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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | ovarian cyst | | ISO | RGD:735859 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21239663 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | ovarian cyst | | ISO | RGD:735859 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21239663 | |
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# | Reference Title | Reference Citation |
1. | trans-Resveratrol protects ischemic PC12 Cells by inhibiting the hypoxia associated transcription factors and increasing the levels of antioxidant defense enzymes. | Agrawal M, etal., ACS Chem Neurosci. 2013 Feb 20;4(2):285-94. doi: 10.1021/cn300143m. Epub 2012 Nov 9. |
2. | BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis. | Beguin P, etal., J Cell Biol. 2014 Apr 28;205(2):233-49. doi: 10.1083/jcb.201304101. Epub 2014 Apr 21. |
3. | Molecular determinants of the CaVbeta-induced plasma membrane targeting of the CaV1.2 channel. | Bourdin B, etal., J Biol Chem. 2010 Jul 23;285(30):22853-63. doi: 10.1074/jbc.M110.111062. Epub 2010 May 17. |
4. | Functional characterization of CaValpha2delta mutations associated with sudden cardiac death. | Bourdin B, etal., J Biol Chem. 2015 Jan 30;290(5):2854-69. doi: 10.1074/jbc.M114.597930. Epub 2014 Dec 19. |
5. | Cloning and expression of a third calcium channel beta subunit. | Castellano A, etal., J Biol Chem 1993 Feb 15;268(5):3450-5. |
6. | Cloning and expression of a neuronal calcium channel beta subunit. | Castellano A, etal., J Biol Chem 1993 Jun 15;268(17):12359-66. |
7. | Voltage-gated calcium channels. | Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947. |
8. | Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. | Chen YH, etal., Nature. 2004 Jun 10;429(6992):675-80. Epub 2004 May 30. |
9. | Direct inhibition of P/Q-type voltage-gated Ca2+ channels by Gem does not require a direct Gem/Cavbeta interaction. | Fan M, etal., Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14887-92. doi: 10.1073/pnas.1007543107. Epub 2010 Aug 2. |
10. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
11. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
12. | Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. | Grueter CE, etal., Biochemistry. 2008 Feb 12;47(6):1760-7. Epub 2008 Jan 19. |
13. | Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. | Leroy J, etal., J Neurosci. 2005 Jul 27;25(30):6984-96. |
14. | Up-regulation of Cavß3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain. | Li L, etal., J Biol Chem. 2012 Feb 17;287(8):6002-13. doi: 10.1074/jbc.M111.310110. Epub 2011 Dec 20. |
15. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
16. | Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. | Morgan EL, etal., J Physiol. 2007 Apr 15;580(Pt. 2):593-604. Epub 2007 Feb 1. |
17. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
18. | The voltage-dependent calcium channel beta subunit contains two stable interacting domains. | Opatowsky Y, etal., J Biol Chem 2003 Dec 26;278(52):52323-32. Epub 2003 Oct 14. |
19. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
20. | GOA pipeline | RGD automated data pipeline |
21. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
22. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
23. | Ca(2+) channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells. | Wei SK, etal., Circ Res. 2000 Feb 4;86(2):175-84. |
24. | Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation. | Yasuda T, etal., J Gen Physiol. 2004 Apr;123(4):401-16. doi: 10.1085/jgp.200308967. Epub 2004 Mar 15. |
PMID:10328888 | PMID:11160515 | PMID:16525042 | PMID:17028169 | PMID:17303572 | PMID:19755851 | PMID:19917615 | PMID:24566975 | PMID:25964431 | PMID:29476059 | PMID:34426509 |
Cacnb3 (Rattus norvegicus - Norway rat) |
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CACNB3 (Homo sapiens - human) |
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Cacnb3 (Mus musculus - house mouse) |
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Cacnb3 (Chinchilla lanigera - long-tailed chinchilla) |
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CACNB3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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CACNB3 (Canis lupus familiaris - dog) |
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Cacnb3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CACNB3 (Sus scrofa - pig) |
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CACNB3 (Chlorocebus sabaeus - green monkey) |
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Cacnb3 (Heterocephalus glaber - naked mole-rat) |
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Variants in Cacnb3
34 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH128224 |
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PMC21756P1 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 4 | 4 | 4 | 2 | 4 | 74 | 21 | 33 | 7 | |||
Low | 39 | 48 | 32 | 17 | 32 | 6 | 9 | 14 | 8 | 4 | 6 | ||
Below cutoff | 5 | 5 | 5 | 2 | 2 | 2 |
RefSeq Transcripts | NM_012828 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006257329 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_006257330 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017594673 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039078460 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC129405 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CB739910 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH474035 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000187 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
M88751 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000081206 ⟹ ENSRNOP00000073026 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000095350 ⟹ ENSRNOP00000089211 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000097309 ⟹ ENSRNOP00000087593 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000102945 ⟹ ENSRNOP00000082583 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_012828 ⟹ NP_036960 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006257329 ⟹ XP_006257391 | ||||||||||||||||
RefSeq Status: | |||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017594673 ⟹ XP_017450162 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039078460 ⟹ XP_038934388 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_036960 | (Get FASTA) | NCBI Sequence Viewer |
XP_006257391 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017450162 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038934388 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA18486 | (Get FASTA) | NCBI Sequence Viewer |
EDL87047 | (Get FASTA) | NCBI Sequence Viewer | |
P54287 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_036960 ⟸ NM_012828 |
- UniProtKB: | P54287 (UniProtKB/Swiss-Prot) |
- Sequence: |
RefSeq Acc Id: | XP_006257391 ⟸ XM_006257329 |
- Peptide Label: | isoform X2 |
- Sequence: |
RefSeq Acc Id: | XP_017450162 ⟸ XM_017594673 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A8I6A832 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000073026 ⟸ ENSRNOT00000081206 |
RefSeq Acc Id: | XP_038934388 ⟸ XM_039078460 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | ENSRNOP00000082583 ⟸ ENSRNOT00000102945 |
RefSeq Acc Id: | ENSRNOP00000087593 ⟸ ENSRNOT00000097309 |
RefSeq Acc Id: | ENSRNOP00000089211 ⟸ ENSRNOT00000095350 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P54287-F1-model_v2 | AlphaFold | P54287 | 1-484 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13695627 | ||||||||
Promoter ID: | EPDNEW_R6152 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Cacnb3_1 | ||||||||
Description: | calcium voltage-gated channel auxiliary subunit beta 3 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:2248 | AgrOrtholog |
BioCyc Gene | G2FUF-32124 | BioCyc |
Ensembl Genes | ENSRNOG00000054274 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000073026 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOP00000082583.1 | UniProtKB/TrEMBL | |
ENSRNOP00000087593 | ENTREZGENE | |
ENSRNOP00000087593.1 | UniProtKB/TrEMBL | |
ENSRNOP00000089211.1 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000081206 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOT00000095350.1 | UniProtKB/TrEMBL | |
ENSRNOT00000097309 | ENTREZGENE | |
ENSRNOT00000097309.1 | UniProtKB/TrEMBL | |
ENSRNOT00000102945.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 3.40.50.300 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | CAB1-4_N_A-dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CACNB3_SH3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
GK/Ca_channel_bsu | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
P-loop_NTPase | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH3-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SH3_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
VDCC_L_b3su | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
VDCC_L_bsu | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:25297 | UniProtKB/Swiss-Prot |
NCBI Gene | 25297 | ENTREZGENE |
Pfam | Guanylate_kin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
VGCC_beta4Aa_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Cacnb3 | PhenoGen |
PRINTS | LCACHANNELB | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
LCACHANNELB3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROSITE | SH3 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SMART | GuKc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | SSF50044 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF52540 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TIGR | TC219369 | |
UniProt | A0A8I5ZTS4_RAT | UniProtKB/TrEMBL |
A0A8I6A832 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6GH08_RAT | UniProtKB/TrEMBL | |
CACB3_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-02-11 | Cacnb3 | calcium voltage-gated channel auxiliary subunit beta 3 | Cacnb3 | calcium channel, voltage-dependent, beta 3 subunit | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2003-04-09 | Cacnb3 | calcium channel, voltage-dependent, beta 3 subunit | Calcium channel subunit beta 3 | Name updated | 629478 | APPROVED | |
2002-06-10 | Cacnb3 | Calcium channel subunit beta 3 | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_expression | expressed exclusively in neuronal tissues, with the highest levels being found in the cerebellum | 634680 |
gene_function | interacts with alpha 1 subunits and increases functional alpha 1 activity | 634680 |