MAPK12 (mitogen-activated protein kinase 12) - Rat Genome Database

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Gene: MAPK12 (mitogen-activated protein kinase 12) Pan paniscus
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Symbol: MAPK12
Name: mitogen-activated protein kinase 12
RGD ID: 12045827
Description: ENCODES a protein that exhibits ATP binding (ortholog); MAP kinase activity (ortholog); INVOLVED IN negative regulation of cell cycle (ortholog); peptidyl-serine phosphorylation (ortholog); protein phosphorylation (ortholog); PARTICIPATES IN p38 MAPK signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); chromosome 22q13 duplication syndrome (ortholog); congenital disorder of glycosylation Ig (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22360,159,076 - 60,167,863 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12262,845,236 - 62,854,000 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,481,898 - 30,490,769 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,481,263 - 49,489,600 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2249,481,763 - 49,489,599 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAPK12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22360,159,076 - 60,167,863 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12262,845,236 - 62,854,000 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,481,898 - 30,490,769 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,481,263 - 49,489,600 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2249,481,763 - 49,489,599 (-)Ensemblpanpan1.1panPan2
MAPK12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,252,901 - 50,261,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,245,450 - 50,261,716 (-)EnsemblGRCh38hg38GRCh38
GRCh372250,691,330 - 50,700,112 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,033,458 - 49,042,216 (-)NCBINCBI36Build 36hg18NCBI36
Build 342248,993,787 - 49,002,546NCBI
Celera2234,566,234 - 34,574,992 (-)NCBICelera
Cytogenetic Map22q13.33NCBI
HuRef2233,590,177 - 33,594,692 (-)NCBIHuRef
CHM1_12250,650,085 - 50,658,843 (-)NCBICHM1_1
T2T-CHM13v2.02250,759,904 - 50,768,686 (-)NCBIT2T-CHM13v2.0
Mapk12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,014,787 - 89,025,270 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,014,787 - 89,024,906 (-)EnsemblGRCm39 Ensembl
GRCm381589,130,584 - 89,141,577 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,130,584 - 89,140,703 (-)EnsemblGRCm38mm10GRCm38
MGSCv371588,961,014 - 88,971,133 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361588,958,350 - 88,968,376 (-)NCBIMGSCv36mm8
Celera1591,259,147 - 91,269,271 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.65NCBI
Mapk12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,085,647 - 122,096,307 (-)NCBIGRCr8
mRatBN7.27120,206,005 - 120,216,711 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,206,271 - 120,216,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7121,957,298 - 121,967,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,183,463 - 124,193,852 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,146,469 - 124,156,860 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,109,214 - 130,120,918 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,109,663 - 130,120,579 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07129,795,269 - 129,805,662 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,430,881 - 127,441,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,465,110 - 127,475,504 (-)NCBI
Celera7116,680,166 - 116,690,559 (-)NCBICelera
Cytogenetic Map7q34NCBI
Mapk12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541333,279,344 - 33,286,422 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541333,278,913 - 33,285,920 (-)NCBIChiLan1.0ChiLan1.0
MAPK12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,986,828 - 16,994,937 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1016,986,828 - 16,994,937 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1016,964,857 - 16,973,137 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,713,650 - 17,721,939 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,713,717 - 17,721,934 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,437,731 - 17,446,013 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,761,009 - 17,769,279 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,893,208 - 17,901,489 (+)NCBIUU_Cfam_GSD_1.0
Mapk12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945552,302 - 560,245 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936629552,296 - 560,461 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936629552,302 - 560,245 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5429,770 - 437,975 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15429,635 - 437,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11932,742,625 - 32,754,152 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604592,601,986 - 92,612,032 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624752510,601 - 518,065 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624752510,593 - 518,065 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000035852   ⟹   ENSPPAP00000013182
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2249,481,763 - 49,489,599 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000035854   ⟹   ENSPPAP00000013184
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2249,481,763 - 49,489,599 (-)Ensembl
RefSeq Acc Id: XM_034949191   ⟹   XP_034805082
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22360,159,076 - 60,167,853 (-)NCBI
NHGRI_mPanPan12262,845,236 - 62,853,992 (-)NCBI
Mhudiblu_PPA_v02230,481,899 - 30,490,764 (-)NCBI
RefSeq Acc Id: XM_034949192   ⟹   XP_034805083
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22360,159,076 - 60,167,863 (-)NCBI
NHGRI_mPanPan12262,845,236 - 62,853,993 (-)NCBI
Mhudiblu_PPA_v02230,481,898 - 30,490,769 (-)NCBI
RefSeq Acc Id: XM_055105805   ⟹   XP_054961780
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22360,159,968 - 60,167,858 (-)NCBI
NHGRI_mPanPan12262,845,821 - 62,854,000 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034805082 (Get FASTA)   NCBI Sequence Viewer  
  XP_034805083 (Get FASTA)   NCBI Sequence Viewer  
  XP_054961780 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000013182.1
  ENSPPAP00000013184.1
RefSeq Acc Id: XP_034805083   ⟸   XM_034949192
- Peptide Label: isoform X3
- UniProtKB: A0A2R9A7E0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034805082   ⟸   XM_034949191
- Peptide Label: isoform X1
- UniProtKB: A0A2R9ACI8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000013184   ⟸   ENSPPAT00000035854
Ensembl Acc Id: ENSPPAP00000013182   ⟸   ENSPPAT00000035852
RefSeq Acc Id: XP_054961780   ⟸   XM_055105805
- Peptide Label: isoform X2
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029760 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035852.1 UniProtKB/TrEMBL
  ENSPPAT00000035854.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  MAPK_p38-like UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
NCBI Gene MAPK12 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE 12 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS P38MAPKINASE UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9A7E0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ACI8 ENTREZGENE, UniProtKB/TrEMBL