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Gene: Shank3 (SH3 and multiple ankyrin repeat domains 3) Rattus norvegicus
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Symbol: Shank3
Name: SH3 and multiple ankyrin repeat domains 3
Description: Exhibits several functions, including GKAP/Homer scaffold activity; SH3 domain binding activity; and protein C-terminus binding activity. Involved in positive regulation of glutamate receptor signaling pathway; protein complex oligomerization; and regulation of synapse organization. Localizes to the ciliary membrane; glutamatergic synapse; and postsynaptic density, intracellular component. Predicted to colocalize with the ionotropic glutamate receptor complex and postsynaptic membrane. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 2,5-hexanedione; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: proline rich synapse associated protein 2; proline-rich synapse-associated protein 2; Prosap2; SH3 and multiple ankyrin repeat domains protein 3; SH3/ankyrin domain gene 3; Shank postsynaptic density protein 3a; SPANK-2
Orthologs:
Homo sapiens (human) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)  HGNC  Alliance
Mus musculus (house mouse) : Shank3 (SH3 and multiple ankyrin repeat domains 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shank3 (SH3 and multiple ankyrin repeat domains 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
Canis lupus familiaris (dog) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shank3 (SH3 and multiple ankyrin repeat domains 3)
Sus scrofa (pig) : SHANK3 (SH3 and multiple ankyrin repeat domains 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07130,474,278 - 130,534,679 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07130,159,246 - 130,220,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,817,026 - 127,877,875 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17127,851,199 - 127,912,102 (+)NCBI
Celera7117,042,941 - 117,102,379 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Shank3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69264
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.