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Gene: Sp1 (Sp1 transcription factor) Rattus norvegicus
Symbol: Sp1
Name: Sp1 transcription factor
RGD ID: 3738
Description: Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone acetyltransferase binding activity. Involved in cellular response to insulin stimulus and positive regulation of transcription by RNA polymerase II. Localizes to nuclear chromatin and protein-DNA complex. Orthologous to human SP1 (Sp1 transcription factor); PARTICIPATES IN forkhead class A signaling pathway; hypoxia inducible factor pathway; interleukin-4 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: trans-acting transcription factor 1; transcription factor Sp1
Homo sapiens (human) : SP1 (Sp1 transcription factor)  HGNC  Alliance
Mus musculus (house mouse) : Sp1 (trans-acting transcription factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sp1 (Sp1 transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : SP1 (Sp1 transcription factor)
Canis lupus familiaris (dog) : SP1 (Sp1 transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sp1 (Sp1 transcription factor)
Sus scrofa (pig) : SP1 (Sp1 transcription factor)
Chlorocebus sabaeus (African green monkey) : SP1 (Sp1 transcription factor)
Heterocephalus glaber (naked mole-rat) : Sp1 (Sp1 transcription factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.07144,014,173 - 144,044,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,014,173 - 144,044,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,805,281 - 141,836,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,164,180 - 141,194,509 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17141,240,616 - 141,265,690 (+)NCBI
Celera7129,968,890 - 129,999,257 (+)NCBICelera
Cytogenetic Map7q36NCBI
RH 3.4 Map71062.1RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sp1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3738
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.