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Gene: Xrcc6 (X-ray repair complementing defective repair in Chinese hamster cells 6) Mus musculus
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Symbol: Xrcc6
Name: X-ray repair complementing defective repair in Chinese hamster cells 6
RGD ID: 1552438
Description: Exhibits double-stranded DNA binding activity. Predicted to contribute to DNA end binding activity and double-stranded telomeric DNA binding activity. Involved in DNA metabolic process; positive regulation of cell differentiation; and response to ionizing radiation. Localizes to cytoplasm and nucleus. Is expressed in several structures, including alimentary system; early conceptus; gonad; liver lobe; and telencephalon ventricular layer. Orthologous to human XRCC6 (X-ray repair cross complementing 6); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH (+)-dexrazoxane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP/AP lyase Ku70; 70kDa; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22p; G22p1; ku autoantigen protein p70 homolog; Ku p70; Ku70; thyroid autoantigen 70 kDa; X-ray repair cross-complementing protein 6
Orthologs:
Homo sapiens (human) : XRCC6 (X-ray repair cross complementing 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Xrcc6 (X-ray repair cross complementing 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrcc6 (X-ray repair cross complementing 6)
Pan paniscus (bonobo/pygmy chimpanzee) : XRCC6 (X-ray repair cross complementing 6)
Canis lupus familiaris (dog) : XRCC6 (X-ray repair cross complementing 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrcc6 (X-ray repair cross complementing 6)
Sus scrofa (pig) : XRCC6 (X-ray repair cross complementing 6)
Chlorocebus sabaeus (African green monkey) : XRCC6 (X-ray repair cross complementing 6)
Heterocephalus glaber (naked mole-rat) : Xrcc6 (X-ray repair cross complementing 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,868,805 - 81,924,286 (+)NCBI
GRCm381581,987,833 - 82,040,085 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,987,835 - 82,040,085 (+)EnsemblGRCm38mm10GRCm38
MGSCv371581,846,799 - 81,870,514 (+)NCBIGRCm37mm9NCBIm37
MGSCv361581,843,555 - 81,867,327 (+)NCBImm8
Celera1584,138,425 - 84,161,793 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Xrcc6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552438
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.