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DNA lesions, particularly double-strand breaks (DSBs), can have severe genotoxic effects if not promptly handled. DSBs can be initiated by DNA damaging agents such as ionizing radiation or arise during replication through exposure to metabolites and are also physiological intermediates generated during V(D)J [variable (V), diversity (D) and the joining (J) recombination] and class switch recombination in lymphocytes of the immune system. The cells possess a robust response mechanism to DNA damag

Pathway Diagram:

Elsevier Inc. Pol X members ---- Xrcc6 Pol X members ---- Xrcc5 Pol X members Aplf ---- Xrcc4 Aplf Prkdc Dclre1c Prkdc ---> Dclre1c Dclre1c ---- Prkdc Xrcc5 --+> Prkdc Xrcc6 --+> Prkdc Xrcc6 Xrcc5 Aptx Rif1 Tp53bp1 Pnkp ---- Xrcc4 Aptx ---- Xrcc4 Xrcc4 Pnkp ataxia telangiectasia-mutated (ATM) signaling pathway Nhej1 ---- Xrcc4 Nhej1 Lig4 ---- Xrcc4 Lig4 Prkdc ---- Xrcc6 Prkdc ---- Xrcc5 Rif1 ---- Tp53bp1

Genes in Pathway:

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non-homologous end joining pathway of double-strand break repair term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplf aprataxin and PNKP like factor JBrowse link 4 119,514,822 119,568,764 RGD:8662352
G Aptx aprataxin JBrowse link 5 56,987,714 57,009,481 RGD:8662352
G Dclre1c DNA cross-link repair 1C JBrowse link 17 78,782,512 78,812,140 RGD:6907045
G Dntt DNA nucleotidylexotransferase JBrowse link 1 260,289,626 260,321,174 RGD:6907045
G Fen1 flap structure-specific endonuclease 1 JBrowse link 1 226,251,516 226,256,160 RGD:6907045
G Lig4 DNA ligase 4 JBrowse link 16 85,331,771 85,339,496 RGD:6907045
G Mre11a MRE11 homolog A, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:6907045
G Nhej1 nonhomologous end-joining factor 1 JBrowse link 9 82,230,230 82,327,923 RGD:6907045
G Pnkp polynucleotide kinase 3'-phosphatase JBrowse link 1 100,853,475 100,859,202 RGD:8662352
G Poll DNA polymerase lambda JBrowse link 1 265,290,337 265,298,847 RGD:6907045
G Polm DNA polymerase mu JBrowse link 14 86,069,378 86,079,327 RGD:6907045
G Prkdc protein kinase, DNA activated, catalytic polypeptide JBrowse link 11 89,293,547 89,510,948 RGD:8662352
G Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:6907045
G Rif1 replication timing regulatory factor 1 JBrowse link 3 37,599,540 37,648,818 RGD:8661237
G Tp53bp1 tumor protein p53 binding protein 1 JBrowse link 3 113,160,030 113,259,701 RGD:8661237
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:6907045
G Xrcc5 X-ray repair cross complementing 5 JBrowse link 9 79,659,275 79,748,050 RGD:6907045
G Xrcc6 X-ray repair cross complementing 6 JBrowse link 7 123,259,881 123,280,613 RGD:6907045

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the non-homologous end joining pathway of double-strand break repair
Phenotype Annotations Associated with Genes in the non-homologous end joining pathway of double-strand break repair

References Associated with the non-homologous end joining pathway of double-strand break repair:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: