Atg101 (autophagy related 101) - Rat Genome Database

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Gene: Atg101 (autophagy related 101) Rattus norvegicus
Analyze
Symbol: Atg101
Name: autophagy related 101
RGD ID: 1359310
Description: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including autophagosome assembly; protein autophosphorylation; and regulation of protein lipidation. Predicted to be part of Atg1/ULK1 kinase complex. Predicted to be active in phagophore assembly site. Orthologous to human ATG101 (autophagy related 101); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: autophagy-related protein 101; MGC94201; RGD1359310; similar to RIKEN cDNA 9430023L20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27132,398,477 - 132,407,643 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,398,483 - 132,407,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,200,027 - 134,209,527 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07136,429,543 - 136,439,043 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07136,339,980 - 136,348,905 (+)NCBIRnor_WKY
Rnor_6.07142,929,381 - 142,938,559 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,929,400 - 142,938,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,730,251 - 140,739,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,029,813 - 140,038,925 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,106,249 - 140,115,362 (+)NCBI
Celera7128,863,838 - 128,872,961 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
4. Development and validation of prognostic model based on the analysis of autophagy-related genes in colon cancer. Wang Y, etal., Aging (Albany NY). 2021 Jul 27;13(14):19028-19047. doi: 10.18632/aging.203352. Epub 2021 Jul 27.
5. Comprehensive Analysis of the Potential Immune-Related Biomarker ATG101 that Regulates Apoptosis of Cholangiocarcinoma Cells After Photodynamic Therapy. Zhang ZJ, etal., Front Pharmacol. 2022 May 3;13:857774. doi: 10.3389/fphar.2022.857774. eCollection 2022.
Additional References at PubMed
PMID:19597335   PMID:20562859  


Genomics

Comparative Map Data
Atg101
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27132,398,477 - 132,407,643 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,398,483 - 132,407,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,200,027 - 134,209,527 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07136,429,543 - 136,439,043 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07136,339,980 - 136,348,905 (+)NCBIRnor_WKY
Rnor_6.07142,929,381 - 142,938,559 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,929,400 - 142,938,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,730,251 - 140,739,416 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,029,813 - 140,038,925 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,106,249 - 140,115,362 (+)NCBI
Celera7128,863,838 - 128,872,961 (+)NCBICelera
Cytogenetic Map7q36NCBI
ATG101
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,065,300 - 52,077,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1252,069,246 - 52,077,495 (+)EnsemblGRCh38hg38GRCh38
GRCh371252,463,762 - 52,471,279 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,750,025 - 50,757,546 (+)NCBINCBI36Build 36hg18NCBI36
Celera1251,266,432 - 51,273,953 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,496,921 - 49,504,446 (+)NCBIHuRef
CHM1_11252,430,002 - 52,437,523 (+)NCBICHM1_1
T2T-CHM13v2.01252,033,558 - 52,041,075 (+)NCBIT2T-CHM13v2.0
Atg101
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,182,182 - 101,188,828 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,182,153 - 101,188,826 (+)EnsemblGRCm39 Ensembl
GRCm3815101,284,301 - 101,290,947 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,284,272 - 101,290,945 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715101,114,732 - 101,121,365 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,112,335 - 101,118,968 (+)NCBIMGSCv36mm8
Celera15103,432,360 - 103,438,993 (+)NCBICelera
Cytogenetic Map15F1NCBI
Atg101
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,436,895 - 2,446,849 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,436,974 - 2,446,849 (+)NCBIChiLan1.0ChiLan1.0
ATG101
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11237,462,533 - 37,470,277 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,462,533 - 37,470,062 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01236,685,897 - 36,693,613 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ATG101
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,931,595 - 2,934,914 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,931,893 - 2,935,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,317,316 - 43,324,391 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,928,791 - 2,935,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,928,794 - 2,935,861 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,945,425 - 2,950,072 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,931,788 - 2,938,961 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,715,530 - 43,722,606 (+)NCBIUU_Cfam_GSD_1.0
Atg101
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,638,844 - 63,646,743 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,518,074 - 9,526,961 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365129,518,128 - 9,525,986 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATG101
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,418,121 - 17,425,624 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,418,085 - 17,425,770 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ATG101
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,243,200 - 48,251,129 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,243,216 - 48,251,371 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037197,841,049 - 197,849,553 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atg101
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816255,432 - 262,151 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624816255,443 - 261,636 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atg101
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:265
Count of miRNA genes:174
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000010194
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
RH142906  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,407,514 - 132,407,617 (+)MAPPERmRatBN7.2
Rnor_6.07142,938,431 - 142,938,533NCBIRnor6.0
Rnor_5.07140,739,288 - 140,739,390UniSTSRnor5.0
RGSC_v3.47140,038,805 - 140,038,907UniSTSRGSC3.4
Celera7128,872,833 - 128,872,935UniSTS
RH 3.4 Map71075.3UniSTS
Cytogenetic Map7q36UniSTS
RH139413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,407,219 - 132,407,456 (+)MAPPERmRatBN7.2
Rnor_6.07142,938,136 - 142,938,372NCBIRnor6.0
Rnor_5.07140,738,993 - 140,739,229UniSTSRnor5.0
RGSC_v3.47140,038,510 - 140,038,746UniSTSRGSC3.4
Celera7128,872,538 - 128,872,774UniSTS
RH 3.4 Map71063.4UniSTS
Cytogenetic Map7q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 37 57 41 19 41 8 11 74 35 39 11 8
Low 6 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010194   ⟹   ENSRNOP00000010195
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,398,483 - 132,407,633 (+)Ensembl
Rnor_6.0 Ensembl7142,929,439 - 142,938,551 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087415   ⟹   ENSRNOP00000071030
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,398,493 - 132,407,595 (+)Ensembl
Rnor_6.0 Ensembl7142,929,400 - 142,938,554 (+)Ensembl
RefSeq Acc Id: NM_001007659   ⟹   NP_001007660
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,398,501 - 132,407,643 (+)NCBI
Rnor_6.07142,929,417 - 142,938,559 (+)NCBI
Rnor_5.07140,730,251 - 140,739,416 (+)NCBI
RGSC_v3.47140,029,813 - 140,038,925 (+)RGD
Celera7128,863,838 - 128,872,961 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001271114   ⟹   NP_001258043
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,398,501 - 132,407,643 (+)NCBI
Rnor_6.07142,929,417 - 142,938,559 (+)NCBI
Rnor_5.07140,730,251 - 140,739,416 (+)NCBI
Celera7128,863,838 - 128,872,961 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242324   ⟹   XP_006242386
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27132,398,477 - 132,407,636 (+)NCBI
Rnor_6.07142,929,381 - 142,938,556 (+)NCBI
Rnor_5.07140,730,251 - 140,739,416 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001007660   ⟸   NM_001007659
- Peptide Label: isoform 1
- UniProtKB: Q6AY69 (UniProtKB/Swiss-Prot),   A0A8L2Q495 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258043   ⟸   NM_001271114
- Peptide Label: isoform 2
- UniProtKB: Q6AY69 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242386   ⟸   XM_006242324
- Peptide Label: isoform X1
- UniProtKB: Q6AY69 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071030   ⟸   ENSRNOT00000087415
RefSeq Acc Id: ENSRNOP00000010195   ⟸   ENSRNOT00000010194

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY69-F1-model_v2 AlphaFold Q6AY69 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695668
Promoter ID:EPDNEW_R6193
Type:multiple initiation site
Name:Atg101_1
Description:autophagy related 101
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07142,929,416 - 142,929,476EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359310 AgrOrtholog
BioCyc Gene G2FUF-31992 BioCyc
Ensembl Genes ENSRNOG00000007756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010195 ENTREZGENE
  ENSRNOP00000010195.3 UniProtKB/TrEMBL
  ENSRNOP00000071030.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010194 ENTREZGENE
  ENSRNOT00000010194.4 UniProtKB/TrEMBL
  ENSRNOT00000087415.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129890 IMAGE-MGC_LOAD
InterPro ATG101 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:300240 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94201 IMAGE-MGC_LOAD
NCBI Gene 300240 ENTREZGENE
PANTHER PTHR13292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATG101 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atg101 PhenoGen
UniProt A0A8L2Q495 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R4A7_RAT UniProtKB/TrEMBL
  ATGA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-11-13 Atg101  autophagy related 101  RGD1359310  similar to RIKEN cDNA 9430023L20  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 RGD1359310  similar to RIKEN cDNA 9430023L20  MGC94201    Symbol updated 1299863 APPROVED
2005-07-29 MGC94201  similar to RIKEN cDNA 9430023L20      Symbol and Name status set to provisional 70820 PROVISIONAL