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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70975
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk12
Name: mitogen-activated protein kinase 12
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:7317166480464CTDMAPK12 mutant form results in decreased susceptibility to Tamoxifen

PMID:22399296
increases phosphorylationISORGD:7317166480464CTDTamoxifen results in increased phosphorylation of MAPK12 protein

PMID:22399296
multiple interactionsISORGD:7317166480464CTD[pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen, [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen, JUN protein inhibits the reaction [MAPK12 mutant form results in decreased susceptibility to Tamoxifen], Tamoxifen promotes the reaction [ESR1 protein binds to JUN protein binds to MAPK12 protein], Tamoxifen promotes the reaction [ESR1 protein modified form binds to JUN protein binds to MAPK12 protein], Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein modified form], Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein], Tamoxifen results in increased activity of and results in increased expression of MAPK12 protein

PMID:22399296
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.