Cyp2d4 Rat (+)-catechin multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA CTD PMID:25663641 Cyp2d4 Rat (+)-epicatechin-3-O-gallate multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA CTD PMID:25663641 Cyp2d4 Rat (-)-epigallocatechin 3-gallate multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA CTD PMID:25663641 Cyp2d4 Rat (1->4)-beta-D-glucan multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP2D22 mRNA CTD PMID:36331819 Cyp2d4 Rat (E,E)-germacrone decreases activity ISO CYP2D6 (Homo sapiens) 6480464 germacrone results in decreased activity of CYP2D6 protein CTD PMID:23850985 Cyp2d4 Rat (R)-lipoic acid multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 Cyp2d4 Rat (R,R)-tramadol affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 affects the susceptibility to Tramadol more ... CTD PMID:16497087 more ... Cyp2d4 Rat (R,R)-tramadol affects methylation ISO Cyp2d22 (Mus musculus) 6480464 CYP2D6 protein affects the methylation of Tramadol CTD PMID:12893130 Cyp2d4 Rat (R,R)-tramadol decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Tramadol CTD PMID:14624403 more ... Cyp2d4 Rat (R,R)-tramadol decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CTD PMID:16960721 Cyp2d4 Rat (R,R)-tramadol increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in increased metabolism of Tramadol and CYP2D6 protein results in increased metabolism of Tramadol CTD PMID:18204346 more ... Cyp2d4 Rat (R,R)-tramadol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol more ... CTD PMID:18204346 and PMID:29555325 Cyp2d4 Rat (R,R)-tramadol increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in increased susceptibility to Tramadol CTD PMID:18204346 Cyp2d4 Rat (R,R)-tramadol affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form affects the metabolism of Tramadol and CYP2D6 gene polymorphism affects the metabolism of Tramadol CTD PMID:12191703 more ... Cyp2d4 Rat (S)-duloxetine hydrochloride multiple interactions EXP 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride and CYP2D6 protein results in increased activity of and results in increased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 Cyp2d4 Rat (S)-nicotine multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 Cyp2d4 Rat (S)-nicotine increases expression ISO Cyp2d22 (Mus musculus) 6480464 Nicotine results in increased expression of CYP2D22 mRNA and Nicotine results in increased expression of CYP2D22 protein CTD PMID:19594327 Cyp2d4 Rat (S)-timolol (anhydrous) affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene SNP affects the susceptibility to Timolol CTD PMID:19284319 and PMID:20925579 Cyp2d4 Rat 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of 1 more ... CTD PMID:9047321 Cyp2d4 Rat 1,4-naphthoquinone increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of 1 and 4-naphthoquinone CTD PMID:16243959 Cyp2d4 Rat 1-(3-chlorophenyl)piperazine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine] CTD PMID:18238857 Cyp2d4 Rat 1-(3-chlorophenyl)piperazine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine CTD PMID:18238857 Cyp2d4 Rat 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Citalopram analog CTD PMID:9110356 Cyp2d4 Rat 1-aminobenzotriazole multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol] CTD PMID:15618748 Cyp2d4 Rat 1-aminobenzotriazole decreases activity ISO CYP2D6 (Homo sapiens) 6480464 1-aminobenzotriazole results in decreased activity of CYP2D6 protein CTD PMID:11375247 Cyp2d4 Rat 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of 1-Methyl-4-phenyl-1 more ... CTD PMID:12464242 Cyp2d4 Rat 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 Cyp2d4 Rat 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO Cyp2d22 (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 Cyp2d4 Rat 1-naphthol increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of 1-naphthol CTD PMID:16243959 Cyp2d4 Rat 1-naphthol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene SNP affects the reaction [1-naphthol affects the abundance of Dehydroepiandrosterone Sulfate] CTD PMID:33771511 Cyp2d4 Rat 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of CYP2D4 mRNA CTD PMID:25380136 Cyp2d4 Rat 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of CYP2D22 mRNA and Ethinyl Estradiol results in decreased expression of CYP2D4 mRNA CTD PMID:16174780 and PMID:17108234 Cyp2d4 Rat 17alpha-ethynylestradiol multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2D22 mRNA CTD PMID:17942748 Cyp2d4 Rat 1H-pyrazole decreases expression ISO Cyp2d22 (Mus musculus) 6480464 pyrazole results in decreased expression of CYP2D22 mRNA CTD PMID:17945193 Cyp2d4 Rat 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:31826744 Cyp2d4 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CYP2D4 protein CTD PMID:12361703 Cyp2d4 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP2D22 mRNA CTD PMID:19770486 and PMID:28213091 Cyp2d4 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2D22 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP2D22 gene] CTD PMID:17942748 and PMID:28213091 Cyp2d4 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Cyp2d22 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of CYP2D22 mRNA CTD PMID:21570461 Cyp2d4 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP2D4 mRNA CTD PMID:21215274 Cyp2d4 Rat 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of CYP2D22 mRNA CTD PMID:21346803 Cyp2d4 Rat 2,6-dinitrotoluene affects expression EXP 6480464 2 and 6-dinitrotoluene affects the expression of CYP2D22 mRNA CTD PMID:21346803 Cyp2d4 Rat 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Verapamil results in decreased activity of CYP2D22 protein and Verapamil results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat 3,4-Methylenedioxyamphetamine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of and results in decreased methylation of 3 more ... CTD PMID:19576971 Cyp2d4 Rat 3,4-methylenedioxymethamphetamine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of N-Methyl-3 and 4-methylenedioxyamphetamine CTD PMID:12464242 Cyp2d4 Rat 3,4-methylenedioxymethamphetamine increases expression ISO Cyp2d22 (Mus musculus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of CYP2D22 mRNA CTD PMID:20188158 Cyp2d4 Rat 3,4-methylenedioxymethamphetamine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased activity of CYP2D6 protein CTD PMID:16049126 and PMID:24211539 Cyp2d4 Rat 3,4-methylenedioxymethamphetamine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol] CTD PMID:16049126 Cyp2d4 Rat 3,5-xylenol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased oxidation of 3 and 5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 Cyp2d4 Rat 3,5-xylenol increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of 3 and 5-xylenol analog CTD PMID:27665777 Cyp2d4 Rat 3-methylcholanthrene increases expression EXP 6480464 Methylcholanthrene results in increased expression of CYP2D4 mRNA CTD PMID:11328961 Cyp2d4 Rat 3-methylthiopropanal multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] CTD PMID:15576237 Cyp2d4 Rat 4'-hydroxydiclofenac multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac and [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac CTD PMID:24246759 Cyp2d4 Rat 4'-hydroxypropanolol increases chemical synthesis ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased chemical synthesis of 4-hydroxypropranolol CTD PMID:21184751 Cyp2d4 Rat 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of CYP2D4 mRNA CTD PMID:25380136 Cyp2d4 Rat 4,4'-sulfonyldiphenol increases expression EXP 6480464 bisphenol S results in increased expression of CYP2D4 mRNA CTD PMID:26186136 Cyp2d4 Rat 4-(methylsulfinyl)phenol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased oxidation of 3 and 5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 Cyp2d4 Rat 4-(methylsulfinyl)phenol increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 Cyp2d4 Rat 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:2070484 Cyp2d4 Rat 4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of 1-(4-hydroxyphenyl)-1 and 2-diphenyl-1-butene CTD PMID:29285606 Cyp2d4 Rat 4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1 more ... CTD PMID:29285606 Cyp2d4 Rat 4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of 1-(4-hydroxyphenyl)-1 and 2-diphenyl-1-butene CTD PMID:29285606 Cyp2d4 Rat 4-Hydroxy-N-desmethyltamoxifen multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen] which results in increased abundance of 4-hydroxy-N-desmethyltamoxifen metabolite more ... CTD PMID:14652237 and PMID:29285606 Cyp2d4 Rat 4-Hydroxy-N-desmethyltamoxifen increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen CTD PMID:29285606 Cyp2d4 Rat 4-Hydroxy-N-desmethyltamoxifen affects abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the abundance of 4-hydroxy-N-desmethyltamoxifen CTD PMID:14652237 Cyp2d4 Rat 4-Hydroxyclonidine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine and [CYP2D6 protein results in increased metabolism of Clonidine] which results in increased chemical synthesis of 4-hydroxyclonidine CTD PMID:31585114 Cyp2d4 Rat 4-hydroxyphenyl retinamide increases expression ISO Cyp2d22 (Mus musculus) 6480464 Fenretinide results in increased expression of CYP2D22 mRNA CTD PMID:28973697 Cyp2d4 Rat 4-Ipomeanol increases activity ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased activity of 4-ipomeanol CTD PMID:15892579 Cyp2d4 Rat 5-aza-2'-deoxycytidine increases expression ISO Cyp2d22 (Mus musculus) 6480464 Decitabine results in increased expression of CYP2D22 mRNA CTD PMID:30503582 Cyp2d4 Rat 5-hydroxydiclofenac multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 Cyp2d4 Rat 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of CYP2D4 mRNA CTD PMID:19483382 Cyp2d4 Rat 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Omeprazole results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat 5-methoxy-N,N-diisopropyltryptamine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 5-methoxy-N and N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 Cyp2d4 Rat 5-methoxy-N,N-diisopropyltryptamine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [5-methoxy-N and N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 Cyp2d4 Rat 5-methoxyindole decreases activity ISO CYP2D6 (Homo sapiens) 6480464 5-methoxyindole results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat 5-methoxytryptamine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine CTD PMID:12777961 Cyp2d4 Rat 5-methyltryptamine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 5-methyltryptamine analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 Cyp2d4 Rat 5-methyltryptamine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [5-methyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 Cyp2d4 Rat 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of CYP2D4 mRNA CTD PMID:19483382 Cyp2d4 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of CYP2D4 mRNA CTD PMID:24780913 Cyp2d4 Rat 7,12-dimethyltetraphene increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased susceptibility to 9 more ... CTD PMID:20507880 Cyp2d4 Rat 8-hydroxy-2'-deoxyguanosine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-Hydroxy-2'-Deoxyguanosine CTD PMID:15576237 Cyp2d4 Rat a-Methyldopamine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of and results in decreased methylation of 3 and 4-Methylenedioxyamphetamine] which results in increased chemical synthesis of alpha-methyldopamine CTD PMID:19576971 Cyp2d4 Rat AB-Fubinaca decreases activity ISO CYP2D6 (Homo sapiens) 6480464 AB-FUBINACA results in decreased activity of CYP2D6 protein CTD PMID:33050066 Cyp2d4 Rat aconitine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Aconitine CTD PMID:21277363 Cyp2d4 Rat aconitine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine and [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite CTD PMID:21277363 Cyp2d4 Rat afimoxifene increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of afimoxifene CTD PMID:29285606 Cyp2d4 Rat afimoxifene multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite CTD PMID:29285606 Cyp2d4 Rat aflatoxin B1 decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of CYP2D22 mRNA CTD PMID:19770486 Cyp2d4 Rat aflatoxin B1 increases methylation ISO CYP2D6 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of CYP2D6 gene CTD PMID:27153756 Cyp2d4 Rat aflatoxin B1 multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Aflatoxin B1 CTD PMID:23397584 Cyp2d4 Rat ajmalicine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 raubasine results in decreased activity of CYP2D6 protein CTD PMID:15930738 Cyp2d4 Rat ajmalicine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] CTD PMID:15930738 Cyp2d4 Rat all-trans-retinoic acid decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Tretinoin results in decreased activity of CYP2D22 protein CTD PMID:18420780 Cyp2d4 Rat all-trans-retinoic acid increases expression ISO Cyp2d22 (Mus musculus) 6480464 Tretinoin results in increased expression of CYP2D22 mRNA CTD PMID:36189433 Cyp2d4 Rat all-trans-retinoic acid multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of CYP2D22 mRNA CTD PMID:36189433 Cyp2d4 Rat all-trans-retinoic acid decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Tretinoin results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat almotriptan decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of almotriptan CTD PMID:12642466 Cyp2d4 Rat almotriptan increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of almotriptan CTD PMID:12642466 Cyp2d4 Rat alpha-methyltryptamine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan and [indopan results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 Cyp2d4 Rat alpha-methyltryptamine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 indopan analog results in decreased activity of CYP2D6 protein and indopan results in decreased activity of CYP2D6 protein CTD PMID:26599973 Cyp2d4 Rat amiodarone affects expression EXP 6480464 Amiodarone affects the expression of CYP2D4 mRNA CTD PMID:19483382 Cyp2d4 Rat amiodarone increases expression ISO CYP2D6 (Homo sapiens) 6480464 Amiodarone results in increased expression of CYP2D6 mRNA CTD PMID:19774075 Cyp2d4 Rat amiodarone multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol] CTD PMID:15541258 Cyp2d4 Rat amiodarone decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Amiodarone results in decreased activity of CYP2D6 protein CTD PMID:16449812 Cyp2d4 Rat amitriptyline increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 Amitriptyline results in increased metabolism of CYP2D6 protein and CYP2D6 protein results in increased metabolism of Amitriptyline CTD PMID:16044105 more ... Cyp2d4 Rat amitriptyline multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline CTD PMID:23397584 Cyp2d4 Rat amitriptyline decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Amitriptyline results in decreased activity of CYP2D6 protein CTD PMID:18359183 Cyp2d4 Rat amitriptylinoxide increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of amitriptyline N-oxide CTD PMID:27320963 Cyp2d4 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CYP2D4 mRNA CTD PMID:16483693 Cyp2d4 Rat amodiaquine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine and [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine CTD PMID:28478157 and PMID:31629065 Cyp2d4 Rat amodiaquine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Amodiaquine CTD PMID:28478157 more ... Cyp2d4 Rat amphetamine increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of Amphetamine analog CTD PMID:29277574 Cyp2d4 Rat amphetamine increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of Amphetamine analog CTD PMID:29277574 Cyp2d4 Rat amphetamine decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Amphetamine analog CTD PMID:29277574 Cyp2d4 Rat amphetamine affects chemical synthesis ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the chemical synthesis of Amphetamine CTD PMID:15294457 Cyp2d4 Rat amphetamines increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Amphetamines CTD PMID:10911933 Cyp2d4 Rat aniline multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 Cyp2d4 Rat arachidonic acid increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 Cyp2d4 Rat aristolochic acid A increases expression ISO CYP2D6 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of CYP2D6 mRNA CTD PMID:33212167 Cyp2d4 Rat arsenous acid multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYP2D6 protein] CTD PMID:26598702 Cyp2d4 Rat atomoxetine hydrochloride increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of Atomoxetine Hydrochloride CTD PMID:17470523 Cyp2d4 Rat atomoxetine hydrochloride multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride] CTD PMID:34431675 Cyp2d4 Rat atomoxetine hydrochloride increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Atomoxetine Hydrochloride CTD PMID:34431675 Cyp2d4 Rat Auriculasin multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin] CTD PMID:31515991 Cyp2d4 Rat Auriculasin increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of auriculasin CTD PMID:31515991 Cyp2d4 Rat bacitracin decreases expression EXP 6480464 Bacitracin results in decreased expression of CYP2D22 mRNA CTD PMID:18289764 Cyp2d4 Rat barnidipine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 mepirodipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 Cyp2d4 Rat benidipine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 benidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 Cyp2d4 Rat benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of CYP2D4 mRNA CTD PMID:19483382 Cyp2d4 Rat benzene increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Benzene CTD PMID:17479406 Cyp2d4 Rat benzene increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Benzene CTD PMID:16737584 and PMID:17479406 Cyp2d4 Rat benzo[a]pyrene decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of CYP2D22 mRNA CTD PMID:19770486 Cyp2d4 Rat benzo[a]pyrene decreases expression ISO CYP2D6 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of CYP2D6 mRNA CTD PMID:32234424 Cyp2d4 Rat benzo[a]pyrene increases methylation ISO CYP2D6 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of CYP2D6 exon CTD PMID:27901495 Cyp2d4 Rat benzo[a]pyrene affects methylation ISO CYP2D6 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of CYP2D6 promoter CTD PMID:27901495 Cyp2d4 Rat benzo[a]pyrene increases expression ISO CYP2D6 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of CYP2D6 mRNA CTD PMID:16269432 Cyp2d4 Rat benzo[b]fluoranthene increases expression ISO CYP2D6 (Homo sapiens) 6480464 benzo(b)fluoranthene results in increased expression of CYP2D6 mRNA CTD PMID:16269432 Cyp2d4 Rat beta-carboline multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 Cyp2d4 Rat beta-naphthoflavone decreases expression ISO CYP2D6 (Homo sapiens) 6480464 beta-Naphthoflavone results in decreased expression of CYP2D6 mRNA CTD PMID:22258563 Cyp2d4 Rat bis(2-ethylhexyl) phthalate multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Diethylhexyl Phthalate results in increased expression of CYP2D6] which results in increased metabolism of and results in decreased activity of Doxorubicin and Diethylhexyl Phthalate promotes the reaction [AHR protein binds to CYP2D6 promoter] CTD PMID:34801851 Cyp2d4 Rat bis(2-ethylhexyl) phthalate increases expression ISO CYP2D6 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of CYP2D6 mRNA CTD PMID:34801851 Cyp2d4 Rat bisphenol A increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of bisphenol A CTD PMID:21402134 Cyp2d4 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CYP2D4 mRNA and bisphenol A results in decreased expression of CYP2D6 mRNA CTD PMID:25181051 more ... Cyp2d4 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CYP2D4 mRNA CTD PMID:26186136 and PMID:32145629 Cyp2d4 Rat bisphenol A multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA and [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA] CTD PMID:27082013 Cyp2d4 Rat bisphenol A multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone CTD PMID:21402134 Cyp2d4 Rat bisphenol F increases expression EXP 6480464 4 and 4'-bisphenol F results in increased expression of CYP2D4 mRNA CTD PMID:26186136 Cyp2d4 Rat bortezomib affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Bortezomib CTD PMID:15764713 Cyp2d4 Rat Bufuralol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol] more ... CTD PMID:11377097 more ... Cyp2d4 Rat Bufuralol affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of bufuralol CTD PMID:15801540 Cyp2d4 Rat Bufuralol increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of bufuralol CTD PMID:21964418 Cyp2d4 Rat Bufuralol increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of bufuralol CTD PMID:10933885 more ... Cyp2d4 Rat Bufuralol affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of bufuralol CTD PMID:15801540 Cyp2d4 Rat Bufuralol increases hydrolysis ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydrolysis of bufuralol CTD PMID:11377097 Cyp2d4 Rat Bufuralol increases hydroxylation ISO Cyp2d22 (Mus musculus) 6480464 CYP2D4 protein results in increased hydroxylation of bufuralol CTD PMID:15742976 Cyp2d4 Rat Bufuralol increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of bufuralol CTD PMID:12401345 more ... Cyp2d4 Rat buprenorphine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Buprenorphine CTD PMID:12756210 Cyp2d4 Rat buprenorphine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Buprenorphine results in decreased activity of CYP2D6 protein CTD PMID:12756210 Cyp2d4 Rat buspirone increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of Buspirone CTD PMID:15640381 Cyp2d4 Rat buspirone increases expression EXP 6480464 Buspirone results in increased expression of CYP2D4 mRNA CTD PMID:24136188 Cyp2d4 Rat butyric acid increases expression ISO CYP2D6 (Homo sapiens) 6480464 Butyric Acid results in increased expression of CYP2D6 mRNA CTD PMID:30439556 Cyp2d4 Rat C.I. Natural Red 20 decreases activity ISO CYP2D6 (Homo sapiens) 6480464 shikonin results in decreased activity of CYP2D6 protein CTD PMID:28941798 Cyp2d4 Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of CYP2D4 mRNA CTD PMID:25993096 Cyp2d4 Rat caffeine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Caffeine CTD PMID:15199075 Cyp2d4 Rat calciol decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Cholecalciferol results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat cannabidiol decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Cannabidiol results in decreased activity of CYP2D6 protein CTD PMID:21821735 and PMID:24667653 Cyp2d4 Rat Cannabidivarin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 cannabidivarin results in decreased activity of CYP2D6 protein CTD PMID:21821735 Cyp2d4 Rat capsaicin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Capsaicin results in decreased activity of CYP2D6 protein CTD PMID:22375877 Cyp2d4 Rat carbamazepine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Carbamazepine CTD PMID:23397584 Cyp2d4 Rat carbendazim decreases activity ISO CYP2D6 (Homo sapiens) 6480464 carbendazim results in decreased activity of CYP2D6 protein CTD PMID:20183062 Cyp2d4 Rat carbon nanotube increases expression ISO Cyp2d22 (Mus musculus) 6480464 Nanotubes and Carbon results in increased expression of CYP2D22 mRNA CTD PMID:25554681 Cyp2d4 Rat Carnosol decreases activity ISO CYP2D6 (Homo sapiens) 6480464 carnosol results in decreased activity of CYP2D6 protein CTD PMID:34592323 Cyp2d4 Rat carvedilol affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the susceptibility to carvedilol CTD PMID:20643254 Cyp2d4 Rat carvedilol affects glucuronidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the glucuronidation of carvedilol CTD PMID:16849011 Cyp2d4 Rat carvedilol affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the metabolism of carvedilol and CYP2D6 protein polymorphism affects the metabolism of carvedilol CTD PMID:15001973 more ... Cyp2d4 Rat chelidonine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of chelidonine CTD PMID:31102647 Cyp2d4 Rat chelidonine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog CTD PMID:31102647 Cyp2d4 Rat chlordecone multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 Chlordecone promotes the reaction [Biomarkers metabolite binds to CYP2D22 gene] CTD PMID:31084621 Cyp2d4 Rat chloroquine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Chloroquine CTD PMID:12920490 Cyp2d4 Rat chloroquine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine CTD PMID:12756207 Cyp2d4 Rat chloroquine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Chloroquine results in decreased activity of CYP2D6 protein CTD PMID:12756207 Cyp2d4 Rat chlorphenamine increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 mutant form results in increased susceptibility to Chlorpheniramine CTD PMID:17089107 Cyp2d4 Rat chlorpromazine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine and CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine CTD PMID:19482014 and PMID:23397584 Cyp2d4 Rat chlorpromazine decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383 Cyp2d4 Rat chlorpyrifos increases expression ISO CYP2D6 (Homo sapiens) 6480464 Chlorpyrifos results in increased expression of CYP2D6 mRNA CTD PMID:16757081 Cyp2d4 Rat chlorpyrifos decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Chlorpyrifos results in decreased activity of CYP2D6 protein CTD PMID:20183062 Cyp2d4 Rat chlorpyrifos multiple interactions EXP 6480464 Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] CTD PMID:14979094 Cyp2d4 Rat chlorpyrifos increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of Chlorpyrifos CTD PMID:14979094 Cyp2d4 Rat choline multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2D22 protein CTD PMID:27712037 Cyp2d4 Rat cimetidine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Cimetidine results in decreased activity of CYP2D6 protein CTD PMID:19909766 Cyp2d4 Rat cimetidine multiple interactions EXP 6480464 Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] CTD PMID:17651725 Cyp2d4 Rat cimetidine decreases activity EXP 6480464 Cimetidine results in decreased activity of CYP2D6 protein CTD PMID:17651725 Cyp2d4 Rat cimetidine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein] CTD PMID:19909766 Cyp2d4 Rat cinacalcet decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Cinacalcet results in decreased activity of CYP2D6 protein CTD PMID:16680561 Cyp2d4 Rat cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of CYP2D22 mRNA CTD PMID:18289764 Cyp2d4 Rat citalopram decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Citalopram analog CTD PMID:9110356 Cyp2d4 Rat clofibrate affects expression EXP 6480464 Clofibrate affects the expression of CYP2D4 mRNA CTD PMID:19483382 Cyp2d4 Rat clofibric acid affects expression EXP 6480464 Clofibric Acid affects the expression of CYP2D22 mRNA CTD PMID:17602206 Cyp2d4 Rat clonidine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Clonidine CTD PMID:31585114 Cyp2d4 Rat clonidine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine more ... CTD PMID:31585114 Cyp2d4 Rat clonidine (amino form) multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine more ... CTD PMID:31585114 Cyp2d4 Rat clonidine (amino form) increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Clonidine CTD PMID:31585114 Cyp2d4 Rat clonidine (imino form) increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Clonidine CTD PMID:31585114 Cyp2d4 Rat clonidine (imino form) multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [[CYP2D6 gene polymorphism results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Clonidine] which results in decreased chemical synthesis of 4-hydroxyclonidine more ... CTD PMID:31585114 Cyp2d4 Rat clopidogrel multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite CTD PMID:19170597 Cyp2d4 Rat clozapine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Clozapine CTD PMID:15286053 Cyp2d4 Rat clozapine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Clozapine CTD PMID:18809730 and PMID:27320963 Cyp2d4 Rat clozapine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine CTD PMID:23397584 Cyp2d4 Rat Clozapine N-oxide increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of clozapine N-oxide CTD PMID:27320963 Cyp2d4 Rat Clozapine N-oxide increases chemical synthesis ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased chemical synthesis of clozapine N-oxide CTD PMID:18809730 Cyp2d4 Rat codeine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in increased metabolism of Codeine and CYP2D6 protein results in increased metabolism of Codeine CTD PMID:10911933 more ... Cyp2d4 Rat codeine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine and [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine CTD PMID:16595712 and PMID:21241245 Cyp2d4 Rat codeine multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 Cyp2d4 Rat codeine increases metabolic processing ISO Cyp2d22 (Mus musculus) 6480464 CYP2D22 protein results in increased metabolism of Codeine CTD PMID:16595712 Cyp2d4 Rat codeine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Codeine and CYP2D6 protein polymorphism affects the metabolism of Codeine CTD PMID:11823760 more ... Cyp2d4 Rat codeine affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein polymorphism affects the susceptibility to Codeine CTD PMID:9696456 Cyp2d4 Rat codeine decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Codeine CTD PMID:17470523 Cyp2d4 Rat copper atom decreases expression EXP 6480464 Copper results in decreased expression of CYP2D22 mRNA CTD PMID:22465980 Cyp2d4 Rat copper atom multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol more ... CTD PMID:15576237 Cyp2d4 Rat copper(0) multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol more ... CTD PMID:15576237 Cyp2d4 Rat copper(0) decreases expression EXP 6480464 Copper results in decreased expression of CYP2D22 mRNA CTD PMID:22465980 Cyp2d4 Rat corticosterone increases expression EXP 6480464 Corticosterone results in increased expression of CYP2D4 mRNA CTD PMID:15755911 Cyp2d4 Rat corticosterone multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Corticosterone promotes the reaction [Ethanol results in increased expression of CYP2D6 mRNA] CTD PMID:35301062 Cyp2d4 Rat corticosterone increases expression ISO CYP2D6 (Homo sapiens) 6480464 Corticosterone results in increased expression of CYP2D6 mRNA CTD PMID:35301062 Cyp2d4 Rat cortisol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene SNP affects the reaction [Ethylenethiourea affects the abundance of Hydrocortisone] CTD PMID:33771511 Cyp2d4 Rat coumarins multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins and Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins] CTD PMID:23850985 Cyp2d4 Rat curcumin decreases expression ISO CYP2D6 (Homo sapiens) 6480464 Curcumin results in decreased expression of CYP2D6 mRNA CTD PMID:33582110 Cyp2d4 Rat cyclophosphamide increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Cyclophosphamide CTD PMID:11377097 Cyp2d4 Rat cyhalothrin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 cyhalothrin results in decreased activity of CYP2D6 protein CTD PMID:20183062 Cyp2d4 Rat cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of CYP2D4 mRNA CTD PMID:29727961 Cyp2d4 Rat cypermethrin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 cypermethrin results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat dacomitinib multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Quinidine affects the reaction [CYP2D6 protein polymorphism affects the metabolism of dacomitinib] CTD PMID:34936353 Cyp2d4 Rat dacomitinib affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein polymorphism affects the metabolism of dacomitinib CTD PMID:34936353 Cyp2d4 Rat daidzein decreases activity ISO Cyp2d22 (Mus musculus) 6480464 daidzein results in decreased activity of CYP2D22 protein CTD PMID:18420780 Cyp2d4 Rat daidzein decreases activity ISO CYP2D6 (Homo sapiens) 6480464 daidzein results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat dapsone multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of and results in increased susceptibility to Dapsone CTD PMID:19998329 Cyp2d4 Rat DDE decreases expression ISO CYP2D6 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of CYP2D6 mRNA CTD PMID:38568856 Cyp2d4 Rat debrisoquin multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin more ... CTD PMID:11673748 Cyp2d4 Rat debrisoquin decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin CTD PMID:11673748 Cyp2d4 Rat debrisoquin increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Debrisoquin CTD PMID:12464242 Cyp2d4 Rat debrisoquin increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite CTD PMID:11673748 Cyp2d4 Rat debrisoquin increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of Debrisoquin CTD PMID:17470523 Cyp2d4 Rat debrisoquin affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Debrisoquin and CYP2D6 protein polymorphism affects the metabolism of Debrisoquin CTD PMID:11823760 and PMID:3577206 Cyp2d4 Rat debrisoquin decreases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in decreased metabolism of Debrisoquin and CYP2D6 gene polymorphism results in decreased metabolism of Debrisoquin CTD PMID:6603386 and PMID:8946814 Cyp2d4 Rat dehydroepiandrosterone sulfate multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene SNP affects the reaction [1-naphthol affects the abundance of Dehydroepiandrosterone Sulfate] CTD PMID:33771511 Cyp2d4 Rat Desethylchloroquine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine CTD PMID:12756207 Cyp2d4 Rat Desethylchloroquine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 desethylchloroquine results in decreased activity of CYP2D6 protein CTD PMID:11124226 Cyp2d4 Rat desipramine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Desipramine CTD PMID:15286053 Cyp2d4 Rat desloratadine affects chemical synthesis ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the chemical synthesis of desloratadine CTD PMID:15932952 Cyp2d4 Rat dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of CYP2D4 mRNA CTD PMID:11328961 Cyp2d4 Rat dexamethasone increases expression ISO Cyp2d22 (Mus musculus) 6480464 Dexamethasone results in increased expression of CYP2D22 mRNA CTD PMID:22733784 Cyp2d4 Rat dextromethorphan multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan and Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan] CTD PMID:16595712 and PMID:30503582 Cyp2d4 Rat dextromethorphan decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Dextromethorphan results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat dextromethorphan multiple interactions EXP 6480464 Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] and ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] CTD PMID:17651725 Cyp2d4 Rat dextromethorphan increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Dextromethorphan CTD PMID:17651725 Cyp2d4 Rat dextromethorphan decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Dextromethorphan CTD PMID:12433797 more ... Cyp2d4 Rat dextromethorphan increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 mRNA results in increased metabolism of Dextromethorphan and CYP2D6 protein results in increased metabolism of Dextromethorphan CTD PMID:10911933 more ... Cyp2d4 Rat dextromethorphan increases metabolic processing ISO Cyp2d22 (Mus musculus) 6480464 CYP2D22 protein results in increased metabolism of Dextromethorphan CTD PMID:16595712 and PMID:30503582 Cyp2d4 Rat dextromethorphan multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan more ... CTD PMID:15863898 more ... Cyp2d4 Rat dextromethorphan increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Dextromethorphan CTD PMID:21228393 Cyp2d4 Rat dextromethorphan affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 polymorphism affects the metabolism of Dextromethorphan more ... CTD PMID:11823760 more ... Cyp2d4 Rat dextrorphan affects chemical synthesis ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the chemical synthesis of Dextrorphan CTD PMID:15988119 Cyp2d4 Rat dextrorphan multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan CTD PMID:30503582 Cyp2d4 Rat dextrorphan multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 mRNA results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan more ... CTD PMID:21915887 more ... Cyp2d4 Rat dextrorphan increases chemical synthesis ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased chemical synthesis of Dextrorphan CTD PMID:15155557 more ... Cyp2d4 Rat diarsenic trioxide multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CYP2D6 protein] CTD PMID:26598702 Cyp2d4 Rat diarylheptanoid decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Diarylheptanoids results in decreased activity of CYP2D6 protein CTD PMID:23850985 Cyp2d4 Rat diazinon increases expression ISO CYP2D6 (Homo sapiens) 6480464 Diazinon results in increased expression of CYP2D6 mRNA CTD PMID:16757081 Cyp2d4 Rat dibenz[a,h]anthracene increases expression ISO CYP2D6 (Homo sapiens) 6480464 1 more ... CTD PMID:16269432 Cyp2d4 Rat Dibutyl phosphate affects expression ISO CYP2D6 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of CYP2D6 mRNA CTD PMID:37042841 Cyp2d4 Rat diclofenac multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac more ... CTD PMID:23397584 and PMID:24246759 Cyp2d4 Rat dihydrocapsaicin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 dihydrocapsaicin results in decreased activity of CYP2D6 protein CTD PMID:22375877 Cyp2d4 Rat Dihydrocorynantheine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 hirsutine results in decreased activity of CYP2D6 protein CTD PMID:31707106 Cyp2d4 Rat dihydroergotamine decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Dihydroergotamine results in decreased activity of CYP2D22 protein CTD PMID:18420780 Cyp2d4 Rat dihydroergotamine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Dihydroergotamine results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat dimemorfan multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Paroxetine inhibits the reaction [CYP2D6 protein results in increased oxidation of dimemorfan] CTD PMID:19593786 Cyp2d4 Rat dimemorfan increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of dimemorfan CTD PMID:19593786 Cyp2d4 Rat dimethocaine increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of dimethocaine CTD PMID:24309420 Cyp2d4 Rat dimethyl sulfoxide multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein] more ... CTD PMID:11368792 Cyp2d4 Rat dioxygen multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA] and CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA] CTD PMID:21566342 Cyp2d4 Rat diquat increases expression ISO Cyp2d22 (Mus musculus) 6480464 Diquat results in increased expression of CYP2D22 mRNA CTD PMID:36851058 Cyp2d4 Rat domperidone increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of Domperidone CTD PMID:15327587 Cyp2d4 Rat dopamine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Dopamine results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat dopamine increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of Dopamine CTD PMID:26763401 Cyp2d4 Rat dopamine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine CTD PMID:26763401 Cyp2d4 Rat doxorubicin multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Diethylhexyl Phthalate results in increased expression of CYP2D6] which results in increased metabolism of and results in decreased activity of Doxorubicin CTD PMID:34801851 Cyp2d4 Rat dronedarone multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Dronedarone] which results in decreased abundance of N-desbutyldronedarone more ... CTD PMID:29616291 Cyp2d4 Rat dronedarone decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased susceptibility to dronedarone CTD PMID:29616291 Cyp2d4 Rat dronedarone increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of dronedarone CTD PMID:29616291 Cyp2d4 Rat ellipticine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 Cyp2d4 Rat emodin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Emodin results in decreased activity of CYP2D6 protein CTD PMID:33438235 Cyp2d4 Rat endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of CYP2D4 mRNA CTD PMID:29391264 Cyp2d4 Rat epoxiconazole decreases expression ISO Cyp2d22 (Mus musculus) 6480464 epoxiconazole results in decreased expression of CYP2D22 mRNA CTD PMID:35436446 Cyp2d4 Rat erythromycin A decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Erythromycin results in decreased activity of CYP2D22 protein CTD PMID:18420780 Cyp2d4 Rat ethambutol decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Ethambutol results in decreased activity of CYP2D6 protein CTD PMID:24910189 Cyp2d4 Rat ethanol increases expression ISO CYP2D6 (Homo sapiens) 6480464 Ethanol results in increased expression of CYP2D6 mRNA and Ethanol results in increased expression of CYP2D6 protein CTD PMID:30373287 and PMID:35301062 Cyp2d4 Rat ethanol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Corticosterone promotes the reaction [Ethanol results in increased expression of CYP2D6 mRNA] CTD PMID:35301062 Cyp2d4 Rat ethanol increases expression ISO Cyp2d22 (Mus musculus) 6480464 Ethanol results in increased expression of CYP2D22 mRNA CTD PMID:30319688 Cyp2d4 Rat Ethylenethiourea multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene SNP affects the reaction [Ethylenethiourea affects the abundance of Hydrocortisone] CTD PMID:33771511 Cyp2d4 Rat eugenol increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Eugenol CTD PMID:15576237 Cyp2d4 Rat eugenol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol more ... CTD PMID:15576237 Cyp2d4 Rat eupatorin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 Cyp2d4 Rat fenofibrate multiple interactions EXP 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA CTD PMID:18253720 Cyp2d4 Rat fenproporex decreases alkylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased alkylation of fenproporex CTD PMID:15294457 Cyp2d4 Rat fenvalerate decreases activity ISO CYP2D6 (Homo sapiens) 6480464 fenvalerate results in decreased activity of CYP2D6 protein CTD PMID:20183062 Cyp2d4 Rat fipronil decreases activity ISO CYP2D6 (Homo sapiens) 6480464 fipronil results in decreased activity of CYP2D6 protein CTD PMID:31278966 Cyp2d4 Rat fipronil-sulfone decreases activity ISO CYP2D6 (Homo sapiens) 6480464 fipronil sulfone results in decreased activity of CYP2D6 protein CTD PMID:31278966 Cyp2d4 Rat flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of CYP2D4 mRNA CTD PMID:18035473 Cyp2d4 Rat fluoxetine affects abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the abundance of Fluoxetine and CYP2D6 protein affects the abundance of Fluoxetine CTD PMID:14726986 and PMID:15094477 Cyp2d4 Rat fluoxetine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Fluoxetine results in decreased activity of CYP2D6 protein CTD PMID:12173784 more ... Cyp2d4 Rat fluoxetine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Fluoxetine CTD PMID:10755579 more ... Cyp2d4 Rat fluoxetine increases metabolic processing ISO Cyp2d22 (Mus musculus) 6480464 CYP2D22 protein results in increased metabolism of Fluoxetine CTD PMID:16595712 Cyp2d4 Rat fluoxetine decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Fluoxetine CTD PMID:17470523 Cyp2d4 Rat fluoxetine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan and Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate] CTD PMID:10583026 and PMID:26599973 Cyp2d4 Rat fluoxetine affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the susceptibility to Fluoxetine CTD PMID:15172931 Cyp2d4 Rat fluoxetine decreases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in decreased metabolism of Fluoxetine CTD PMID:10755579 Cyp2d4 Rat fluoxetine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the metabolism of Fluoxetine and CYP2D6 protein affects the metabolism of Fluoxetine CTD PMID:14639062 more ... Cyp2d4 Rat flutamide multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Flutamide CTD PMID:23397584 Cyp2d4 Rat flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of CYP2D4 mRNA CTD PMID:24793618 Cyp2d4 Rat folic acid decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Folic Acid results in decreased expression of CYP2D22 mRNA CTD PMID:25006883 Cyp2d4 Rat formononetin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 formononetin results in decreased activity of CYP2D6 protein CTD PMID:26278343 Cyp2d4 Rat furan decreases expression EXP 6480464 furan results in decreased expression of CYP2D4 mRNA CTD PMID:15120968 Cyp2d4 Rat gallocatechin multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA CTD PMID:25663641 Cyp2d4 Rat gamma-hexachlorocyclohexane decreases expression ISO CYP2D6 (Homo sapiens) 6480464 Hexachlorocyclohexane results in decreased expression of CYP2D6 mRNA CTD PMID:20035023 Cyp2d4 Rat gefitinib affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Gefitinib and CYP2D6 protein polymorphism affects the metabolism of Gefitinib CTD PMID:15788367 and PMID:34936353 Cyp2d4 Rat glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of CYP2D4 mRNA CTD PMID:24136188 Cyp2d4 Rat glutathione multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac more ... CTD PMID:20825217 more ... Cyp2d4 Rat glyphosate decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Glyphosate results in decreased expression of CYP2D22 protein CTD PMID:36173347 Cyp2d4 Rat gold atom multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA CTD PMID:28433809 Cyp2d4 Rat gold atom decreases expression ISO CYP2D6 (Homo sapiens) 6480464 Gold analog results in decreased expression of CYP2D6 mRNA CTD PMID:36057382 Cyp2d4 Rat gold(0) multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA CTD PMID:28433809 Cyp2d4 Rat gold(0) decreases expression ISO CYP2D6 (Homo sapiens) 6480464 Gold analog results in decreased expression of CYP2D6 mRNA CTD PMID:36057382 Cyp2d4 Rat haloperidol affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein polymorphism affects the susceptibility to Haloperidol CTD PMID:15538130 Cyp2d4 Rat hemin multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]] more ... CTD PMID:11368792 Cyp2d4 Rat heroin increases activity ISO Cyp2d22 (Mus musculus) 6480464 Heroin results in increased activity of CYP2D6 protein CTD PMID:35914676 Cyp2d4 Rat HET0016 decreases activity ISO CYP2D6 (Homo sapiens) 6480464 HET0016 results in decreased activity of CYP2D6 protein CTD PMID:11375247 Cyp2d4 Rat hydrogen peroxide increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of Hydrogen Peroxide CTD PMID:25061110 Cyp2d4 Rat hydroquinone multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone CTD PMID:21402134 Cyp2d4 Rat hydroxychloroquine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] CTD PMID:10848718 Cyp2d4 Rat hydroxychloroquine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Hydroxychloroquine results in decreased activity of CYP2D6 protein CTD PMID:10848718 Cyp2d4 Rat hyodeoxycholic acid multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid CTD PMID:18039809 Cyp2d4 Rat Hypaconitine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of hypaconitine CTD PMID:21550385 Cyp2d4 Rat ifosfamide increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased susceptibility to Ifosfamide CTD PMID:20507880 Cyp2d4 Rat imipramine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Imipramine CTD PMID:15286053 Cyp2d4 Rat imipramine oxide increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of imipramine N-oxide CTD PMID:27320963 Cyp2d4 Rat imiquimod increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Imiquimod CTD PMID:31111189 Cyp2d4 Rat inulin multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of CYP2D22 mRNA CTD PMID:36331819 Cyp2d4 Rat isatin increases expression ISO CYP2D6 (Homo sapiens) 6480464 Isatin results in increased expression of CYP2D6 mRNA CTD PMID:15056799 Cyp2d4 Rat isocarbophos multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 Cyp2d4 Rat isoimperatorin increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 Cyp2d4 Rat isoproturon decreases activity ISO CYP2D6 (Homo sapiens) 6480464 isoproturon results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat ivermectin decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Ivermectin results in decreased activity of CYP2D22 protein CTD PMID:18420780 Cyp2d4 Rat ivermectin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Ivermectin results in decreased activity of CYP2D6 protein CTD PMID:11124226 and PMID:18420780 Cyp2d4 Rat ketoconazole multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan] more ... CTD PMID:16595712 more ... Cyp2d4 Rat ketoconazole decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Ketoconazole results in decreased expression of CYP2D22 mRNA and Ketoconazole results in decreased expression of CYP2D22 protein CTD PMID:19594327 Cyp2d4 Rat ketoconazole decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Ketoconazole results in decreased activity of CYP2D6 protein CTD PMID:15618748 Cyp2d4 Rat ketoconazole multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] and Ketoconazole inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758] CTD PMID:19230594 and PMID:24120545 Cyp2d4 Rat ketoconazole decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Ketoconazole results in decreased activity of CYP2D22 protein and Ketoconazole results in decreased activity of CYP2D6 protein CTD PMID:18420780 and PMID:22334051 Cyp2d4 Rat kojic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA and [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP2D22 mRNA CTD PMID:18544905 Cyp2d4 Rat L-ethionine affects expression EXP 6480464 Ethionine affects the expression of CYP2D4 mRNA CTD PMID:19483382 Cyp2d4 Rat L-methionine multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2D22 protein CTD PMID:27712037 Cyp2d4 Rat lamotrigine increases glutathionylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 Cyp2d4 Rat lefetamine decreases alkylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased alkylation of lephetamine CTD PMID:26276083 Cyp2d4 Rat Licochalcone A affects activity ISO CYP2D6 (Homo sapiens) 6480464 licochalcone A affects the activity of CYP2D6 protein CTD PMID:26100226 Cyp2d4 Rat lipoic acid multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 Cyp2d4 Rat lithocholic acid increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Lithocholic Acid CTD PMID:18039809 Cyp2d4 Rat lithocholic acid decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Lithocholic Acid results in decreased activity of CYP2D22 protein CTD PMID:18420780 Cyp2d4 Rat lithocholic acid multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid CTD PMID:18039809 Cyp2d4 Rat loratadine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the metabolism of Loratadine and CYP2D6 protein affects the metabolism of Loratadine CTD PMID:15932952 Cyp2d4 Rat loxapine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 results in increased metabolism of Loxapine CTD PMID:21826677 Cyp2d4 Rat maneb multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein] CTD PMID:22334051 Cyp2d4 Rat maneb decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Maneb results in decreased expression of CYP2D22 protein CTD PMID:22334051 Cyp2d4 Rat manganese atom decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 Cyp2d4 Rat manganese(0) decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 Cyp2d4 Rat mangiferin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 mangiferin results in decreased activity of CYP2D6 protein CTD PMID:22815239 Cyp2d4 Rat manidipine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 manidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 Cyp2d4 Rat Melarsoprol decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Melarsoprol results in decreased activity of CYP2D6 protein CTD PMID:11124226 Cyp2d4 Rat Mequitazine increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of mequitazine CTD PMID:15863898 Cyp2d4 Rat Mequitazine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine] CTD PMID:15863898 Cyp2d4 Rat methadone increases metabolic processing ISO Cyp2d22 (Mus musculus) 6480464 CYP2D22 protein results in increased metabolism of Methadone CTD PMID:16595712 Cyp2d4 Rat methadone decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Methadone results in decreased activity of CYP2D6 protein CTD PMID:16595712 Cyp2d4 Rat methamphetamine affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D4 gene polymorphism affects the susceptibility to Methamphetamine and CYP2D6 protein affects the susceptibility to Methamphetamine CTD PMID:18280655 and PMID:20727252 Cyp2d4 Rat methamphetamine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Methamphetamine CTD PMID:27320963 Cyp2d4 Rat methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of CYP2D4 mRNA CTD PMID:15120968 Cyp2d4 Rat methiocarb increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Methiocarb CTD PMID:27665777 Cyp2d4 Rat methiocarb multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 Cyp2d4 Rat methiocarb-sulfoxide increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 Cyp2d4 Rat methiocarb-sulfoxide multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 Cyp2d4 Rat methoxsalen decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Methoxsalen results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat methoxychlor decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Methoxychlor results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat methoxychlor decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Methoxychlor CTD PMID:12167570 and PMID:12433799 Cyp2d4 Rat metoclopramide affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the metabolism of Metoclopramide CTD PMID:16702617 Cyp2d4 Rat metoprolol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol more ... CTD PMID:10470702 more ... Cyp2d4 Rat metoprolol increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Metoprolol CTD PMID:10848718 more ... Cyp2d4 Rat metoprolol affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Metoprolol and CYP2D6 protein polymorphism affects the metabolism of Metoprolol CTD PMID:11823760 more ... Cyp2d4 Rat metoprolol affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene affects the susceptibility to Metoprolol and CYP2D6 gene polymorphism affects the susceptibility to Metoprolol CTD PMID:12172215 more ... Cyp2d4 Rat midazolam decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Midazolam results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat Mitragynine increases expression ISO CYP2D6 (Homo sapiens) 6480464 mitragynine results in increased expression of CYP2D6 protein CTD PMID:23274770 Cyp2d4 Rat Mitragynine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 mitragynine results in decreased activity of CYP2D6 protein CTD PMID:31707106 Cyp2d4 Rat mono(2-ethylhexyl) phthalate multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of CYP2D22 mRNA CTD PMID:36189433 Cyp2d4 Rat monosodium L-glutamate multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP2D22 mRNA and [Sodium Glutamate co-treated with Tea] affects the expression of CYP2D22 mRNA CTD PMID:25663641 Cyp2d4 Rat morphine affects chemical synthesis ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the chemical synthesis of Morphine CTD PMID:15625333 Cyp2d4 Rat morphine increases activity ISO Cyp2d22 (Mus musculus) 6480464 Morphine results in increased activity of CYP2D6 protein CTD PMID:35914676 Cyp2d4 Rat morphine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine CTD PMID:16595712 and PMID:21241245 Cyp2d4 Rat myricetin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 myricetin results in decreased activity of CYP2D6 protein CTD PMID:29753067 Cyp2d4 Rat N,N-Didesmethyltamoxifen multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of N more ... CTD PMID:29285606 Cyp2d4 Rat N,N-Didesmethyltamoxifen increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of N and N-didesmethyltamoxifen CTD PMID:29285606 Cyp2d4 Rat N,N-diethyl-m-toluamide increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of DEET CTD PMID:11854147 Cyp2d4 Rat N,N-diisopropyltryptamine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 N and N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 Cyp2d4 Rat N,N-diisopropyltryptamine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [N and N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 Cyp2d4 Rat N-acetyl-1,4-benzoquinone imine increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 Cyp2d4 Rat N-acetyl-S-phenyl-L-cysteine affects abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 affects the abundance of S-phenyl-N-acetylcysteine CTD PMID:10780264 Cyp2d4 Rat N-desmethylclozapine increases chemical synthesis ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 Cyp2d4 Rat N-Desmethyltamoxifen multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1 more ... CTD PMID:14652237 and PMID:29285606 Cyp2d4 Rat N-Desmethyltamoxifen increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen CTD PMID:29285606 Cyp2d4 Rat N-Desmethyltamoxifen increases abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased abundance of N-desmethyltamoxifen CTD PMID:29285606 Cyp2d4 Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA more ... CTD PMID:18253720 more ... Cyp2d4 Rat N-nitrosodiethylamine increases expression ISO Cyp2d22 (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of CYP2D22 mRNA CTD PMID:17942915 Cyp2d4 Rat N-nitrosodiethylamine multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP2D22 mRNA] CTD PMID:17942915 Cyp2d4 Rat N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of CYP2D4 mRNA CTD PMID:25380136 Cyp2d4 Rat N-Nitrosopyrrolidine decreases expression ISO CYP2D6 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of CYP2D6 mRNA CTD PMID:32234424 Cyp2d4 Rat NADP zwitterion multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1 more ... CTD PMID:20825217 more ... Cyp2d4 Rat NADP(+) multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1 more ... CTD PMID:20825217 more ... Cyp2d4 Rat naphthalene increases expression ISO CYP2D6 (Homo sapiens) 6480464 naphthalene results in increased expression of CYP2D6 mRNA CTD PMID:20500019 Cyp2d4 Rat Neferine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of and results in decreased methylation of neferine CTD PMID:25451576 Cyp2d4 Rat Neferine increases glutathionylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased glutathionylation of neferine metabolite CTD PMID:25451576 Cyp2d4 Rat nicardipine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Nicardipine CTD PMID:15863898 Cyp2d4 Rat nicardipine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Nicardipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 and PMID:15863898 Cyp2d4 Rat nicardipine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] and Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine] CTD PMID:15863898 Cyp2d4 Rat niclosamide decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Niclosamide results in decreased activity of CYP2D6 protein CTD PMID:11124226 Cyp2d4 Rat nicotine multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1 more ... CTD PMID:19594327 Cyp2d4 Rat nicotine increases expression ISO Cyp2d22 (Mus musculus) 6480464 Nicotine results in increased expression of CYP2D22 mRNA and Nicotine results in increased expression of CYP2D22 protein CTD PMID:19594327 Cyp2d4 Rat nifedipine decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Nifedipine results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat nimesulide increases glutathionylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased glutathionylation of nimesulide CTD PMID:26524229 Cyp2d4 Rat Norbuprenorphine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 norbuprenorphine results in decreased activity of CYP2D6 protein CTD PMID:12756210 Cyp2d4 Rat norcodeine multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 Cyp2d4 Rat nortriptyline increases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased hydroxylation of Nortriptyline CTD PMID:17470523 Cyp2d4 Rat nortriptyline decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline CTD PMID:11673748 Cyp2d4 Rat nortriptyline multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline] CTD PMID:11673748 Cyp2d4 Rat nortriptyline increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 Nortriptyline results in increased metabolism of CYP2D6 protein CTD PMID:18359012 Cyp2d4 Rat Notopterol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] more ... CTD PMID:32198085 Cyp2d4 Rat Notopterol increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of notopterol CTD PMID:32198085 Cyp2d4 Rat Notopterol decreases activity ISO CYP2D6 (Homo sapiens) 6480464 notopterol results in decreased activity of CYP2D6 protein CTD PMID:32198085 Cyp2d4 Rat o-anisidine increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 Cyp2d4 Rat O-methyleugenol decreases expression ISO CYP2D6 (Homo sapiens) 6480464 methyleugenol results in decreased expression of CYP2D6 mRNA CTD PMID:32234424 Cyp2d4 Rat obeticholic acid increases expression ISO CYP2D6 (Homo sapiens) 6480464 obeticholic acid results in increased expression of CYP2D6 mRNA CTD PMID:27939613 Cyp2d4 Rat ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of CYP2D4 mRNA CTD PMID:12700408 Cyp2d4 Rat olivetol decreases activity ISO CYP2D6 (Homo sapiens) 6480464 olivetol results in decreased activity of CYP2D6 protein CTD PMID:21821735 Cyp2d4 Rat omeprazole affects expression EXP 6480464 Omeprazole affects the expression of CYP2D4 mRNA CTD PMID:19483382 Cyp2d4 Rat omeprazole decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Omeprazole results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat Ondansetron increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Ondansetron CTD PMID:12464242 Cyp2d4 Rat Ondansetron affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Ondansetron CTD PMID:15286053 Cyp2d4 Rat oxatomide decreases activity ISO CYP2D6 (Homo sapiens) 6480464 oxatomide results in decreased activity of CYP2D6 protein CTD PMID:15684493 Cyp2d4 Rat oxycodone affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the susceptibility to Oxycodone CTD PMID:20590588 Cyp2d4 Rat oxycodone multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone CTD PMID:20590588 Cyp2d4 Rat ozagrel increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of ozagrel CTD PMID:17651725 Cyp2d4 Rat ozagrel multiple interactions EXP 6480464 ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] and ozagrel results in increased expression of and results in increased activity of CYP2D6 protein CTD PMID:17651725 Cyp2d4 Rat ozone multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of CYP2D22 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of CYP2D22 mRNA CTD PMID:34911549 Cyp2d4 Rat p-cresol increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of 4-cresol CTD PMID:16174805 Cyp2d4 Rat paclitaxel decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Paclitaxel results in decreased activity of CYP2D6 protein CTD PMID:19909766 Cyp2d4 Rat paliperidone palmitate affects abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the abundance of Paliperidone Palmitate and CYP2D6 protein affects the abundance of Paliperidone Palmitate CTD PMID:10639689 more ... Cyp2d4 Rat paraquat decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Paraquat results in decreased expression of CYP2D22 protein CTD PMID:22334051 Cyp2d4 Rat paraquat multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein] and resveratrol inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein] CTD PMID:22334051 Cyp2d4 Rat parathion affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Parathion CTD PMID:12669189 Cyp2d4 Rat parathion increases expression ISO Cyp2d22 (Mus musculus) 6480464 Parathion results in increased expression of CYP2D22 mRNA CTD PMID:34813904 Cyp2d4 Rat paroxetine increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in increased susceptibility to Paroxetine CTD PMID:15570195 Cyp2d4 Rat paroxetine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Paroxetine results in decreased activity of CYP2D6 protein CTD PMID:12173784 more ... Cyp2d4 Rat paroxetine decreases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in decreased metabolism of Paroxetine CTD PMID:15570195 Cyp2d4 Rat paroxetine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased abundance of 4-hydroxy-N-desmethyltamoxifen more ... CTD PMID:10470702 more ... Cyp2d4 Rat paroxetine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Paroxetine CTD PMID:14639062 Cyp2d4 Rat pentamidine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Pentamidine results in decreased activity of CYP2D6 protein CTD PMID:11124226 Cyp2d4 Rat perfluorodecanoic acid decreases activity ISO CYP2D6 (Homo sapiens) 6480464 perfluorodecanoic acid results in decreased activity of CYP2D6 protein CTD PMID:35121066 Cyp2d4 Rat perfluoroheptanoic acid decreases activity ISO CYP2D6 (Homo sapiens) 6480464 perfluoro-n-heptanoic acid results in decreased activity of CYP2D6 protein CTD PMID:35121066 Cyp2d4 Rat perfluorohexanesulfonic acid decreases activity ISO CYP2D6 (Homo sapiens) 6480464 perfluorohexanesulfonic acid results in decreased activity of CYP2D6 protein CTD PMID:35121066 Cyp2d4 Rat perfluorohexanesulfonic acid increases expression ISO Cyp2d22 (Mus musculus) 6480464 perfluorohexanesulfonic acid results in increased expression of CYP2D22 mRNA CTD PMID:37995155 Cyp2d4 Rat perfluorooctane-1-sulfonic acid affects expression ISO Cyp2d22 (Mus musculus) 6480464 perfluorooctane sulfonic acid affects the expression of CYP2D22 mRNA CTD PMID:19429403 Cyp2d4 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP2D22 mRNA more ... CTD PMID:36331819 Cyp2d4 Rat perfluorooctane-1-sulfonic acid decreases activity ISO CYP2D6 (Homo sapiens) 6480464 perfluorooctane sulfonic acid results in decreased activity of CYP2D6 protein CTD PMID:35121066 Cyp2d4 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 perfluorooctane sulfonic acid inhibits the reaction [CYP2D6 protein results in increased oxidation of bufuralol] CTD PMID:21964418 Cyp2d4 Rat perfluorooctanoic acid affects expression ISO Cyp2d22 (Mus musculus) 6480464 perfluorooctanoic acid affects the expression of CYP2D22 mRNA CTD PMID:19429403 Cyp2d4 Rat perfluorooctanoic acid decreases activity ISO CYP2D6 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased activity of CYP2D6 protein CTD PMID:35121066 Cyp2d4 Rat perfluorooctanoic acid decreases expression ISO Cyp2d22 (Mus musculus) 6480464 perfluorooctanoic acid results in decreased expression of CYP2D6 mRNA CTD PMID:17681415 Cyp2d4 Rat perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of CYP2D4 mRNA CTD PMID:19162173 Cyp2d4 Rat perhexiline decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased susceptibility to Perhexiline CTD PMID:28762043 Cyp2d4 Rat perhexiline multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA] more ... CTD PMID:36083301 Cyp2d4 Rat Perhexiline maleate multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein inhibits the reaction [[perhexiline maleate results in increased abundance of Perhexiline] which results in increased expression of ATF4 mRNA] more ... CTD PMID:36083301 Cyp2d4 Rat phenanthrene increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of phenanthrene CTD PMID:9429232 Cyp2d4 Rat phencyclidine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Phencyclidine CTD PMID:16782764 Cyp2d4 Rat phenobarbital decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Phenobarbital results in decreased activity of CYP2D6 protein CTD PMID:19909766 Cyp2d4 Rat phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of CYP2D22 mRNA CTD PMID:20607812 Cyp2d4 Rat phenobarbital decreases expression ISO CYP2D6 (Homo sapiens) 6480464 Phenobarbital results in decreased expression of CYP2D6 protein CTD PMID:35881160 Cyp2d4 Rat phenthoate decreases activity ISO CYP2D6 (Homo sapiens) 6480464 phenthoate results in decreased activity of CYP2D6 protein CTD PMID:20183062 Cyp2d4 Rat phenytoin multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 Cyp2d4 Rat PhIP increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine CTD PMID:17279779 Cyp2d4 Rat PhIP multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:17279779 Cyp2d4 Rat phlorizin increases expression ISO Cyp2d22 (Mus musculus) 6480464 Phlorhizin results in increased expression of CYP2D6 mRNA CTD PMID:22538082 Cyp2d4 Rat pirinixic acid decreases expression ISO Cyp2d22 (Mus musculus) 6480464 pirinixic acid results in decreased expression of CYP2D22 mRNA CTD PMID:20813756 Cyp2d4 Rat pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of CYP2D4 mRNA CTD PMID:19162173 Cyp2d4 Rat pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of CYP2D4 mRNA CTD PMID:19483382 Cyp2d4 Rat pirinixic acid increases expression ISO Cyp2d22 (Mus musculus) 6480464 pirinixic acid results in increased expression of CYP2D22 mRNA CTD PMID:17426115 Cyp2d4 Rat poly(styrene) multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein] CTD PMID:19909766 Cyp2d4 Rat poly(styrene) decreases activity ISO CYP2D6 (Homo sapiens) 6480464 styrofoam analog results in decreased activity of CYP2D6 protein CTD PMID:19909766 Cyp2d4 Rat potassium bromate affects expression ISO Cyp2d22 (Mus musculus) 6480464 potassium bromate affects the expression of CYP2D22 mRNA CTD PMID:27082013 Cyp2d4 Rat potassium bromate multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA more ... CTD PMID:27082013 Cyp2d4 Rat potassium dichromate increases expression ISO Cyp2d22 (Mus musculus) 6480464 Potassium Dichromate results in increased expression of CYP2D22 mRNA CTD PMID:23608068 Cyp2d4 Rat potassium dichromate increases expression ISO CYP2D6 (Homo sapiens) 6480464 Potassium Dichromate results in increased expression of CYP2D6 mRNA CTD PMID:18332044 Cyp2d4 Rat primaquine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Primaquine CTD PMID:12920490 Cyp2d4 Rat primaquine increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased susceptibility to Primaquine CTD PMID:26477383 Cyp2d4 Rat primaquine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Primaquine CTD PMID:19616568 Cyp2d4 Rat primaquine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine CTD PMID:19616568 Cyp2d4 Rat prochloraz decreases expression ISO CYP2D6 (Homo sapiens) 6480464 prochloraz results in decreased expression of CYP2D6 mRNA CTD PMID:20035023 Cyp2d4 Rat proguanil decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Proguanil results in decreased activity of CYP2D6 protein CTD PMID:11124226 Cyp2d4 Rat promethazine decreases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in decreased metabolism of Promethazine CTD PMID:19814645 Cyp2d4 Rat propafenone affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein mutant form affects the susceptibility to Propafenone CTD PMID:12421483 Cyp2d4 Rat propafenone increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Propafenone CTD PMID:35442037 Cyp2d4 Rat propranolol increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of Propranolol CTD PMID:19853591 Cyp2d4 Rat propranolol increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Propranolol CTD PMID:12464242 and PMID:21184751 Cyp2d4 Rat propranolol affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Propranolol CTD PMID:15286053 Cyp2d4 Rat pyrantel affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Pyrantel CTD PMID:12920490 Cyp2d4 Rat pyrazinecarboxamide increases expression EXP 6480464 Pyrazinamide results in increased expression of CYP2D4 mRNA CTD PMID:22431067 Cyp2d4 Rat pyrrolidines affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Pyrrolidines CTD PMID:21053377 Cyp2d4 Rat quercetin decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Quercetin results in decreased activity of CYP2D22 protein CTD PMID:18420780 Cyp2d4 Rat quercetin multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 Cyp2d4 Rat quercetin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Quercetin results in decreased activity of CYP2D6 protein CTD PMID:18420780 and PMID:29753067 Cyp2d4 Rat quinidine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone more ... CTD PMID:11377097 more ... Cyp2d4 Rat quinidine decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Quinidine results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat quinidine multiple interactions EXP 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 Cyp2d4 Rat quinidine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Quinidine results in decreased activity of CYP2D6 gene mutant form and Quinidine results in decreased activity of CYP2D6 protein CTD PMID:11673748 more ... Cyp2d4 Rat quinidine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Quinidine CTD PMID:17702393 Cyp2d4 Rat quinine multiple interactions EXP 6480464 Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] CTD PMID:14979094 Cyp2d4 Rat resveratrol multiple interactions ISO Cyp2d22 (Mus musculus) 6480464 resveratrol inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein] CTD PMID:22334051 Cyp2d4 Rat resveratrol decreases activity ISO Cyp2d22 (Mus musculus) 6480464 resveratrol results in decreased activity of CYP2D22 protein CTD PMID:18420780 Cyp2d4 Rat resveratrol decreases activity ISO CYP2D6 (Homo sapiens) 6480464 resveratrol results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat resveratrol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 resveratrol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] CTD PMID:20716633 Cyp2d4 Rat Rhein decreases activity ISO CYP2D6 (Homo sapiens) 6480464 rhein results in decreased activity of CYP2D6 protein CTD PMID:33438235 Cyp2d4 Rat rifampicin increases expression ISO CYP2D6 (Homo sapiens) 6480464 Rifampin results in increased expression of CYP2D6 mRNA CTD PMID:19041851 and PMID:33844597 Cyp2d4 Rat rifampicin increases activity ISO CYP2D6 (Homo sapiens) 6480464 Rifampin results in increased activity of CYP2D6 protein CTD PMID:33844597 Cyp2d4 Rat rifampicin decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Rifampin results in decreased expression of CYP2D22 mRNA CTD PMID:30503582 Cyp2d4 Rat risperidone affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the metabolism of Risperidone and CYP2D6 protein affects the metabolism of Risperidone CTD PMID:15669884 more ... Cyp2d4 Rat risperidone decreases hydroxylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in decreased hydroxylation of Risperidone CTD PMID:15565299 Cyp2d4 Rat risperidone affects abundance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the abundance of Risperidone and CYP2D6 protein affects the abundance of Risperidone CTD PMID:15089809 more ... Cyp2d4 Rat risperidone multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the metabolism of and affects the abundance of Risperidone and CYP2D6 protein affects the metabolism of and affects the abundance of Risperidone CTD PMID:10639689 and PMID:15260906 Cyp2d4 Rat risperidone increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Risperidone CTD PMID:16044105 more ... Cyp2d4 Rat risperidone increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased susceptibility to Risperidone CTD PMID:23609392 Cyp2d4 Rat risperidone affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the susceptibility to Risperidone and CYP2D6 protein polymorphism affects the susceptibility to Risperidone CTD PMID:15669884 and PMID:23609392 Cyp2d4 Rat risperidone decreases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in decreased metabolism of Risperidone CTD PMID:17541883 Cyp2d4 Rat ritonavir affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Ritonavir CTD PMID:15286053 Cyp2d4 Rat rotenone increases expression EXP 6480464 Rotenone results in increased expression of CYP2D4 mRNA CTD PMID:28374803 Cyp2d4 Rat rubiadin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 rubiadin results in decreased activity of CYP2D6 protein CTD PMID:33438235 Cyp2d4 Rat Sabeluzole increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of sabeluzole CTD PMID:11259989 Cyp2d4 Rat safrole decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Safrole results in decreased activity of CYP2D6 protein CTD PMID:15778010 Cyp2d4 Rat safrole increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Safrole CTD PMID:20507880 Cyp2d4 Rat safrole multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Safrole] which results in increased abundance of 1'-hydroxysafrole CTD PMID:20507880 Cyp2d4 Rat Salinomycin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 salinomycin results in decreased activity of CYP2D6 protein CTD PMID:26282489 Cyp2d4 Rat saracatinib increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of saracatinib CTD PMID:27769111 Cyp2d4 Rat sarpogrelate decreases activity ISO CYP2D6 (Homo sapiens) 6480464 sarpogrelate metabolite results in decreased activity of CYP2D6 protein and sarpogrelate results in decreased activity of CYP2D6 protein CTD PMID:24167220 Cyp2d4 Rat sarpogrelate multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] and sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan] CTD PMID:24167220 Cyp2d4 Rat Senkirkine decreases expression ISO CYP2D6 (Homo sapiens) 6480464 senkirkine results in decreased expression of CYP2D6 mRNA CTD PMID:26100227 Cyp2d4 Rat serpentine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 serpentine (alkaloid) results in decreased activity of CYP2D6 protein CTD PMID:15930738 Cyp2d4 Rat serpentine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] CTD PMID:15930738 Cyp2d4 Rat sertraline multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of and results in increased metabolism of Sertraline CTD PMID:15547048 Cyp2d4 Rat Shikonin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 shikonin results in decreased activity of CYP2D6 protein CTD PMID:28941798 Cyp2d4 Rat sibutramine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 sibutramine results in decreased activity of CYP2D6 protein CTD PMID:23777987 Cyp2d4 Rat simvastatin affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 polymorphism affects the susceptibility to Simvastatin CTD PMID:11753271 Cyp2d4 Rat sodium arsenite decreases expression ISO CYP2D6 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of CYP2D6 protein CTD PMID:11368792 Cyp2d4 Rat sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of CYP2D4 mRNA CTD PMID:25993096 Cyp2d4 Rat sophoranone decreases activity ISO CYP2D6 (Homo sapiens) 6480464 sophoranone results in decreased activity of CYP2D6 protein CTD PMID:29753067 Cyp2d4 Rat sparteine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Sparteine CTD PMID:11907490 Cyp2d4 Rat Sudan I multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 Cyp2d4 Rat Sudan I increases oxidation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 Cyp2d4 Rat sulindac multiple interactions EXP 6480464 [Sulindac co-treated with lipopolysaccharide and E coli O55-B5] affects the expression of CYP2D4 mRNA CTD PMID:20371263 Cyp2d4 Rat tamoxifen increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Tamoxifen and CYP2D6 protein results in increased susceptibility to Tamoxifen CTD PMID:19244106 and PMID:21152245 Cyp2d4 Rat tamoxifen decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Tamoxifen results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat tamoxifen increases expression ISO CYP2D6 (Homo sapiens) 6480464 Tamoxifen results in increased expression of CYP2D6 protein CTD PMID:19812351 Cyp2d4 Rat tamoxifen decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Tamoxifen CTD PMID:20309015 Cyp2d4 Rat tamoxifen increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Tamoxifen CTD PMID:20123649 Cyp2d4 Rat tamoxifen affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the metabolism of Tamoxifen CTD PMID:15632378 more ... Cyp2d4 Rat tamoxifen affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the susceptibility to Tamoxifen and CYP2D6 polymorphism affects the susceptibility to Tamoxifen CTD PMID:19189210 more ... Cyp2d4 Rat tamoxifen multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen more ... CTD PMID:20124171 more ... Cyp2d4 Rat tegaserod increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of tegaserod CTD PMID:11560869 Cyp2d4 Rat tegaserod multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod] CTD PMID:11560869 Cyp2d4 Rat tegaserod decreases activity ISO CYP2D6 (Homo sapiens) 6480464 tegaserod results in decreased activity of CYP2D6 protein CTD PMID:11560869 Cyp2d4 Rat terbinafine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 terbinafine results in decreased activity of CYP2D6 protein CTD PMID:24894748 Cyp2d4 Rat terbinafine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] CTD PMID:24894748 Cyp2d4 Rat testosterone decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Testosterone results in decreased activity of CYP2D22 protein CTD PMID:18420780 Cyp2d4 Rat testosterone increases expression ISO Cyp2d22 (Mus musculus) 6480464 Testosterone deficiency results in increased expression of CYP2D22 mRNA CTD PMID:33848595 Cyp2d4 Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CYP2D4 mRNA CTD PMID:12921627 Cyp2d4 Rat tetrachloromethane decreases expression ISO Cyp2d22 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of CYP2D22 mRNA CTD PMID:17484886 more ... Cyp2d4 Rat thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of CYP2D4 mRNA CTD PMID:19483382 Cyp2d4 Rat thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP2D22 mRNA CTD PMID:28943392 Cyp2d4 Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of CYP2D4 mRNA CTD PMID:23411599 and PMID:34492290 Cyp2d4 Rat thioridazine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine and CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 and PMID:23397584 Cyp2d4 Rat ticlopidine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite CTD PMID:19170597 Cyp2d4 Rat ticlopidine decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Ticlopidine results in decreased activity of CYP2D6 protein CTD PMID:10759690 Cyp2d4 Rat titanium dioxide increases expression ISO Cyp2d22 (Mus musculus) 6480464 titanium dioxide results in increased expression of CYP2D22 mRNA CTD PMID:23557971 and PMID:29264374 Cyp2d4 Rat titanium dioxide increases expression ISO CYP2D6 (Homo sapiens) 6480464 titanium dioxide results in increased expression of CYP2D6 mRNA CTD PMID:34973136 Cyp2d4 Rat tofacitinib increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of tofacitinib CTD PMID:31414593 Cyp2d4 Rat tolterodine tartrate increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Tolterodine Tartrate CTD PMID:10583026 Cyp2d4 Rat tolterodine tartrate affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate CTD PMID:28087463 Cyp2d4 Rat tolterodine tartrate multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate] CTD PMID:10583026 Cyp2d4 Rat toluene affects expression EXP 6480464 Toluene affects the expression of CYP2D22 mRNA CTD PMID:18653662 Cyp2d4 Rat toluene increases expression EXP 6480464 Toluene results in increased expression of CYP2D4 mRNA CTD PMID:14703099 Cyp2d4 Rat toluene multiple interactions EXP 6480464 Toluene results in increased expression of and results in increased activity of CYP2D4 protein CTD PMID:14703099 Cyp2d4 Rat tramadol affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 affects the susceptibility to Tramadol more ... CTD PMID:16497087 more ... Cyp2d4 Rat tramadol affects methylation ISO Cyp2d22 (Mus musculus) 6480464 CYP2D6 protein affects the methylation of Tramadol CTD PMID:12893130 Cyp2d4 Rat tramadol decreases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CTD PMID:16960721 Cyp2d4 Rat tramadol multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol more ... CTD PMID:18204346 and PMID:29555325 Cyp2d4 Rat tramadol increases response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in increased susceptibility to Tramadol CTD PMID:18204346 Cyp2d4 Rat tramadol affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form affects the metabolism of Tramadol and CYP2D6 gene polymorphism affects the metabolism of Tramadol CTD PMID:12191703 more ... Cyp2d4 Rat tramadol decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Tramadol CTD PMID:14624403 more ... Cyp2d4 Rat tramadol increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form results in increased metabolism of Tramadol and CYP2D6 protein results in increased metabolism of Tramadol CTD PMID:18204346 more ... Cyp2d4 Rat trans-cinnamic acid decreases activity ISO CYP2D6 (Homo sapiens) 6480464 cinnamic acid analog results in decreased activity of CYP2D6 protein CTD PMID:15072549 Cyp2d4 Rat tranylcypromine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 Cyp2d4 Rat trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of CYP2D4 mRNA CTD PMID:33387578 Cyp2d4 Rat triclosan increases expression ISO CYP2D6 (Homo sapiens) 6480464 Triclosan results in increased expression of CYP2D6 mRNA CTD PMID:29849464 Cyp2d4 Rat triflumuron increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of triflumuron CTD PMID:31082524 Cyp2d4 Rat trimellitic anhydride decreases expression ISO Cyp2d22 (Mus musculus) 6480464 trimellitic anhydride results in decreased expression of CYP2D22 mRNA CTD PMID:19042947 Cyp2d4 Rat troglitazone multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to troglitazone CTD PMID:23397584 Cyp2d4 Rat tryptamines decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Tryptamines analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 Cyp2d4 Rat tryptamines multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [Tryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 Cyp2d4 Rat tyramine multiple interactions ISO CYP2D6 (Homo sapiens) 6480464 [CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine CTD PMID:26763401 Cyp2d4 Rat tyramine increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Tyramine CTD PMID:26763401 Cyp2d4 Rat valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of CYP2D4 mRNA CTD PMID:24136188 Cyp2d4 Rat valproic acid affects expression ISO Cyp2d22 (Mus musculus) 6480464 Valproic Acid affects the expression of CYP2D22 mRNA CTD PMID:17292431 Cyp2d4 Rat valproic acid decreases expression ISO CYP2D6 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of CYP2D6 mRNA CTD PMID:29501571 Cyp2d4 Rat valproic acid increases methylation ISO CYP2D6 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of CYP2D6 gene CTD PMID:29154799 Cyp2d4 Rat vancomycin increases expression ISO Cyp2d22 (Mus musculus) 6480464 Vancomycin results in increased expression of CYP2D22 mRNA CTD PMID:18930951 Cyp2d4 Rat veliparib increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of veliparib CTD PMID:21436403 Cyp2d4 Rat venlafaxine hydrochloride affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the susceptibility to Venlafaxine Hydrochloride CTD PMID:17803873 Cyp2d4 Rat venlafaxine hydrochloride affects methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the methylation of Venlafaxine Hydrochloride CTD PMID:10877013 and PMID:10933885 Cyp2d4 Rat venlafaxine hydrochloride decreases methylation ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in decreased methylation of Venlafaxine Hydrochloride CTD PMID:10877013 and PMID:10933885 Cyp2d4 Rat venlafaxine hydrochloride decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Venlafaxine Hydrochloride results in decreased activity of CYP2D6 protein CTD PMID:15632378 Cyp2d4 Rat venlafaxine hydrochloride affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene mutant form affects the metabolism of Venlafaxine Hydrochloride and CYP2D6 gene polymorphism affects the metabolism of Venlafaxine Hydrochloride CTD PMID:10774634 more ... Cyp2d4 Rat venlafaxine hydrochloride increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride CTD PMID:10774634 more ... Cyp2d4 Rat verapamil decreases activity ISO Cyp2d22 (Mus musculus) 6480464 Verapamil results in decreased activity of CYP2D22 protein and Verapamil results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat vernakalant increases metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein results in increased metabolism of vernakalant CTD PMID:18927241 Cyp2d4 Rat vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of CYP2D4 mRNA CTD PMID:23034163 Cyp2d4 Rat warfarin decreases activity ISO CYP2D6 (Homo sapiens) 6480464 Warfarin results in decreased activity of CYP2D6 protein CTD PMID:18420780 Cyp2d4 Rat yohimbine affects metabolic processing ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 gene polymorphism affects the metabolism of Yohimbine CTD PMID:15289791 Cyp2d4 Rat yohimbine affects response to substance ISO CYP2D6 (Homo sapiens) 6480464 CYP2D6 protein affects the susceptibility to Yohimbine CTD PMID:34027562 Cyp2d4 Rat zerumbone decreases expression ISO CYP2D6 (Homo sapiens) 6480464 zerumbone results in decreased expression of CYP2D6 mRNA CTD PMID:36122806 Cyp2d4 Rat zinc atom increases expression ISO CYP2D6 (Homo sapiens) 6480464 Zinc deficiency results in increased expression of CYP2D6 mRNA CTD PMID:18356318 Cyp2d4 Rat zinc(0) increases expression ISO CYP2D6 (Homo sapiens) 6480464 Zinc deficiency results in increased expression of CYP2D6 mRNA CTD PMID:18356318
