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Gene: CD81 (CD81 molecule) Homo sapiens
Symbol: CD81
Name: CD81 molecule
RGD ID: 731700
Description: Exhibits cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of immune response; and positive regulation of lymphocyte activation. Localizes to several cellular components, including basal plasma membrane; immunological synapse; and tetraspanin-enriched microdomain. Implicated in common variable immunodeficiency.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 26 kDa cell surface protein TAPA-1; cd 81 antigen; CD81 antigen; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; TAPA1; target of antiproliferative antibody 1; target of the antiproliferative antibody 1; tetraspanin-28; tspan-28; TSPAN28
Mus musculus (house mouse) : Cd81 (CD81 antigen)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd81 (Cd81 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd81 (CD81 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD81 (CD81 molecule)
Canis lupus familiaris (dog) : CD81 (CD81 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd81 (CD81 molecule)
Sus scrofa (pig) : CD81 (CD81 molecule)
Chlorocebus sabaeus (African green monkey) : CD81 (CD81 molecule)
Heterocephalus glaber (naked mole-rat) : Cd81 (CD81 molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl112,376,177 - 2,397,397 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl112,376,177 - 2,397,419 (+)EnsemblGRCh38hg38GRCh38
GRCh38112,376,180 - 2,397,402 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,397,391 - 2,418,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,355,123 - 2,375,225 (+)NCBINCBI36hg18NCBI36
Build 34112,355,315 - 2,375,202NCBI
Celera112,433,431 - 2,453,456 (+)NCBI
Cytogenetic Map11p15.5NCBI
HuRef112,188,870 - 2,209,001 (+)NCBIHuRef
CHM1_1112,396,358 - 2,417,522 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CD81
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731700
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.