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Gene: Shank3 (SH3 and multiple ankyrin repeat domains 3) Rattus norvegicus
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Symbol: Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Description: Exhibits several functions, including GKAP/Homer scaffold activity; SH3 domain binding activity; and protein C-terminus binding activity. Involved in positive regulation of glutamate receptor signaling pathway; protein complex oligomerization; and regulation of synapse organization. Localizes to the ciliary membrane; glutamatergic synapse; and postsynaptic density, intracellular component. Predicted to colocalize with the ionotropic glutamate receptor complex and postsynaptic membrane. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 2,5-hexanedione; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: proline rich synapse associated protein 2; proline-rich synapse-associated protein 2; Prosap2; SH3 and multiple ankyrin repeat domains protein 3; SH3/ankyrin domain gene 3; Shank postsynaptic density protein 3a; SPANK-2
Orthologs:
Homo sapiens (human) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)  HGNC  Alliance
Mus musculus (house mouse) : Shank3 (SH3 and multiple ankyrin repeat domains 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shank3 (SH3 and multiple ankyrin repeat domains 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
Canis lupus familiaris (dog) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shank3 (SH3 and multiple ankyrin repeat domains 3)
Sus scrofa (pig) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07130,474,278 - 130,534,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07130,159,246 - 130,220,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,817,026 - 127,877,875 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17127,851,199 - 127,912,102 (+)NCBI
Celera7117,042,941 - 117,102,379 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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More on Shank3
Alliance Gene
NCBI Gene
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JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 69264
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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