   PMID:26359349   PMID:27248496   PMID:28712728   PMID:32103174  


Genomics

Comparative Map Data
Xrcc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2973,955,220 - 74,044,020 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl973,955,216 - 74,044,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx982,419,375 - 82,508,055 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0987,548,243 - 87,636,932 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0985,935,851 - 86,024,584 (+)NCBIRnor_WKY
Rnor_6.0979,659,275 - 79,748,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl979,659,251 - 79,748,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0979,432,205 - 79,520,611 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4971,472,459 - 71,581,936 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1971,619,440 - 71,728,918 (+)NCBI
Celera971,352,925 - 71,440,328 (+)NCBICelera
Cytogenetic Map9q33NCBI
XRCC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382216,109,348 - 216,206,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2216,107,464 - 216,206,303 (+)EnsemblGRCh38hg38GRCh38
GRCh372216,974,071 - 217,071,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362216,682,378 - 216,779,248 (+)NCBINCBI36Build 36hg18NCBI36
Build 342216,799,637 - 216,896,509NCBI
Celera2210,743,609 - 210,840,560 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2208,830,614 - 208,927,713 (+)NCBIHuRef
CHM1_12216,979,976 - 217,076,949 (+)NCBICHM1_1
T2T-CHM13v2.02216,594,753 - 216,691,715 (+)NCBIT2T-CHM13v2.0
Xrcc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39172,346,576 - 72,434,112 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl172,346,586 - 72,434,111 (+)EnsemblGRCm39 Ensembl
GRCm38172,307,417 - 72,394,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl172,307,427 - 72,394,952 (+)EnsemblGRCm38mm10GRCm38
MGSCv37172,353,995 - 72,441,527 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36172,240,728 - 72,328,156 (+)NCBIMGSCv36mm8
Celera172,875,673 - 72,963,703 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.5NCBI
Xrcc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545316,967,453 - 17,054,634 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545316,967,453 - 17,054,634 (-)NCBIChiLan1.0ChiLan1.0
XRCC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B221,972,607 - 222,072,318 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B221,972,742 - 222,071,235 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B103,371,459 - 103,468,419 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
XRCC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13723,095,769 - 23,185,680 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3723,095,754 - 23,185,586 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3723,923,245 - 24,015,080 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03723,120,975 - 23,212,731 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3723,120,932 - 23,212,731 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13723,007,952 - 23,098,174 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03722,960,108 - 23,051,031 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03722,977,769 - 23,068,341 (+)NCBIUU_Cfam_GSD_1.0
Xrcc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303171,487,889 - 171,588,600 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365861,055,478 - 1,137,924 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XRCC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15118,354,796 - 118,451,960 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115118,354,943 - 118,451,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215131,235,804 - 131,332,992 (+)NCBISscrofa10.2Sscrofa10.2susScr3
XRCC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110101,952,909 - 102,051,059 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10101,953,067 - 102,049,964 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604097,347,634 - 97,445,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Position Markers
D9Mco23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,006,592 - 74,007,038 (+)MAPPERmRatBN7.2
Rnor_6.0979,710,630 - 79,711,077NCBIRnor6.0
Rnor_5.0979,483,369 - 79,483,816UniSTSRnor5.0
RGSC_v3.4971,544,278 - 71,544,725UniSTSRGSC3.4
Celera971,402,636 - 71,403,083UniSTS
Cytogenetic Map9q34UniSTS
RH141867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2974,042,999 - 74,043,950 (+)MAPPERmRatBN7.2
Rnor_6.0979,747,031 - 79,747,981NCBIRnor6.0
Rnor_5.0979,519,592 - 79,520,542UniSTSRnor5.0
RGSC_v3.4971,580,917 - 71,581,867UniSTSRGSC3.4
Celera971,439,309 - 71,440,259UniSTS
RH 3.4 Map9674.6UniSTS
Cytogenetic Map9q34UniSTS
RH143010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2973,987,766 - 73,987,906 (+)MAPPERmRatBN7.2
Rnor_6.0979,691,804 - 79,691,943NCBIRnor6.0
Rnor_5.0979,464,543 - 79,464,682UniSTSRnor5.0
RGSC_v3.4971,525,452 - 71,525,591UniSTSRGSC3.4
Celera971,383,817 - 71,383,956UniSTS
RH 3.4 Map9675.7UniSTS
Cytogenetic Map9q34UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)95662771378595166Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:120
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000021656
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 46 33 19 33 1 3 74 35 34 11 1
Low 16 11 8 8 7 8 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021656   ⟹   ENSRNOP00000021656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl973,955,216 - 74,044,018 (+)Ensembl
Rnor_6.0 Ensembl979,659,251 - 79,748,078 (+)Ensembl
RefSeq Acc Id: NM_177419   ⟹   NP_803154
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,955,258 - 74,044,019 (+)NCBI
Rnor_6.0979,659,275 - 79,748,050 (+)NCBI
Rnor_5.0979,432,205 - 79,520,611 (+)NCBI
RGSC_v3.4971,472,459 - 71,581,936 (+)RGD
Celera971,352,925 - 71,440,328 (+)RGD
Sequence:
RefSeq Acc Id: XM_039083873   ⟹   XP_038939801
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,955,220 - 74,044,020 (+)NCBI
RefSeq Acc Id: XM_039083874   ⟹   XP_038939802
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,982,556 - 74,044,020 (+)NCBI
RefSeq Acc Id: XM_039083875   ⟹   XP_038939803
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2973,983,856 - 74,044,020 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_803154   ⟸   NM_177419
- UniProtKB: G3V817 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021656   ⟸   ENSRNOT00000021656
RefSeq Acc Id: XP_038939801   ⟸   XM_039083873
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038939802   ⟸   XM_039083874
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038939803   ⟸   XM_039083875
- Peptide Label: isoform X3
Protein Domains
Ku

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V817-F1-model_v2 AlphaFold G3V817 1-732 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696737
Promoter ID:EPDNEW_R7261
Type:initiation region
Name:Xrcc5_1
Description:X-ray repair cross complementing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0979,659,252 - 79,659,312EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3976 AgrOrtholog
BioCyc Gene G2FUF-27206 BioCyc
Ensembl Genes ENSRNOG00000016105 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021656 ENTREZGENE
  ENSRNOP00000021656.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021656 ENTREZGENE
  ENSRNOT00000021656.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.240 UniProtKB/TrEMBL
  2.40.290.10 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6887693 IMAGE-MGC_LOAD
InterPro DNA_helicase_ATP-dep_Ku UniProtKB/TrEMBL
  DNA_helicase_ATP-dep_Ku80 UniProtKB/TrEMBL
  Ku_C UniProtKB/TrEMBL
  Ku_C_sf UniProtKB/TrEMBL
  Ku_N UniProtKB/TrEMBL
  Ku_PK_bind UniProtKB/TrEMBL
  SPOC-like UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:363247 UniProtKB/TrEMBL
MGC_CLONE MGC:72979 IMAGE-MGC_LOAD
NCBI Gene 363247 ENTREZGENE
Pfam Ku_C UniProtKB/TrEMBL
  Ku_N UniProtKB/TrEMBL
  Ku_PK_bind UniProtKB/TrEMBL
  PF02735 UniProtKB/TrEMBL
PharmGKB XRCC5 RGD
PhenoGen Xrcc5 PhenoGen
PIRSF Ku80 UniProtKB/TrEMBL
SMART Ku78 UniProtKB/TrEMBL
Superfamily-SCOP Ku_PK_bind UniProtKB/TrEMBL
  SPOC-like UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
UniProt G3V817 ENTREZGENE, UniProtKB/TrEMBL
  Q6P7P8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-08 Xrcc5  X-ray repair cross complementing 5  Xrcc5  X-ray repair complementing defective repair in Chinese hamster cells 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Xrcc5  X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function component of the DNA dependent protein kinase complex 727219