Has2 (hyaluronan synthase 2) - Rat Genome Database

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Gene: Has2 (hyaluronan synthase 2) Rattus norvegicus
Analyze
Symbol: Has2
Name: hyaluronan synthase 2
RGD ID: 2781
Description: Enables hyaluronan synthase activity. Involved in several processes, including estrous cycle; hyaluronan biosynthetic process; and positive regulation of cell migration. Predicted to be located in several cellular components, including Golgi apparatus; extracellular vesicle; and plasma membrane raft. Predicted to be active in plasma membrane. Biomarker of diabetes insipidus; middle cerebral artery infarction; and pulmonary hypertension. Orthologous to human HAS2 (hyaluronan synthase 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HA synthase 2; hyaluronate synthase 2; hyaluronic acid synthase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Has2m1Mcwi  
Genetic Models: BN-Has2m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2788,113,326 - 88,139,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl788,113,326 - 88,128,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx789,997,804 - 90,023,812 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0792,199,040 - 92,225,048 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0792,001,677 - 92,027,674 (-)NCBIRnor_WKY
Rnor_6.0796,438,046 - 96,464,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl796,438,046 - 96,464,049 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0797,055,458 - 97,081,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4793,230,135 - 93,256,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1793,264,364 - 93,290,369 (-)NCBI
Celera784,901,996 - 84,927,998 (-)NCBICelera
RH 3.4 Map7607.6RGD
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
fluoranthene  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glutathione  (ISO)
glycidol  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
oxaliplatin  (EXP)
oxytocin  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
panobinostat  (ISO)
PCB138  (ISO)
PD 0325901  (ISO)
pentane-2,3-dione  (EXP)
potassium chromate  (ISO)
raloxifene  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Synthesis and fragmentation of hyaluronan in renal ischaemia. Decleves AE, etal., Nephrol Dial Transplant. 2012 Oct;27(10):3771-81. doi: 10.1093/ndt/gfs098. Epub 2012 Apr 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. Hellman U, etal., Cell Tissue Res. 2008 Jan 15;.
5. CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention. Huang Y, etal., Matrix Biol. 2016 Dec;56:74-94. doi: 10.1016/j.matbio.2016.04.002. Epub 2016 Apr 14.
6. Expression of type II hyaluronan-synthase gene in kidneys Wistar and Brattleboro rats with diabetes insipidus: effect of vasopressin and its analogues. Kabilova NO, etal., Dokl Biochem Biophys. 2009 Mar-Apr;425:61-4.
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension. Ormiston ML, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L148-57. doi: 10.1152/ajplung.00097.2009. Epub 2009 Nov 13.
11. EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation. Pasonen-Seppanen S, etal., J Invest Dermatol 2003 Jun;120(6):1038-44.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes. Rilla K, etal., J Cell Sci. 2002 Sep 15;115(Pt 18):3633-43.
17. The effect of hyaluronic acid size and concentration on branching morphogenesis and tubule differentiation in developing kidney culture systems: potential applications to engineering of renal tissues. Rosines E, etal., Biomaterials. 2007 Nov;28(32):4806-17. Epub 2007 Aug 15.
18. Renal hyaluronan content during experimental uncontrolled diabetes in rats. Rugheimer L, etal., J Physiol Pharmacol. 2008 Mar;59(1):115-28.
19. Hyaluronan synthases and hyaluronidases in the kidney during changes in hydration status. Rugheimer L, etal., Matrix Biol. 2009 Sep;28(7):390-5. doi: 10.1016/j.matbio.2009.07.002. Epub 2009 Jul 25.
20. Involvement of hyaluronan synthesis in ovarian follicle growth in rats. Takahashi N, etal., Reproduction. 2013 Dec 19;147(2):189-97. doi: 10.1530/REP-13-0464. Print 2014 Feb.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Use of suppression subtractive hybridization for differential gene expression in stroke: discovery of CD44 gene expression and localization in permanent focal stroke in rats. Wang H, etal., Stroke. 2001 Apr;32(4):1020-7.
23. Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus. Yokoyama U, etal., J Clin Invest. 2006 Nov;116(11):3026-34.
Additional References at PubMed
PMID:10455188   PMID:10930438   PMID:12784612   PMID:14506240   PMID:15722343   PMID:17324121   PMID:17451373   PMID:17989988   PMID:18834074   PMID:19393425   PMID:20522558   PMID:21246657  
PMID:21551265   PMID:22016393   PMID:22383528   PMID:23645665   PMID:24057227   PMID:25499520   PMID:25795779  


Genomics

Comparative Map Data
Has2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2788,113,326 - 88,139,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl788,113,326 - 88,128,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx789,997,804 - 90,023,812 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0792,199,040 - 92,225,048 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0792,001,677 - 92,027,674 (-)NCBIRnor_WKY
Rnor_6.0796,438,046 - 96,464,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl796,438,046 - 96,464,049 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0797,055,458 - 97,081,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4793,230,135 - 93,256,139 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1793,264,364 - 93,290,369 (-)NCBI
Celera784,901,996 - 84,927,998 (-)NCBICelera
RH 3.4 Map7607.6RGD
Cytogenetic Map7q33NCBI
HAS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388121,612,116 - 121,641,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl8121,612,116 - 121,641,440 (-)EnsemblGRCh38hg38GRCh38
GRCh378122,624,356 - 122,653,680 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368122,694,719 - 122,722,811 (-)NCBINCBI36Build 36hg18NCBI36
Build 348122,694,720 - 122,722,811NCBI
Celera8118,814,049 - 118,842,240 (-)NCBICelera
Cytogenetic Map8q24.13NCBI
HuRef8117,950,042 - 117,978,400 (-)NCBIHuRef
CHM1_18122,665,454 - 122,693,813 (-)NCBICHM1_1
T2T-CHM13v2.08122,742,348 - 122,771,670 (-)NCBIT2T-CHM13v2.0
Has2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391556,529,023 - 56,557,942 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1556,529,023 - 56,557,935 (-)EnsemblGRCm39 Ensembl
GRCm381556,665,627 - 56,694,546 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1556,665,627 - 56,694,539 (-)EnsemblGRCm38mm10GRCm38
MGSCv371556,497,182 - 56,526,101 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361556,495,712 - 56,524,587 (-)NCBIMGSCv36mm8
Celera1558,189,438 - 58,218,384 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1523.31NCBI
Has2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955540593,316 - 609,865 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955540593,316 - 609,760 (-)NCBIChiLan1.0ChiLan1.0
HAS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18121,073,419 - 121,101,450 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8121,072,154 - 121,089,365 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08118,313,186 - 118,342,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HAS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11320,310,946 - 20,342,647 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1320,309,872 - 20,341,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1320,341,670 - 20,392,564 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01320,646,614 - 20,697,736 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1320,647,874 - 20,664,774 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11320,379,420 - 20,429,051 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01320,482,900 - 20,533,502 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01320,720,804 - 20,770,669 (-)NCBIUU_Cfam_GSD_1.0
Has2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530317,991,598 - 18,018,681 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647025,418,069 - 25,443,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHAS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl417,596,492 - 17,615,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1417,583,154 - 17,613,524 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2418,458,703 - 18,489,076 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18116,199,516 - 116,228,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8116,200,799 - 116,228,788 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603924,042,921 - 24,072,107 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Has2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473533,095,515 - 33,121,237 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473533,095,441 - 33,121,030 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Has2
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:825
Count of miRNA genes:318
Interacting mature miRNAs:408
Transcripts:ENSRNOT00000006517
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78022129993595843Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78022129994811326Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat

Markers in Region
PMC314332P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2788,115,795 - 88,116,189 (+)MAPPERmRatBN7.2
Rnor_6.0796,440,516 - 96,440,909NCBIRnor6.0
Rnor_5.0797,057,928 - 97,058,321UniSTSRnor5.0
RGSC_v3.4793,232,605 - 93,232,998UniSTSRGSC3.4
Celera784,904,466 - 84,904,859UniSTS
Cytogenetic Map7q32UniSTS
RH94426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2788,114,706 - 88,114,867 (+)MAPPERmRatBN7.2
Rnor_6.0796,439,427 - 96,439,587NCBIRnor6.0
Rnor_5.0797,056,839 - 97,056,999UniSTSRnor5.0
RGSC_v3.4793,231,516 - 93,231,676UniSTSRGSC3.4
Celera784,903,377 - 84,903,537UniSTS
RH 3.4 Map7607.6UniSTS
Cytogenetic Map7q32UniSTS
Hsh  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2788,115,771 - 88,115,994 (+)MAPPERmRatBN7.2
Rnor_6.0796,440,492 - 96,440,714NCBIRnor6.0
Rnor_5.0797,057,904 - 97,058,126UniSTSRnor5.0
RGSC_v3.4793,232,581 - 93,232,803UniSTSRGSC3.4
Celera784,904,442 - 84,904,664UniSTS
Cytogenetic Map7q32UniSTS


Genetic Models
This gene Has2 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 2 14 16
Low 2 31 24 16 8 16 7 8 60 9 15 7 7
Below cutoff 1 2 27 19 11 19 1 2 12 12 3 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006517   ⟹   ENSRNOP00000006517
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl788,113,326 - 88,128,933 (-)Ensembl
Rnor_6.0 Ensembl796,438,046 - 96,464,049 (-)Ensembl
RefSeq Acc Id: NM_013153   ⟹   NP_037285
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2788,113,326 - 88,139,337 (-)NCBI
Rnor_6.0796,438,046 - 96,464,049 (-)NCBI
Rnor_5.0797,055,458 - 97,081,461 (-)NCBI
RGSC_v3.4793,230,135 - 93,256,139 (-)RGD
Celera784,901,996 - 84,927,998 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037285   ⟸   NM_013153
- UniProtKB: O35776 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006517   ⟸   ENSRNOT00000006517

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35776-F1-model_v2 AlphaFold O35776 1-552 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695339
Promoter ID:EPDNEW_R5863
Type:multiple initiation site
Name:Has2_1
Description:hyaluronan synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0796,464,082 - 96,464,142EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2781 AgrOrtholog
BioCyc Gene G2FUF-33365 BioCyc
Ensembl Genes ENSRNOG00000004854 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000006517 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006517 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.550.10 UniProtKB/Swiss-Prot
InterPro Glyco_trans_2-like UniProtKB/Swiss-Prot
  HAS2 UniProtKB/Swiss-Prot
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot
KEGG Report rno:25694 UniProtKB/Swiss-Prot
NCBI Gene 25694 ENTREZGENE
PANTHER PTHR22913:SF7 UniProtKB/Swiss-Prot
Pfam Glycos_transf_2 UniProtKB/Swiss-Prot
PhenoGen Has2 PhenoGen
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot
TIGR TC208915
UniProt HYAS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Has2  Hyaluronan synthase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA is upregulated by epidermal growth factor, downregulated by transforming growth factor beta 708315