Mapk12 (mitogen-activated protein kinase 12)

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Gene: Mapk12 (mitogen-activated protein kinase 12) Rattus norvegicus

Analyze

Symbol:

Mapk12

Name:

mitogen-activated protein kinase 12

RGD ID:

70975

Description:

Enables ATP binding activity and MAP kinase activity. Involved in negative regulation of cell cycle. Located in cytoplasm. Orthologous to human MAPK12 (mitogen-activated protein kinase 12); PARTICIPATES IN p38 MAPK signaling pathway; amyotrophic lateral sclerosis pathway; Chagas disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ERK-6; extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; MGC156834; mitogen-activated protein kinase p38 gamma; SAP kinase-3; Sapk3; stress-activated protein kinase 3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MAPK12 (mitogen-activated protein kinase 12)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Mapk12 (mitogen-activated protein kinase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mapk12 (mitogen-activated protein kinase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MAPK12 (mitogen-activated protein kinase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MAPK12 (mitogen-activated protein kinase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mapk12 (mitogen-activated protein kinase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MAPK12 (mitogen-activated protein kinase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MAPK12 (mitogen-activated protein kinase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mapk12 (mitogen-activated protein kinase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MAPK12 (mitogen-activated protein kinase 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mapk12 (mitogen-activated protein kinase 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mapk12b (mitogen-activated protein kinase 12b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	mapk12a (mitogen-activated protein kinase 12a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HOG1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	p38c	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	mapk12	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	120,206,005 - 120,216,711 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	120,206,271 - 120,216,664 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	121,957,298 - 121,967,689 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	124,183,463 - 124,193,852 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	124,146,469 - 124,156,860 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	130,109,214 - 130,120,918 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	130,109,663 - 130,120,579 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	129,795,269 - 129,805,662 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	127,430,881 - 127,441,274 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	127,465,110 - 127,475,504 (-)	NCBI
Celera	7	116,680,166 - 116,690,559 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

chromosome 22q13 duplication syndrome (ISO)

congenital disorder of glycosylation Ig (ISO)

genetic disease (ISO)

intellectual disability (ISO)

metachromatic leukodystrophy (ISO)

Phelan-McDermid syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

acrylamide (EXP,ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

amsacrine (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

calciol (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

curcumin (ISO)

cyclosporin A (ISO)

D-glucitol (ISO)

deguelin (ISO)

deoxynivalenol (ISO)

diazinon (EXP)

dieldrin (EXP)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (EXP)

etoposide (ISO)

lapatinib (ISO)

methoxyacetic acid (EXP)

methyl methanesulfonate (ISO)

methylmercury(1+) (ISO)

monosodium L-glutamate (EXP)

myristicin (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel dichloride (EXP)

Nor-9-carboxy-delta9-THC (ISO)

obeticholic acid (ISO)

ochratoxin A (ISO)

orphenadrine (EXP)

perfluorooctane-1-sulfonic acid (ISO)

pirfenidone (ISO)

pirinixic acid (ISO)

SB 203580 (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

tipifarnib (EXP)

tributylstannane (ISO)

Tributyltin oxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

vorinostat (ISO)

xanthohumol (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IBA)

MAPK cascade (IEA)

myoblast differentiation (ISO)

negative regulation of cell cycle (IDA)

phosphorylation (IEA)

protein modification process (IEA)

protein phosphorylation (IDA)

Cellular Component

cytoplasm (IBA,IDA)

mitochondrion (IEA)

nucleus (IBA)

Molecular Function

ATP binding (IDA,IEA)

magnesium ion binding (ISO)

MAP kinase activity (IDA,IEA)

protein binding (IPI,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IDA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis pathway (IEA)

Chagas disease pathway (IEA)

Fc epsilon receptor mediated signaling pathway (IEA)

gonadotropin-releasing hormone signaling pathway (IEA)

hepatitis C pathway (IEA)

influenza A pathway (IEA)

Leishmaniasis pathway (IEA)

mitogen activated protein kinase signaling pathway (IEA)

neurotrophic factor signaling pathway (IEA)

NOD-like receptor signaling pathway (IEA)

p38 MAPK signaling pathway (ISO)

Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway (IEA)

T cell receptor signaling pathway (IEA)

Toll-like receptor signaling pathway (IEA)

toxoplasmosis pathway (IEA)

tuberculosis pathway (IEA)

vascular endothelial growth factor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells.	Conrad PW, etal., J Biol Chem. 1999 Aug 13;274(33):23570-6.
2.	Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3).	Court NW, etal., J Mol Cell Cardiol 2002 Apr;34(4):413-26.
3.	p38 MAP-kinases pathway regulation, function and role in human diseases.	Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.	Hasegawa M, etal., J Biol Chem. 1999 Apr 30;274(18):12626-31.
7.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
8.	SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases.	Mertens S, etal., FEBS Lett 1996 Apr 1;383(3):273-6.
9.	Gene Data Set	MGD Curation, June 12, 2002
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.	Sabio G, etal., Biochem J 2004 May 15;380(Pt 1):19-30.
17.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18.	Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain.	Yin J, etal., J Pineal Res. 2006 Sep;41(2):124-9.

Additional References at PubMed

PMID:8633070	PMID:9199504	PMID:10508788	PMID:12788083	PMID:15158451	PMID:15729360	PMID:15850461	PMID:15878399	PMID:27574735	PMID:31505169	PMID:34814904

Genomics

Comparative Map Data

Mapk12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	120,206,005 - 120,216,711 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	120,206,271 - 120,216,664 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	121,957,298 - 121,967,689 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	124,183,463 - 124,193,852 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	124,146,469 - 124,156,860 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	130,109,214 - 130,120,918 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	130,109,663 - 130,120,579 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	129,795,269 - 129,805,662 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	127,430,881 - 127,441,274 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	127,465,110 - 127,475,504 (-)	NCBI
Celera	7	116,680,166 - 116,690,559 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

MAPK12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	50,252,901 - 50,261,683 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	50,245,450 - 50,261,716 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	50,691,330 - 50,700,112 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	49,033,458 - 49,042,216 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	48,993,787 - 49,002,546	NCBI
Celera	22	34,566,234 - 34,574,992 (-)	NCBI		Celera
Cytogenetic Map	22	q13.33	NCBI
HuRef	22	33,590,177 - 33,594,692 (-)	NCBI		HuRef
CHM1_1	22	50,650,085 - 50,658,843 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	50,759,904 - 50,768,686 (-)	NCBI		T2T-CHM13v2.0

Mapk12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	89,014,787 - 89,025,270 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	89,014,787 - 89,024,906 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	89,130,584 - 89,141,577 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	89,130,584 - 89,140,703 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	88,961,014 - 88,971,133 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	88,958,350 - 88,968,376 (-)	NCBI		MGSCv36	mm8
Celera	15	91,259,147 - 91,269,271 (-)	NCBI		Celera
Cytogenetic Map	15	E3	NCBI
cM Map	15	44.65	NCBI

Mapk12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	33,279,344 - 33,286,422 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	33,278,913 - 33,285,920 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAPK12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	22	62,845,236 - 62,854,000 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	30,481,898 - 30,490,769 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	49,481,263 - 49,489,600 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	49,481,763 - 49,489,599 (-)	Ensembl	panpan1.1		panPan2

MAPK12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	16,986,828 - 16,994,937 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	16,986,828 - 16,994,937 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	16,964,857 - 16,973,137 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	17,713,650 - 17,721,939 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	17,713,717 - 17,721,934 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	17,437,731 - 17,446,013 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	17,761,009 - 17,769,279 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	17,893,208 - 17,901,489 (+)	NCBI		UU_Cfam_GSD_1.0

Mapk12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	552,302 - 560,245 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936629	552,296 - 560,461 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936629	552,302 - 560,245 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAPK12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	429,770 - 437,975 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	429,635 - 437,970 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MAPK12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	32,742,625 - 32,754,152 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	92,601,986 - 92,612,032 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mapk12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	510,601 - 518,065 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	510,593 - 518,065 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mapk12
37 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	185
Count of miRNA genes:	129
Interacting mature miRNAs:	140
Transcripts:	ENSRNOT00000044376
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
1582240	Sffal1	Serum free fatty acids level QTL 1	3.4	0.0021	blood free fatty acid amount (VT:0001553)	serum free fatty acids level (CMO:0000547)	7	116677010	124049952	Rat
631201	Panci1	Pancreas inflammation QTL 1	0	0.001	pancreas integrity trait (VT:0010560)	percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)	7	116677189	127103496	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	119513385	135012528	Rat

Markers in Region

RH128844

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	120,206,034 - 120,206,219 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	130,109,244 - 130,109,428	NCBI	Rnor6.0
Rnor_5.0	7	129,795,033 - 129,795,217	UniSTS	Rnor5.0
RGSC_v3.4	7	127,430,645 - 127,430,829	UniSTS	RGSC3.4
Celera	7	116,679,930 - 116,680,114	UniSTS
RH 3.4 Map	7	958.5	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		19	4	4	5	4	8	11	18	2	4	11	8
Low	3	24	52	37	13	37			56	33	37
Below cutoff			1		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_021746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062396	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC127549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X96488	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000044376 ⟹ ENSRNOP00000046455

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	120,206,271 - 120,216,664 (-)	Ensembl
Rnor_6.0 Ensembl	7	130,109,663 - 130,120,579 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093842 ⟹ ENSRNOP00000086001

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	120,206,271 - 120,216,664 (-)	Ensembl

RefSeq Acc Id:

NM_021746 ⟹ NP_068514

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	120,206,271 - 120,216,664 (-)	NCBI
Rnor_6.0	7	130,109,480 - 130,119,873 (-)	NCBI
Rnor_5.0	7	129,795,269 - 129,805,662 (-)	NCBI
RGSC_v3.4	7	127,430,881 - 127,441,274 (-)	RGD
Celera	7	116,680,166 - 116,690,559 (-)	RGD

Sequence:

show sequence

GTTGGCGGCTATACAGAGTTCAGGGTGGCGACCCCGAGAGAAGAGCCCGCAAAGGAAAGCCCCA
GAGGCGGGCAGGCGGGTGGCCGGCGCGGAGCCGGCCCTGCCACGCAGTGACCCGGGGCGCACGG
GCGGAGCCCCTGATCCCAAGTCCGGTCCTAGAGCGCGGTGCTCCGGCCGGGGATGAGCTCCCCG
CCACCCGCCCGCAAGGGCTTTTACCGCCAGGAGGTGACCAAAACGGCCTGGGAGGTGCGCGCCG
TGTACCAGGACCTGCAGCCCGTTGGCTCTGGTGCCTATGGTGCAGTGTGCTCTGCAGTAGACAG
CCGCACTGGCAACAAGGTGGCCATCAAGAAGTTGTACCGGCCCTTCCAGTCGGAGCTGTTTGCC
AAGCGCGCCTACAGAGAGTTGCGCCTCCTCAAACACATGCGCCACGAGAACGTCATTGGGCTGC
TGGATGTGTTCACTCCCGATGAGACTCTGGATGACTTCACAGACTTCTACCTGGTGATGCCATT
CATGGGCACTGACCTGGGCAAGCTCATGAAGCACGAGACTCTGAGTGAAGACAGAATCCAGTTT
CTTGTGTATCAGATGCTGAAGGGGCTGAAGTATATCCACGCTGCCGGCGTCATCCACAGGGACT
TGAAACCTGGAAACCTGGCTGTGAACGAGGACTGTGAGCTGAAGATCCTAGATTTTGGCCTTGC
CAGGCAGGCGGACAGTGAGATGACAGGATATGTGGTAACCCGGTGGTATCGGGCACCAGAGGTC
ATCTTGAATTGGATGCGTTACACACAGACAGTGGACATTTGGTCTGTTGGCTGCATCATGGCAG
AGATGATTACTGGAAAGATCCTGTTCAAAGGCAATGACCACCTGGACCAGCTGAAGGAGATCAT
GAAAGTCACAGGGACACCCCCTCCTGAGTTTGTACAGAAGCTACAGAGTGCTGAGGCCAAGAAC
TACATGGAAGGCCTCCCTGAGTTGGAAAAGAAGGATTTTGCTTCTGTCCTGACCAATGCAAGCC
CTCAGGCCGTGAATCTCCTGGAAAAGATGCTGGTGTTGGATGCGGAACAGCGGGTGACAGCAGC
TGAGGCATTAGCCCACCCATACTTTGAGTCCCTTCGGGACACTGAGGATGAGCCCAAGGCCCAG
AAATATGATGACTCCTTTGATGACGTAGACCGCACCCTTGAGGAATGGAAGCGTGTTACGTATA
AGGAAGTGCTCAGCTTCAAGCCTCCCAGGCAGCTAGGAGCCAGAGTTCCAAAGGAGACAGCTCT
GTGAAGACCTCCGGGTGGTTTGGGGGGTATCCTAAGGAGGCTGTCTGGGAGCTTCGCAGACACC
TTGGCTTCCCTTCTCCGGAAGAGGAATCCTGGTTGGCACCAGTGCCTGGTGCTTTTATCCCAAG
TCATCCACCTGGAAAGGCTGTGTAGACCCCTTGAATCACGAACCCTCCATCTCCAAGCCAGTTC
TTCAGATTTTGAGCGCCCGAGATGACCCTGGCAGAACATCTAAGCTTTTTTTTTTTCTTTTTTC
TTTTTTTCGGAGCTGGGGACCGAACCCAGGGCCTTGCGCTTGCTAGGCAAGCGCTCTACTACTG
AGCTAAATCCCCAACCCCACATCTAAGCTTTCTGTCCAAGACCCCTACCCAACATGGGACTAGC
C

hide sequence

RefSeq Acc Id:

XM_039079833 ⟹ XP_038935761

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	120,206,005 - 120,216,711 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_068514	(Get FASTA)	NCBI Sequence Viewer
	XP_038935761	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81950	(Get FASTA)	NCBI Sequence Viewer
	AAI27550	(Get FASTA)	NCBI Sequence Viewer
	CAA65342	(Get FASTA)	NCBI Sequence Viewer
	EDL76544	(Get FASTA)	NCBI Sequence Viewer
	EDL76545	(Get FASTA)	NCBI Sequence Viewer
	EDL76546	(Get FASTA)	NCBI Sequence Viewer
	Q63538	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_068514 ⟸ NM_021746

- UniProtKB:

Q63538 (UniProtKB/Swiss-Prot), A6K7K1 (UniProtKB/TrEMBL), A0A8I6A4Z8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSPPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQS
ELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHETLSED
RIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYR
APEVILNWMRYTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKVTGTPPPEFVQKLQSA
EAKNYMEGLPELEKKDFASVLTNASPQAVNLLEKMLVLDAEQRVTAAEALAHPYFESLRDTEDE
PKAQKYDDSFDDVDRTLEEWKRVTYKEVLSFKPPRQLGARVPKETAL

hide sequence

RefSeq Acc Id:

ENSRNOP00000046455 ⟸ ENSRNOT00000044376

RefSeq Acc Id:	XP_038935761 ⟸ XM_039079833
- Peptide Label:	isoform X1
- UniProtKB:	A6K7K2 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000086001 ⟸ ENSRNOT00000093842

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63538-F1-model_v2	AlphaFold	Q63538	1-367	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70975	AgrOrtholog
BioCyc Gene	G2FUF-32461	BioCyc
Ensembl Genes	ENSRNOG00000031233	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000046455	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000086001.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000044376	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000093842.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5623226	IMAGE-MGC_LOAD
	IMAGE:7122406	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAP_kinase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAPK12	UniProtKB/TrEMBL
	MAPK_p38-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	p38gamma	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:60352	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72466	IMAGE-MGC_LOAD
	MGC:94035	IMAGE-MGC_LOAD
NCBI Gene	60352	ENTREZGENE
PANTHER	MITOGEN-ACTIVATED PROTEIN KINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MITOGEN-ACTIVATED PROTEIN KINASE 12	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mapk12	PhenoGen
PRINTS	P38MAPKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	MAPK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A4Z8	ENTREZGENE, UniProtKB/TrEMBL
	A0JPR2_RAT	UniProtKB/TrEMBL
	A6K7K1	ENTREZGENE, UniProtKB/TrEMBL
	A6K7K2	ENTREZGENE, UniProtKB/TrEMBL
	A6K7K3_RAT	UniProtKB/TrEMBL
	MK12_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q66HA3_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-07-09	Mapk12	mitogen-activated protein kinase 12			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	activated by dual threonine/tyrosine phosphorylation within a TGY sequence	70781

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)