Scn8a (sodium voltage-gated channel alpha subunit 8) - Rat Genome Database

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Gene: Scn8a (sodium voltage-gated channel alpha subunit 8) Rattus norvegicus
Analyze
Symbol: Scn8a
Name: sodium voltage-gated channel alpha subunit 8
RGD ID: 3638
Description: Enables sodium ion binding activity and voltage-gated sodium channel activity. Involved in nervous system development; neuronal action potential; and sodium ion transport. Located in axon initial segment and node of Ranvier. Part of voltage-gated sodium channel complex. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in benign familial infantile seizures 5 and developmental and epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8); INTERACTS WITH (+)-pilocarpine; (+)-trans-(S)-allethrin; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Na+ channel; naCh6; peripheral nerve protein type 4; PN4; sodium channel 6; sodium channel protein type 8 subunit alpha; sodium channel protein type VIII subunit alpha; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type VIII, alpha; sodium channel, voltage-gated, type VIII, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,860,901 - 134,034,809 (+)NCBIGRCr8
mRatBN7.27131,982,152 - 132,156,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,982,480 - 132,151,292 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,784,484 - 133,952,871 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,014,006 - 136,182,387 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,924,362 - 136,093,194 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,575,629 - 142,683,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,575,672 - 142,684,114 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,377,038 - 140,485,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,686,180 - 139,794,282 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,762,616 - 139,870,727 (+)NCBI
Celera7128,450,559 - 128,618,862 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
ATP binding  (IEA)
protein binding  (IPI,ISO)
sodium ion binding  (IDA,IEA,ISO)
voltage-gated sodium channel activity  (IC,IDA,IEA,IMP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses. Caldwell JH, etal., Proc Natl Acad Sci U S A. 2000 May 9;97(10):5616-20. doi: 10.1073/pnas.090034797.
2. Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia. Dietrich PS, etal., J Neurochem 1998 Jun;70(6):2262-72.
3. Downregulation of neuronal sodium channel subunits Nav1.1 and Nav1.6 in the sinoatrial node from volume-overloaded heart failure rat. Du Y, etal., Pflugers Arch. 2007 Jun;454(3):451-9. Epub 2007 Feb 2.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
6. Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. Jenkins SM and Bennett V, J Cell Biol. 2001 Nov 26;155(5):739-46. Epub 2001 Nov 26.
7. Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells. Mechaly I, etal., Neuroscience. 2005;130(2):389-96.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals. Persson AK, etal., Mol Pain. 2010 Nov 30;6:84. doi: 10.1186/1744-8069-6-84.
12. Sodium currents in medullary neurons isolated from the pre-Botzinger complex region. Ptak K, etal., J Neurosci. 2005 May 25;25(21):5159-70.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Early events in node of Ranvier formation during myelination and remyelination in the PNS. Schafer DP, etal., Neuron Glia Biol. 2006 May;2(2):69-79.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. Wittmack EK, etal., J Neurosci. 2004 Jul 28;24(30):6765-75.
19. Increased late sodium currents are related to transcription of neuronal isoforms in a pressure-overload model. Xi Y, etal., Eur J Heart Fail. 2009 Aug;11(8):749-57. Epub 2009 Jul 7.
Additional References at PubMed
PMID:2544627   PMID:3674018   PMID:7670495   PMID:7751906   PMID:11807096   PMID:12204355   PMID:12920299   PMID:15170223   PMID:15272007   PMID:16014723   PMID:16029194   PMID:17537961  
PMID:17662136   PMID:17884088   PMID:17928448   PMID:19306853   PMID:19465131   PMID:20466935   PMID:21078353   PMID:21439942   PMID:22465659   PMID:22871113   PMID:23622763   PMID:23640885  
PMID:25239001   PMID:25686526   PMID:25725044   PMID:25874799   PMID:27653482   PMID:27905510   PMID:28655185   PMID:29956586   PMID:30699332   PMID:36359772   PMID:37572007  


Genomics

Comparative Map Data
Scn8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,860,901 - 134,034,809 (+)NCBIGRCr8
mRatBN7.27131,982,152 - 132,156,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,982,480 - 132,151,292 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7133,784,484 - 133,952,871 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,014,006 - 136,182,387 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,924,362 - 136,093,194 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07142,575,629 - 142,683,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,575,672 - 142,684,114 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,377,038 - 140,485,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,686,180 - 139,794,282 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17139,762,616 - 139,870,727 (+)NCBI
Celera7128,450,559 - 128,618,862 (+)NCBICelera
Cytogenetic Map7q36NCBI
SCN8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,591,233 - 51,812,864 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,590,266 - 51,812,864 (+)EnsemblGRCh38hg38GRCh38
GRCh371251,985,017 - 52,206,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,271,287 - 50,488,574 (+)NCBINCBI36Build 36hg18NCBI36
Build 341250,271,286 - 50,488,365NCBI
Celera1250,787,152 - 51,004,408 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,089,349 - 49,239,456 (+)NCBIHuRef
CHM1_11251,951,468 - 52,173,106 (+)NCBICHM1_1
T2T-CHM13v2.01251,554,795 - 51,776,384 (+)NCBIT2T-CHM13v2.0
Scn8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,766,600 - 100,943,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,767,739 - 100,943,819 (+)EnsemblGRCm39 Ensembl
GRCm3815100,869,863 - 101,045,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,869,858 - 101,045,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715100,701,114 - 100,876,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,764,359 - 100,868,722 (+)NCBIMGSCv36mm8
Celera15103,017,992 - 103,192,774 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.39NCBI
Scn8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,086,178 - 2,195,971 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBIChiLan1.0ChiLan1.0
SCN8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,385,627 - 42,604,490 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,382,391 - 42,601,856 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,950,057 - 37,172,235 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,725,471 - 38,057,190 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,730,900 - 37,876,357 (-)Ensemblpanpan1.1panPan2
SCN8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,174,257 - 3,348,349 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,176,013 - 3,296,482 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2742,959,130 - 43,080,423 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,170,259 - 3,346,792 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,172,854 - 3,345,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,189,615 - 3,363,479 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,173,058 - 3,350,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,304,862 - 43,478,762 (+)NCBIUU_Cfam_GSD_1.0
Scn8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,880,790 - 64,000,520 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,164,262 - 9,279,688 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,164,310 - 9,281,795 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl516,977,700 - 17,169,543 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1516,977,468 - 17,173,831 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,560,130 - 17,767,953 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCN8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,770,513 - 47,983,843 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,838,358 - 47,978,399 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037198,106,707 - 198,322,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816499,179 - 631,936 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624816498,737 - 631,850 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scn8a
1416 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:261
Count of miRNA genes:169
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000008160
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
BE103200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,073,788 - 132,073,944 (+)MAPPERmRatBN7.2
Rnor_6.07142,606,192 - 142,606,347NCBIRnor6.0
Rnor_5.07140,407,601 - 140,407,756UniSTSRnor5.0
RGSC_v3.47139,716,743 - 139,716,898UniSTSRGSC3.4
Celera7128,541,585 - 128,541,740UniSTS
RH 3.4 Map71073.2UniSTS
Cytogenetic Map7q36UniSTS
AU049240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,064,031 - 132,064,255 (+)MAPPERmRatBN7.2
Rnor_6.07142,596,435 - 142,596,658NCBIRnor6.0
Rnor_5.07140,397,844 - 140,398,067UniSTSRnor5.0
RGSC_v3.47139,706,986 - 139,707,209UniSTSRGSC3.4
Celera7128,531,844 - 128,532,051UniSTS
Cytogenetic Map7q36UniSTS
AU049825  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,008,213 - 132,008,426 (+)MAPPERmRatBN7.2
Rnor_6.07142,540,553 - 142,540,765NCBIRnor6.0
Rnor_5.07140,343,152 - 140,343,364UniSTSRnor5.0
RGSC_v3.47139,651,335 - 139,651,547UniSTSRGSC3.4
Celera7128,476,324 - 128,476,536UniSTS
Cytogenetic Map7q36UniSTS
G64248  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,150,549 - 132,150,811 (+)MAPPERmRatBN7.2
Rnor_6.07142,682,919 - 142,683,180NCBIRnor6.0
Rnor_5.07140,484,399 - 140,484,660UniSTSRnor5.0
RGSC_v3.47139,793,542 - 139,793,803UniSTSRGSC3.4
Celera7128,618,122 - 128,618,383UniSTS
Cytogenetic Map7q36UniSTS
Scn3a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2350,432,608 - 50,433,887 (+)MAPPERmRatBN7.2
Rnor_6.0351,817,586 - 51,818,864NCBIRnor6.0
Rnor_5.0358,452,236 - 58,453,514UniSTSRnor5.0
RGSC_v3.4347,718,197 - 47,719,475UniSTSRGSC3.4
Celera350,025,799 - 50,027,077UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map8q32UniSTS
Cytogenetic Map3q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 66 2 2
Low 20 24 10 8 10 8 33 39 8
Below cutoff 3 20 33 31 11 31 8 8 3 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008160   ⟹   ENSRNOP00000008160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,982,480 - 132,151,292 (+)Ensembl
Rnor_6.0 Ensembl7142,575,677 - 142,683,213 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080923   ⟹   ENSRNOP00000075703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,982,480 - 132,151,292 (+)Ensembl
Rnor_6.0 Ensembl7142,575,672 - 142,684,114 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114577   ⟹   ENSRNOP00000082508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,982,480 - 132,151,292 (+)Ensembl
RefSeq Acc Id: NM_019266   ⟹   NP_062139
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,861,227 - 134,030,024 (+)NCBI
mRatBN7.27131,982,480 - 132,151,290 (+)NCBI
Rnor_6.07142,575,629 - 142,683,659 (+)NCBI
Rnor_5.07140,377,038 - 140,485,139 (+)NCBI
RGSC_v3.47139,686,180 - 139,794,282 (+)RGD
Celera7128,450,559 - 128,618,862 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063263130   ⟹   XP_063119200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,861,187 - 134,034,809 (+)NCBI
RefSeq Acc Id: XM_063263131   ⟹   XP_063119201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,861,187 - 134,034,809 (+)NCBI
RefSeq Acc Id: XM_063263132   ⟹   XP_063119202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,860,901 - 134,034,809 (+)NCBI
RefSeq Acc Id: XM_063263133   ⟹   XP_063119203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,861,187 - 134,034,809 (+)NCBI
RefSeq Acc Id: XM_063263134   ⟹   XP_063119204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,861,187 - 134,034,809 (+)NCBI
RefSeq Acc Id: XM_063263135   ⟹   XP_063119205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,925,706 - 134,034,809 (+)NCBI
RefSeq Acc Id: XM_063263137   ⟹   XP_063119207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,861,187 - 134,018,907 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_062139   ⟸   NM_019266
- UniProtKB: O88421 (UniProtKB/Swiss-Prot),   O88420 (UniProtKB/Swiss-Prot),   A6KCM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008160   ⟸   ENSRNOT00000008160
RefSeq Acc Id: ENSRNOP00000075703   ⟸   ENSRNOT00000080923
RefSeq Acc Id: ENSRNOP00000082508   ⟸   ENSRNOT00000114577
RefSeq Acc Id: XP_063119202   ⟸   XM_063263132
- Peptide Label: isoform X1
- UniProtKB: O88421 (UniProtKB/Swiss-Prot),   O88420 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063119201   ⟸   XM_063263131
- Peptide Label: isoform X2
- UniProtKB: F1LMH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119204   ⟸   XM_063263134
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZX68 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119200   ⟸   XM_063263130
- Peptide Label: isoform X1
- UniProtKB: O88421 (UniProtKB/Swiss-Prot),   O88420 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063119203   ⟸   XM_063263133
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119207   ⟸   XM_063263137
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063119205   ⟸   XM_063263135
- Peptide Label: isoform X5
Protein Domains
Ion transport   IQ   Sodium ion transport-associated   Voltage-gated Na+ ion channel cytoplasmic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88420-F1-model_v2 AlphaFold O88420 1-1978 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3638 AgrOrtholog
BioCyc Gene G2FUF-32005 BioCyc
Ensembl Genes ENSRNOG00000005309 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055027400 UniProtKB/Swiss-Prot
  ENSRNOG00065021763 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008160.8 UniProtKB/TrEMBL
  ENSRNOT00000080923 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000080923.2 UniProtKB/Swiss-Prot
  ENSRNOT00000114577.1 UniProtKB/TrEMBL
  ENSRNOT00055048321 UniProtKB/Swiss-Prot
  ENSRNOT00065037782 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  iswi atpase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_channel_a8su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29710 UniProtKB/Swiss-Prot
NCBI Gene 29710 ENTREZGENE
PANTHER PTHR10037 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00612 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Scn8a PhenoGen
PRINTS NACHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHANNEL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005309 RatGTEx
  ENSRNOG00055027400 RatGTEx
  ENSRNOG00065021763 RatGTEx
SMART SM00015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209146
UniProt A0A0G2KB93_RAT UniProtKB/TrEMBL
  A0A8I5ZX68 ENTREZGENE, UniProtKB/TrEMBL
  A6KCM1_RAT UniProtKB/TrEMBL
  A6KCM2 ENTREZGENE, UniProtKB/TrEMBL
  A6KCM3_RAT UniProtKB/TrEMBL
  A6KCM4_RAT UniProtKB/TrEMBL
  F1LMH2 ENTREZGENE, UniProtKB/TrEMBL
  O88420 ENTREZGENE
  O88421 ENTREZGENE
  SCN8A_RAT UniProtKB/Swiss-Prot
UniProt Secondary O88421 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Scn8a  sodium voltage-gated channel alpha subunit 8  Scn8a  sodium channel, voltage gated, type VIII, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-16 Scn8a  sodium channel, voltage gated, type VIII, alpha subunit  Scn8a  sodium channel, voltage-gated, type VIII, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Scn8a  sodium channel, voltage-gated, type VIII, alpha  Scn8a  sodium channel, voltage gated, type VIII, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-03-25 Scn8a  sodium channel, voltage gated, type VIII, alpha subunit  Scn8a  sodium channel, voltage-gated, type 8, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Scn8a  sodium channel, voltage-gated, type 8, alpha subunit  Scn8a  sodium channel, voltage-gated, type VIII, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Scn8a  sodium channel, voltage-gated, type VIII, alpha polypeptide    sodium channel, voltage-gated, type 8, alpha polypeptide  Name updated 1299863 APPROVED
2002-06-10 Scn8a  sodium channel, voltage-gated, type 8, alpha polypeptide      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_transcript a splice variant rPN4a exists 69984