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Gene: Xrcc6 (X-ray repair complementing defective repair in Chinese hamster cells 6) Mus musculus
Symbol: Xrcc6
Name: X-ray repair complementing defective repair in Chinese hamster cells 6
RGD ID: 1552438
Description: Exhibits double-stranded DNA binding activity. Predicted to contribute to DNA end binding activity and double-stranded telomeric DNA binding activity. Involved in DNA metabolic process; positive regulation of cell differentiation; and response to ionizing radiation. Localizes to cytoplasm and nucleus. Is expressed in several structures, including alimentary system; early conceptus; gonad; liver lobe; and telencephalon ventricular layer. Orthologous to human XRCC6 (X-ray repair cross complementing 6); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH (+)-dexrazoxane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP/AP lyase Ku70; 70kDa; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22p; G22p1; ku autoantigen protein p70 homolog; Ku p70; Ku70; thyroid autoantigen 70 kDa; X-ray repair cross-complementing protein 6
Homo sapiens (human) : XRCC6 (X-ray repair cross complementing 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Xrcc6 (X-ray repair cross complementing 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xrcc6 (X-ray repair cross complementing 6)
Pan paniscus (bonobo/pygmy chimpanzee) : XRCC6 (X-ray repair cross complementing 6)
Canis lupus familiaris (dog) : XRCC6 (X-ray repair cross complementing 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xrcc6 (X-ray repair cross complementing 6)
Sus scrofa (pig) : XRCC6 (X-ray repair cross complementing 6)
Chlorocebus sabaeus (African green monkey) : XRCC6 (X-ray repair cross complementing 6)
Heterocephalus glaber (naked mole-rat) : Xrcc6 (X-ray repair cross complementing 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391581,868,805 - 81,924,286 (+)NCBI
GRCm381581,987,833 - 82,040,085 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,987,835 - 82,040,085 (+)EnsemblGRCm38mm10GRCm38
MGSCv371581,846,799 - 81,870,514 (+)NCBIGRCm37mm9NCBIm37
MGSCv361581,843,555 - 81,867,327 (+)NCBImm8
Celera1584,138,425 - 84,161,793 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Xrcc6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552438
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.