Cyp2d4 (cytochrome P450, family 2, subfamily d, polypeptide 4) - Rat Genome Database

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Gene: Cyp2d4 (cytochrome P450, family 2, subfamily d, polypeptide 4) Rattus norvegicus
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
RGD ID: 620640
Description: Enables arachidonic acid monooxygenase activity and progesterone 21-hydroxylase activity. Involved in several processes, including arachidonic acid metabolic process; oxidative demethylation; and phenol-containing compound biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); PARTICIPATES IN celecoxib pharmacodynamics pathway; celecoxib pharmacokinetics pathway; citalopram pharmacodynamics pathway; INTERACTS WITH (S)-duloxetine hydrochloride; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: Cyp2d18; Cyp2d22; Cyp2d4v1; Cyp2d4v2; Cyp2d6; Cyp2d6_mapped; CYPIID18; CYPIID4; cytochrome P450 2D-29; cytochrome P450 2D-35; cytochrome P450 2D18; cytochrome P450 2D4; Cytochrome P450 subfamily IID4; cytochrome P450, family 2, subfamily d, polypeptide 22; cytochrome P450, subfamily 2D, polypeptide 6; Cytochrome P450, subfamily IID, polypeptide 6; cytochrome P450, subfamily IID, polypeptide 6 (mapped); Cytochrome P450, subfamily IID4; cytochrome P450-CMF3; cytochrome P450-DB4; debrisoquine 4-hydroxylase; P450 2D-29/2D-35; P450-CMF3; P450-DB4
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27113,882,584 - 113,891,754 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,881,618 - 113,891,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,638,375 - 115,646,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,861,892 - 117,871,066 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,831,341 - 117,840,516 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,599,264 - 123,608,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,599,266 - 123,608,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,583,983 - 123,593,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,742,273 - 120,752,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17120,775,536 - 120,786,502 (-)NCBI
Celera7110,197,422 - 110,206,650 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E,E)-germacrone  (ISO)
(R)-lipoic acid  (ISO)
(R,R)-tramadol  (ISO)
(S)-duloxetine hydrochloride  (EXP)
(S)-nicotine  (ISO)
(S)-timolol (anhydrous)  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,4-naphthoquinone  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-xylenol  (ISO)
3-methylcholanthrene  (EXP)
3-methylthiopropanal  (ISO)
4'-hydroxydiclofenac  (ISO)
4'-hydroxypropanolol  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(methylsulfinyl)phenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-Hydroxyclonidine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Ipomeanol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-hydroxydiclofenac  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
5-methoxy-N,N-diisopropyltryptamine  (ISO)
5-methoxyindole  (ISO)
5-methoxytryptamine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
a-Methyldopamine  (ISO)
aconitine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
ajmalicine  (ISO)
all-trans-retinoic acid  (ISO)
almotriptan  (ISO)
alpha-methyltryptamine  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
amitriptylinoxide  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphetamine  (ISO)
amphetamines  (ISO)
aniline  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atomoxetine hydrochloride  (ISO)
Auriculasin  (ISO)
bacitracin  (EXP)
barnidipine  (ISO)
benidipine  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-carboline  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
Bufuralol  (EXP,ISO)
buprenorphine  (ISO)
buspirone  (EXP,ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
Cannabidivarin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
Carnosol  (ISO)
carvedilol  (ISO)
chelidonine  (ISO)
chlordecone  (ISO)
chloroquine  (ISO)
chlorphenamine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cimetidine  (EXP,ISO)
cinacalcet  (ISO)
cisplatin  (EXP)
citalopram  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clopidogrel  (ISO)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
codeine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP,ISO)
coumarins  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (EXP,ISO)
cypermethrin  (ISO)
dacomitinib  (ISO)
daidzein  (ISO)
dapsone  (ISO)
debrisoquin  (ISO)
Desethylchloroquine  (ISO)
desipramine  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
dextromethorphan  (EXP,ISO)
dextrorphan  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dihydrocapsaicin  (ISO)
Dihydrocorynantheine  (ISO)
dihydroergotamine  (ISO)
dimemorfan  (ISO)
dimethocaine  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
domperidone  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
ellipticine  (ISO)
emodin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythromycin A  (ISO)
ethambutol  (ISO)
ethanol  (ISO)
eugenol  (ISO)
eupatorin  (ISO)
fenofibrate  (EXP)
fenproporex  (ISO)
fenvalerate  (ISO)
fipronil  (ISO)
fipronil-sulfone  (ISO)
flavonoids  (EXP)
fluoxetine  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
formononetin  (ISO)
furan  (EXP)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (ISO)
glafenine  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (ISO)
hemin  (ISO)
heroin  (ISO)
HET0016  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hyodeoxycholic acid  (EXP)
Hypaconitine  (ISO)
ifosfamide  (ISO)
imipramine  (ISO)
imipramine oxide  (ISO)
imiquimod  (ISO)
inulin  (ISO)
isatin  (ISO)
isocarbophos  (ISO)
isoimperatorin  (ISO)
isoproturon  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
kojic acid  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lamotrigine  (ISO)
lefetamine  (ISO)
Licochalcone A  (ISO)
lipoic acid  (ISO)
lithocholic acid  (EXP,ISO)
loratadine  (ISO)
loxapine  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mangiferin  (ISO)
manidipine  (ISO)
Melarsoprol  (ISO)
Mequitazine  (ISO)
methadone  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methiocarb  (ISO)
methiocarb-sulfoxide  (ISO)
methoxsalen  (ISO)
methoxychlor  (ISO)
metoclopramide  (ISO)
metoprolol  (ISO)
midazolam  (ISO)
Mitragynine  (ISO)
monosodium L-glutamate  (ISO)
morphine  (ISO)
myricetin  (ISO)
N,N-Didesmethyltamoxifen  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-diisopropyltryptamine  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-S-phenyl-L-cysteine  (ISO)
N-desmethylclozapine  (ISO)
N-Desmethyltamoxifen  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
Neferine  (ISO)
nicardipine  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nifedipine  (ISO)
nimesulide  (ISO)
Norbuprenorphine  (ISO)
norcodeine  (ISO)
nortriptyline  (ISO)
Notopterol  (ISO)
o-anisidine  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
olivetol  (ISO)
omeprazole  (EXP,ISO)
Ondansetron  (ISO)
oxatomide  (ISO)
oxycodone  (ISO)
ozagrel  (EXP)
ozone  (ISO)
p-cresol  (ISO)
paclitaxel  (ISO)
paliperidone palmitate  (ISO)
paraquat  (ISO)
parathion  (ISO)
paroxetine  (ISO)
pentamidine  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phenanthrene  (ISO)
phencyclidine  (ISO)
phenobarbital  (EXP,ISO)
phenthoate  (ISO)
phenytoin  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
poly(styrene)  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
primaquine  (ISO)
prochloraz  (ISO)
proguanil  (ISO)
promethazine  (ISO)
propafenone  (ISO)
propranolol  (ISO)
pyrantel  (ISO)
pyrazinecarboxamide  (EXP)
pyrrolidines  (ISO)
quercetin  (ISO)
quinidine  (EXP,ISO)
quinine  (EXP)
resveratrol  (ISO)
Rhein  (ISO)
rifampicin  (ISO)
risperidone  (ISO)
ritonavir  (ISO)
rotenone  (EXP)
rubiadin  (ISO)
Sabeluzole  (ISO)
safrole  (ISO)
Salinomycin  (ISO)
saracatinib  (ISO)
sarpogrelate  (ISO)
Senkirkine  (ISO)
serpentine  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
sibutramine  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sophoranone  (ISO)
sparteine  (ISO)
Sudan I  (ISO)
sulindac  (EXP)
tamoxifen  (ISO)
tegaserod  (ISO)
terbinafine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
ticlopidine  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tolterodine tartrate  (ISO)
toluene  (EXP)
tramadol  (ISO)
trans-cinnamic acid  (ISO)
tranylcypromine  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triflumuron  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tryptamines  (ISO)
tyramine  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
veliparib  (ISO)
venlafaxine hydrochloride  (ISO)
verapamil  (ISO)
vernakalant  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)
yohimbine  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model. Anderson GD, etal., AAPS J. 2015 Sep;17(5):1255-67. doi: 10.1208/s12248-015-9792-y. Epub 2015 Jun 12.
2. The ability of cytochrome P450 2D isoforms to synthesize dopamine in the brain: An in vitro study. Bromek E, etal., Eur J Pharmacol. 2010 Jan 25;626(2-3):171-8. Epub 2009 Oct 8.
3. Changes in maternal liver Cyp2c and Cyp2d expression and activity during rat pregnancy. Dickmann LJ, etal., Biochem Pharmacol. 2008 Apr 15;75(8):1677-87. Epub 2008 Feb 7.
4. [Association of xenobiotic-metabolizing gene polymorphisms with childhood atopic diseases in Russian patients from the Republic of Bashkortostan]. Fedorova IuIu, etal., Mol Biol (Mosk). 2009 Nov-Dec;43(6):1032-9.
5. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Gaedigk A, etal., Am J Hum Genet 1991 May;48(5):943-50.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon. Gilbert EA, etal., J Neural Transm 2003 Oct;110(10):1091-101.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. The catalytic competence of cytochrome P450 in the synthesis of serotonin from 5-methoxytryptamine in the brain: an in vitro study. Haduch A, etal., Pharmacol Res. 2013 Jan;67(1):53-9. doi: 10.1016/j.phrs.2012.10.009. Epub 2012 Oct 23.
10. Progesterone oxidation by cytochrome P450 2D isoforms in the brain. Hiroi T, etal., Endocrinology. 2001 Sep;142(9):3901-8. doi: 10.1210/endo.142.9.8363.
11. Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily. Ishida N, etal., Biochem Biophys Res Commun 1988 Oct 31;156(2):681-8.
12. cDNA cloning of a novel rat brain cytochrome P450 belonging to the CYP2D subfamily. Kawashima H and Strobel HW, Biochem Biophys Res Commun 1995 Apr 17;209(2):535-40.
13. Genomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18* catalyzing imipramine N-demethylation. Kawashima H, etal., J Biol Chem 1996 Nov 8;271(45):28176-80.
14. Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain. Kishimoto W, etal., Endocrinology. 2004 Feb;145(2):699-705. Epub 2003 Oct 16.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics. Miksys S, etal., J Neurochem. 2002 Sep;82(6):1376-87. doi: 10.1046/j.1471-4159.2002.01069.x.
17. Detection of anti-LKM-1(anti-CYP2D6) by an enzyme-linked immunosorbent assay in adult patients with chronic liver diseases. Miyakawa H, etal., Autoimmunity. 1999;30(2):107-14.
18. A novel transcriptional element which regulates expression of the CYP2D4 gene by Oct-1 and YY-1 binding. Mizuno D, etal., Biochim Biophys Acta 2003 Jun 19;1627(2-3):121-8.
19. Regulation of CYP2D expression in rat brain by toluene. Mizuno D, etal., Osaka City Med J. 2003 Jun;49(1):49-56.
20. The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol. Narimatsu S, etal., Biochem Pharmacol. 2009 Mar 1;77(5):920-31. doi: 10.1016/j.bcp.2008.11.006. Epub 2008 Nov 17.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Association between CYP2D6 genotype and tardive dyskinesia in Korean schizophrenics. Nikoloff D, etal., Pharmacogenomics J 2002;2(6):400-7.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene-gene and gene-environment interactions for disease susceptibility. Polonikov AV, etal., J Hum Genet. 2009 Aug;54(8):440-9. Epub 2009 Jul 3.
27. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Comprehensive gene review and curation RGD comprehensive gene curation
32. Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia. Roddam PL, etal., Pharmacogenetics. 2000 Oct;10(7):605-15.
33. Cytochrome P450 2D6 and treatment of codeine dependence. Romach MK, etal., J Clin Psychopharmacol. 2000 Feb;20(1):43-5. doi: 10.1097/00004714-200002000-00008.
34. Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: a case-control study. Schillevoort I, etal., Pharmacogenetics. 2002 Apr;12(3):235-40. doi: 10.1097/00008571-200204000-00008.
35. Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children. Silveira Vda S, etal., Environ Mol Mutagen. 2010 Jan;51(1):48-56. doi: 10.1002/em.20510.
36. Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid. Thompson CM, etal., J Pharmacol Exp Ther. 2000 Sep;294(3):1120-30.
37. No influence of the polymorphisms CYP2C19 and CYP2D6 on the efficacy of cyclophosphamide, thalidomide, and bortezomib in patients with Multiple Myeloma. Vangsted AJ, etal., BMC Cancer. 2010 Aug 4;10:404. doi: 10.1186/1471-2407-10-404.
38. [Relationships between the gene polymorphisms of drug metabolizing enzymes and the outcome of the first induction chemotherapy in patients with de novo acute myeloid leukemia]. Wang N, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Apr;19(2):327-31.
39. Metabolic gene polymorphisms and risk of dysmenorrhea. Wu D, etal., Epidemiology. 2000 Nov;11(6):648-53. doi: 10.1097/00001648-200011000-00006.
40. Interaction of drug metabolizing cytochrome P450 2D6 poor metabolizers with cytochrome P450 2C9 and 2C19 genotypes modify the susceptibility to head and neck cancer and treatment response. Yadav SS, etal., Mutat Res. 2010 Feb 3;684(1-2):49-55. doi: 10.1016/j.mrfmmm.2009.11.010. Epub 2009 Nov 30.
41. Fatal intoxication cases: cytochrome P450 2D6 and 2C19 genotype distributions. Zackrisson AL, etal., Eur J Clin Pharmacol. 2004 Oct;60(8):547-52. doi: 10.1007/s00228-004-0800-x. Epub 2004 Sep 2.
42. Effect of Genetic Polymorphism of the CYP2D6 Gene on the Efficacy and Safety of Fluvoxamine in Major Depressive Disorder. Zastrozhin M, etal., Am J Ther. 2021 Jun 3;29(1):e26-e33. doi: 10.1097/MJT.0000000000001388.
43. Correlation of CpG Island Methylation of the Cytochrome P450 2E1/2D6 Genes with Liver Injury Induced by Anti-Tuberculosis Drugs: A Nested Case-Control Study. Zhang J, etal., Int J Environ Res Public Health. 2016 Aug 1;13(8). pii: ijerph13080776. doi: 10.3390/ijerph13080776.
44. Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes. Zhu Z, etal., Biochem Biophys Res Commun 2002 Sep 13;297(1):65.
Additional References at PubMed
PMID:2107330   PMID:7712118   PMID:9434752   PMID:10681376   PMID:11032406   PMID:12477932   PMID:12865317   PMID:15039299   PMID:15327587   PMID:16352597   PMID:16401082   PMID:18356043  
PMID:19219744   PMID:19420131   PMID:19438707   PMID:19448135   PMID:19651758   PMID:21289075   PMID:22162298   PMID:23235327   PMID:23623752   PMID:34096834  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.27113,882,584 - 113,891,754 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,881,618 - 113,891,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,638,375 - 115,646,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,861,892 - 117,871,066 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,831,341 - 117,840,516 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,599,264 - 123,608,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,599,266 - 123,608,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,583,983 - 123,593,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,742,273 - 120,752,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17120,775,536 - 120,786,502 (-)NCBI
Celera7110,197,422 - 110,206,650 (-)NCBICelera
Cytogenetic Map7q34NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382242,126,499 - 42,130,810 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2242,126,499 - 42,130,865 (-)EnsemblGRCh38hg38GRCh38
GRCh372242,522,501 - 42,526,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,852,445 - 40,856,827 (-)NCBINCBI36Build 36hg18NCBI36
Build 342240,847,000 - 40,851,379NCBI
Celera2226,328,694 - 26,333,076 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,488,519 - 25,492,901 (-)NCBIHuRef
CHM1_12242,482,242 - 42,486,624 (-)NCBICHM1_1
T2T-CHM13v2.02242,605,990 - 42,610,301 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391582,254,728 - 82,264,461 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,254,728 - 82,264,461 (-)EnsemblGRCm39 Ensembl
GRCm381582,370,527 - 82,380,260 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,370,527 - 82,380,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv371582,200,957 - 82,210,690 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361582,199,236 - 82,207,926 (-)NCBIMGSCv36mm8
Celera1584,494,227 - 84,513,082 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.57NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12254,654,160 - 54,664,840 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,022,449 - 23,031,627 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11023,255,259 - 23,259,380 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,255,249 - 23,259,298 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,190,268 - 23,194,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,000,262 - 24,004,211 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,000,212 - 24,004,212 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11023,717,484 - 23,721,432 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,037,966 - 24,041,898 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,212,712 - 24,216,661 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049456,804,025 - 6,843,868 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936718153,340 - 157,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl56,538,907 - 6,543,642 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.156,539,021 - 6,543,643 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,810,426 - 3,815,068 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11924,667,207 - 24,672,580 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1924,667,282 - 24,671,513 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045100,727,530 - 100,732,209 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Variants in Cyp2d4
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:107
Interacting mature miRNAs:116
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 12 12 12 15 5 1 8
Low 1 43 45 29 19 29 8 11 59 30 36 3 8
Below cutoff 4


RefSeq Acc Id: ENSRNOT00000011880   ⟹   ENSRNOP00000011880
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7113,881,618 - 113,891,759 (-)Ensembl
Rnor_6.0 Ensembl7123,599,266 - 123,608,436 (-)Ensembl
RefSeq Acc Id: NM_138515   ⟹   NP_612524
Rat AssemblyChrPosition (strand)Source
mRatBN7.27113,882,584 - 113,891,743 (-)NCBI
Rnor_6.07123,599,264 - 123,608,436 (-)NCBI
Rnor_5.07123,583,983 - 123,593,008 (-)NCBI
RGSC_v3.47120,742,273 - 120,752,274 (-)RGD
Celera7110,197,422 - 110,206,650 (-)RGD
RefSeq Acc Id: XM_039078359   ⟹   XP_038934287
Rat AssemblyChrPosition (strand)Source
mRatBN7.27113,883,929 - 113,891,754 (-)NCBI
RefSeq Acc Id: NP_612524   ⟸   NM_138515
- UniProtKB: P13108 (UniProtKB/Swiss-Prot),   O35107 (UniProtKB/Swiss-Prot),   Q566D3 (UniProtKB/Swiss-Prot),   Q64680 (UniProtKB/Swiss-Prot),   A6HT70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011880   ⟸   ENSRNOT00000011880
RefSeq Acc Id: XP_038934287   ⟸   XM_039078359
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64680-F1-model_v2 AlphaFold Q64680 1-500 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695535
Promoter ID:EPDNEW_R6060
Type:multiple initiation site
Description:cytochrome P450, family 2, subfamily d, polypeptide 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.07123,608,452 - 123,608,512EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620640 AgrOrtholog
BioCyc Gene G2FUF-32626 BioCyc
Ensembl Genes ENSRNOG00000032261 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011880 ENTREZGENE
  ENSRNOT00000011880.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2D-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171522 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp2d4 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032261 RatGTEx
Superfamily-SCOP Cytochrome P450 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  CP2D4_RAT UniProtKB/Swiss-Prot
UniProt Secondary O35107 UniProtKB/Swiss-Prot
  P13108 UniProtKB/Swiss-Prot
  Q566D3 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2d4  cytochrome P450, family 2, subfamily d, polypeptide 4  Cyp2d4v1  cytochrome P450, family 2, subfamily d, polypeptide 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-07-06 Cyp2d4v1  cytochrome P450, family 2, subfamily d, polypeptide 4  Cyp2d22  cytochrome P450, family 2, subfamily d, polypeptide 22  Name updated 1299863 APPROVED
2007-04-23 Cyp2d22  cytochrome P450, family 2, subfamily d, polypeptide 22  Cyp2d6_mapped  cytochrome P450, subfamily IID, polypeptide 6 (mapped)  Data merged from RGD:68939 737654 APPROVED
2005-11-17 Cyp2d6_mapped  cytochrome P450, subfamily IID, polypeptide 6 (mapped)      Symbol and Name updated 1556543 APPROVED
2004-09-10 Cyp2d22  cytochrome P450, family 2, subfamily d, polypeptide 22  Cyp2d18  cytochrome P450 2d18  Symbol and Name updated 1299863 APPROVED
2003-04-09 Cyp2d18  cytochrome P450 2d18      Symbol and Name updated 629477 APPROVED
2003-04-09 Cyp2d6  cytochrome P450, subfamily IID, polypeptide 6    cytochrome P450, subfamily 2D, polypeptide 6  Symbol and Name status set to approved 629479 APPROVED
2003-03-07 Cyp2d18  cytochrome P450 2d18  Cyp2d4  Cytochrome P450, subfamily IID4  Data merged from RGD:2473 628472 PROVISIONAL
2002-08-07 Cyp2d18  cytochrome P450 2D18      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Cyp2d4  Cytochrome P450, subfamily IID4      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Cyp2d6  cytochrome P450, subfamily 2D, polypeptide 6      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in skin but not in liver 625597