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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2643
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xrcc6
Name: X-ray repair cross complementing 6
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xrcc6multiple interactionsISOXRCC6 (Homo sapiens)6480464CTDXRCC6 mRNA results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]; XRCC6 protein results in increased susceptibility to [Fluorouracil co-treated with Cisplatin]PMID:18546291
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