GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk12 | decreases response to substance | ISO | MAPK12 (Homo sapiens) | 6480464 | CTD | MAPK12 mutant form results in decreased susceptibility to Tamoxifen | PMID:22399296 | Mapk12 | increases phosphorylation | ISO | MAPK12 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in increased phosphorylation of MAPK12 protein | PMID:22399296 | Mapk12 | multiple interactions | ISO | MAPK12 (Homo sapiens) | 6480464 | CTD | [pirfenidone inhibits the reaction [MAPK12 protein results in increased expression of JUN protein]] which results in decreased susceptibility to Tamoxifen; [pirfenidone inhibits the reaction [MAPK12 protein results in increased phosphorylation of ESR1 protein]] which results in decreased susceptibility to Tamoxifen; JUN protein inhibits the reaction [MAPK12 mutant form results in decreased susceptibility to Tamoxifen]; Tamoxifen promotes the reaction [ESR1 protein binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [ESR1 protein modified form binds to JUN protein binds to MAPK12 protein]; Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein modified form]; Tamoxifen promotes the reaction [MAPK12 protein binds to ESR1 protein]; Tamoxifen results in increased activity of and results in increased expression of MAPK12 protein | PMID:22399296 | | ||||||||||||||||||||||
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