Dazap2 (DAZ associated protein 2) - Rat Genome Database

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Gene: Dazap2 (DAZ associated protein 2) Rattus norvegicus
Analyze
Symbol: Dazap2
Name: DAZ associated protein 2
RGD ID: 1307407
Description: Predicted to enable several functions, including WW domain binding activity; enzyme binding activity; and p53 binding activity. Predicted to be involved in protein destabilization and stress granule assembly. Predicted to be located in cytoplasmic stress granule and nuclear speck. Predicted to be part of protein-containing complex. Orthologous to human DAZAP2 (DAZ associated protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DAZ-associated protein 2; deleted in azoospermia-associated protein 2; LOC300235
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,593,503 - 133,599,044 (+)NCBIGRCr8
mRatBN7.27131,714,749 - 131,720,266 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,714,745 - 131,720,265 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,516,759 - 133,522,236 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,742,342 - 135,747,819 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,656,004 - 135,661,480 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,238,780 - 142,244,301 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,239,035 - 142,243,241 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,043,449 - 140,048,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,362,248 - 139,367,387 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,438,684 - 139,443,823 (+)NCBI
Celera7128,190,356 - 128,195,495 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10857750   PMID:11342538   PMID:15489334   PMID:16189514   PMID:18762249   PMID:25416956  


Genomics

Comparative Map Data
Dazap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,593,503 - 133,599,044 (+)NCBIGRCr8
mRatBN7.27131,714,749 - 131,720,266 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,714,745 - 131,720,265 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,516,759 - 133,522,236 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07135,742,342 - 135,747,819 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,656,004 - 135,661,480 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,238,780 - 142,244,301 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,239,035 - 142,243,241 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,043,449 - 140,048,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,362,248 - 139,367,387 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,438,684 - 139,443,823 (+)NCBI
Celera7128,190,356 - 128,195,495 (+)NCBICelera
Cytogenetic Map7q36NCBI
DAZAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,238,826 - 51,246,717 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,238,724 - 51,271,362 (+)EnsemblGRCh38hg38GRCh38
GRCh371251,632,610 - 51,640,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361249,918,893 - 49,923,834 (+)NCBINCBI36Build 36hg18NCBI36
Build 341249,918,892 - 49,923,833NCBI
Celera1250,433,966 - 50,441,964 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1248,665,512 - 48,673,510 (+)NCBIHuRef
CHM1_11251,598,686 - 51,606,683 (+)NCBICHM1_1
T2T-CHM13v2.01251,201,722 - 51,209,619 (+)NCBIT2T-CHM13v2.0
Dazap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,513,543 - 100,518,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,513,230 - 100,518,642 (+)EnsemblGRCm39 Ensembl
GRCm3815100,615,662 - 100,620,761 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,615,349 - 100,620,761 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715100,446,093 - 100,451,192 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,443,696 - 100,448,795 (+)NCBIMGSCv36mm8
Celera15102,769,390 - 102,774,462 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.36NCBI
Dazap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555471,736,809 - 1,741,623 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555471,736,945 - 1,741,623 (+)NCBIChiLan1.0ChiLan1.0
DAZAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,943,003 - 42,948,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,939,760 - 42,944,815 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01237,510,449 - 37,515,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11238,393,419 - 38,398,471 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,367,216 - 38,398,471 (-)Ensemblpanpan1.1panPan2
DAZAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,617,346 - 3,621,592 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,615,726 - 3,621,587 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2742,633,911 - 42,638,171 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,665,057 - 3,669,321 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,646,331 - 3,669,314 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,632,269 - 3,636,529 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,618,818 - 3,623,072 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,030,970 - 43,035,233 (+)NCBIUU_Cfam_GSD_1.0
Dazap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,321,921 - 64,326,333 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365128,838,469 - 8,842,951 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365128,838,469 - 8,842,904 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAZAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.2517,304,309 - 17,308,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DAZAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,437,957 - 47,443,042 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,437,746 - 47,443,243 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037198,653,823 - 198,658,933 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dazap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248161,020,382 - 1,024,808 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248161,020,074 - 1,024,834 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dazap2
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:122
Interacting mature miRNAs:134
Transcripts:ENSRNOT00000006239
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH127546  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,719,950 - 131,720,150 (+)MAPPERmRatBN7.2
Rnor_6.07142,243,986 - 142,244,185NCBIRnor6.0
Rnor_5.07140,048,641 - 140,048,840UniSTSRnor5.0
RGSC_v3.47139,367,077 - 139,367,276UniSTSRGSC3.4
Celera7128,195,185 - 128,195,384UniSTS
RH 3.4 Map71075.3UniSTS
Cytogenetic Map7q36UniSTS
RH134787  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,713,410 - 131,713,598 (+)MAPPERmRatBN7.2
Rnor_6.07142,237,446 - 142,237,633NCBIRnor6.0
Rnor_5.07140,042,101 - 140,042,288UniSTSRnor5.0
RGSC_v3.47139,360,537 - 139,360,724UniSTSRGSC3.4
Celera7128,188,645 - 128,188,832UniSTS
RH 3.4 Map71064.8UniSTS
Cytogenetic Map7q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000006239   ⟹   ENSRNOP00000006239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,714,745 - 131,720,265 (+)Ensembl
Rnor_6.0 Ensembl7142,239,035 - 142,243,241 (+)Ensembl
RefSeq Acc Id: NM_001395672   ⟹   NP_001382601
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,593,537 - 133,599,044 (+)NCBI
mRatBN7.27131,714,754 - 131,720,261 (+)NCBI
RefSeq Acc Id: NM_001395673   ⟹   NP_001382602
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,593,537 - 133,599,044 (+)NCBI
mRatBN7.27131,714,754 - 131,720,261 (+)NCBI
RefSeq Acc Id: XM_039078934   ⟹   XP_038934862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,593,503 - 133,599,044 (+)NCBI
mRatBN7.27131,714,749 - 131,720,266 (+)NCBI
RefSeq Acc Id: ENSRNOP00000006239   ⟸   ENSRNOT00000006239
RefSeq Acc Id: XP_038934862   ⟸   XM_039078934
- Peptide Label: isoform X1
- UniProtKB: P60486 (UniProtKB/Swiss-Prot),   A0A0H2UHD1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382601   ⟸   NM_001395672
- Peptide Label: isoform 1
- UniProtKB: P60486 (UniProtKB/Swiss-Prot),   A0A0H2UHD1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001382602   ⟸   NM_001395673
- Peptide Label: isoform 2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60486-F1-model_v2 AlphaFold P60486 1-108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695661
Promoter ID:EPDNEW_R6185
Type:initiation region
Name:Dazap2_1
Description:DAZ associated protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,239,107 - 142,239,167EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307407 AgrOrtholog
BioCyc Gene G2FUF-32014 BioCyc
Ensembl Genes ENSRNOG00000004628 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055026630 UniProtKB/Swiss-Prot
  ENSRNOG00060015232 UniProtKB/Swiss-Prot
  ENSRNOG00065020794 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006239 ENTREZGENE
  ENSRNOT00000006239.8 UniProtKB/Swiss-Prot
  ENSRNOT00055045976 UniProtKB/Swiss-Prot
  ENSRNOT00060026115 UniProtKB/Swiss-Prot
  ENSRNOT00065035264 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598966 IMAGE-MGC_LOAD
InterPro DAZ_assoc-2 UniProtKB/Swiss-Prot
KEGG Report rno:300235 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72595 IMAGE-MGC_LOAD
NCBI Gene 300235 ENTREZGENE
PANTHER DAZ-ASSOCIATED PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR31638 UniProtKB/Swiss-Prot
Pfam DAZAP2 UniProtKB/Swiss-Prot
PhenoGen Dazap2 PhenoGen
RatGTEx ENSRNOG00000004628 RatGTEx
  ENSRNOG00055026630 RatGTEx
  ENSRNOG00060015232 RatGTEx
  ENSRNOG00065020794 RatGTEx
UniProt A0A0H2UHD1 ENTREZGENE
  DAZP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0H2UHD1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Dazap2  DAZ associated protein 2  Dazap2_predicted  DAZ associated protein 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dazap2_predicted  DAZ associated protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED