Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Mapk12 | Rat | 1,2-dichloroethane | increases expression | ISO | Mapk12 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of MAPK12 mRNA | CTD | PMID:28960355 | Mapk12 | Rat | 1-chloro-2,4-dinitrobenzene | decreases methylation | ISO | Mapk12 (Mus musculus) | 6480464 | Dinitrochlorobenzene results in decreased methylation of MAPK12 promoter | CTD | PMID:24675093 | Mapk12 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MAPK12 mRNA | CTD | PMID:33387578 | Mapk12 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of MAPK12 mRNA | CTD | PMID:24780913 | Mapk12 | Rat | acetylsalicylic acid | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Aspirin results in decreased expression of MAPK12 mRNA | CTD | PMID:20514442 | Mapk12 | Rat | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of MAPK12 mRNA | CTD | PMID:28959563 | Mapk12 | Rat | acrylamide | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of MAPK12 mRNA | CTD | PMID:32763439 | Mapk12 | Rat | afimoxifene | decreases response to substance | ISO | MAPK12 (Homo sapiens) | 6480464 | MAPK12 results in decreased susceptibility to afimoxifene | CTD | PMID:21233418 | Mapk12 | Rat | aflatoxin B1 | decreases methylation | ISO | MAPK12 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of MAPK12 intron | CTD | PMID:30157460 | Mapk12 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of MAPK12 mRNA | CTD | PMID:16483693 | Mapk12 | Rat | amsacrine | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Amsacrine and [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Amsacrine | CTD | PMID:21878638 | Mapk12 | Rat | amsacrine | affects response to substance | ISO | MAPK12 (Homo sapiens) | 6480464 | MAPK12 protein affects the susceptibility to Amsacrine | CTD | PMID:21878638 | Mapk12 | Rat | amsacrine | increases activity | ISO | MAPK12 (Homo sapiens) | 6480464 | Amsacrine results in increased activity of MAPK12 protein | CTD | PMID:21878638 | Mapk12 | Rat | arsenite(3-) | multiple interactions | ISO | Mapk12 (Mus musculus) | 6480464 | MAPK12 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein] | CTD | PMID:23639288 | Mapk12 | Rat | benzo[a]pyrene | decreases expression | ISO | Mapk12 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of MAPK12 mRNA | CTD | PMID:22228805 | Mapk12 | Rat | benzo[a]pyrene | affects methylation | ISO | MAPK12 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of MAPK12 promoter | CTD | PMID:27901495 | Mapk12 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of MAPK12 mRNA | CTD | PMID:25181051 | Mapk12 | Rat | bisphenol A | increases expression | ISO | Mapk12 (Mus musculus) | 6480464 | bisphenol A results in increased expression of MAPK12 mRNA | CTD | PMID:32156529 | Mapk12 | Rat | bisphenol A | affects expression | ISO | MAPK12 (Homo sapiens) | 6480464 | bisphenol A affects the expression of MAPK12 mRNA | CTD | PMID:30903817 | Mapk12 | Rat | bisphenol A | increases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of MAPK12 mRNA | CTD | PMID:29275510 | Mapk12 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of MAPK12 gene | CTD | PMID:28505145 | Mapk12 | Rat | cadmium dichloride | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of MAPK12 protein | CTD | PMID:19757093 | Mapk12 | Rat | cadmium dichloride | increases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of MAPK12 mRNA | CTD | PMID:19757093 | Mapk12 | Rat | cadmium dichloride | multiple interactions | ISO | Mapk12 (Mus musculus) | 6480464 | MAPK12 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]] and MAPK12 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein] | CTD | PMID:18348256 | Mapk12 | Rat | calciol | increases expression | ISO | Mapk12 (Mus musculus) | 6480464 | Cholecalciferol results in increased expression of MAPK12 mRNA | CTD | PMID:17170073 | Mapk12 | Rat | cannabidiol | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Cannabidiol results in decreased expression of MAPK12 mRNA | CTD | PMID:27714895 more ... | Mapk12 | Rat | carbon nanotube | decreases expression | ISO | Mapk12 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of MAPK12 mRNA | CTD | PMID:25554681 | Mapk12 | Rat | cisplatin | increases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of MAPK12 mRNA | CTD | PMID:21603599 | Mapk12 | Rat | cisplatin | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of MAPK12 mRNA | CTD | PMID:27392435 | Mapk12 | Rat | cobalt dichloride | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of MAPK12 mRNA | CTD | PMID:19320972 and PMID:26314263 | Mapk12 | Rat | copper atom | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of MAPK12 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of MAPK12 mRNA | CTD | PMID:20971185 and PMID:30911355 | Mapk12 | Rat | copper(0) | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [Chelating Agents binds to Copper] which results in decreased expression of MAPK12 mRNA and [NSC 689534 binds to Copper] which results in decreased expression of MAPK12 mRNA | CTD | PMID:20971185 and PMID:30911355 | Mapk12 | Rat | crocidolite asbestos | decreases expression | ISO | Mapk12 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of MAPK12 mRNA | CTD | PMID:29279043 | Mapk12 | Rat | curcumin | increases activity | ISO | MAPK12 (Homo sapiens) | 6480464 | Curcumin results in increased activity of MAPK12 protein | CTD | PMID:21594647 | Mapk12 | Rat | cyclosporin A | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of MAPK12 mRNA | CTD | PMID:27989131 | Mapk12 | Rat | D-glucitol | increases phosphorylation | ISO | MAPK12 (Homo sapiens) | 6480464 | Sorbitol results in increased phosphorylation of MAPK12 protein | CTD | PMID:15362974 | Mapk12 | Rat | deguelin | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | deguelin results in decreased expression of MAPK12 mRNA | CTD | PMID:33512557 | Mapk12 | Rat | deoxynivalenol | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | deoxynivalenol results in decreased expression of MAPK12 mRNA | CTD | PMID:31863870 | Mapk12 | Rat | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of MAPK12 mRNA | CTD | PMID:22546817 | Mapk12 | Rat | dieldrin | affects expression | EXP | | 6480464 | Dieldrin affects the expression of MAPK12 mRNA | CTD | PMID:22546817 | Mapk12 | Rat | disodium selenite | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Sodium Selenite results in decreased expression of MAPK12 mRNA | CTD | PMID:16705456 | Mapk12 | Rat | dorsomorphin | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Mapk12 | Rat | doxorubicin | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of MAPK12 mRNA | CTD | PMID:36634904 | Mapk12 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of MAPK12 mRNA | CTD | PMID:29391264 | Mapk12 | Rat | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of MAPK12 mRNA | CTD | PMID:17920746 | Mapk12 | Rat | etoposide | increases activity | ISO | MAPK12 (Homo sapiens) | 6480464 | Etoposide results in increased activity of MAPK12 protein | CTD | PMID:21878638 | Mapk12 | Rat | etoposide | affects response to substance | ISO | MAPK12 (Homo sapiens) | 6480464 | MAPK12 protein affects the susceptibility to Etoposide | CTD | PMID:21878638 | Mapk12 | Rat | etoposide | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Etoposide and [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Etoposide | CTD | PMID:21878638 | Mapk12 | Rat | lapatinib | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | lapatinib inhibits the reaction [EGFR protein binds to MAPK12 protein] more ... | CTD | PMID:28739874 | Mapk12 | Rat | methoxyacetic acid | affects expression | EXP | | 6480464 | methoxyacetic acid affects the expression of MAPK12 mRNA | CTD | PMID:20864626 | Mapk12 | Rat | methyl methanesulfonate | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of MAPK12 mRNA | CTD | PMID:23649840 | Mapk12 | Rat | methylmercury(1+) | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | methylmercury II results in decreased expression of MAPK12 mRNA | CTD | PMID:26314263 | Mapk12 | Rat | monosodium L-glutamate | decreases expression | EXP | | 6480464 | Sodium Glutamate results in decreased expression of MAPK12 mRNA | CTD | PMID:28954212 | Mapk12 | Rat | myristicin | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | myristicin results in decreased expression of MAPK12 mRNA | CTD | PMID:24792648 | Mapk12 | Rat | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | Acetylcysteine inhibits the reaction [[nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK12 protein] | CTD | PMID:38642822 | Mapk12 | Rat | N-methyl-4-phenylpyridinium | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of MAPK12 mRNA | CTD | PMID:25234470 | Mapk12 | Rat | N-methyl-4-phenylpyridinium | multiple interactions | EXP | | 6480464 | H 1356 inhibits the reaction [IGF1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK12 protein]] and IGF1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK12 protein] | CTD | PMID:33035625 | Mapk12 | Rat | N-methyl-4-phenylpyridinium | increases phosphorylation | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased phosphorylation of MAPK12 protein | CTD | PMID:33035625 | Mapk12 | Rat | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of MAPK12 mRNA | CTD | PMID:22546817 | Mapk12 | Rat | nilotinib | decreases expression | ISO | Mapk12 (Mus musculus) | 6480464 | nilotinib results in decreased expression of MAPK12 protein | CTD | PMID:38061604 | Mapk12 | Rat | Nonylphenol | multiple interactions | EXP | | 6480464 | [nonylphenol co-treated with octylphenol] results in increased phosphorylation of MAPK12 protein more ... | CTD | PMID:38642822 | Mapk12 | Rat | Nor-9-carboxy-delta9-THC | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [Cannabinoids results in increased abundance of 11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid] which affects the methylation of MAPK12 gene | CTD | PMID:30521419 | Mapk12 | Rat | obeticholic acid | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | obeticholic acid results in decreased expression of MAPK12 mRNA | CTD | PMID:27939613 | Mapk12 | Rat | ochratoxin A | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | ochratoxin A metabolite results in decreased expression of MAPK12 mRNA and ochratoxin A results in decreased expression of MAPK12 mRNA | CTD | PMID:26314263 | Mapk12 | Rat | orphenadrine | affects expression | EXP | | 6480464 | Orphenadrine affects the expression of MAPK12 mRNA | CTD | PMID:23665939 | Mapk12 | Rat | ozone | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of MAPK12 mRNA | CTD | PMID:35430440 | Mapk12 | Rat | perfluorooctane-1-sulfonic acid | increases expression | ISO | Mapk12 (Mus musculus) | 6480464 | perfluorooctane sulfonic acid results in increased expression of MAPK12 mRNA | CTD | PMID:26300304 | Mapk12 | Rat | pirfenidone | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [pirfenidone inhibits the reaction [EGFR protein binds to MAPK12 protein]] which results in decreased phosphorylation of PTPN3 protein more ... | CTD | PMID:22399296 and PMID:28739874 | Mapk12 | Rat | pirinixic acid | multiple interactions | ISO | Mapk12 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MAPK12 mRNA | CTD | PMID:19710929 | Mapk12 | Rat | SB 203580 | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | SB 203580 results in decreased expression of MAPK12 mRNA | CTD | PMID:19757093 | Mapk12 | Rat | SB 431542 | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Mapk12 | Rat | sodium arsenite | multiple interactions | ISO | Mapk12 (Mus musculus) | 6480464 | MAPK12 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein] | CTD | PMID:23639288 | Mapk12 | Rat | sodium arsenite | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of MAPK12 mRNA | CTD | PMID:38568856 | Mapk12 | Rat | sodium arsenite | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | sodium arsenite results in increased phosphorylation of and results in increased activity of MAPK12 protein | CTD | PMID:15504454 | Mapk12 | Rat | tamoxifen | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen more ... | CTD | PMID:22399296 | Mapk12 | Rat | tamoxifen | increases phosphorylation | ISO | MAPK12 (Homo sapiens) | 6480464 | Tamoxifen results in increased phosphorylation of MAPK12 protein | CTD | PMID:22399296 | Mapk12 | Rat | tamoxifen | decreases response to substance | ISO | MAPK12 (Homo sapiens) | 6480464 | MAPK12 mutant form results in decreased susceptibility to Tamoxifen | CTD | PMID:22399296 | Mapk12 | Rat | tert-butyl hydroperoxide | increases expression | ISO | Mapk12 (Mus musculus) | 6480464 | tert-Butylhydroperoxide results in increased expression of MAPK12 mRNA | CTD | PMID:14729362 | Mapk12 | Rat | tetrachloromethane | increases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Carbon Tetrachloride results in increased expression of MAPK12 mRNA | CTD | PMID:11566570 | Mapk12 | Rat | tetrachloromethane | affects expression | ISO | Mapk12 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of MAPK12 mRNA | CTD | PMID:17484886 | Mapk12 | Rat | tipifarnib | increases expression | EXP | | 6480464 | tipifarnib results in increased expression of MAPK12 mRNA | CTD | PMID:16403772 | Mapk12 | Rat | titanium dioxide | decreases methylation | ISO | Mapk12 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of MAPK12 gene and titanium dioxide results in decreased methylation of MAPK12 promoter | CTD | PMID:35295148 | Mapk12 | Rat | tributylstannane | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | tributyltin results in decreased expression of MAPK12 mRNA | CTD | PMID:26314263 | Mapk12 | Rat | Tributyltin oxide | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | bis(tri-n-butyltin)oxide results in decreased expression of MAPK12 mRNA | CTD | PMID:26314263 | Mapk12 | Rat | trichostatin A | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of MAPK12 mRNA | CTD | PMID:24935251 and PMID:26272509 | Mapk12 | Rat | trichostatin A | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPK12 mRNA | CTD | PMID:27188386 | Mapk12 | Rat | valproic acid | increases methylation | ISO | MAPK12 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of MAPK12 gene | CTD | PMID:29154799 | Mapk12 | Rat | vorinostat | decreases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of MAPK12 mRNA | CTD | PMID:26272509 | Mapk12 | Rat | vorinostat | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAPK12 mRNA | CTD | PMID:27188386 | Mapk12 | Rat | xanthohumol | decreases phosphorylation | ISO | MAPK12 (Homo sapiens) | 6480464 | xanthohumol results in decreased phosphorylation of MAPK12 protein | CTD | PMID:35229981 | Mapk12 | Rat | zinc atom | increases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of MAPK12 mRNA | CTD | PMID:12888634 | Mapk12 | Rat | zinc(0) | increases expression | ISO | MAPK12 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of MAPK12 mRNA | CTD | PMID:12888634 | |