(+)-catechin increases expression ISO RGD:732035 6480464 Catechin results in increased expression of SP1 protein CTD PMID:28768059 (+)-catechin multiple interactions ISO RGD:732035 6480464 Catechin inhibits the reaction [arsenic trioxide results in decreased expression of SP1 protein] CTD PMID:28768059 (-)-demecolcine decreases expression ISO RGD:732035 6480464 Demecolcine results in decreased expression of SP1 mRNA CTD PMID:23649840 (20S)-ginsenoside Rg3 multiple interactions ISO RGD:732035 6480464 ginsenoside Rg3 inhibits the reaction [cagA protein, Helicobacter pylori results in decreased expression of SP1 protein] CTD PMID:26427350 (R)-lipoic acid multiple interactions ISO RGD:11334 6480464 Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 (S)-nicotine multiple interactions ISO RGD:732035 6480464 Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein] more ... CTD PMID:24089524 1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of SP1 mRNA CTD PMID:32387197 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression EXP 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:23538867 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects response to substance ISO RGD:11334 6480464 SP1 affects the susceptibility to 1-Methyl-4-phenyl-1 more ... CTD PMID:25851821 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions EXP 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:23538867 17alpha-ethynylestradiol multiple interactions ISO RGD:732035 6480464 SP1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of AGER mRNA] CTD PMID:15878629 17alpha-ethynylestradiol increases activity ISO RGD:732035 6480464 Ethinyl Estradiol results in increased activity of SP1 protein CTD PMID:15878629 17beta-estradiol multiple interactions ISO RGD:732035 6480464 [Estradiol co-treated with bisphenol A] results in increased expression of SP1 mRNA more ... CTD PMID:16675542 more ... 17beta-estradiol decreases expression ISO RGD:732035 6480464 Estradiol results in decreased expression of SP1 mRNA CTD PMID:29783106 17beta-estradiol increases activity ISO RGD:732035 6480464 Estradiol results in increased activity of SP1 protein CTD PMID:17088408 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:27291303 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:11334 6480464 Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNA CTD PMID:14708085 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SP1 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine increases phosphorylation ISO RGD:732035 6480464 Tetrachlorodibenzodioxin results in increased phosphorylation of SP1 protein CTD PMID:20971882 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11334 6480464 Tetrachlorodibenzodioxin affects the expression of SP1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects activity EXP 6480464 Tetrachlorodibenzodioxin affects the activity of SP1 protein CTD PMID:11926288 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:11334 6480464 [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of SP1 mRNA CTD PMID:15251184 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732035 6480464 [SP1 protein binds to CYP1B1 enhancer] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] more ... CTD PMID:12801909 , PMID:16675542 2-chloroethanol multiple interactions EXP 6480464 Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein more ... CTD PMID:31585129 2-chloroethanol increases expression EXP 6480464 Ethylene Chlorohydrin results in increased expression of SP1 mRNA CTD PMID:31585129 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione increases expression ISO RGD:732035 6480464 bisindolylmaleimide I results in increased expression of SP1 mRNA, bisindolylmaleimide I results in increased expression of SP1 protein CTD PMID:14653808 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions EXP 6480464 bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in decreased activity of SP1 protein] CTD PMID:12499119 3-methylcholanthrene multiple interactions EXP 6480464 alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]] more ... CTD PMID:29094188 3-methylcholanthrene increases acetylation EXP 6480464 Methylcholanthrene results in increased acetylation of SP1 promoter CTD PMID:29094188 3-methylcholanthrene increases expression EXP 6480464 Methylcholanthrene results in increased expression of SP1 mRNA CTD PMID:29094188 4,4'-diaminodiphenylmethane decreases expression ISO RGD:11334 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of SP1 mRNA CTD PMID:18648102 4-hydroxyphenyl retinamide increases expression ISO RGD:11334 6480464 Fenretinide results in increased expression of SP1 mRNA CTD PMID:28973697 4-hydroxyphenyl retinamide multiple interactions ISO RGD:11334 6480464 Fenretinide results in increased cleavage of and results in decreased activity of SP1 protein CTD PMID:9343396 4-nonylphenol multiple interactions ISO RGD:11334 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 4-tert-Octylphenol multiple interactions ISO RGD:11334 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 5-aza-2'-deoxycytidine multiple interactions ISO RGD:732035 6480464 [[Decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNA more ... CTD PMID:17986852 more ... 5-aza-2'-deoxycytidine increases expression ISO RGD:11334 6480464 Decitabine results in increased expression of SP1 mRNA CTD PMID:15251184 , PMID:27915011 5-aza-2'-deoxycytidine increases expression ISO RGD:732035 6480464 Decitabine results in increased expression of SP1 mRNA, Decitabine results in increased expression of SP1 protein CTD PMID:19027835 5-aza-2'-deoxycytidine multiple interactions ISO RGD:11334 6480464 [Tetrachlorodibenzodioxin co-treated with Decitabine] results in increased expression of SP1 mRNA CTD PMID:15251184 5-azacytidine multiple interactions ISO RGD:732035 6480464 Azacitidine promotes the reaction [SP1 protein binds to KIR2DL2 promoter], Azacitidine promotes the reaction [SP1 protein binds to KIR2DL4 promoter] CTD PMID:18945643 5-azacytidine decreases expression ISO RGD:732035 6480464 Azacitidine results in decreased expression of SP1 mRNA CTD PMID:20823114 5-azacytidine multiple interactions ISO RGD:11334 6480464 Azacitidine promotes the reaction [SP1 protein binds to AQP5 promoter] CTD PMID:17198683 5-fluorouracil multiple interactions ISO RGD:732035 6480464 Fluorouracil promotes the reaction [[TP53 protein binds to SP1 protein] which binds to CDKN1A promoter], SP1 protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] CTD PMID:15489892 , PMID:18927307 7,12-dimethyltetraphene multiple interactions ISO RGD:732035 6480464 [[9 more ... CTD PMID:22009531 , PMID:29663660 7,12-dimethyltetraphene increases expression ISO RGD:732035 6480464 9 more ... CTD PMID:29663660 acetaldehyde multiple interactions ISO RGD:732035 6480464 SP1 protein promotes the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA] CTD PMID:16025520 AH23848 multiple interactions ISO RGD:732035 6480464 [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of SP1 protein CTD PMID:19407222 aldehydo-D-glucose multiple interactions ISO RGD:732035 6480464 SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein], SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 aldehydo-D-glucose multiple interactions EXP 6480464 UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein], UCP1 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 all-trans-retinoic acid increases activity ISO RGD:732035 6480464 Tretinoin results in increased activity of SP1 protein CTD PMID:16757381 all-trans-retinoic acid increases expression ISO RGD:732035 6480464 Tretinoin results in increased expression of SP1 mRNA, Tretinoin results in increased expression of SP1 protein CTD PMID:23724009 more ... all-trans-retinoic acid increases activity ISO RGD:11334 6480464 Tretinoin results in increased activity of SP1 protein CTD PMID:17097063 all-trans-retinoic acid multiple interactions ISO RGD:732035 6480464 arsenic trioxide promotes the reaction [Tretinoin results in increased expression of SP1 protein] more ... CTD PMID:16740727 more ... allethrin increases activity ISO RGD:732035 6480464 Allethrins results in increased activity of SP1 protein CTD PMID:20143881 alpha-D-galactose multiple interactions EXP 6480464 Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of SP1 protein] CTD PMID:30367734 alpha-D-galactose increases expression EXP 6480464 Galactose results in increased expression of SP1 protein CTD PMID:30367734 alpha-naphthoflavone multiple interactions EXP 6480464 alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]] more ... CTD PMID:29094188 ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of SP1 mRNA, Ammonium Chloride results in decreased expression of SP1 protein CTD PMID:17442060 ammonium chloride decreases phosphorylation EXP 6480464 Ammonium Chloride results in decreased phosphorylation of SP1 protein CTD PMID:17442060 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SP1 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:732035 6480464 pyrazolanthrone inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein] CTD PMID:26385185 antirheumatic drug decreases expression ISO RGD:732035 6480464 Antirheumatic Agents results in decreased expression of SP1 mRNA CTD PMID:25339124 aristolochic acid A decreases expression ISO RGD:732035 6480464 aristolochic acid I results in decreased expression of SP1 mRNA, aristolochic acid I results in decreased expression of SP1 protein CTD PMID:33212167 Aroclor 1254 increases activity EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased activity of SP1 protein CTD PMID:16159668 arsane multiple interactions ISO RGD:11334 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein, [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein CTD PMID:32179164 arsenic atom multiple interactions ISO RGD:11334 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein, [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein CTD PMID:32179164 arsenous acid affects methylation ISO RGD:732035 6480464 Arsenic Trioxide affects the methylation of SP1 promoter CTD PMID:26046465 arsenous acid decreases expression ISO RGD:732035 6480464 Arsenic Trioxide results in decreased expression of SP1 mRNA, Arsenic Trioxide results in decreased expression of SP1 protein CTD PMID:17617380 more ... arsenous acid multiple interactions ISO RGD:732035 6480464 Arsenic Trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter] more ... CTD PMID:11714746 more ... arsenous acid decreases activity ISO RGD:732035 6480464 Arsenic Trioxide results in decreased activity of SP1 protein CTD PMID:11714746 artesunate decreases expression ISO RGD:732035 6480464 artesunate results in decreased expression of SP1 protein CTD PMID:19513562 asbestos increases expression ISO RGD:732035 6480464 Asbestos results in increased expression of SP1 CTD PMID:15636197 astaxanthin multiple interactions EXP 6480464 [mithramycin A co-treated with astaxanthine] inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:23538867 bathocuproine disulfonic acid multiple interactions ISO RGD:732035 6480464 bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA] CTD PMID:18483225 benzene decreases expression ISO RGD:732035 6480464 Benzene results in decreased expression of SP1 mRNA CTD PMID:21382456 benzo[a]pyrene affects activity ISO RGD:732035 6480464 Benzo(a)pyrene affects the activity of SP1 protein CTD PMID:20624995 benzo[a]pyrene increases expression ISO RGD:11334 6480464 Benzo(a)pyrene results in increased expression of SP1 mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:11334 6480464 POR protein affects the reaction [Benzo(a)pyrene affects the expression of SP1 protein] CTD PMID:21987461 benzo[a]pyrene affects expression ISO RGD:11334 6480464 Benzo(a)pyrene affects the expression of SP1 protein CTD PMID:21987461 Benzo[ghi]perylene increases expression ISO RGD:732035 6480464 1, 12-benzoperylene results in increased expression of SP1 mRNA CTD PMID:35182551 biotin increases expression ISO RGD:11334 6480464 Biotin results in increased expression of SP1 mRNA CTD PMID:34699867 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:11334 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SP1 mRNA CTD PMID:25181051 , PMID:33296240 bisphenol A decreases expression ISO RGD:11334 6480464 bisphenol A results in decreased expression of SP1 mRNA CTD PMID:33221593 bisphenol A increases expression ISO RGD:732035 6480464 bisphenol A results in increased expression of SP1 mRNA, bisphenol A results in increased expression of SP1 protein CTD PMID:29783106 , PMID:30206973 bisphenol A multiple interactions ISO RGD:732035 6480464 [Estradiol co-treated with bisphenol A] results in increased expression of SP1 mRNA CTD PMID:29783106 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SP1 mRNA CTD PMID:30816183 more ... bisphenol A affects methylation ISO RGD:11334 6480464 bisphenol A affects the methylation of SP1 promoter CTD PMID:27334623 butan-1-ol multiple interactions ISO RGD:732035 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of SP1 mRNA CTD PMID:29432896 Butylbenzyl phthalate decreases expression ISO RGD:11334 6480464 butylbenzyl phthalate results in decreased expression of SP1 mRNA CTD PMID:29029336 Butylbenzyl phthalate multiple interactions ISO RGD:11334 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 cadmium atom multiple interactions ISO RGD:11334 6480464 Cadmium inhibits the reaction [SP1 protein binds to SLC5A1 promoter], Cadmium promotes the reaction [MTF1 protein binds to SP1 protein] CTD PMID:15664265 , PMID:18458062 cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA more ... CTD PMID:35384129 cadmium atom affects binding ISO RGD:732035 6480464 SP1 protein binds to Cadmium CTD PMID:20073493 cadmium atom multiple interactions ISO RGD:732035 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA more ... CTD PMID:15760895 more ... cadmium dichloride multiple interactions ISO RGD:732035 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA more ... CTD PMID:18556457 , PMID:35384129 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of SP1 mRNA CTD PMID:35525383 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of SP1 mRNA, Cadmium Chloride results in decreased expression of SP1 protein CTD PMID:33865896 cadmium dichloride increases cleavage EXP 6480464 Cadmium Chloride results in increased cleavage of SP1 protein CTD PMID:12499119 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA more ... CTD PMID:12499119 , PMID:35384129 cadmium dichloride multiple interactions ISO RGD:11334 6480464 Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter] more ... CTD PMID:20060848 , PMID:25046863 cadmium dichloride affects response to substance ISO RGD:732035 6480464 SP1 affects the susceptibility to Cadmium Chloride CTD PMID:18556457 caffeine affects phosphorylation ISO RGD:732035 6480464 Caffeine affects the phosphorylation of SP1 protein CTD PMID:35688186 Calcimycin multiple interactions ISO RGD:732035 6480464 [Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of SP1 protein CTD PMID:24244623 camptothecin multiple interactions ISO RGD:732035 6480464 Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA] more ... CTD PMID:11261509 more ... camptothecin increases expression ISO RGD:732035 6480464 Camptothecin results in increased expression of SP1 mRNA CTD PMID:30851366 camptothecin increases activity ISO RGD:732035 6480464 Camptothecin results in increased activity of SP1 protein CTD PMID:11261509 capsaicin increases localization ISO RGD:732035 6480464 Capsaicin results in increased localization of SP1 protein CTD PMID:22200406 capsaicin multiple interactions ISO RGD:732035 6480464 Capsaicin promotes the reaction [SP1 protein binds to TNFSF10 promoter] CTD PMID:22200406 carbon nanotube decreases expression ISO RGD:11334 6480464 Nanotubes more ... CTD PMID:25554681 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of SP1 mRNA CTD PMID:23125180 chloroquine multiple interactions ISO RGD:732035 6480464 Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in increased expression of SP1 protein] CTD PMID:35561756 chlorpyrifos affects expression EXP 6480464 Chlorpyrifos affects the expression of SP1 mRNA CTD PMID:17452286 chlorpyrifos increases expression ISO RGD:732035 6480464 Chlorpyrifos results in increased expression of SP1 mRNA CTD PMID:24979751 choline multiple interactions ISO RGD:11334 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SP1 gene CTD PMID:20938992 chromium(6+) multiple interactions EXP 6480464 chromium hexavalent ion inhibits the reaction [SP1 protein binds to AR promoter] CTD PMID:32679048 cisplatin decreases expression ISO RGD:11334 6480464 Cisplatin results in decreased expression of SP1 mRNA CTD PMID:21151649 cisplatin increases expression ISO RGD:732035 6480464 [Cisplatin results in increased expression of SP1 protein] which results in increased expression of SLC31A1 mRNA more ... CTD PMID:22914438 , PMID:24132751 cisplatin multiple interactions ISO RGD:732035 6480464 Copper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA] CTD PMID:24132751 clofarabine multiple interactions ISO RGD:732035 6480464 [resveratrol co-treated with clofarabine] affects the localization of SP1 protein, [resveratrol co-treated with clofarabine] results in decreased expression of SP1 protein CTD PMID:23146690 clofibrate increases expression ISO RGD:11334 6480464 Clofibrate results in increased expression of SP1 mRNA CTD PMID:17585979 cobalt dichloride multiple interactions ISO RGD:732035 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein] more ... CTD PMID:17307335 cobalt dichloride increases phosphorylation EXP 6480464 cobaltous chloride results in increased phosphorylation of SP1 protein CTD PMID:23814049 cobalt dichloride increases expression ISO RGD:732035 6480464 cobaltous chloride results in increased expression of SP1 protein CTD PMID:17307335 cobalt dichloride increases activity ISO RGD:732035 6480464 cobaltous chloride results in increased activity of SP1 protein CTD PMID:17307335 cocaine affects expression EXP 6480464 Cocaine affects the expression of SP1 mRNA, Cocaine affects the expression of SP1 protein CTD PMID:16179556 , PMID:20187946 copper atom increases expression ISO RGD:732035 6480464 Copper deficiency results in increased expression of SP1 mRNA, Copper deficiency results in increased expression of SP1 protein CTD PMID:22172574 , PMID:24132751 copper atom multiple interactions ISO RGD:732035 6480464 [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein] more ... CTD PMID:12633744 more ... copper(0) increases expression ISO RGD:732035 6480464 Copper deficiency results in increased expression of SP1 mRNA, Copper deficiency results in increased expression of SP1 protein CTD PMID:22172574 , PMID:24132751 copper(0) multiple interactions ISO RGD:732035 6480464 [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein] more ... CTD PMID:12633744 more ... copper(II) sulfate multiple interactions ISO RGD:732035 6480464 Copper Sulfate inhibits the reaction [Cisplatin results in increased expression of SP1 mRNA] more ... CTD PMID:22172574 more ... copper(II) sulfate decreases expression ISO RGD:732035 6480464 [Copper Sulfate results in decreased expression of SP1 mRNA] which results in decreased expression of SLC31A1 mRNA, Copper Sulfate results in decreased expression of SP1 mRNA CTD PMID:22172574 , PMID:22914438 copper(II) sulfate increases expression ISO RGD:732035 6480464 Copper Sulfate results in increased expression of SP1 mRNA CTD PMID:19549813 copper(II) sulfate decreases activity ISO RGD:732035 6480464 Copper Sulfate results in decreased activity of SP1 protein CTD PMID:22172574 , PMID:26241054 cordycepin multiple interactions EXP 6480464 cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein], cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA] CTD PMID:23690541 coumarin decreases phosphorylation ISO RGD:732035 6480464 coumarin results in decreased phosphorylation of SP1 protein CTD PMID:35688186 crocidolite asbestos affects expression ISO RGD:732035 6480464 Asbestos, Crocidolite affects the expression of SP1 mRNA CTD PMID:17331233 CU-O LINKAGE increases expression ISO RGD:732035 6480464 cupric oxide results in increased expression of SP1 mRNA CTD PMID:22077320 curcumin decreases expression ISO RGD:732035 6480464 Curcumin results in decreased expression of SP1 protein CTD PMID:18347134 , PMID:18593936 cyclosporin A multiple interactions ISO RGD:732035 6480464 [Cyclosporine co-treated with NGF protein] affects the localization of SP1 protein, [Cyclosporine co-treated with NGF protein] promotes the reaction [SP1 protein binds to CDKN1A promoter] CTD PMID:24244623 D-glucose multiple interactions EXP 6480464 UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein], UCP1 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 D-glucose multiple interactions ISO RGD:732035 6480464 SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein], SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 D-penicillamine increases expression ISO RGD:732035 6480464 Penicillamine results in increased expression of SP1 mRNA CTD PMID:22914438 daunorubicin decreases expression ISO RGD:732035 6480464 Daunorubicin results in decreased expression of SP1 protein CTD PMID:34963561 daunorubicin multiple interactions ISO RGD:732035 6480464 AKT1 protein inhibits the reaction [Daunorubicin results in decreased expression of SP1 protein] more ... CTD PMID:34963561 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of SP1 mRNA CTD PMID:23640034 deoxynivalenol multiple interactions ISO RGD:732035 6480464 deoxynivalenol promotes the reaction [SP1 protein binds to KMT2A promoter], SP1 protein promotes the reaction [deoxynivalenol results in increased expression of KMT2A mRNA] CTD PMID:19438726 deoxynivalenol affects expression ISO RGD:732035 6480464 deoxynivalenol affects the expression of SP1 protein CTD PMID:33890134 deoxynivalenol increases phosphorylation ISO RGD:732035 6480464 deoxynivalenol results in increased phosphorylation of SP1 protein CTD PMID:19438726 desferrioxamine B multiple interactions ISO RGD:732035 6480464 [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 diarsenic trioxide affects methylation ISO RGD:732035 6480464 Arsenic Trioxide affects the methylation of SP1 promoter CTD PMID:26046465 diarsenic trioxide decreases activity ISO RGD:732035 6480464 Arsenic Trioxide results in decreased activity of SP1 protein CTD PMID:11714746 diarsenic trioxide decreases expression ISO RGD:732035 6480464 Arsenic Trioxide results in decreased expression of SP1 mRNA, Arsenic Trioxide results in decreased expression of SP1 protein CTD PMID:17617380 more ... diarsenic trioxide multiple interactions ISO RGD:732035 6480464 Arsenic Trioxide inhibits the reaction [SP1 protein binds to CYTL1 promoter] more ... CTD PMID:11714746 more ... diazinon increases methylation ISO RGD:732035 6480464 Diazinon results in increased methylation of SP1 gene CTD PMID:22964155 dibutyl phthalate decreases expression ISO RGD:11334 6480464 Dibutyl Phthalate results in decreased expression of SP1 mRNA CTD PMID:29029336 dibutyl phthalate multiple interactions ISO RGD:11334 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 dieldrin decreases response to substance ISO RGD:732035 6480464 SP1 gene mutant form results in decreased susceptibility to Dieldrin CTD PMID:32421776 diethylstilbestrol increases expression ISO RGD:11334 6480464 Diethylstilbestrol results in increased expression of SP1 mRNA CTD PMID:16714842 dimethyl sulfoxide multiple interactions ISO RGD:732035 6480464 Dimethyl Sulfoxide promotes the reaction [SP1 protein binds to CAD promoter] CTD PMID:16675542 dioxygen increases expression ISO RGD:732035 6480464 Oxygen deficiency results in increased expression of SP1 protein CTD PMID:17307335 dioxygen increases phosphorylation EXP 6480464 Oxygen deficiency results in increased phosphorylation of SP1 protein CTD PMID:23814049 dioxygen multiple interactions ISO RGD:732035 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SP1 protein], SP1 protein affects the reaction [Oxygen deficiency results in increased expression of DDIT4 mRNA] CTD PMID:17307335 disodium selenite multiple interactions ISO RGD:732035 6480464 [Sodium Selenite results in decreased activity of SP1 protein] which results in decreased expression of AR protein more ... CTD PMID:16928829 , PMID:35384129 disodium selenite multiple interactions EXP 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA] more ... CTD PMID:35384129 disodium selenite multiple interactions ISO RGD:11334 6480464 Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of SP1 protein] CTD PMID:15650415 doxorubicin affects activity ISO RGD:732035 6480464 Doxorubicin affects the activity of SP1 protein CTD PMID:17108358 doxorubicin increases ribosylation ISO RGD:732035 6480464 Doxorubicin results in increased ribosylation of SP1 protein CTD PMID:22293659 doxorubicin decreases expression ISO RGD:732035 6480464 Doxorubicin results in decreased expression of SP1 mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:732035 6480464 [Doxorubicin results in increased ribosylation of SP1 protein] affects the reaction [SP1 protein binds to TOP2A promoter] more ... CTD PMID:17124180 more ... elemental selenium multiple interactions EXP 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA] more ... CTD PMID:35384129 elemental selenium multiple interactions ISO RGD:732035 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA], [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein] CTD PMID:35384129 enzyme inhibitor multiple interactions ISO RGD:732035 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SP1 protein CTD PMID:23301498 epoxomicin multiple interactions ISO RGD:732035 6480464 epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2 more ... CTD PMID:17409431 epoxomicin increases ubiquitination ISO RGD:732035 6480464 epoxomicin results in increased ubiquitination of SP1 protein CTD PMID:17409431 esculetin decreases expression ISO RGD:732035 6480464 esculetin results in decreased expression of SP1 protein CTD PMID:31313495 estrogen increases expression EXP 152177689 estrogen increases expression of Sp1 mRNA in rat uterus RGD ethanol multiple interactions ISO RGD:732035 6480464 Ethanol promotes the reaction [SP1 protein binds to FASLG promoter] CTD PMID:24899502 ethanol multiple interactions ISO RGD:11334 6480464 Ethanol promotes the reaction [SP1 protein binds to CYP2B10 promoter], PPARD gene mutant form inhibits the reaction [Ethanol promotes the reaction [SP1 protein binds to CYP2B10 promoter]] CTD PMID:27765815 etoposide increases phosphorylation ISO RGD:732035 6480464 Etoposide results in increased phosphorylation of SP1 protein CTD PMID:17441964 etoposide increases activity EXP 6480464 Etoposide results in increased activity of SP1 protein CTD PMID:23690541 etoposide multiple interactions EXP 6480464 cordycepin inhibits the reaction [Etoposide results in increased activity of SP1 protein], cordycepin inhibits the reaction [Etoposide results in increased expression of SP1 mRNA] CTD PMID:23690541 etoposide increases expression EXP 6480464 Etoposide results in increased expression of SP1 mRNA CTD PMID:23690541 etoposide multiple interactions ISO RGD:732035 6480464 PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein], wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein] CTD PMID:17441964 flutamide increases expression EXP 6480464 Flutamide results in increased expression of SP1 mRNA CTD PMID:24793618 folic acid multiple interactions ISO RGD:732035 6480464 Folic Acid inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein], Folic Acid inhibits the reaction [SP1 protein binds to IGF1R promoter] CTD PMID:16728583 , PMID:33360347 folic acid decreases expression ISO RGD:11334 6480464 Folic Acid results in decreased expression of SP1 mRNA CTD PMID:25629700 folic acid multiple interactions ISO RGD:11334 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SP1 gene CTD PMID:20938992 fulvestrant multiple interactions ISO RGD:732035 6480464 fulvestrant promotes the reaction [SP1 protein binds to ESRRA promoter] CTD PMID:20211987 galactose increases expression EXP 6480464 Galactose results in increased expression of SP1 protein CTD PMID:30367734 galactose multiple interactions EXP 6480464 Alpinia oxyphylla fruit extract inhibits the reaction [Galactose results in increased expression of SP1 protein] CTD PMID:30367734 genistein multiple interactions ISO RGD:732035 6480464 Genistein promotes the reaction [SP1 protein binds to VDR promoter], U 0126 inhibits the reaction [Genistein results in increased activity of SP1 protein] CTD PMID:17088408 genistein increases expression ISO RGD:732035 6480464 Genistein results in increased expression of SP1 protein CTD PMID:24685904 genistein increases activity ISO RGD:732035 6480464 Genistein results in increased activity of SP1 protein CTD PMID:17088408 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of SP1 mRNA CTD PMID:22061828 glucose multiple interactions EXP 6480464 UCP1 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein], UCP1 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 glucose multiple interactions ISO RGD:732035 6480464 SOD2 protein inhibits the reaction [Glucose results in decreased phosphorylation of SP1 protein], SOD2 protein inhibits the reaction [Glucose results in increased O-linked glycosylation of SP1 protein] CTD PMID:11050244 glutathione multiple interactions ISO RGD:732035 6480464 Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein] CTD PMID:20435036 glutathione decreases expression ISO RGD:732035 6480464 Glutathione results in decreased expression of SP1 CTD PMID:18556457 glycitein increases activity ISO RGD:732035 6480464 glycitein results in increased activity of SP1 protein CTD PMID:17088408 glycitein multiple interactions ISO RGD:732035 6480464 glycitein promotes the reaction [SP1 protein binds to VDR promoter], U 0126 inhibits the reaction [glycitein results in increased activity of SP1 protein] CTD PMID:17088408 glyphosate increases expression ISO RGD:732035 6480464 glyphosate results in increased expression of SP1 mRNA CTD PMID:31295307 homocysteic acid increases activity ISO RGD:732035 6480464 homocysteic acid results in increased activity of SP1 protein CTD PMID:11261509 homocysteic acid multiple interactions ISO RGD:732035 6480464 mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein] CTD PMID:11261509 hydrogen peroxide multiple interactions ISO RGD:732035 6480464 [Hydrogen Peroxide results in increased activity of PARP1 protein] which results in decreased activity of SP1 protein more ... CTD PMID:17108117 more ... hydrogen peroxide affects expression ISO RGD:732035 6480464 Hydrogen Peroxide affects the expression of SP1 protein CTD PMID:17961220 hydrogen peroxide multiple interactions ISO RGD:11334 6480464 [Hydrogen Peroxide results in increased activity of and results in increased ADP-ribosylation of PARP1 protein] which results in increased ADP-ribosylation of and results in decreased activity of SP1 protein more ... CTD PMID:17108117 more ... hydrogen peroxide decreases expression ISO RGD:732035 6480464 Hydrogen Peroxide results in decreased expression of SP1 protein CTD PMID:20435036 , PMID:33360347 hydrogen peroxide increases phosphorylation ISO RGD:11334 6480464 Hydrogen Peroxide results in increased phosphorylation of SP1 protein CTD PMID:31494107 hydroquinone multiple interactions ISO RGD:732035 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in increased expression of SP1 protein] more ... CTD PMID:35561756 indole-3-methanol multiple interactions ISO RGD:732035 6480464 indole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter] CTD PMID:20570586 indole-3-methanol decreases activity ISO RGD:732035 6480464 indole-3-carbinol results in decreased activity of SP1 protein CTD PMID:16082211 irinotecan decreases expression ISO RGD:732035 6480464 Irinotecan analog results in decreased expression of SP1 mRNA CTD PMID:18927307 irinotecan increases phosphorylation ISO RGD:732035 6480464 Irinotecan results in increased phosphorylation of SP1 protein CTD PMID:17441964 irinotecan multiple interactions ISO RGD:732035 6480464 SP1 protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog] CTD PMID:18927307 iron atom multiple interactions ISO RGD:732035 6480464 [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 iron(0) multiple interactions ISO RGD:732035 6480464 [Deferoxamine affects the abundance of Iron] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 isoprenaline multiple interactions ISO RGD:11334 6480464 [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA, EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] CTD PMID:10710348 jaceosidin multiple interactions ISO RGD:732035 6480464 SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein], SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 L-ascorbic acid decreases expression ISO RGD:732035 6480464 Ascorbic Acid results in decreased expression of SP1 protein CTD PMID:21919647 L-methionine multiple interactions ISO RGD:11334 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SP1 gene CTD PMID:20938992 lead diacetate increases expression ISO RGD:11334 6480464 lead acetate results in increased expression of SP1 mRNA, lead acetate results in increased expression of SP1 protein CTD PMID:23867794 , PMID:24260418 lead diacetate increases expression ISO RGD:732035 6480464 lead acetate results in increased expression of SP1 protein CTD PMID:24462621 lead diacetate multiple interactions ISO RGD:732035 6480464 tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] CTD PMID:24462621 lead(0) increases expression ISO RGD:732035 6480464 Lead results in increased expression of SP1 protein CTD PMID:22272629 lead(0) multiple interactions ISO RGD:11334 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein, [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein CTD PMID:32179164 lead(2+) increases expression ISO RGD:732035 6480464 Lead results in increased expression of SP1 protein CTD PMID:22272629 lead(2+) multiple interactions ISO RGD:11334 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein, [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein CTD PMID:32179164 lead(II) chloride multiple interactions ISO RGD:11334 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein, [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein CTD PMID:32179164 lipoic acid multiple interactions ISO RGD:11334 6480464 Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 protein CTD PMID:21351249 lipopolysaccharide multiple interactions ISO RGD:732035 6480464 Lipopolysaccharides promotes the reaction [SP1 protein binds to BAG3 promoter], trichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of SP1 mRNA] CTD PMID:21911040 , PMID:22020323 lipopolysaccharide multiple interactions ISO RGD:11334 6480464 Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of SP1 protein] CTD PMID:15650415 lipopolysaccharide increases expression ISO RGD:732035 6480464 Lipopolysaccharides results in increased expression of SP1 mRNA CTD PMID:21911040 LY294002 multiple interactions ISO RGD:732035 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein] more ... CTD PMID:17307335 , PMID:26385185 LY294002 increases phosphorylation ISO RGD:11334 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of SP1 protein CTD PMID:21351249 manganese atom multiple interactions EXP 6480464 Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter], Manganese results in increased phosphorylation of and results in increased activity of SP1 protein CTD PMID:22975163 manganese(0) multiple interactions EXP 6480464 Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter], Manganese results in increased phosphorylation of and results in increased activity of SP1 protein CTD PMID:22975163 mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of SP1 mRNA CTD PMID:16507785 metformin multiple interactions ISO RGD:732035 6480464 Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein] CTD PMID:25110054 metformin decreases expression ISO RGD:732035 6480464 Metformin results in decreased expression of SP1 protein CTD PMID:25110054 , PMID:26317792 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of SP1 mRNA CTD PMID:30467583 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of SP1 protein CTD PMID:28736149 methylmercury chloride multiple interactions ISO RGD:11334 6480464 [[lead chloride results in increased abundance of Lead] which co-treated with methylmercuric chloride] results in increased expression of SP1 protein, [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein CTD PMID:32179164 methylmercury chloride decreases expression ISO RGD:732035 6480464 methylmercuric chloride results in decreased expression of SP1 mRNA CTD PMID:28001369 methylparaben decreases expression ISO RGD:732035 6480464 methylparaben results in decreased expression of SP1 mRNA CTD PMID:31745603 methylseleninic acid multiple interactions ISO RGD:732035 6480464 methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter] CTD PMID:17876054 mibolerone multiple interactions ISO RGD:732035 6480464 [Quercetin co-treated with mibolerone] promotes the reaction [SP1 protein binds to JUN protein binds to AR protein] more ... CTD PMID:15661808 , PMID:20148354 mithramycin decreases activity ISO RGD:732035 6480464 Plicamycin results in decreased activity of SP1 protein CTD PMID:15946989 mithramycin decreases expression ISO RGD:11334 6480464 Plicamycin results in decreased expression of SP1 protein CTD PMID:34087332 mithramycin decreases expression EXP 6480464 Plicamycin results in decreased expression of SP1 mRNA CTD PMID:23814049 mithramycin multiple interactions ISO RGD:732035 6480464 [Plicamycin inhibits the reaction [SP1 protein binds to TNFSF10 promoter]] which results in increased expression of TNFSF10 protein more ... CTD PMID:17307335 more ... monosodium L-glutamate increases expression EXP 6480464 Sodium Glutamate results in increased expression of SP1 mRNA CTD PMID:20928830 N-acetyl-L-cysteine decreases expression ISO RGD:732035 6480464 Acetylcysteine results in decreased expression of SP1 protein CTD PMID:18556457 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein] CTD PMID:33360347 N-acetyl-L-cysteine multiple interactions ISO RGD:732035 6480464 Acetylcysteine inhibits the reaction [Camptothecin results in increased expression of SP1 mRNA] more ... CTD PMID:16928829 more ... N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:11334 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [SP1 protein binds to ARNT promoter], benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of and results in increased activity of SP1 protein CTD PMID:14529614 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:732035 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [5-(4-((6-(allyloxy)-2 more ... CTD PMID:17409431 , PMID:34963561 N-butyl-N-(4-hydroxybutyl)nitrosamine increases expression ISO RGD:11334 6480464 Butylhydroxybutylnitrosamine results in increased expression of SP1 protein CTD PMID:24998975 N-ethylmaleimide multiple interactions ISO RGD:11334 6480464 Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 N-ethylmaleimide multiple interactions ISO RGD:732035 6480464 Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 SP1 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TIGAR protein] CTD PMID:33359019 neocuproine multiple interactions ISO RGD:732035 6480464 [neocuproine affects the abundance of Copper] inhibits the reaction [TNF protein results in increased activity of SP1 protein] CTD PMID:12633744 nickel atom increases activity ISO RGD:732035 6480464 Nickel results in increased activity of SP1 protein CTD PMID:19403854 nickel dichloride multiple interactions ISO RGD:732035 6480464 nickel chloride inhibits the reaction [SP1 protein binds to CTH promoter] more ... CTD PMID:30055191 nicotine multiple interactions ISO RGD:732035 6480464 Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein] more ... CTD PMID:24089524 nimustine decreases response to substance ISO RGD:732035 6480464 SP1 protein results in decreased susceptibility to Nimustine CTD PMID:29164620 nimustine multiple interactions ISO RGD:732035 6480464 [SP1 protein results in decreased susceptibility to Nimustine] which affects the expression of MGMT protein CTD PMID:29164620 olomoucine increases expression ISO RGD:732035 6480464 olomoucine results in increased expression of SP1 mRNA, olomoucine results in increased expression of SP1 protein CTD PMID:14653808 oxaliplatin multiple interactions ISO RGD:732035 6480464 oxaliplatin inhibits the reaction [SP1 protein binds to DUT promoter] CTD PMID:19015155 p-tert-Amylphenol multiple interactions ISO RGD:11334 6480464 [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 palbociclib multiple interactions ISO RGD:732035 6480464 palbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]], palbociclib promotes the reaction [RB1 protein binds to SP1 protein] CTD PMID:21880723 paracetamol affects expression ISO RGD:11334 6480464 Acetaminophen affects the expression of SP1 mRNA CTD PMID:17562736 PD 168393 multiple interactions EXP 6480464 PD168393 inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]], PD168393 inhibits the reaction [AGT protein results in increased expression of SP1 mRNA] CTD PMID:25398788 pentachlorophenol increases expression ISO RGD:11334 6480464 Pentachlorophenol results in increased expression of SP1 mRNA CTD PMID:23892564 phenobarbital affects expression ISO RGD:11334 6480464 Phenobarbital affects the expression of SP1 mRNA CTD PMID:23091169 phenylephrine multiple interactions ISO RGD:11334 6480464 [Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA, EGR1 protein affects the reaction [[Phenylephrine co-treated with Isoproterenol] results in increased expression of SP1 mRNA] CTD PMID:10710348 PhIP increases expression ISO RGD:732035 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of SP1 protein CTD PMID:22307971 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:732035 6480464 [Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of SP1 protein more ... CTD PMID:10669635 more ... phorbol 13-acetate 12-myristate increases expression ISO RGD:11334 6480464 Tetradecanoylphorbol Acetate results in increased expression of SP1 mRNA CTD PMID:27351882 phorbol 13-acetate 12-myristate increases activity ISO RGD:732035 6480464 Tetradecanoylphorbol Acetate results in increased activity of SP1 protein CTD PMID:15978937 platycodin D multiple interactions ISO RGD:732035 6480464 platycodin D results in decreased expression of and results in decreased activity of SP1 protein CTD PMID:18093727 promegestone increases expression ISO RGD:732035 6480464 Promegestone results in increased expression of SP1 mRNA, Promegestone results in increased expression of SP1 protein CTD PMID:16807381 promegestone multiple interactions ISO RGD:732035 6480464 mithramycin A inhibits the reaction [Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter]], Promegestone promotes the reaction [SP1 protein binds to HSD17B2 promoter] CTD PMID:16807381 propiconazole decreases expression ISO RGD:11334 6480464 propiconazole results in decreased expression of SP1 mRNA CTD PMID:21278054 protein kinase inhibitor multiple interactions ISO RGD:732035 6480464 Protein Kinase Inhibitors inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein] CTD PMID:26385185 pterostilbene multiple interactions ISO RGD:732035 6480464 SP1 protein affects the reaction [[pterostilbene co-treated with Quercetin] results in increased expression of SOD2 protein] CTD PMID:18852136 quercetin decreases expression ISO RGD:732035 6480464 Quercetin results in decreased expression of SP1 protein CTD PMID:18377872 quercetin multiple interactions ISO RGD:732035 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]] more ... CTD PMID:15661808 more ... quercetin multiple interactions ISO RGD:11334 6480464 MAPK14 protein promotes the reaction [Quercetin promotes the reaction [SP1 protein binds to ABCA1 promoter]] more ... CTD PMID:22711909 quercetin increases activity ISO RGD:732035 6480464 Quercetin results in increased activity of SP1 protein CTD PMID:18980244 quercetin 3-O-beta-D-galactopyranoside multiple interactions ISO RGD:732035 6480464 [Quercetin co-treated with hyperoside] inhibits the reaction [MIR27A mRNA results in increased expression of SP1 mRNA] more ... CTD PMID:24173369 quinacrine multiple interactions ISO RGD:732035 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quinacrine results in increased expression of SP1 protein] more ... CTD PMID:28867437 resveratrol multiple interactions ISO RGD:732035 6480464 [Resveratrol co-treated with Clofarabine] affects the localization of SP1 protein more ... CTD PMID:16614140 more ... resveratrol decreases acetylation ISO RGD:732035 6480464 resveratrol results in decreased acetylation of SP1 protein CTD PMID:25875864 resveratrol decreases expression ISO RGD:11334 6480464 resveratrol results in decreased expression of SP1 protein CTD PMID:25505154 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of SP1 mRNA CTD PMID:25905778 resveratrol affects localization ISO RGD:732035 6480464 resveratrol affects the localization of SP1 protein CTD PMID:23437203 resveratrol decreases activity ISO RGD:732035 6480464 resveratrol results in decreased activity of SP1 protein CTD PMID:23437203 resveratrol decreases activity EXP 6480464 resveratrol results in decreased activity of SP1 protein CTD PMID:18420994 resveratrol increases activity ISO RGD:732035 6480464 resveratrol results in increased activity of SP1 protein CTD PMID:17049495 S-adenosyl-L-homocysteine multiple interactions EXP 6480464 S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 S-adenosyl-L-methioninate multiple interactions ISO RGD:11334 6480464 S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter] CTD PMID:15983038 S-adenosyl-L-methioninate multiple interactions ISO RGD:732035 6480464 S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]], S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] CTD PMID:15983038 S-adenosyl-L-methionine multiple interactions ISO RGD:732035 6480464 S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK1 protein modified form]], S-Adenosylmethionine inhibits the reaction [TGFB1 protein promotes the reaction [SP1 protein binds to MAPK3 protein modified form]] CTD PMID:15983038 S-adenosyl-L-methionine multiple interactions ISO RGD:11334 6480464 S-Adenosylmethionine inhibits the reaction [SP1 protein binds to COL1A2 promoter] CTD PMID:15983038 S-butyl-DL-homocysteine (S,R)-sulfoximine increases activity ISO RGD:732035 6480464 Buthionine Sulfoximine results in increased activity of SP1 protein CTD PMID:11261509 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:732035 6480464 mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP1 protein] CTD PMID:11261509 S-nitrosoglutathione increases activity ISO RGD:732035 6480464 S-Nitrosoglutathione results in increased activity of SP1 protein CTD PMID:14766015 SB 203580 multiple interactions ISO RGD:732035 6480464 SB 203580 inhibits the reaction [Hydrogen Peroxide promotes the reaction [SP1 protein results in increased expression of CAV1 protein]] CTD PMID:17108117 SCH772984 multiple interactions EXP 6480464 SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of and results in increased phosphorylation of SP1 protein], SCH772984 inhibits the reaction [Ethylene Chlorohydrin results in increased expression of SP1 mRNA] CTD PMID:31585129 selenium atom multiple interactions EXP 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA] more ... CTD PMID:35384129 selenium atom multiple interactions ISO RGD:732035 6480464 [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 mRNA], [Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SP1 protein] CTD PMID:35384129 silicon dioxide decreases expression ISO RGD:732035 6480464 Silicon Dioxide results in decreased expression of SP1 mRNA CTD PMID:25351596 silver atom decreases expression ISO RGD:732035 6480464 Silver results in decreased expression of SP1 mRNA CTD PMID:26551752 silver(0) decreases expression ISO RGD:732035 6480464 Silver results in decreased expression of SP1 mRNA CTD PMID:26551752 silver(1+) nitrate increases expression ISO RGD:732035 6480464 Silver Nitrate results in increased expression of SP1 mRNA CTD PMID:24132751 simvastatin multiple interactions ISO RGD:732035 6480464 Simvastatin inhibits the reaction [SP1 binds to COL1A1 promoter] CTD PMID:16575855 sodium arsenite increases expression ISO RGD:732035 6480464 sodium arsenite results in increased expression of SP1 mRNA, sodium arsenite results in increased expression of SP1 protein CTD PMID:23562784 , PMID:31170415 sodium arsenite multiple interactions ISO RGD:11334 6480464 [[lead chloride results in increased abundance of Lead] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein, [methylmercuric chloride co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of SP1 protein CTD PMID:32179164 sodium arsenite decreases expression ISO RGD:732035 6480464 sodium arsenite results in decreased expression of SP1 mRNA, sodium arsenite results in decreased expression of SP1 protein CTD PMID:33360347 sodium arsenite multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein] CTD PMID:33360347 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of SP1 mRNA, sodium arsenite results in decreased expression of SP1 protein CTD PMID:33360347 sodium arsenite multiple interactions ISO RGD:732035 6480464 Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein] more ... CTD PMID:33360347 sodium chloride multiple interactions EXP 6480464 [[SP1 protein co-treated with JUN protein] binds to CLDN4 promoter] promotes the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 sodium dichromate increases activity ISO RGD:732035 6480464 sodium bichromate results in increased activity of SP1 protein CTD PMID:10411148 T-2 toxin multiple interactions ISO RGD:732035 6480464 T-2 Toxin promotes the reaction [SP1 protein binds to CYP1A1 promoter] CTD PMID:31470059 tamoxifen multiple interactions ISO RGD:732035 6480464 Tamoxifen promotes the reaction [[[ESR1 protein binds to SP1 protein] which binds to E2F1 promoter] which results in increased expression of E2F1 mRNA] more ... CTD PMID:20211987 , PMID:20215421 tamoxifen multiple interactions ISO RGD:11334 6480464 Tamoxifen promotes the reaction [[SP1 protein binds to PEMT promoter] which results in decreased expression of PEMT mRNA] CTD PMID:20150657 temozolomide multiple interactions ISO RGD:732035 6480464 Temozolomide promotes the reaction [TP53 protein binds to SP1 protein] CTD PMID:29164620 terameprocol decreases activity ISO RGD:732035 6480464 terameprocol results in decreased activity of SP1 protein CTD PMID:16544145 terameprocol multiple interactions ISO RGD:732035 6480464 terameprocol inhibits the reaction [SP1 protein results in increased expression of ABCB1 mRNA] CTD PMID:16544145 tetrachloroethene increases expression ISO RGD:11334 6480464 Tetrachloroethylene results in increased expression of SP1 mRNA CTD PMID:28973375 tetrathiomolybdate(2-) multiple interactions ISO RGD:732035 6480464 [tetrathiomolybdate results in decreased abundance of Copper] which results in increased expression of SP1 protein more ... CTD PMID:22172574 tetrathiomolybdate(2-) increases expression ISO RGD:732035 6480464 tetrathiomolybdate results in increased expression of SP1, tetrathiomolybdate results in increased expression of SP1 mRNA CTD PMID:22172574 , PMID:22914438 tetrathiomolybdate(2-) increases activity ISO RGD:732035 6480464 tetrathiomolybdate results in increased activity of SP1 protein CTD PMID:22172574 thalidomide decreases activity ISO RGD:732035 6480464 Thalidomide results in decreased activity of SP1 protein CTD PMID:10533722 thapsigargin decreases expression EXP 6480464 Thapsigargin results in decreased expression of SP1 mRNA CTD PMID:25398788 Tiron multiple interactions ISO RGD:11334 6480464 SP1 protein affects the reaction [1 more ... CTD PMID:11163763 tolfenamic acid multiple interactions ISO RGD:732035 6480464 tolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein] CTD PMID:24462621 trichloroethene increases expression ISO RGD:11334 6480464 Trichloroethylene results in increased expression of SP1 mRNA CTD PMID:21135412 trichostatin A multiple interactions ISO RGD:732035 6480464 [[decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to SLC25A1 promoter]] which results in increased expression of SLC25A1 mRNA more ... CTD PMID:16740727 more ... trichostatin A increases activity ISO RGD:732035 6480464 trichostatin A results in increased activity of SP1 protein CTD PMID:16757381 trichostatin A affects expression ISO RGD:732035 6480464 trichostatin A affects the expression of SP1 mRNA, trichostatin A affects the expression of SP1 protein CTD PMID:18801729 Triptolide increases expression ISO RGD:11334 6480464 triptolide results in increased expression of SP1 mRNA CTD PMID:32835833 Triptolide decreases expression ISO RGD:11334 6480464 triptolide results in decreased expression of SP1 protein CTD PMID:34087332 triptonide decreases expression ISO RGD:11334 6480464 triptonide results in decreased expression of SP1 mRNA CTD PMID:33045310 troglitazone decreases expression ISO RGD:11334 6480464 troglitazone results in decreased expression of SP1 mRNA CTD PMID:28973697 troglitazone multiple interactions ISO RGD:732035 6480464 [troglitazone results in increased degradation of SP1 protein] which results in decreased expression of AR mRNA CTD PMID:17409431 troglitazone increases degradation ISO RGD:732035 6480464 troglitazone results in increased degradation of SP1 protein CTD PMID:17409431 troglitazone decreases expression ISO RGD:732035 6480464 troglitazone results in decreased expression of SP1 protein CTD PMID:15908479 , PMID:17409431 tunicamycin decreases expression EXP 6480464 Tunicamycin results in decreased expression of SP1 mRNA CTD PMID:25398788 tyrphostin AG 1478 multiple interactions EXP 6480464 RTKI cpd inhibits the reaction [AGT protein promotes the reaction [SP1 protein binds to TGFB1 promoter]], RTKI cpd inhibits the reaction [AGT protein results in increased expression of SP1 mRNA] CTD PMID:25398788 urethane decreases expression ISO RGD:732035 6480464 Urethane results in decreased expression of SP1 mRNA CTD PMID:28818685 valproic acid multiple interactions ISO RGD:732035 6480464 Valproic Acid promotes the reaction [SP1 protein binds to XPC promoter] CTD PMID:21507255 valproic acid decreases expression ISO RGD:732035 6480464 Valproic Acid results in decreased expression of SP1 mRNA CTD PMID:23179753 , PMID:28001369 valproic acid decreases expression ISO RGD:11334 6480464 Valproic Acid results in decreased expression of SP1 mRNA CTD PMID:21427059 venetoclax multiple interactions ISO RGD:732035 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in increased expression of SP1 protein] more ... CTD PMID:35561756 vincristine decreases expression ISO RGD:732035 6480464 Vincristine results in decreased expression of SP1 mRNA CTD PMID:23649840 vorinostat multiple interactions ISO RGD:732035 6480464 SP1 protein promotes the reaction [vorinostat results in increased expression of CDKN1A mRNA] CTD PMID:11126357 wortmannin multiple interactions ISO RGD:732035 6480464 wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein] CTD PMID:17441964 wortmannin decreases reaction EXP 152177689 wortmannin inhibits the reaction [estrogen increases expression of Sp1 mRNA] in rat uterus RGD zinc acetate increases expression ISO RGD:732035 6480464 Zinc Acetate results in increased expression of SP1 mRNA CTD PMID:24132751 zinc atom multiple interactions ISO RGD:732035 6480464 Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter] more ... CTD PMID:20073493 zinc atom decreases expression EXP 6480464 Zinc deficiency results in decreased expression of SP1 protein CTD PMID:21893222 zinc atom multiple interactions ISO RGD:11334 6480464 Zinc promotes the reaction [MTF1 protein binds to SP1 protein], Zinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]] CTD PMID:18458062 zinc atom increases activity ISO RGD:732035 6480464 Zinc deficiency results in increased activity of SP1 protein CTD PMID:18356318 zinc atom affects binding ISO RGD:732035 6480464 SP1 protein binds to Zinc CTD PMID:20073493 zinc dichloride multiple interactions ISO RGD:11334 6480464 zinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP1 protein binds to and affects the expression of SLC5A1 promoter]] CTD PMID:20060848 zinc dichloride increases activity ISO RGD:732035 6480464 zinc chloride results in increased activity of SP1 protein CTD PMID:9330853 zinc sulfate multiple interactions ISO RGD:732035 6480464 Zinc Sulfate inhibits the reaction [Copper Sulfate results in decreased activity of SP1 protein] CTD PMID:26241054 zinc(0) multiple interactions ISO RGD:732035 6480464 Cadmium inhibits the reaction [[SP1 protein binds to Zinc] which binds to SLC5A1 promoter] more ... CTD PMID:20073493 zinc(0) affects binding ISO RGD:732035 6480464 SP1 protein binds to Zinc CTD PMID:20073493 zinc(0) increases activity ISO RGD:732035 6480464 Zinc deficiency results in increased activity of SP1 protein CTD PMID:18356318 zinc(0) multiple interactions ISO RGD:11334 6480464 Zinc promotes the reaction [MTF1 protein binds to SP1 protein], Zinc promotes the reaction [MTF1 protein promotes the reaction [EP300 protein binds to SP1 protein]] CTD PMID:18458062 zinc(0) decreases expression EXP 6480464 Zinc deficiency results in decreased expression of SP1 protein CTD PMID:21893222 zoledronic acid increases expression ISO RGD:732035 6480464 zoledronic acid results in increased expression of SP1 mRNA CTD PMID:20977926
