(R)-lipoic acid multiple interactions ISO RGD:736217 6480464 Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 (R,R)-tramadol affects response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the susceptibility to Tramadol; more ... CTD PMID:16497087 PMID:16960721 (R,R)-tramadol affects methylation ISO RGD:736218 6480464 CYP2D6 protein affects the methylation of Tramadol CTD PMID:12893130 (R,R)-tramadol decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Tramadol CTD PMID:14624403 more ... (R,R)-tramadol decreases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CTD PMID:16960721 (R,R)-tramadol increases metabolic processing ISO RGD:736217 6480464 CYP2D6 gene mutant form results in increased metabolism of Tramadol; more ... CTD PMID:18204346 more ... (R,R)-tramadol multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; more ... CTD PMID:18204346 PMID:29555325 (R,R)-tramadol increases response to substance ISO RGD:736217 6480464 CYP2D6 gene mutant form results in increased susceptibility to Tramadol CTD PMID:18204346 (R,R)-tramadol affects metabolic processing ISO RGD:736217 6480464 CYP2D6 gene mutant form affects the metabolism of Tramadol; more ... CTD PMID:12191703 more ... (RS)-amphetamine affects chemical synthesis ISO RGD:736217 6480464 CYP2D6 protein affects the chemical synthesis of Amphetamine CTD PMID:15294457 (RS)-amphetamine increases oxidation ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of Amphetamine analog CTD PMID:29277574 (RS)-amphetamine increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of Amphetamine analog CTD PMID:29277574 (RS)-amphetamine decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Amphetamine analog CTD PMID:29277574 (S)-duloxetine hydrochloride multiple interactions EXP 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride; more ... CTD PMID:20669986 (S)-nicotine multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; more ... CTD PMID:19594327 (S)-nicotine increases expression ISO RGD:736218 6480464 Nicotine results in increased expression of CYP2D22 mRNA; more ... CTD PMID:19594327 (S)-timolol (anhydrous) affects response to substance ISO RGD:736217 6480464 CYP2D6 gene SNP affects the susceptibility to Timolol CTD PMID:19284319 PMID:20925579 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane CTD PMID:9047321 1,4-naphthoquinone increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of 1,4-naphthoquinone CTD PMID:16243959 1-(3-chlorophenyl)piperazine multiple interactions ISO RGD:736217 6480464 Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine] CTD PMID:18238857 1-(3-chlorophenyl)piperazine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine CTD PMID:18238857 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Citalopram analog CTD PMID:9110356 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine CTD PMID:12464242 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; more ... CTD PMID:19594327 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression ISO RGD:736218 6480464 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA; more ... CTD PMID:19594327 1-naphthol increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of 1-naphthol CTD PMID:16243959 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of CYP2D4 mRNA CTD PMID:25380136 17alpha-ethynylestradiol multiple interactions ISO RGD:736218 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2D22 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of CYP2D22 mRNA; more ... CTD PMID:16174780 PMID:17108234 1H-pyrazole decreases expression ISO RGD:736218 6480464 pyrazole results in decreased expression of CYP2D22 mRNA CTD PMID:17945193 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736218 6480464 Tetrachlorodibenzodioxin affects the expression of CYP2D22 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP2D4 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CYP2D4 protein CTD PMID:12361703 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:736218 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP2D22 mRNA CTD PMID:19770486 PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736218 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2D22 mRNA; more ... CTD PMID:17942748 PMID:28213091 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of CYP2D22 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of CYP2D22 mRNA CTD PMID:21346803 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile decreases activity ISO RGD:736218 6480464 Verapamil results in decreased activity of CYP2D22 protein; more ... CTD PMID:18420780 3,4-methylenedioxymethamphetamine increases expression ISO RGD:736218 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CYP2D22 mRNA CTD PMID:20188158 3,4-methylenedioxymethamphetamine decreases activity ISO RGD:736217 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of CYP2D6 protein CTD PMID:16049126 PMID:24211539 3,4-methylenedioxymethamphetamine multiple interactions ISO RGD:736217 6480464 N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol] CTD PMID:16049126 3,4-methylenedioxymethamphetamine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of N-Methyl-3,4-methylenedioxyamphetamine CTD PMID:12464242 3,5-xylenol multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 3,5-xylenol increases oxidation ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of 3,5-xylenol analog CTD PMID:27665777 3-methylcholanthrene increases expression EXP 6480464 Methylcholanthrene results in increased expression of CYP2D4 mRNA CTD PMID:11328961 3-methylthiopropanal multiple interactions ISO RGD:736217 6480464 methional inhibits the reaction [[CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol] CTD PMID:15576237 4'-hydroxydiclofenac multiple interactions ISO RGD:736217 6480464 [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; more ... CTD PMID:24246759 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4,4'-diaminodiphenylmethane results in decreased expression of CYP2D4 mRNA CTD PMID:25380136 4,4'-sulfonyldiphenol increases expression EXP 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of CYP2D4 mRNA CTD PMID:26186136 4-(8-chloro-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid ethyl ester affects metabolic processing ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the metabolism of Loratadine; more ... CTD PMID:15932952 4-(methylsulfinyl)phenol multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased oxidation of 3,5-xylenol analog] which results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 4-(methylsulfinyl)phenol increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of 4-(methylsulfinyl)phenol analog CTD PMID:27665777 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:2070484 4-Hydroxy-N-desmethyltamoxifen multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen] which results in increased abundance of 4-hydroxy-N-desmethyltamoxifen metabolite; more ... CTD PMID:14652237 PMID:29285606 4-Hydroxy-N-desmethyltamoxifen increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen CTD PMID:29285606 4-Hydroxy-N-desmethyltamoxifen affects abundance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the abundance of 4-hydroxy-N-desmethyltamoxifen CTD PMID:14652237 4-hydroxyphenyl retinamide increases expression ISO RGD:736218 6480464 Fenretinide results in increased expression of CYP2D22 mRNA CTD PMID:28973697 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide decreases activity ISO RGD:736217 6480464 Niclosamide results in decreased activity of CYP2D6 protein CTD PMID:11124226 5-hydroxydiclofenac multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression EXP 6480464 Omeprazole affects the expression of CYP2D4 mRNA CTD PMID:19483382 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole decreases activity ISO RGD:736218 6480464 Omeprazole results in decreased activity of CYP2D6 protein CTD PMID:18420780 5-methoxy-N,N-diisopropyltryptamine decreases activity ISO RGD:736217 6480464 5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 5-methoxy-N,N-diisopropyltryptamine multiple interactions ISO RGD:736217 6480464 [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 5-methoxyindole-3-acetic acid multiple interactions ISO RGD:736217 6480464 CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine CTD PMID:12777961 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of CYP2D4 mRNA CTD PMID:19483382 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of CYP2D4 mRNA CTD PMID:24780913 7,12-dimethyltetraphene increases response to substance ISO RGD:736217 6480464 CYP2D6 protein results in increased susceptibility to 9,10-Dimethyl-1,2-benzanthracene CTD PMID:20507880 8-hydroxy-2'-deoxyguanosine multiple interactions ISO RGD:736217 6480464 [Eugenol co-treated with Copper co-treated with CYP2D6 protein] results in increased abundance of 8-oxo-7-hydrodeoxyguanosine CTD PMID:15576237 aconitine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Aconitine CTD PMID:21277363 aconitine multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine; more ... CTD PMID:21277363 afimoxifene increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of afimoxifene CTD PMID:29285606 afimoxifene multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite CTD PMID:29285606 aflatoxin B1 decreases expression ISO RGD:736218 6480464 Aflatoxin B1 results in decreased expression of CYP2D22 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:736217 6480464 Aflatoxin B1 results in increased methylation of CYP2D6 gene CTD PMID:27153756 aflatoxin B1 multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Aflatoxin B1 CTD PMID:23397584 ajmalicine decreases activity ISO RGD:736217 6480464 raubasine results in decreased activity of CYP2D6 protein CTD PMID:15930738 ajmalicine multiple interactions ISO RGD:736217 6480464 raubasine inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] CTD PMID:15930738 all-trans-retinoic acid decreases activity ISO RGD:736218 6480464 Tretinoin results in decreased activity of CYP2D22 protein CTD PMID:18420780 all-trans-retinoic acid decreases activity ISO RGD:736217 6480464 Tretinoin results in decreased activity of CYP2D6 protein CTD PMID:18420780 almotriptan decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of almotriptan CTD PMID:12642466 almotriptan increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of almotriptan CTD PMID:12642466 alpha-methyltryptamine multiple interactions ISO RGD:736217 6480464 [indopan analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; more ... CTD PMID:26599973 alpha-methyltryptamine decreases activity ISO RGD:736217 6480464 indopan analog results in decreased activity of CYP2D6 protein; more ... CTD PMID:26599973 amiodarone affects expression EXP 6480464 Amiodarone affects the expression of CYP2D4 mRNA CTD PMID:19483382 amiodarone increases expression ISO RGD:736217 6480464 Amiodarone results in increased expression of CYP2D6 mRNA CTD PMID:19774075 amiodarone multiple interactions ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the reaction [Amiodarone results in increased abundance of Metoprolol] CTD PMID:15541258 amiodarone decreases activity ISO RGD:736217 6480464 Amiodarone results in decreased activity of CYP2D6 protein CTD PMID:16449812 amitriptyline increases metabolic processing ISO RGD:736217 6480464 Amitriptyline results in increased metabolism of CYP2D6 protein; more ... CTD PMID:16044105 more ... amitriptyline multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline CTD PMID:23397584 amitriptyline decreases activity ISO RGD:736217 6480464 Amitriptyline results in decreased activity of CYP2D6 protein CTD PMID:18359183 amitriptylinoxide increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of amitriptyline N-oxide CTD PMID:27320963 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CYP2D4 mRNA CTD PMID:16483693 amodiaquine multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine CTD PMID:28478157 amodiaquine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Amodiaquine CTD PMID:28478157 amphetamines increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Amphetamines CTD PMID:10911933 aniline multiple interactions ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 arachidonic acid increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 atomoxetine hydrochloride increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of Atomoxetine Hydrochloride CTD PMID:17470523 bacitracin decreases expression EXP 6480464 Bacitracin results in decreased expression of CYP2D22 mRNA CTD PMID:18289764 barnidipine decreases activity ISO RGD:736217 6480464 mepirodipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 benidipine decreases activity ISO RGD:736217 6480464 benidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 benzbromarone affects expression EXP 6480464 Benzbromarone affects the expression of CYP2D4 mRNA CTD PMID:19483382 benzene increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Benzene CTD PMID:17479406 benzene increases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Benzene CTD PMID:16737584 PMID:17479406 benzo[a]pyrene decreases expression ISO RGD:736218 6480464 Benzo(a)pyrene results in decreased expression of CYP2D22 mRNA CTD PMID:19770486 benzo[a]pyrene increases expression ISO RGD:736217 6480464 Benzo(a)pyrene results in increased expression of CYP2D6 mRNA CTD PMID:16269432 benzo[b]fluoranthene increases expression ISO RGD:736217 6480464 benzo(b)fluoranthene results in increased expression of CYP2D6 mRNA CTD PMID:16269432 beta-carboline multiple interactions ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 beta-naphthoflavone decreases expression ISO RGD:736217 6480464 beta-Naphthoflavone results in decreased expression of CYP2D6 mRNA CTD PMID:22258563 bisphenol A increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of bisphenol A CTD PMID:21402134 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CYP2D6 mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CYP2D4 mRNA CTD PMID:26186136 bisphenol A multiple interactions ISO RGD:736218 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA; more ... CTD PMID:27082013 bisphenol A multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone CTD PMID:21402134 bisphenol F increases expression EXP 6480464 4,4'-bisphenol F results in increased expression of CYP2D4 mRNA CTD PMID:26186136 bortezomib affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Bortezomib CTD PMID:15764713 Bufuralol multiple interactions ISO RGD:736217 6480464 1-aminobenzotriazole inhibits the reaction [CYP2D6 protein results in increased hydroxylation of bufuralol]; more ... CTD PMID:11377097 more ... Bufuralol affects metabolic processing EXP 6480464 CYP2D6 protein affects the metabolism of bufuralol CTD PMID:15801540 Bufuralol increases oxidation ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of bufuralol CTD PMID:21964418 Bufuralol increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of bufuralol CTD PMID:10933885 more ... Bufuralol affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of bufuralol CTD PMID:15801540 Bufuralol increases hydrolysis ISO RGD:736217 6480464 CYP2D6 protein results in increased hydrolysis of bufuralol CTD PMID:11377097 Bufuralol increases hydroxylation ISO RGD:736218 6480464 CYP2D4 protein results in increased hydroxylation of bufuralol CTD PMID:15742976 Bufuralol increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of bufuralol CTD PMID:12401345 more ... buprenorphine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Buprenorphine CTD PMID:12756210 buprenorphine decreases activity ISO RGD:736217 6480464 Buprenorphine results in decreased activity of CYP2D6 protein CTD PMID:12756210 buspirone increases oxidation ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of Buspirone CTD PMID:15640381 buspirone increases expression EXP 6480464 Buspirone results in increased expression of CYP2D4 mRNA CTD PMID:24136188 butyric acid increases expression ISO RGD:736217 6480464 Butyric Acid results in increased expression of CYP2D6 mRNA CTD PMID:30439556 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of CYP2D4 mRNA CTD PMID:25993096 caffeine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Caffeine CTD PMID:15199075 calciol decreases activity ISO RGD:736217 6480464 Cholecalciferol results in decreased activity of CYP2D6 protein CTD PMID:18420780 cannabidiol decreases activity ISO RGD:736217 6480464 Cannabidiol results in decreased activity of CYP2D6 protein CTD PMID:24667653 capsaicin decreases activity ISO RGD:736217 6480464 Capsaicin results in decreased activity of CYP2D6 protein CTD PMID:22375877 carbamazepine multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Carbamazepine CTD PMID:23397584 carbendazim decreases activity ISO RGD:736217 6480464 carbendazim results in decreased activity of CYP2D6 protein CTD PMID:20183062 carbon nanotube increases expression ISO RGD:736218 6480464 Nanotubes, Carbon results in increased expression of CYP2D22 mRNA CTD PMID:25554681 carvedilol affects response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the susceptibility to carvedilol CTD PMID:20643254 carvedilol affects glucuronidation ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the glucuronidation of carvedilol CTD PMID:16849011 carvedilol affects metabolic processing ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the metabolism of carvedilol; more ... CTD PMID:15001973 more ... chloroquine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Chloroquine CTD PMID:12920490 chlorphenamine increases response to substance ISO RGD:736217 6480464 CYP2D6 mutant form results in increased susceptibility to Chlorpheniramine CTD PMID:17089107 chlorpromazine multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; more ... CTD PMID:19482014 PMID:23397584 chlorpromazine decreases response to substance ISO RGD:736217 6480464 CYP2D6 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383 chlorpyrifos increases expression ISO RGD:736217 6480464 Chlorpyrifos results in increased expression of CYP2D6 mRNA CTD PMID:16757081 chlorpyrifos decreases activity ISO RGD:736217 6480464 Chlorpyrifos results in decreased activity of CYP2D6 protein CTD PMID:20183062 chlorpyrifos multiple interactions EXP 6480464 Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] CTD PMID:14979094 chlorpyrifos increases oxidation EXP 6480464 CYP2D6 protein results in increased oxidation of Chlorpyrifos CTD PMID:14979094 choline multiple interactions ISO RGD:736218 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2D22 protein CTD PMID:27712037 cimetidine decreases activity ISO RGD:736217 6480464 Cimetidine results in decreased activity of CYP2D6 protein CTD PMID:19909766 cimetidine multiple interactions EXP 6480464 Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] CTD PMID:17651725 cimetidine decreases activity EXP 6480464 Cimetidine results in decreased activity of CYP2D6 protein CTD PMID:17651725 cimetidine multiple interactions ISO RGD:736217 6480464 styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein] CTD PMID:19909766 cinacalcet decreases activity ISO RGD:736217 6480464 Cinacalcet results in decreased activity of CYP2D6 protein CTD PMID:16680561 cinnamic acid decreases activity ISO RGD:736217 6480464 cinnamic acid analog results in decreased activity of CYP2D6 protein CTD PMID:15072549 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of CYP2D22 mRNA CTD PMID:18289764 citalopram decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Citalopram analog CTD PMID:9110356 clofibrate affects expression EXP 6480464 Clofibrate affects the expression of CYP2D4 mRNA CTD PMID:19483382 clofibric acid affects expression EXP 6480464 Clofibric Acid affects the expression of CYP2D22 mRNA CTD PMID:17602206 clopidogrel multiple interactions ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite CTD PMID:19170597 clozapine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Clozapine CTD PMID:15286053 clozapine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Clozapine CTD PMID:18809730 PMID:27320963 clozapine multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine CTD PMID:23397584 codeine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in increased metabolism of Codeine; more ... CTD PMID:10911933 more ... codeine multiple interactions ISO RGD:736217 6480464 [CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; more ... CTD PMID:16595712 PMID:21241245 codeine multiple interactions ISO RGD:736218 6480464 [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 codeine increases metabolic processing ISO RGD:736218 6480464 CYP2D22 protein results in increased metabolism of Codeine CTD PMID:16595712 codeine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Codeine; more ... CTD PMID:11823760 more ... codeine affects response to substance ISO RGD:736217 6480464 CYP2D6 protein polymorphism affects the susceptibility to Codeine CTD PMID:9696456 codeine decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Codeine CTD PMID:17470523 copper atom decreases expression EXP 6480464 Copper results in decreased expression of CYP2D22 mRNA CTD PMID:22465980 copper atom multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol; more ... CTD PMID:15576237 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of CYP2D22 mRNA CTD PMID:22465980 copper(0) multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol; more ... CTD PMID:15576237 copper(2+) decreases expression EXP 6480464 Copper results in decreased expression of CYP2D22 mRNA CTD PMID:22465980 copper(2+) multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol; more ... CTD PMID:15576237 corticosterone increases expression EXP 6480464 Corticosterone results in increased expression of CYP2D4 mRNA CTD PMID:15755911 coumarins multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins; more ... CTD PMID:23850985 cyclophosphamide increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Cyclophosphamide CTD PMID:11377097 cyhalothrin decreases activity ISO RGD:736217 6480464 cyhalothrin results in decreased activity of CYP2D6 protein CTD PMID:20183062 cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of CYP2D4 mRNA CTD PMID:29727961 cypermethrin decreases activity ISO RGD:736217 6480464 cypermethrin results in decreased activity of CYP2D6 protein CTD PMID:18420780 daidzein decreases activity ISO RGD:736218 6480464 daidzein results in decreased activity of CYP2D22 protein CTD PMID:18420780 daidzein decreases activity ISO RGD:736217 6480464 daidzein results in decreased activity of CYP2D6 protein CTD PMID:18420780 dapsone multiple interactions ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of and results in increased susceptibility to Dapsone CTD PMID:19998329 debrisoquin multiple interactions ISO RGD:736217 6480464 CYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin; more ... CTD PMID:11673748 debrisoquin decreases response to substance ISO RGD:736217 6480464 CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin CTD PMID:11673748 debrisoquin increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Debrisoquin CTD PMID:12464242 debrisoquin increases abundance ISO RGD:736217 6480464 CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite CTD PMID:11673748 debrisoquin increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of Debrisoquin CTD PMID:17470523 debrisoquin affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Debrisoquin; more ... CTD PMID:11823760 PMID:3577206 debrisoquin decreases metabolic processing ISO RGD:736217 6480464 CYP2D6 gene mutant form results in decreased metabolism of Debrisoquin; more ... CTD PMID:6603386 PMID:8946814 desipramine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Desipramine CTD PMID:15286053 desloratadine affects chemical synthesis ISO RGD:736217 6480464 CYP2D6 protein affects the chemical synthesis of desloratadine CTD PMID:15932952 dexamethasone increases expression ISO RGD:736218 6480464 Dexamethasone results in increased expression of CYP2D22 mRNA CTD PMID:22733784 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of CYP2D4 mRNA CTD PMID:11328961 dextromethorphan multiple interactions ISO RGD:736218 6480464 [CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; more ... CTD PMID:16595712 PMID:30503582 dextromethorphan decreases activity ISO RGD:736218 6480464 Dextromethorphan results in decreased activity of CYP2D6 protein CTD PMID:18420780 dextromethorphan multiple interactions EXP 6480464 Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; more ... CTD PMID:17651725 dextromethorphan increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Dextromethorphan CTD PMID:17651725 dextromethorphan decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Dextromethorphan CTD PMID:12433797 more ... dextromethorphan increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Dextromethorphan CTD PMID:10911933 more ... dextromethorphan increases metabolic processing ISO RGD:736218 6480464 CYP2D22 protein results in increased metabolism of Dextromethorphan CTD PMID:16595712 PMID:30503582 dextromethorphan multiple interactions ISO RGD:736217 6480464 [5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; more ... CTD PMID:15863898 more ... dextromethorphan increases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Dextromethorphan CTD PMID:21228393 dextromethorphan affects metabolic processing ISO RGD:736217 6480464 CYP2D6 polymorphism affects the metabolism of Dextromethorphan; more ... CTD PMID:11823760 more ... dextrorphan affects chemical synthesis ISO RGD:736217 6480464 CYP2D6 protein affects the chemical synthesis of Dextrorphan CTD PMID:15988119 dextrorphan multiple interactions ISO RGD:736218 6480464 [CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan CTD PMID:30503582 dextrorphan multiple interactions ISO RGD:736217 6480464 Paroxetine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; more ... CTD PMID:21915887 dextrorphan increases chemical synthesis ISO RGD:736217 6480464 CYP2D6 protein results in increased chemical synthesis of Dextrorphan CTD PMID:15155557 more ... diarylheptanoid decreases activity ISO RGD:736217 6480464 Diarylheptanoids results in decreased activity of CYP2D6 protein CTD PMID:23850985 diazinon increases expression ISO RGD:736217 6480464 Diazinon results in increased expression of CYP2D6 mRNA CTD PMID:16757081 dibenz[a,h]anthracene increases expression ISO RGD:736217 6480464 1,2,5,6-dibenzanthracene results in increased expression of CYP2D6 mRNA CTD PMID:16269432 diclofenac multiple interactions ISO RGD:736217 6480464 [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; more ... CTD PMID:23397584 PMID:24246759 dihydrocapsaicin decreases activity ISO RGD:736217 6480464 dihydrocapsaicin results in decreased activity of CYP2D6 protein CTD PMID:22375877 dihydroergotamine decreases activity ISO RGD:736218 6480464 Dihydroergotamine results in decreased activity of CYP2D22 protein CTD PMID:18420780 dihydroergotamine decreases activity ISO RGD:736217 6480464 Dihydroergotamine results in decreased activity of CYP2D6 protein CTD PMID:18420780 dimemorfan multiple interactions ISO RGD:736217 6480464 Paroxetine inhibits the reaction [CYP2D6 protein results in increased oxidation of dimemorfan] CTD PMID:19593786 dimemorfan increases oxidation ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of dimemorfan CTD PMID:19593786 dimethocaine increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of dimethocaine CTD PMID:24309420 dimethyl sulfoxide multiple interactions ISO RGD:736217 6480464 Dimethyl Sulfoxide inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]; more ... CTD PMID:11368792 dioxygen multiple interactions ISO RGD:736217 6480464 CYP2D6 protein inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]; more ... CTD PMID:21566342 domperidone increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of Domperidone CTD PMID:15327587 dopamine decreases activity ISO RGD:736217 6480464 Dopamine results in decreased activity of CYP2D6 protein CTD PMID:18420780 dopamine increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of Dopamine CTD PMID:26763401 dopamine multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine CTD PMID:26763401 dronedarone multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of dronedarone] which results in decreased abundance of N-desbutyldronedarone; more ... CTD PMID:29616291 dronedarone decreases response to substance ISO RGD:736217 6480464 CYP2D6 protein results in decreased susceptibility to dronedarone CTD PMID:29616291 dronedarone increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of dronedarone CTD PMID:29616291 ellipticine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein mutant form results in increased metabolism of ellipticine CTD PMID:22917556 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of CYP2D4 mRNA CTD PMID:29391264 erythromycin A decreases activity ISO RGD:736218 6480464 Erythromycin results in decreased activity of CYP2D22 protein CTD PMID:18420780 ethambutol decreases activity ISO RGD:736217 6480464 Ethambutol results in decreased activity of CYP2D6 protein CTD PMID:24910189 ethanol increases expression ISO RGD:736218 6480464 Ethanol results in increased expression of CYP2D22 mRNA CTD PMID:30319688 eugenol increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Eugenol CTD PMID:15576237 eugenol multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein co-treated with Copper] results in increased activity of Eugenol; more ... CTD PMID:15576237 eupatorin decreases activity ISO RGD:736217 6480464 eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 fenofibrate multiple interactions EXP 6480464 [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA CTD PMID:18253720 fenproporex decreases alkylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased alkylation of fenproporex CTD PMID:15294457 fenvalerate decreases activity ISO RGD:736217 6480464 fenvalerate results in decreased activity of CYP2D6 protein CTD PMID:20183062 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of CYP2D4 mRNA CTD PMID:18035473 fluoxetine affects abundance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the abundance of Fluoxetine; more ... CTD PMID:14726986 PMID:15094477 fluoxetine decreases activity ISO RGD:736217 6480464 Fluoxetine results in decreased activity of CYP2D6 protein CTD PMID:12173784 more ... fluoxetine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Fluoxetine CTD PMID:10755579 more ... fluoxetine increases metabolic processing ISO RGD:736218 6480464 CYP2D22 protein results in increased metabolism of Fluoxetine CTD PMID:16595712 fluoxetine decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Fluoxetine CTD PMID:17470523 fluoxetine multiple interactions ISO RGD:736217 6480464 [Fluoxetine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; more ... CTD PMID:10583026 PMID:26599973 fluoxetine affects response to substance ISO RGD:736217 6480464 CYP2D6 protein affects the susceptibility to Fluoxetine CTD PMID:15172931 fluoxetine decreases metabolic processing ISO RGD:736217 6480464 CYP2D6 gene mutant form results in decreased metabolism of Fluoxetine CTD PMID:10755579 fluoxetine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the metabolism of Fluoxetine; more ... CTD PMID:14639062 more ... flutamide multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Flutamide CTD PMID:23397584 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of CYP2D4 mRNA CTD PMID:24793618 folic acid decreases expression ISO RGD:736218 6480464 Folic Acid results in decreased expression of CYP2D22 mRNA CTD PMID:25006883 formononetin decreases activity ISO RGD:736217 6480464 formononetin results in decreased activity of CYP2D6 protein CTD PMID:26278343 furan decreases expression EXP 6480464 furan results in decreased expression of CYP2D4 mRNA CTD PMID:15120968 gamma-hexachlorocyclohexane decreases expression ISO RGD:736217 6480464 Hexachlorocyclohexane results in decreased expression of CYP2D6 mRNA CTD PMID:20035023 gefitinib affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of gefitinib CTD PMID:15788367 Germacrone decreases activity ISO RGD:736217 6480464 germacrone results in decreased activity of CYP2D6 protein CTD PMID:23850985 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of CYP2D4 mRNA CTD PMID:24136188 glutathione multiple interactions ISO RGD:736217 6480464 [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; more ... CTD PMID:20825217 PMID:24246759 gold atom multiple interactions ISO RGD:736217 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA CTD PMID:28433809 gold(0) multiple interactions ISO RGD:736217 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA CTD PMID:28433809 gold(1+) multiple interactions ISO RGD:736217 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA CTD PMID:28433809 haloperidol affects response to substance ISO RGD:736217 6480464 CYP2D6 protein polymorphism affects the susceptibility to Haloperidol CTD PMID:15538130 hemin multiple interactions ISO RGD:736217 6480464 Dimethyl Sulfoxide promotes the reaction [Hemin inhibits the reaction [POR protein results in decreased expression of CYP2D6 protein]]; more ... CTD PMID:11368792 hydrogen peroxide increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of Hydrogen Peroxide CTD PMID:25061110 hydroquinone multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone CTD PMID:21402134 hyodeoxycholic acid multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid CTD PMID:18039809 Hypaconitine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of hypaconitine CTD PMID:21550385 ifosfamide increases response to substance ISO RGD:736217 6480464 CYP2D6 protein results in increased susceptibility to Ifosfamide CTD PMID:20507880 imipramine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Imipramine CTD PMID:15286053 imipramine oxide increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of imipramine N-oxide CTD PMID:27320963 isatin increases expression ISO RGD:736217 6480464 Isatin results in increased expression of CYP2D6 mRNA CTD PMID:15056799 isocarbophos multiple interactions ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 isoimperatorin increases oxidation ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of isoimperatorin CTD PMID:25500267 isoproturon decreases activity ISO RGD:736217 6480464 isoproturon results in decreased activity of CYP2D6 protein CTD PMID:18420780 ivermectin decreases activity ISO RGD:736218 6480464 Ivermectin results in decreased activity of CYP2D22 protein CTD PMID:18420780 ivermectin decreases activity ISO RGD:736217 6480464 Ivermectin results in decreased activity of CYP2D6 protein CTD PMID:11124226 PMID:18420780 ketoconazole multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [CYP2D22 protein results in increased metabolism of Dextromethorphan]; more ... CTD PMID:16595712 more ... ketoconazole decreases expression ISO RGD:736218 6480464 Ketoconazole results in decreased expression of CYP2D22 mRNA; more ... CTD PMID:19594327 ketoconazole decreases activity ISO RGD:736217 6480464 Ketoconazole results in decreased activity of CYP2D6 protein CTD PMID:15618748 ketoconazole multiple interactions ISO RGD:736217 6480464 Ketoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; more ... CTD PMID:19230594 PMID:24120545 ketoconazole decreases activity ISO RGD:736218 6480464 Ketoconazole results in decreased activity of CYP2D22 protein; more ... CTD PMID:18420780 PMID:22334051 kojic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA; more ... CTD PMID:18544905 L-ethionine affects expression EXP 6480464 Ethionine affects the expression of CYP2D4 mRNA CTD PMID:19483382 L-methionine multiple interactions ISO RGD:736218 6480464 [LEP gene mutant form results in increased susceptibility to [Methionine co-treated with Choline]] which results in decreased expression of CYP2D22 protein CTD PMID:27712037 lamotrigine increases glutathionylation ISO RGD:736217 6480464 CYP2D6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 lefetamine decreases alkylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased alkylation of lephetamine CTD PMID:26276083 lipoic acid multiple interactions ISO RGD:736217 6480464 Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 lithocholic acid decreases activity ISO RGD:736218 6480464 Lithocholic Acid results in decreased activity of CYP2D22 protein CTD PMID:18420780 lithocholic acid multiple interactions EXP 6480464 [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid CTD PMID:18039809 lithocholic acid increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Lithocholic Acid CTD PMID:18039809 loxapine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 results in increased metabolism of Loxapine CTD PMID:21826677 LSM-2726 multiple interactions ISO RGD:736218 6480464 [CYP2D22 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan; more ... CTD PMID:16595712 PMID:30503582 LSM-2726 decreases activity ISO RGD:736218 6480464 Dextromethorphan results in decreased activity of CYP2D6 protein CTD PMID:18420780 LSM-2726 increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Dextromethorphan CTD PMID:10911933 more ... LSM-2726 decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Dextromethorphan CTD PMID:12433797 more ... LSM-2726 increases metabolic processing ISO RGD:736218 6480464 CYP2D22 protein results in increased metabolism of Dextromethorphan CTD PMID:16595712 PMID:30503582 LSM-2726 increases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Dextromethorphan CTD PMID:21228393 LSM-2726 multiple interactions EXP 6480464 Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; more ... CTD PMID:17651725 LSM-2726 increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of Dextromethorphan CTD PMID:17651725 LSM-2726 multiple interactions ISO RGD:736217 6480464 [5-bromotryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; more ... CTD PMID:15863898 more ... LSM-2726 affects metabolic processing ISO RGD:736217 6480464 CYP2D6 polymorphism affects the metabolism of Dextromethorphan; more ... CTD PMID:11823760 more ... maneb multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein] CTD PMID:22334051 maneb decreases expression ISO RGD:736218 6480464 Maneb results in decreased expression of CYP2D22 protein CTD PMID:22334051 manganese atom decreases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 manganese(0) decreases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 manganese(2+) decreases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 mangiferin decreases activity ISO RGD:736217 6480464 mangiferin results in decreased activity of CYP2D6 protein CTD PMID:22815239 manidipine decreases activity ISO RGD:736217 6480464 manidipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 Melarsoprol decreases activity ISO RGD:736217 6480464 Melarsoprol results in decreased activity of CYP2D6 protein CTD PMID:11124226 Mequitazine increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of mequitazine CTD PMID:15863898 Mequitazine multiple interactions ISO RGD:736217 6480464 Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine] CTD PMID:15863898 methadone increases metabolic processing ISO RGD:736218 6480464 CYP2D22 protein results in increased metabolism of Methadone CTD PMID:16595712 methadone decreases activity ISO RGD:736217 6480464 Methadone results in decreased activity of CYP2D6 protein CTD PMID:16595712 methamphetamine affects response to substance ISO RGD:736217 6480464 CYP2D4 gene polymorphism affects the susceptibility to Methamphetamine; more ... CTD PMID:18280655 PMID:20727252 methamphetamine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Methamphetamine CTD PMID:27320963 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of CYP2D4 mRNA CTD PMID:15120968 methiocarb increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Methiocarb CTD PMID:27665777 methiocarb multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 methiocarb-sulfoxide increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 methiocarb-sulfoxide multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of Methiocarb] which results in increased abundance of methiocarb sulfoxide CTD PMID:27665777 methoxsalen decreases activity ISO RGD:736217 6480464 Methoxsalen results in decreased activity of CYP2D6 protein CTD PMID:18420780 methoxychlor decreases activity ISO RGD:736217 6480464 Methoxychlor results in decreased activity of CYP2D6 protein CTD PMID:18420780 methoxychlor decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Methoxychlor CTD PMID:12167570 PMID:12433799 metoclopramide affects metabolic processing ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the metabolism of Metoclopramide CTD PMID:16702617 metoprolol multiple interactions ISO RGD:736217 6480464 [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased degradation of Metoprolol; more ... CTD PMID:10470702 more ... metoprolol increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Metoprolol CTD PMID:12464242 more ... metoprolol affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Metoprolol; more ... CTD PMID:11823760 more ... metoprolol affects response to substance ISO RGD:736217 6480464 CYP2D6 gene affects the susceptibility to Metoprolol; more ... CTD PMID:12172215 more ... midazolam decreases activity ISO RGD:736218 6480464 Midazolam results in decreased activity of CYP2D6 protein CTD PMID:18420780 Mitragynine increases expression ISO RGD:736217 6480464 mitragynine results in increased expression of CYP2D6 protein CTD PMID:23274770 morphine affects chemical synthesis ISO RGD:736217 6480464 CYP2D6 protein affects the chemical synthesis of Morphine CTD PMID:15625333 morphine multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine CTD PMID:16595712 PMID:21241245 myricetin decreases activity ISO RGD:736217 6480464 myricetin results in decreased activity of CYP2D6 protein CTD PMID:29753067 N,N-Didesmethyltamoxifen multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of N,N-didesmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene CTD PMID:29285606 N,N-Didesmethyltamoxifen increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of N,N-didesmethyltamoxifen CTD PMID:29285606 N,N-diethyl-m-toluamide increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of DEET CTD PMID:11854147 N,N-diisopropyltryptamine decreases activity ISO RGD:736217 6480464 N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 N,N-diisopropyltryptamine multiple interactions ISO RGD:736217 6480464 [N,N-diisopropyltryptamine analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 N-acetyl-1,4-benzoquinone imine increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 N-desmethylclozapine increases chemical synthesis ISO RGD:736217 6480464 CYP2D6 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 N-Desmethyltamoxifen multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene; more ... CTD PMID:14652237 PMID:29285606 N-Desmethyltamoxifen increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of N-desmethyltamoxifen CTD PMID:29285606 N-Desmethyltamoxifen increases abundance ISO RGD:736217 6480464 CYP2D6 protein results in increased abundance of N-desmethyltamoxifen CTD PMID:29285606 N-nitrosodiethylamine increases expression ISO RGD:736218 6480464 Diethylnitrosamine results in increased expression of CYP2D22 mRNA CTD PMID:17942915 N-nitrosodiethylamine multiple interactions ISO RGD:736218 6480464 MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP2D22 mRNA] CTD PMID:17942915 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA; more ... CTD PMID:18253720 more ... N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of CYP2D4 mRNA CTD PMID:25380136 NADP zwitterion multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; more ... CTD PMID:20825217 PMID:24120545 NADP(+) multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; more ... CTD PMID:20825217 PMID:24120545 naphthalene increases expression ISO RGD:736217 6480464 naphthalene results in increased expression of CYP2D6 mRNA CTD PMID:20500019 Nicardipine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Nicardipine CTD PMID:15863898 Nicardipine decreases activity ISO RGD:736217 6480464 Nicardipine results in decreased activity of CYP2D6 protein CTD PMID:10805063 PMID:15863898 Nicardipine multiple interactions ISO RGD:736217 6480464 Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; more ... CTD PMID:15863898 nicotine multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CYP2D22 mRNA]]; more ... CTD PMID:19594327 nicotine increases expression ISO RGD:736218 6480464 Nicotine results in increased expression of CYP2D22 mRNA; more ... CTD PMID:19594327 nifedipine decreases activity ISO RGD:736218 6480464 Nifedipine results in decreased activity of CYP2D6 protein CTD PMID:18420780 nimesulide increases glutathionylation ISO RGD:736217 6480464 CYP2D6 protein results in increased glutathionylation of nimesulide CTD PMID:26524229 norcodeine multiple interactions ISO RGD:736218 6480464 [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 nortriptyline increases hydroxylation ISO RGD:736217 6480464 CYP2D6 protein results in increased hydroxylation of Nortriptyline CTD PMID:17470523 nortriptyline decreases response to substance ISO RGD:736217 6480464 CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline CTD PMID:11673748 nortriptyline multiple interactions ISO RGD:736217 6480464 Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Nortriptyline] CTD PMID:11673748 nortriptyline increases metabolic processing ISO RGD:736217 6480464 Nortriptyline results in increased metabolism of CYP2D6 protein CTD PMID:18359012 o-anisidine increases oxidation ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 O-methylserotonin multiple interactions ISO RGD:736217 6480464 CYP2D6 protein binds to and results in decreased methylation of 5-Methoxytryptamine CTD PMID:12777961 obeticholic acid increases expression ISO RGD:736217 6480464 obeticholic acid results in increased expression of CYP2D6 mRNA CTD PMID:27939613 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of CYP2D4 mRNA CTD PMID:12700408 omeprazole affects expression EXP 6480464 Omeprazole affects the expression of CYP2D4 mRNA CTD PMID:19483382 omeprazole decreases activity ISO RGD:736218 6480464 Omeprazole results in decreased activity of CYP2D6 protein CTD PMID:18420780 Ondansetron increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Ondansetron CTD PMID:12464242 Ondansetron affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Ondansetron CTD PMID:15286053 Oxatomide decreases activity ISO RGD:736217 6480464 oxatomide results in decreased activity of CYP2D6 protein CTD PMID:15684493 oxycodone affects response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the susceptibility to Oxycodone CTD PMID:20590588 oxycodone multiple interactions ISO RGD:736217 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone CTD PMID:20590588 ozagrel increases metabolic processing EXP 6480464 CYP2D6 protein results in increased metabolism of ozagrel CTD PMID:17651725 ozagrel multiple interactions EXP 6480464 ozagrel promotes the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; more ... CTD PMID:17651725 p-cresol increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of 4-cresol CTD PMID:16174805 paclitaxel decreases activity ISO RGD:736217 6480464 Paclitaxel results in decreased activity of CYP2D6 protein CTD PMID:19909766 paliperidone palmitate affects abundance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the abundance of Paliperidone Palmitate; more ... CTD PMID:10639689 more ... paraquat decreases expression ISO RGD:736218 6480464 Paraquat results in decreased expression of CYP2D22 protein CTD PMID:22334051 paraquat multiple interactions ISO RGD:736218 6480464 Ketoconazole inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein]; more ... CTD PMID:22334051 parathion affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Parathion CTD PMID:12669189 paroxetine increases response to substance ISO RGD:736217 6480464 CYP2D6 gene mutant form results in increased susceptibility to Paroxetine CTD PMID:15570195 paroxetine decreases activity ISO RGD:736217 6480464 Paroxetine results in decreased activity of CYP2D6 protein CTD PMID:12173784 more ... paroxetine decreases metabolic processing ISO RGD:736217 6480464 CYP2D6 gene mutant form results in decreased metabolism of Paroxetine CTD PMID:15570195 paroxetine multiple interactions ISO RGD:736217 6480464 [Paroxetine results in decreased activity of CYP2D6 protein] which results in decreased abundance of 4-hydroxy-N-desmethyltamoxifen; more ... CTD PMID:10470702 more ... paroxetine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Paroxetine CTD PMID:14639062 pentamidine decreases activity ISO RGD:736217 6480464 Pentamidine results in decreased activity of CYP2D6 protein CTD PMID:11124226 perfluorooctane-1-sulfonic acid affects expression ISO RGD:736218 6480464 perfluorooctane sulfonic acid affects the expression of CYP2D22 mRNA CTD PMID:19429403 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:736217 6480464 perfluorooctane sulfonic acid inhibits the reaction [CYP2D6 protein results in increased oxidation of bufuralol] CTD PMID:21964418 perfluorooctanoic acid affects expression ISO RGD:736218 6480464 perfluorooctanoic acid affects the expression of CYP2D22 mRNA CTD PMID:19429403 perfluorooctanoic acid decreases expression ISO RGD:736218 6480464 perfluorooctanoic acid results in decreased expression of CYP2D6 mRNA CTD PMID:17681415 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of CYP2D4 mRNA CTD PMID:19162173 perhexiline decreases response to substance ISO RGD:736217 6480464 CYP2D6 protein results in decreased susceptibility to Perhexiline CTD PMID:28762043 phenanthrene increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of phenanthrene CTD PMID:9429232 phencyclidine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Phencyclidine CTD PMID:16782764 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of CYP2D22 mRNA CTD PMID:20607812 phenobarbital decreases activity ISO RGD:736217 6480464 Phenobarbital results in decreased activity of CYP2D6 protein CTD PMID:19909766 phenthoate decreases activity ISO RGD:736217 6480464 phenthoate results in decreased activity of CYP2D6 protein CTD PMID:20183062 phenytoin multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin CTD PMID:23397584 PhIP increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine CTD PMID:17279779 PhIP multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased chemical synthesis of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b)pyridine CTD PMID:17279779 phlorizin increases expression ISO RGD:736218 6480464 Phlorhizin results in increased expression of CYP2D6 mRNA CTD PMID:22538082 pirinixic acid decreases expression ISO RGD:736218 6480464 pirinixic acid results in decreased expression of CYP2D22 mRNA CTD PMID:20813756 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of CYP2D4 mRNA CTD PMID:19162173 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of CYP2D4 mRNA CTD PMID:19483382 pirinixic acid increases expression ISO RGD:736218 6480464 pirinixic acid results in increased expression of CYP2D22 mRNA CTD PMID:17426115 poly(styrene) multiple interactions ISO RGD:736217 6480464 styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein] CTD PMID:19909766 poly(styrene) decreases activity ISO RGD:736217 6480464 styrofoam analog results in decreased activity of CYP2D6 protein CTD PMID:19909766 potassium bromate affects expression ISO RGD:736218 6480464 potassium bromate affects the expression of CYP2D22 mRNA CTD PMID:27082013 potassium bromate multiple interactions ISO RGD:736218 6480464 [potassium bromate co-treated with bisphenol A] affects the expression of CYP2D22 mRNA; more ... CTD PMID:27082013 potassium dichromate increases expression ISO RGD:736218 6480464 Potassium Dichromate results in increased expression of CYP2D22 mRNA CTD PMID:23608068 potassium dichromate increases expression ISO RGD:736217 6480464 Potassium Dichromate results in increased expression of CYP2D6 mRNA CTD PMID:18332044 primaquine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Primaquine CTD PMID:12920490 primaquine increases response to substance ISO RGD:736217 6480464 CYP2D6 protein results in increased susceptibility to Primaquine CTD PMID:26477383 primaquine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Primaquine CTD PMID:19616568 primaquine multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine CTD PMID:19616568 prochloraz decreases expression ISO RGD:736217 6480464 prochloraz results in decreased expression of CYP2D6 mRNA CTD PMID:20035023 proguanil decreases activity ISO RGD:736217 6480464 Proguanil results in decreased activity of CYP2D6 protein CTD PMID:11124226 promethazine decreases metabolic processing ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in decreased metabolism of Promethazine CTD PMID:19814645 propafenone affects response to substance ISO RGD:736217 6480464 CYP2D6 protein mutant form affects the susceptibility to Propafenone CTD PMID:12421483 propranolol increases oxidation ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of Propranolol CTD PMID:19853591 propranolol increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Propranolol CTD PMID:12464242 PMID:21184751 propranolol affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Propranolol CTD PMID:15286053 pyrantel affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Pyrantel CTD PMID:12920490 pyrazinecarboxamide increases expression EXP 6480464 Pyrazinamide results in increased expression of CYP2D4 mRNA CTD PMID:22431067 pyrrolidines affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Pyrrolidines CTD PMID:21053377 quercetin decreases activity ISO RGD:736218 6480464 Quercetin results in decreased activity of CYP2D22 protein CTD PMID:18420780 quercetin multiple interactions ISO RGD:736217 6480464 Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 quercetin decreases activity ISO RGD:736217 6480464 Quercetin results in decreased activity of CYP2D6 protein CTD PMID:18420780 PMID:29753067 quinidine multiple interactions ISO RGD:736217 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone; more ... CTD PMID:11377097 more ... quinidine decreases activity ISO RGD:736218 6480464 Quinidine results in decreased activity of CYP2D6 protein CTD PMID:18420780 quinidine multiple interactions EXP 6480464 [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride CTD PMID:20669986 quinidine decreases activity ISO RGD:736217 6480464 Quinidine results in decreased activity of CYP2D6 gene mutant form; more ... CTD PMID:11673748 more ... quinidine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Quinidine CTD PMID:17702393 quinine multiple interactions EXP 6480464 Quinine inhibits the reaction [CYP2D6 protein results in increased oxidation of Chlorpyrifos] CTD PMID:14979094 resveratrol decreases activity ISO RGD:736218 6480464 resveratrol results in decreased activity of CYP2D22 protein CTD PMID:18420780 resveratrol decreases activity ISO RGD:736217 6480464 resveratrol results in decreased activity of CYP2D6 protein CTD PMID:18420780 resveratrol multiple interactions ISO RGD:736217 6480464 resveratrol inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] CTD PMID:20716633 resveratrol multiple interactions ISO RGD:736218 6480464 resveratrol inhibits the reaction [Paraquat results in decreased expression of CYP2D22 protein] CTD PMID:22334051 rifampicin increases expression ISO RGD:736217 6480464 Rifampin results in increased expression of CYP2D6 mRNA CTD PMID:19041851 rifampicin decreases expression ISO RGD:736218 6480464 Rifampin results in decreased expression of CYP2D22 mRNA CTD PMID:30503582 risperidone affects metabolic processing ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the metabolism of Risperidone; more ... CTD PMID:15669884 more ... risperidone decreases hydroxylation ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in decreased hydroxylation of Risperidone CTD PMID:15565299 risperidone affects abundance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the abundance of Risperidone; more ... CTD PMID:15089809 more ... risperidone multiple interactions ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the metabolism of and affects the abundance of Risperidone; more ... CTD PMID:10639689 PMID:15260906 risperidone increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Risperidone CTD PMID:16044105 more ... risperidone increases response to substance ISO RGD:736217 6480464 CYP2D6 protein results in increased susceptibility to Risperidone CTD PMID:23609392 risperidone affects response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the susceptibility to Risperidone; more ... CTD PMID:15669884 PMID:23609392 risperidone decreases metabolic processing ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in decreased metabolism of Risperidone CTD PMID:17541883 ritonavir affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Ritonavir CTD PMID:15286053 safrole decreases activity ISO RGD:736217 6480464 Safrole results in decreased activity of CYP2D6 protein CTD PMID:15778010 safrole increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Safrole CTD PMID:20507880 safrole multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of Safrole] which results in increased abundance of 1'-hydroxysafrole CTD PMID:20507880 Salinomycin decreases activity ISO RGD:736217 6480464 salinomycin results in decreased activity of CYP2D6 protein CTD PMID:26282489 sarpogrelate decreases activity ISO RGD:736217 6480464 sarpogrelate metabolite results in decreased activity of CYP2D6 protein; more ... CTD PMID:24167220 sarpogrelate multiple interactions ISO RGD:736217 6480464 sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; more ... CTD PMID:24167220 Senkirkine decreases expression ISO RGD:736217 6480464 senkirkine results in decreased expression of CYP2D6 mRNA CTD PMID:26100227 serpentine decreases activity ISO RGD:736217 6480464 serpentine (alkaloid) results in decreased activity of CYP2D6 protein CTD PMID:15930738 serpentine multiple interactions ISO RGD:736217 6480464 serpentine (alkaloid) inhibits the reaction [CYP2D6 protein affects the metabolism of Dextromethorphan] CTD PMID:15930738 sertraline multiple interactions ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of and results in increased metabolism of Sertraline CTD PMID:15547048 Shikonin decreases activity ISO RGD:736217 6480464 shikonin results in decreased activity of CYP2D6 protein CTD PMID:28941798 sibutramine decreases activity ISO RGD:736217 6480464 sibutramine results in decreased activity of CYP2D6 protein CTD PMID:23777987 simvastatin affects response to substance ISO RGD:736217 6480464 CYP2D6 polymorphism affects the susceptibility to Simvastatin CTD PMID:11753271 sodium arsenite decreases expression ISO RGD:736217 6480464 sodium arsenite results in decreased expression of CYP2D6 protein CTD PMID:11368792 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of CYP2D4 mRNA CTD PMID:25993096 sophoranone decreases activity ISO RGD:736217 6480464 sophoranone results in decreased activity of CYP2D6 protein CTD PMID:29753067 sparteine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Sparteine CTD PMID:11907490 Sudan I multiple interactions ISO RGD:736217 6480464 CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 Sudan I increases oxidation ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 sulindac multiple interactions EXP 6480464 [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP2D4 mRNA CTD PMID:20371263 tamoxifen increases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in increased susceptibility to Tamoxifen; more ... CTD PMID:19244106 PMID:21152245 tamoxifen decreases activity ISO RGD:736218 6480464 Tamoxifen results in decreased activity of CYP2D6 protein CTD PMID:18420780 tamoxifen increases expression ISO RGD:736217 6480464 Tamoxifen results in increased expression of CYP2D6 protein CTD PMID:19812351 tamoxifen decreases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Tamoxifen CTD PMID:20309015 tamoxifen increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Tamoxifen CTD PMID:20123649 tamoxifen affects metabolic processing ISO RGD:736217 6480464 CYP2D6 protein affects the metabolism of Tamoxifen CTD PMID:15632378 more ... tamoxifen affects response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the susceptibility to Tamoxifen CTD PMID:19189210 PMID:19189212 tamoxifen multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen; more ... CTD PMID:20124171 more ... tegaserod increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of tegaserod CTD PMID:11560869 tegaserod multiple interactions ISO RGD:736217 6480464 Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod] CTD PMID:11560869 tegaserod decreases activity ISO RGD:736217 6480464 tegaserod results in decreased activity of CYP2D6 protein CTD PMID:11560869 terbinafine decreases activity ISO RGD:736217 6480464 terbinafine results in decreased activity of CYP2D6 protein CTD PMID:24894748 terbinafine multiple interactions ISO RGD:736217 6480464 [terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] CTD PMID:24894748 testosterone decreases activity ISO RGD:736218 6480464 Testosterone results in decreased activity of CYP2D22 protein CTD PMID:18420780 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CYP2D4 mRNA CTD PMID:12921627 tetrachloromethane decreases expression ISO RGD:736218 6480464 Carbon Tetrachloride results in decreased expression of CYP2D22 mRNA CTD PMID:17484886 PMID:27339419 thioacetamide affects expression EXP 6480464 Thioacetamide affects the expression of CYP2D4 mRNA CTD PMID:19483382 thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP2D22 mRNA CTD PMID:28943392 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of CYP2D4 mRNA CTD PMID:23411599 thioridazine multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; more ... CTD PMID:19482014 PMID:23397584 ticlopidine multiple interactions ISO RGD:736217 6480464 CYP2D6 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite CTD PMID:19170597 ticlopidine decreases activity ISO RGD:736217 6480464 Ticlopidine results in decreased activity of CYP2D6 protein CTD PMID:10759690 titanium dioxide increases expression ISO RGD:736218 6480464 titanium dioxide results in increased expression of CYP2D22 mRNA CTD PMID:23557971 tolterodine tartrate increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Tolterodine Tartrate CTD PMID:10583026 tolterodine tartrate affects metabolic processing ISO RGD:736217 6480464 CYP2D6 polymorphism affects the metabolism of Tolterodine Tartrate CTD PMID:28087463 tolterodine tartrate multiple interactions ISO RGD:736217 6480464 Fluoxetine inhibits the reaction [CYP2D6 protein results in increased metabolism of Tolterodine Tartrate] CTD PMID:10583026 toluene affects expression EXP 6480464 Toluene affects the expression of CYP2D22 mRNA CTD PMID:18653662 toluene increases expression EXP 6480464 Toluene results in increased expression of CYP2D4 mRNA CTD PMID:14703099 toluene multiple interactions EXP 6480464 Toluene results in increased expression of and results in increased activity of CYP2D4 protein CTD PMID:14703099 tramadol affects response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the susceptibility to Tramadol; more ... CTD PMID:16497087 PMID:16960721 tramadol affects methylation ISO RGD:736218 6480464 CYP2D6 protein affects the methylation of Tramadol CTD PMID:12893130 tramadol decreases response to substance ISO RGD:736217 6480464 CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol CTD PMID:16960721 tramadol multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; more ... CTD PMID:18204346 PMID:29555325 tramadol increases response to substance ISO RGD:736217 6480464 CYP2D6 gene mutant form results in increased susceptibility to Tramadol CTD PMID:18204346 tramadol affects metabolic processing ISO RGD:736217 6480464 CYP2D6 gene mutant form affects the metabolism of Tramadol; more ... CTD PMID:12191703 more ... tramadol decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Tramadol CTD PMID:14624403 more ... tramadol increases metabolic processing ISO RGD:736217 6480464 CYP2D6 gene mutant form results in increased metabolism of Tramadol; more ... CTD PMID:18204346 more ... trans-cinnamic acid decreases activity ISO RGD:736217 6480464 cinnamic acid analog results in decreased activity of CYP2D6 protein CTD PMID:15072549 tranylcypromine multiple interactions ISO RGD:736217 6480464 Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 trimellitic anhydride decreases expression ISO RGD:736218 6480464 trimellitic anhydride results in decreased expression of CYP2D22 mRNA CTD PMID:19042947 troglitazone multiple interactions ISO RGD:736217 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to troglitazone CTD PMID:23397584 tryptamines decreases activity ISO RGD:736217 6480464 Tryptamines analog results in decreased activity of CYP2D6 protein CTD PMID:26599973 tryptamines multiple interactions ISO RGD:736217 6480464 [Tryptamines analog results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan CTD PMID:26599973 tyramine multiple interactions ISO RGD:736217 6480464 [CYP2D6 protein results in increased metabolism of Tyramine] which results in increased abundance of Dopamine CTD PMID:26763401 tyramine increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Tyramine CTD PMID:26763401 valdecoxib decreases expression EXP 6480464 valdecoxib results in decreased expression of CYP2D4 mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:736218 6480464 Valproic Acid affects the expression of CYP2D22 mRNA CTD PMID:17292431 valproic acid decreases expression ISO RGD:736217 6480464 Valproic Acid results in decreased expression of CYP2D6 mRNA CTD PMID:29501571 valproic acid increases methylation ISO RGD:736217 6480464 Valproic Acid results in increased methylation of CYP2D6 gene CTD PMID:29154799 vancomycin increases expression ISO RGD:736218 6480464 Vancomycin results in increased expression of CYP2D22 mRNA CTD PMID:18930951 veliparib increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of veliparib CTD PMID:21436403 venlafaxine hydrochloride affects response to substance ISO RGD:736217 6480464 CYP2D6 protein affects the susceptibility to Venlafaxine Hydrochloride CTD PMID:17803873 venlafaxine hydrochloride affects methylation ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the methylation of Venlafaxine Hydrochloride CTD PMID:10877013 PMID:10933885 venlafaxine hydrochloride decreases methylation ISO RGD:736217 6480464 CYP2D6 protein results in decreased methylation of Venlafaxine Hydrochloride CTD PMID:10877013 PMID:10933885 venlafaxine hydrochloride decreases activity ISO RGD:736217 6480464 Venlafaxine Hydrochloride results in decreased activity of CYP2D6 protein CTD PMID:15632378 venlafaxine hydrochloride affects metabolic processing ISO RGD:736217 6480464 CYP2D6 gene mutant form affects the metabolism of Venlafaxine Hydrochloride; more ... CTD PMID:10774634 more ... venlafaxine hydrochloride increases metabolic processing ISO RGD:736217 6480464 CYP2D6 protein results in increased metabolism of Venlafaxine Hydrochloride CTD PMID:10774634 more ... verapamil decreases activity ISO RGD:736218 6480464 Verapamil results in decreased activity of CYP2D22 protein; more ... CTD PMID:18420780 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of CYP2D4 mRNA CTD PMID:23034163 warfarin decreases activity ISO RGD:736217 6480464 Warfarin results in decreased activity of CYP2D6 protein CTD PMID:18420780 yohimbine affects metabolic processing ISO RGD:736217 6480464 CYP2D6 gene polymorphism affects the metabolism of Yohimbine CTD PMID:15289791 zinc atom increases expression ISO RGD:736217 6480464 Zinc deficiency results in increased expression of CYP2D6 mRNA CTD PMID:18356318 zinc(0) increases expression ISO RGD:736217 6480464 Zinc deficiency results in increased expression of CYP2D6 mRNA CTD PMID:18356318
Gene-Chemical Interaction Annotations
