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Gene: Ppp6r2 (protein phosphatase 6, regulatory subunit 2) Rattus norvegicus

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Symbol:

Ppp6r2

Name:

protein phosphatase 6, regulatory subunit 2

RGD ID:

1563990

Description:

Predicted to enable protein phosphatase regulator activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R2 (protein phosphatase 6 regulatory subunit 2); INTERACTS WITH bisphenol A; cadmium dichloride; rotenone.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC300146; RGD1563990; SAPS domain family, member 2; Saps2; serine/threonine-protein phosphatase 6 regulatory subunit 2; similar to 8430411H09Rik protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PPP6R2 (protein phosphatase 6 regulatory subunit 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Ppp6r2 (protein phosphatase 6, regulatory subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ppp6r2 (protein phosphatase 6 regulatory subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PPP6R2 (protein phosphatase 6 regulatory subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PPP6R2 (protein phosphatase 6 regulatory subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ppp6r2 (protein phosphatase 6 regulatory subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PPP6R2 (protein phosphatase 6 regulatory subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PPP6R2 (protein phosphatase 6 regulatory subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ppp6r2 (protein phosphatase 6 regulatory subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FXYD5 (FXYD domain containing ion transport regulator 5)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PPP6R2 (protein phosphatase 6 regulatory subunit 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ppp6r2 (protein phosphatase 6, regulatory subunit 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ppp6r2a (protein phosphatase 6, regulatory subunit 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ppp6r2b (protein phosphatase 6, regulatory subunit 2b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	saps-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SAP155	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SAP185	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	fmt	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SAP4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ppp6r2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	122,164,968 - 122,236,625 (+)	NCBI		GRCr8
mRatBN7.2	7	120,285,378 - 120,356,995 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	120,285,406 - 120,356,395 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	122,036,409 - 122,107,320 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	124,262,571 - 124,333,478 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	124,226,336 - 124,297,427 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	130,188,609 - 130,260,209 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	130,227,456 - 130,259,609 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	129,874,214 - 129,944,629 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	127,510,323 - 127,581,836 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	116,759,219 - 116,830,063 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Charcot-Marie-Tooth disease type 4B3 (ISO)

chromosome 22q13 duplication syndrome (ISO)

congenital disorder of glycosylation Ig (ISO)

intellectual disability (ISO)

metachromatic leukodystrophy (ISO)

Phelan-McDermid syndrome (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

CGP 52608 (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

fenthion (ISO)

folic acid (ISO)

FR900359 (ISO)

isobutanol (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methamphetamine (ISO)

methidathion (ISO)

methylmercury chloride (ISO)

okadaic acid (ISO)

ozone (ISO)

potassium dichromate (ISO)

quercetin (ISO)

rotenone (EXP)

selenium atom (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

triphenyl phosphate (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of signal transduction (IBA)

Cellular Component

cytoplasmic ribonucleoprotein granule (IEA,ISO)

cytosol (IBA,IEA,ISO)

nucleus (IBA)

Molecular Function

protein binding (ISO)

protein phosphatase binding (IEA)

protein phosphatase regulator activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:16903783

Genomics

Comparative Map Data

Ppp6r2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	122,164,968 - 122,236,625 (+)	NCBI		GRCr8
mRatBN7.2	7	120,285,378 - 120,356,995 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	120,285,406 - 120,356,395 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	122,036,409 - 122,107,320 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	124,262,571 - 124,333,478 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	124,226,336 - 124,297,427 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	130,188,609 - 130,260,209 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	130,227,456 - 130,259,609 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	129,874,214 - 129,944,629 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	127,510,323 - 127,581,836 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	116,759,219 - 116,830,063 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

PPP6R2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	50,330,774 - 50,445,090 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	50,343,304 - 50,445,090 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	50,781,756 - 50,883,519 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	49,128,626 - 49,230,380 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	49,071,903 - 49,173,658	NCBI
Celera	22	34,685,889 - 34,759,532 (+)	NCBI		Celera
Cytogenetic Map	22	q13.33	NCBI
HuRef	22	33,700,610 - 33,773,971 (+)	NCBI		HuRef
CHM1_1	22	50,740,456 - 50,842,262 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	50,838,642 - 50,954,283 (+)	NCBI		T2T-CHM13v2.0

Ppp6r2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	89,095,654 - 89,171,218 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	89,095,756 - 89,171,213 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	89,211,451 - 89,287,015 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	89,211,553 - 89,287,010 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	89,041,990 - 89,116,692 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	89,039,326 - 89,114,028 (+)	NCBI		MGSCv36	mm8
Celera	15	91,340,744 - 91,415,186 (+)	NCBI		Celera
Cytogenetic Map	15	E3	NCBI
cM Map	15	44.76	NCBI

Ppp6r2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	33,385,084 - 33,425,226 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	33,362,879 - 33,425,361 (+)	NCBI	ChiLan1.0	ChiLan1.0

PPP6R2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	60,236,004 - 60,361,887 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	62,935,751 - 63,053,881 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	30,572,446 - 30,690,242 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	49,600,643 - 49,674,482 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	49,600,643 - 49,674,482 (+)	Ensembl	panpan1.1		panPan2

PPP6R2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	16,846,250 - 16,929,855 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	16,846,899 - 16,929,884 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	16,823,360 - 16,906,921 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	17,571,953 - 17,655,671 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	17,571,974 - 17,665,478 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	17,296,371 - 17,379,940 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	17,619,533 - 17,703,112 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	17,751,658 - 17,835,270 (-)	NCBI		UU_Cfam_GSD_1.0

Ppp6r2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	394,535 - 462,669 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936629	395,419 - 435,453 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936629	394,535 - 462,710 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPP6R2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	285,386 - 361,548 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	285,381 - 361,309 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	110,441,061 - 110,497,384 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPP6R2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	32,824,732 - 32,917,356 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	32,866,039 - 32,916,534 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	92,423,699 - 92,524,895 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppp6r2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	332,145 - 411,391 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	331,301 - 434,191 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ppp6r2
288 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	454
Count of miRNA genes:	247
Interacting mature miRNAs:	298
Transcripts:	ENSRNOT00000011070
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	119513385	135012528	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
631201	Panci1	Pancreas inflammation QTL 1	0	0.001	pancreas integrity trait (VT:0010560)	percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)	7	116677189	127103496	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
1582240	Sffal1	Serum free fatty acids level QTL 1	3.4	0.0021	blood free fatty acid amount (VT:0001553)	serum free fatty acids level (CMO:0000547)	7	116677010	124049952	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Markers in Region

BF406365

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	120,310,875 - 120,311,097 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	130,214,073 - 130,214,294	NCBI	Rnor6.0
Rnor_5.0	7	129,899,678 - 129,899,899	UniSTS	Rnor5.0
RGSC_v3.4	7	127,535,787 - 127,536,008	UniSTS	RGSC3.4
Celera	7	116,784,719 - 116,784,940	UniSTS
RH 3.4 Map	7	958.3	UniSTS
Cytogenetic Map	7	q34	UniSTS

SGC30261

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	120,356,123 - 120,356,261 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	130,259,338 - 130,259,475	NCBI	Rnor6.0
Rnor_5.0	7	129,944,358 - 129,944,495	UniSTS	Rnor5.0
RGSC_v3.4	7	127,581,565 - 127,581,702	UniSTS	RGSC3.4
Celera	7	116,829,792 - 116,829,929	UniSTS
Cytogenetic Map	7	q34	UniSTS

BE107372

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	120,286,837 - 120,287,026 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	130,190,041 - 130,190,229	NCBI	Rnor6.0
Rnor_5.0	7	129,875,646 - 129,875,834	UniSTS	Rnor5.0
RGSC_v3.4	7	127,511,755 - 127,511,943	UniSTS	RGSC3.4
Celera	7	116,760,651 - 116,760,839	UniSTS
RH 3.4 Map	7	957.6	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437901	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078866	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078869	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263340	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011070 ⟹ ENSRNOP00000011070

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	120,285,406 - 120,356,395 (+)	Ensembl
Rnor_6.0 Ensembl	7	130,227,477 - 130,259,609 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000078423 ⟹ ENSRNOP00000069349

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	120,285,406 - 120,356,395 (+)	Ensembl
Rnor_6.0 Ensembl	7	130,227,456 - 130,259,563 (+)	Ensembl

RefSeq Acc Id:

NM_001106789 ⟹ NP_001100259

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,044 - 122,236,025 (+)	NCBI
mRatBN7.2	7	120,285,406 - 120,356,395 (+)	NCBI
Rnor_6.0	7	130,188,609 - 130,259,609 (+)	NCBI
Rnor_5.0	7	129,874,214 - 129,944,629 (+)	NCBI
RGSC_v3.4	7	127,510,323 - 127,581,836 (+)	RGD
Celera	7	116,759,219 - 116,830,063 (+)	RGD

Sequence:

show sequence

CGCCATTTTGGAGCGATCTCGCCCGCGGCCCCGAGCCGGTCCCGAGCGGGTCCCGAGCCTCCCG
CCCGCTGCGCCAGAGTCCGAAGGCGCCGCGCCGCGGGGCCGGGCCCATATGCGTGCGGCCCGCT
CCAGGCGGTCCGCACTTCACCTCTGGGAGCGTCCTGGCCTCCCTCGGGCCTCGGAGGAGTCGCC
GCGACCCCCAGCCTGCGGGGCAGGTAAACCAACCAAAACTCTTTGCAGAATGAAAACACCTTTT
TTAAAATTGCATGTATACAAAAGAAAGAGCCCAAATGCTTTTTATTTTGCCTGAATACAAGATT
TAAACAAGGTATTGCCATAGAAGTCTCTACCACAGCGCGTTCTGTTGGACTCTTTCACGGAACT
ATAGGATCACATGGGCAGCACTTGTGTTTGATTCTACCCTCTTTCTTCCGGTCGGTTCTGTCAC
CCTGGGAAATAGAGAAGCAGAACGTACGGCTCCTTTCTTCATTCACTGCTGGATCAATGTCCAG
GGCCAAGGCAGTTTTGTTTGTGTGGATTTCTGTTTACTGCTGCATGGTAGAGGCTGCCGAACCC
CATAAGCTCTGTGACCACCATCATGTTCTGGAAATTTGACTTGAATACCACGTCCCACGTTGAC
AAGCTCCTCGACAAGGAACATGTGACACTGCAGGAATTAATGGATGAAGATGACATCTTGCAAG
AGTGTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGTGCAGGCAGCAGTGTATGGAGGAGCT
GGTGAACCTCATCACACAAGACCCACCCCAGGACATGGAAGAGAAGGTCCGATTCAAATATCCA
AACACAGCCTGTGAGCTTCTGACTTGTGATGTGCCGCAGATCAGCGACAGACTAGGCGAGGACG
AGAGTCTGCTGAACCTTCTGTATGACTTCTTGGACCAGGAGCCACCACTCAACCCTCTGCTTGC
CAGTTTTTTTAGCAAGACCATTGGCAATCTCATTGCAAGGAAAACCGAACAGGTGATCATGTTC
TTGAAGAAGAAGGACAAGTTCATCAGTCTGATACTGAAGCACATAGGCACCTCAGCTCTCATGG
ACCTGCTGCTACGCCTGGTCAGCTGCGTGGAACCAGTTGTTCTCCGGCAGGAGGTCCTACATTG
GCTTAATGAAGAGAAAGTCATCCAGAGACTTGTGGAATTGATCCATCCCCACCAGGATGAAGAT
AGGCAGTCAAATGCTTCTCAGGCACTCTGTGACATCATCAGGCTGGGCAGAGACCAGGGCAGTC
AGCTGCAGGAGACTGTGGAGCCGGATCCCCTCCTCACAGCACTGGAGTCGCAGGACTGTGTGGA
ACAGCTTCTGAAGAACATGTTTGATGGGGATCGGACGGAGAGCTGCCTGGTCAGTGGGATGCAG
GTGCTGCTTGCCCTGCTGGAGCCAAGGCGTGTTGGAACAGAAGGCTTGGTGGACTCCTTTTCTC
AGGGACTGGAAAGGTCATACTCTGTCAGCAGCAGCATCCTGCACGGCATTGAGCCATGGCTGAA
GAATTTCCATCAGCTCCTGCTCAACCCACCAAAGAAGAAAGCAATCCTGACCACTATTGGCGTG
CTAGAGGAGCCCCTGGGGAATGCTCGTCTTCATGGTGCACGCCTCATGGCTGCACTGCTGCACA
CAAATACGCCCAGCATCAACCAGGAGCTCTGCCGGCTCAACACCATGGACTTACTGCTGGACCT
GTTTTTTAAGTACACCTGGAATAACTTCTTACACTTGCAAGTGGAGCTGTGCATAGCCGCTATT
CTCTCCCACGCTGGTCGGGAGGAGCAGGCAGAAGCTGGCAGATCAGATGGCAAAGTGGAACCTG
TGCAGGGGAGTGGAGATGGGGGTGGGAAGCCGGAGACCACCCCGTCCATCACCAGCCCTCCTGA
GAACACAATGGTGACCCATCTGTTCCAGAAGTGCTGCCTGGTTCAGAGGATCCTGGAAGCCTGG
GAAGCCAATGACAACACACAGGCGGCAGGTGGCATGAGACGTGGGAATATGGGCCACCTCACAA
GGATCGCCAACGCAGTTGTACAGAACCTGGAGCAGGGCCCGGTGCAGACACACATCAGTGAAGT
CATCCGAGGGCTCCCTGCAGAGTGCCGTGGACGCTGGGAGAGCTTTGTGGAAGAGACACTGATG
GAGACCAACCGCAGGAACACTGTGGACCTGGCCTTCTCTGAGTACCAGATCCAGCAGATGACAG
CAAACTTTGTGGATCAGTTTGGCTTCAATGATGAGGAGTTTGCAGACCAGGATGACAACATCAA
TGCCCCATTTGACCGGATTGCAGAGATCAACTTCAACATTGAAGCCGATGAGGACAGTCCCAGT
GCAGCTCTGTTTGAAGCTTGCTGCAGTGATCGGATCCAGCCCTTCGATGATGACGAGGAGGACA
TTTGGGAGGATGAGGAGACTCGATGCACGGCCCGGGTGATGGCCAGAGCCAGGTTTGGAGCCCC
TCACACCTCAGAAAACTACTCAAAGAAGGCCGTGGGACATGGAGGCCAGGGCAGGAAGACTGGC
TCCCCCACAGCTAGGAATGTGCCTGGACTGGCCACGCCTTCATCCCCTACACAGAAAGAAGGTC
CTCGCTCAGAAAGTGATTCAGCAGGTACTACATGGACAGCAGTTTTTGATGAGCCAGTGAACCC
GCTGTCTGCAGCCTCAGGAGCTGCGAGGGATGTGGGTTCTAGTGCATGGGCGGCTGGTCCTTCA
GTTGCAGAGGAGAAAGGCTGGGCCAAATTCACCGACTTCCAGCCTTTCTGCTGCTCTGAGACAG
GGCCCCGGTGCAGCTCTCCTGTGGACATGGACCACAGCAATGCCGAGGGTGGCCAGAGTCCAGG
CCCAGAGAAAGCCTTTGGTCCTACCTCGCCTTGTGCCTGGAACGTGTGTGTCACTAGGAAGGCC
CCACTGGTAGCCTCTGACAGCAGCTCCTCTGGGGGATCTGACAGTGAAGATGACGAGAAGGCAG
CGGGTGCTGTGGAAGCTCTGTGCGCAGGCCATACTGGAAAGGCCTCCCCGCCACCCAGGACAGC
AGAGGCTGCTGCTGGCAGGGCCGAGTGTCCTGACAGCACCGTGTTAGCCCCTGCCTGCCCTGCT
CCTTCAGAAGTGACCATCAGTCCTGCCGTGGCTACCATAGCACCAAGCAAGGCAGGCTCTCCCA
CAGCCACCATAGTGGTCTCTTCCTCAGTGGCTACTGCGGTACCCCCAGGACCAATCATGGCAGT
AACCACAACAGCTCCAGCCATAGTTGCAACCCTGGGGACAATGACAAAGGACAGGAAGACAGAT
GCCCTGCCAGATGGAGCTGCCTTAAATGGCCCTGTGTAATGGCTGCCGCCCAGCTATGGCCCAC
CCTGGTCAGGCTGCCTCCTTAATCAAGAAGACTACCTGGTGATGCAATTTTTTTTAATTTAACT
TTAAAATAAATGCTGCATTTGGTAAAGCTGGCAGTGGAACCCGTTGGATGACCCAGCTCATGTT
TCTCCTGCCTGCCCTTGGTCCTGTTGGAGGACAGGATGCACCTGGCCATTCCCAGGCCCAGGTC
TTGGTGTGGCAATGCAGCCCTGACGCG

hide sequence

RefSeq Acc Id:

XM_008765688 ⟹ XP_008763910

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,028 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,285,384 - 120,356,995 (+)	NCBI
Rnor_6.0	7	130,227,496 - 130,260,209 (+)	NCBI

Sequence:

show sequence

TGGAATGAAGATGACATCTGCAAGAGTGCTAAGGCTCAGAACCAGAAGCTGCTGGACTTCCTGT
GCAGGCAGCAGTGTATGGAGGAGCTGGTGAACCTCATCACACAAGACCCACCCCAGGACATGGA
AGAGAAGGTCCGATTCAAATATCCAAACACAGCCTGTGAGCTTCTGACTTGTGATGTGCCGCAG
ATCAGCGACAGACTAGGCGAGGACGAGAGTCTGCTGAACCTTCTGTATGACTTCTTGGACCAGG
AGCCACCACTCAACCCTCTGCTTGCCAGTTTTTTTAGCAAGACCATTGGCAATCTCATTGCAAG
GAAAACCGAACAGGTGATCATGTTCTTGAAGAAGAAGGACAAGTTCATCAGTCTGATACTGAAG
CACATAGGCACCTCAGCTCTCATGGACCTGCTGCTACGCCTGGTCAGCTGCGTGGAACCAGTTG
TTCTCCGGCAGGAGGTCCTACATTGGCTTAATGAAGAGAAAGTCATCCAGAGACTTGTGGAATT
GATCCATCCCCACCAGGATGAAGATAGGCAGTCAAATGCTTCTCAGGCACTCTGTGACATCATC
AGGCTGGGCAGAGACCAGGGCAGTCAGCTGCAGGAGACTGTGGAGCCGGATCCCCTCCTCACAG
CACTGGAGTCGCAGGACTGTGTGGAACAGCTTCTGAAGAACATGTTTGATGGGGATCGGACGGA
GAGCTGCCTGGTCAGTGGGATGCAGGTGCTGCTTGCCCTGCTGGAGCCAAGGCGTGTTGGAACA
GAAGGCTTGGTGGACTCCTTTTCTCAGGGACTGGAAAGGTCATACTCTGTCAGCAGCAGCATCC
TGCACGGCATTGAGCCATGGCTGAAGAATTTCCATCAGCTCCTGCTCAACCCACCAAAGAAGAA
AGCAATCCTGACCACTATTGGCGTGCTAGAGGAGCCCCTGGGGAATGCTCGTCTTCATGGTGCA
CGCCTCATGGCTGCACTGCTGCACACAAATACGCCCAGCATCAACCAGGAGCTCTGCCGGCTCA
ACACCATGGACTTACTGCTGGACCTGTTTTTTAAGTACACCTGGAATAACTTCTTACACTTGCA
AGTGGAGCTGTGCATAGCCGCTATTCTCTCCCACGCTGGTCGGGAGGAGCAGGCAGAAGCTGGC
AGATCAGATGGCAAAGTGGAACCTGTGCAGGGGAGTGGAGATGGGGGTGGGAAGCCGGAGACCA
CCCCGTCCATCACCAGCCCTCCTGAGAACACAATGGTGACCCATCTGTTCCAGAAGTGCTGCCT
GGTTCAGAGGATCCTGGAAGCCTGGGAAGCCAATGACAACACACAGGCGGCAGGTGGCATGAGA
CGTGGGAATATGGGCCACCTCACAAGGATCGCCAACGCAGTTGTACAGAACCTGGAGCAGGGCC
CGGTGCAGACACACATCAGTGAAGTCATCCGAGGGCTCCCTGCAGAGTGCCGTGGACGCTGGGA
GAGCTTTGTGGAAGAGACACTGATGGAGACCAACCGCAGGAACACTGTGGACCTGGTGAGCACT
CACCACCTTCACTCCTCAAGTGAGGACGAGGACATTGAGGGTACTTTCCCTAACGAGCTGTCCC
TTCAGCAGGCCTTCTCTGAGTACCAGATCCAGCAGATGACAGCAAACTTTGTGGATCAGTTTGG
CTTCAATGATGAGGAGTTTGCAGACCAGGATGACAACATCAATGCCCCATTTGACCGGATTGCA
GAGATCAACTTCAACATTGAAGCCGATGAGGACAGTCCCAGTGCAGCTCTGTTTGAAGCTTGCT
GCAGTGATCGGATCCAGCCCTTCGATGATGACGAGGAGGACATTTGGGAGGATGAGGAGACTCG
ATGCACGGCCCGGGTGATGGCCAGAGCCAGGTTTGGAGCCCCTCACACCTCAGAAAACTACTCA
AAGAAGGCCGTGGGACATGGAGGCCAGGGCAGGAAGACTGGCTCCCCCACAGCTAGGAATGTGC
CTGGACTGGCCACGCCTTCATCCCCTACACAGAAAGAAGGTCCTCGCTCAGAAAGTGATTCAGC
AGGTACTACATGGACAGCAGTTTTTGATGAGCCAGTGAACCCGCTGTCTGCAGCCTCAGGAGCT
GCGAGGGATGTGGGTTCTAGTGCATGGGCGGCTGGTCCTTCAGTTGCAGAGGAGAAAGGCTGGG
CCAAATTCACCGACTTCCAGCCTTTCTGCTGCTCTGAGACAGGGCCCCGGTGCAGCTCTCCTGT
GGACATGGACCACAGCAATGCCGAGGGTGGCCAGAGTCCAGGCCCAGAGAAAGCCTTTGGTCCT
ACCTCGCCTTGTGCCTGGAACGTGTGTGTCACTAGGAAGGCCCCACTGGTAGCCTCTGACAGCA
GCTCCTCTGGGGGATCTGACAGTGAAGATGACGAGAAGGCAGCGGGTGCTGTGGAAGCTCTGTG
CGCAGGCCATACTGGAAAGGCCTCCCCGCCACCCAGGACAGCAGAGGCTGCTGCTGGCAGGGCC
GAGTGTCCTGACAGCACCGTGTTAGCCCCTGCCTGCCCTGCTCCTTCAGAAGTGACCATCAGTC
CTGCCGTGGCTACCATAGCACCAAGCAAGGCAGGCTCTCCCACAGCCACCATAGTGGTCTCTTC
CTCAGTGGCTACTGCGGTACCCCCAGGACCAATCATGGCAGTAACCACAACAGCTCCAGCCATA
GTTGCAACCCTGGGGACAATGACAAAGGACAGGAAGACAGATGCCCTGCCAGATGGAGCTGCCT
TAAATGGCCCTGTGTAATGGCTGCCGCCCAGCTATGGCCCACCCTGGTCAGGCTGCCTCCTTAA
TCAAGAAGACTACCTGGTGATGCAATTTTTTTTAATTTAACTTTAAAATAAATGCTGCATTTGG
TAAAGCTGGCAGTGGAACCCGTTGGATGACCCAGCTCATGTTTCTCCTGCCTGCCCTTGGTCCT
GTTGGAGGACAGGATGCACCTGGCCATTCCCAGGCCCAGGTCTTGGTGTGGCAATGCAGCCCTG
ACGCGCAGCTTCAACCTGCAGGAGTTGGGGAGGGAACAAGACCCTAAGGGGCCAGCACCATCGG
ATGGGCAGGAAGGGTGCGGATCTCCAGGCGCTGGTTTCATCTGTATTTTTAACGCATGGAGGAA
AAGCCGTTTTTTGCACTTTGTACCCAGCTACAGTACAGGGTCTCTCTAGGCTCAGGGCAGATGT
ACAGGCCTGAGTTGGAGAGACCTGATCCCCACTAATAATACTACATGGGGGTCTGGCACTAGTT
TGGCCACATGAGGTCAAACCCCAGTTCTAGCTGCCCAGGGACTCCTGGGAGCTGGTGTTGAATC
AGGCTACACATTTTGACTGCCTTAAAAACAAAGACCCTCTGGACCCGGTGCAGTGGTCTCTGTG
CTCAGCAGGGCAGACTGGCACACTCGGGTGGGGGTTGGAGCTGCACCAGACATGTAAGAGTGGA
CACGGAAGAGCACTGGGAGGCCTAGGGACCGGGCGGGCCCATAGTGTCCAGGAAGAGTCTAAAG
TCTATGTTGTCTTTTTTTTTTTTTTTTTTTAAATGTTCTGACCTTCTGACAGGGCATCTAACCC
CCAATAAAAAGGATCATTCTTACTGAAAA

hide sequence

RefSeq Acc Id:

XM_039078856 ⟹ XP_038934784

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,164,968 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,285,384 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078857 ⟹ XP_038934785

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,021 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,285,384 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078858 ⟹ XP_038934786

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,019 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,285,384 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078859 ⟹ XP_038934787

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,028 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,285,384 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078860 ⟹ XP_038934788

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,016 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,285,384 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078863 ⟹ XP_038934791

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,014 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,285,384 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078866 ⟹ XP_038934794

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,164,968 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,285,385 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078867 ⟹ XP_038934795

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,021 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,285,385 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078868 ⟹ XP_038934796

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,029 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,324,281 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078869 ⟹ XP_038934797

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,203,903 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,324,177 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078870 ⟹ XP_038934798

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,203,909 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,324,279 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_039078871 ⟹ XP_038934799

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,216,165 - 122,236,625 (+)	NCBI
mRatBN7.2	7	120,336,535 - 120,356,995 (+)	NCBI

RefSeq Acc Id:

XM_063263333 ⟹ XP_063119403

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,015 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263334 ⟹ XP_063119404

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,027 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263335 ⟹ XP_063119405

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,027 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263336 ⟹ XP_063119406

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,028 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263337 ⟹ XP_063119407

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,014 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263338 ⟹ XP_063119408

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,022 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263339 ⟹ XP_063119409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,021 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263340 ⟹ XP_063119410

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,028 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263341 ⟹ XP_063119411

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,028 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263342 ⟹ XP_063119412

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,028 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263343 ⟹ XP_063119413

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,028 - 122,236,625 (+)	NCBI

RefSeq Acc Id:

XM_063263344 ⟹ XP_063119414

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,026 - 122,232,766 (+)	NCBI

RefSeq Acc Id:

XM_063263345 ⟹ XP_063119415

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	122,165,023 - 122,216,277 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100259	(Get FASTA)	NCBI Sequence Viewer
	NP_001424825	(Get FASTA)	NCBI Sequence Viewer
	NP_001424826	(Get FASTA)	NCBI Sequence Viewer
	NP_001424827	(Get FASTA)	NCBI Sequence Viewer
	NP_001424828	(Get FASTA)	NCBI Sequence Viewer
	NP_001424829	(Get FASTA)	NCBI Sequence Viewer
	NP_001424830	(Get FASTA)	NCBI Sequence Viewer
	NP_001424831	(Get FASTA)	NCBI Sequence Viewer
	NP_001424832	(Get FASTA)	NCBI Sequence Viewer
	XP_008763910	(Get FASTA)	NCBI Sequence Viewer
	XP_038934784	(Get FASTA)	NCBI Sequence Viewer
	XP_038934785	(Get FASTA)	NCBI Sequence Viewer
	XP_038934786	(Get FASTA)	NCBI Sequence Viewer
	XP_038934787	(Get FASTA)	NCBI Sequence Viewer
	XP_038934788	(Get FASTA)	NCBI Sequence Viewer
	XP_038934791	(Get FASTA)	NCBI Sequence Viewer
	XP_038934794	(Get FASTA)	NCBI Sequence Viewer
	XP_038934795	(Get FASTA)	NCBI Sequence Viewer
	XP_038934796	(Get FASTA)	NCBI Sequence Viewer
	XP_038934797	(Get FASTA)	NCBI Sequence Viewer
	XP_038934798	(Get FASTA)	NCBI Sequence Viewer
	XP_038934799	(Get FASTA)	NCBI Sequence Viewer
	XP_063119403	(Get FASTA)	NCBI Sequence Viewer
	XP_063119404	(Get FASTA)	NCBI Sequence Viewer
	XP_063119405	(Get FASTA)	NCBI Sequence Viewer
	XP_063119406	(Get FASTA)	NCBI Sequence Viewer
	XP_063119407	(Get FASTA)	NCBI Sequence Viewer
	XP_063119408	(Get FASTA)	NCBI Sequence Viewer
	XP_063119409	(Get FASTA)	NCBI Sequence Viewer
	XP_063119410	(Get FASTA)	NCBI Sequence Viewer
	XP_063119411	(Get FASTA)	NCBI Sequence Viewer
	XP_063119412	(Get FASTA)	NCBI Sequence Viewer
	XP_063119413	(Get FASTA)	NCBI Sequence Viewer
	XP_063119414	(Get FASTA)	NCBI Sequence Viewer
	XP_063119415	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76552	(Get FASTA)	NCBI Sequence Viewer
	EDL76553	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011070
	ENSRNOP00000011070.8
	ENSRNOP00000069349
	ENSRNOP00000069349.2

RefSeq Acc Id:

NP_001100259 ⟸ NM_001106789

- UniProtKB:

F1M6T6 (UniProtKB/TrEMBL), A6K7L0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFWKFDLNTTSHVDKLLDKEHVTLQELMDEDDILQECKAQNQKLLDFLCRQQCMEELVNLITQD
PPQDMEEKVRFKYPNTACELLTCDVPQISDRLGEDESLLNLLYDFLDQEPPLNPLLASFFSKTI
GNLIARKTEQVIMFLKKKDKFISLILKHIGTSALMDLLLRLVSCVEPVVLRQEVLHWLNEEKVI
QRLVELIHPHQDEDRQSNASQALCDIIRLGRDQGSQLQETVEPDPLLTALESQDCVEQLLKNMF
DGDRTESCLVSGMQVLLALLEPRRVGTEGLVDSFSQGLERSYSVSSSILHGIEPWLKNFHQLLL
NPPKKKAILTTIGVLEEPLGNARLHGARLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWN
NFLHLQVELCIAAILSHAGREEQAEAGRSDGKVEPVQGSGDGGGKPETTPSITSPPENTMVTHL
FQKCCLVQRILEAWEANDNTQAAGGMRRGNMGHLTRIANAVVQNLEQGPVQTHISEVIRGLPAE
CRGRWESFVEETLMETNRRNTVDLAFSEYQIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIA
EINFNIEADEDSPSAALFEACCSDRIQPFDDDEEDIWEDEETRCTARVMARARFGAPHTSENYS
KKAVGHGGQGRKTGSPTARNVPGLATPSSPTQKEGPRSESDSAGTTWTAVFDEPVNPLSAASGA
ARDVGSSAWAAGPSVAEEKGWAKFTDFQPFCCSETGPRCSSPVDMDHSNAEGGQSPGPEKAFGP
TSPCAWNVCVTRKAPLVASDSSSSGGSDSEDDEKAAGAVEALCAGHTGKASPPPRTAEAAAGRA
ECPDSTVLAPACPAPSEVTISPAVATIAPSKAGSPTATIVVSSSVATAVPPGPIMAVTTTAPAI
VATLGTMTKDRKTDALPDGAALNGPV

hide sequence

RefSeq Acc Id:	XP_008763910 ⟸ XM_008765688
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JV49 (UniProtKB/TrEMBL)
- Sequence:	show sequence WNEDDICKSAKAQNQKLLDFLCRQQCMEELVNLITQDPPQDMEEKVRFKYPNTACELLTCDVPQ ISDRLGEDESLLNLLYDFLDQEPPLNPLLASFFSKTIGNLIARKTEQVIMFLKKKDKFISLILK HIGTSALMDLLLRLVSCVEPVVLRQEVLHWLNEEKVIQRLVELIHPHQDEDRQSNASQALCDII RLGRDQGSQLQETVEPDPLLTALESQDCVEQLLKNMFDGDRTESCLVSGMQVLLALLEPRRVGT EGLVDSFSQGLERSYSVSSSILHGIEPWLKNFHQLLLNPPKKKAILTTIGVLEEPLGNARLHGA RLMAALLHTNTPSINQELCRLNTMDLLLDLFFKYTWNNFLHLQVELCIAAILSHAGREEQAEAG RSDGKVEPVQGSGDGGGKPETTPSITSPPENTMVTHLFQKCCLVQRILEAWEANDNTQAAGGMR RGNMGHLTRIANAVVQNLEQGPVQTHISEVIRGLPAECRGRWESFVEETLMETNRRNTVDLVST HHLHSSSEDEDIEGTFPNELSLQQAFSEYQIQQMTANFVDQFGFNDEEFADQDDNINAPFDRIA EINFNIEADEDSPSAALFEACCSDRIQPFDDDEEDIWEDEETRCTARVMARARFGAPHTSENYS KKAVGHGGQGRKTGSPTARNVPGLATPSSPTQKEGPRSESDSAGTTWTAVFDEPVNPLSAASGA ARDVGSSAWAAGPSVAEEKGWAKFTDFQPFCCSETGPRCSSPVDMDHSNAEGGQSPGPEKAFGP TSPCAWNVCVTRKAPLVASDSSSSGGSDSEDDEKAAGAVEALCAGHTGKASPPPRTAEAAAGRA ECPDSTVLAPACPAPSEVTISPAVATIAPSKAGSPTATIVVSSSVATAVPPGPIMAVTTTAPAI VATLGTMTKDRKTDALPDGAALNGPV hide sequence

Ensembl Acc Id:

ENSRNOP00000069349 ⟸ ENSRNOT00000078423

Ensembl Acc Id:

ENSRNOP00000011070 ⟸ ENSRNOT00000011070

RefSeq Acc Id:	XP_038934785 ⟸ XM_039078857
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JV49 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934787 ⟸ XM_039078859
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JV49 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934788 ⟸ XM_039078860
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JV49 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934784 ⟸ XM_039078856
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JV49 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934791 ⟸ XM_039078863
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JV49 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934786 ⟸ XM_039078858
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JV49 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934794 ⟸ XM_039078866
- Peptide Label:	isoform X4
- UniProtKB:	F1M6T6 (UniProtKB/TrEMBL), A6K7L0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934795 ⟸ XM_039078867
- Peptide Label:	isoform X4
- UniProtKB:	F1M6T6 (UniProtKB/TrEMBL), A6K7L0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038934797 ⟸ XM_039078869
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038934798 ⟸ XM_039078870
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038934796 ⟸ XM_039078868
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038934799 ⟸ XM_039078871
- Peptide Label:	isoform X8

RefSeq Acc Id:	XP_063119407 ⟸ XM_063263337
- Peptide Label:	isoform X4
- UniProtKB:	A6K7L0 (UniProtKB/TrEMBL), F1M6T6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063119403 ⟸ XM_063263333
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JV49 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063119409 ⟸ XM_063263339
- Peptide Label:	isoform X4
- UniProtKB:	A6K7L0 (UniProtKB/TrEMBL), F1M6T6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063119408 ⟸ XM_063263338
- Peptide Label:	isoform X4
- UniProtKB:	A6K7L0 (UniProtKB/TrEMBL), F1M6T6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063119415 ⟸ XM_063263345
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_063119414 ⟸ XM_063263344
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_063119405 ⟸ XM_063263335
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063119404 ⟸ XM_063263334
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JV49 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063119411 ⟸ XM_063263341
- Peptide Label:	isoform X4
- UniProtKB:	A6K7L0 (UniProtKB/TrEMBL), F1M6T6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063119406 ⟸ XM_063263336
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063119410 ⟸ XM_063263340
- Peptide Label:	isoform X4
- UniProtKB:	A6K7L0 (UniProtKB/TrEMBL), F1M6T6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063119412 ⟸ XM_063263342
- Peptide Label:	isoform X4
- UniProtKB:	A6K7L0 (UniProtKB/TrEMBL), F1M6T6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063119413 ⟸ XM_063263343
- Peptide Label:	isoform X4
- UniProtKB:	A6K7L0 (UniProtKB/TrEMBL), F1M6T6 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M6T6-F1-model_v2	AlphaFold	F1M6T6	1-901	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563990	AgrOrtholog
BioCyc Gene	G2FUF-32451	BioCyc
Ensembl Genes	ENSRNOG00000026425	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011070	ENTREZGENE
	ENSRNOT00000011070.8	UniProtKB/TrEMBL
	ENSRNOT00000078423	ENTREZGENE
	ENSRNOT00000078423.2	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	SAPS	UniProtKB/TrEMBL
KEGG Report	rno:300146	UniProtKB/TrEMBL
NCBI Gene	300146	ENTREZGENE
PANTHER	SAPS	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN PHOSPHATASE 6 REGULATORY SUBUNIT 2	UniProtKB/TrEMBL
Pfam	SAPS	UniProtKB/TrEMBL
PhenoGen	Ppp6r2	PhenoGen
RatGTEx	ENSRNOG00000026425	RatGTEx
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
UniProt	A0A0G2JV49	ENTREZGENE, UniProtKB/TrEMBL
	A6K7L0	ENTREZGENE, UniProtKB/TrEMBL
	F1M6T6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-01	Ppp6r2	protein phosphatase 6, regulatory subunit 2	Saps2	SAPS domain family, member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Saps2	SAPS domain family, member 2	RGD1563990_predicted	similar to 8430411H09Rik protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1563990_predicted	similar to 8430411H09Rik protein (predicted)	LOC300146	similar to 8430411H09Rik protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC300146	similar to 8430411H09Rik protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar