Gene: Shank3 (SH3 and multiple ankyrin repeat domains 3) Rattus norvegicus
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Symbol:
Shank3
Name:
SH3 and multiple ankyrin repeat domains 3
Description:
Exhibits several functions, including SH3 domain binding activity; protein C-terminus binding activity; and scaffold protein binding activity. Involved in positive regulation of glutamate receptor signaling pathway and regulation of synapse organization. Localizes to ciliary membrane; glutamatergic synapse; and postsynaptic density, intracellular component. Predicted to colocalize with ionotropic glutamate receptor complex and postsynaptic membrane. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 2,5-hexanedione; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
proline rich synapse associated protein 2; proline-rich synapse-associated protein 2; Prosap2; SH3 and multiple ankyrin repeat domains protein 3; SH3/ankyrin domain gene 3; Shank postsynaptic density protein 3a; SPANK-2
Orthologs:
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 130,474,278 - 130,534,679 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 130,474,279 - 130,534,679 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 7 130,159,246 - 130,220,171 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 127,817,026 - 127,877,875 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 127,851,199 - 127,912,102 (+) NCBI Celera 7 117,042,941 - 117,102,379 (+) NCBI Celera Cytogenetic Map 7 q34 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
amenorrhea ISO RGD:732251 8554872 ClinVar Annotator: match by term: Primary amenorrhea ClinVar PMID:21681106 autism spectrum disorder ISO RGD:732251 8554872 ClinVar Annotator: match by term: Autism spectrum disorders ClinVar PMID:11391650 more ... autism spectrum disorder ISO RGD:732251 8554872 ClinVar Annotator: match by term: Autism spectrum disorders ClinVar PMID:17173049 more ... autism spectrum disorder ISO RGD:732251 8554872 ClinVar Annotator: match by term: Autism spectrum disorder ClinVar PMID:30763456 autism spectrum disorder ISO RGD:732251 8554872 ClinVar Annotator: match by term: Autism spectrum disorders ClinVar PMID:11391650 more ... autism spectrum disorder ISO RGD:732251 8554872 ClinVar Annotator: match by term: Autism spectrum disorders ClinVar PMID:11391650 more ... autistic disorder ISO RGD:732251 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar Developmental Disabilities ISO RGD:732251 8554872 ClinVar Annotator: match by term: Global developmental delay ClinVar Developmental Disabilities ISO RGD:732251 8554872 ClinVar Annotator: match by term: Global developmental delay ClinVar PMID:25741868 epilepsy ISO RGD:732251 8554872 ClinVar Annotator: match by term: Seizures ClinVar genetic disease ISO RGD:732251 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:11431708 more ... genetic disease ISO RGD:732251 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:17173049 more ... intellectual disability ISO RGD:732251 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar PMID:25167861 intellectual disability ISO RGD:732251 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar long QT syndrome ISO RGD:732251 8554872 ClinVar Annotator: match by term: Long QT syndrome ClinVar PMID:26132555 Phelan-McDermid syndrome ISO RGD:732251 8554872 ClinVar Annotator: match by term: Phelan-McDermid syndrome ClinVar PMID:17173049 more ... Phelan-McDermid syndrome ISO RGD:732251 8554872 ClinVar Annotator: match by term: 22q13.3 deletion syndrome ClinVar PMID:30763456 Phelan-McDermid syndrome ISO RGD:732251 8554872 ClinVar Annotator: match by term: 22q13.3 deletion syndrome ClinVar PMID:24759409 , PMID:25741868 Phelan-McDermid syndrome ISO RGD:732251 8554872 ClinVar Annotator: match by term: Phelan-McDermid syndrome ClinVar PMID:25724810 more ... Phelan-McDermid syndrome ISO RGD:732251 8554872 ClinVar Annotator: match by term: 22q13.3 deletion syndrome ClinVar PMID:25741868 Phelan-McDermid syndrome ISO RGD:732251 8554872 ClinVar Annotator: match by OMIM:606232 ClinVar Phelan-McDermid syndrome ISO RGD:732251 8554872 ClinVar Annotator: match by OMIM:606232 ClinVar PMID:21062623 , PMID:22892527 Phelan-McDermid syndrome ISO RGD:732251 8554872 ClinVar Annotator: match by OMIM:606232 ClinVar PMID:22892527 psychotic disorder ISO RGD:732251 8554872 ClinVar Annotator: match by term: Psychosis ClinVar PMID:24759409 , PMID:25741868 schizophrenia 15 ISO RGD:732251 8554872 ClinVar Annotator: match by term: SCHIZOPHRENIA SUSCEPTIBILITY LOCUS, CHROMOSOME 22q13-RELATED ClinVar PMID:25741868 schizophrenia 15 ISO RGD:732251 8554872 ClinVar Annotator: match by term: SHANK3-Related Disorder ClinVar schizophrenia 15 ISO RGD:732251 8554872 ClinVar Annotator: match by term: SHANK3-Related Disorder ClinVar PMID:30763456 schizophrenia 15 ISO RGD:732251 8554872 ClinVar Annotator: match by OMIM:613950 ClinVar PMID:20385823 visual epilepsy ISO RGD:732251 8554872 ClinVar Annotator: match by term: Seizures ClinVar
Imported Annotations - CTD
autism spectrum disorder ISO RGD:732251 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17173049 , PMID:18252227 autistic disorder ISO RGD:732251 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18621663 , PMID:26027926 Developmental Disabilities ISO RGD:732251 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16284256 intellectual disability ISO RGD:732251 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16284256 Language Development Disorders ISO RGD:732251 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16284256 , PMID:17173049 Phelan-McDermid syndrome ISO RGD:732251 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16284256 schizophrenia ISO RGD:732251 11554173 CTD Direct Evidence: marker/mechanism CTD Imported Annotations - OMIM
Phelan-McDermid syndrome ISO RGD:732251 7240710 OMIM schizophrenia 15 ISO RGD:732251 7240710 OMIM
17beta-estradiol multiple interactions ISO RGD:732251 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of SHANK3 mRNA CTD PMID:30165855 2,5-hexanedione multiple interactions EXP 6480464 [carbendazim co-treated with 2, 5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of SHANK3 mRNA CTD PMID:21346803 4,4'-sulfonyldiphenol increases expression ISO RGD:732252 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of SHANK3 mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide increases expression ISO RGD:732252 6480464 Fenretinide results in increased expression of SHANK3 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine increases expression ISO RGD:732251 6480464 Decitabine results in increased expression of SHANK3 mRNA CTD PMID:17419801 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SHANK3 mRNA CTD PMID:24780913 aflatoxin B1 decreases expression ISO RGD:732251 6480464 Aflatoxin B1 results in decreased expression of SHANK3 mRNA CTD PMID:27153756 aflatoxin B1 increases methylation ISO RGD:732251 6480464 Aflatoxin B1 results in increased methylation of SHANK3 intron CTD PMID:30157460 aflatoxin B2 increases methylation ISO RGD:732251 6480464 aflatoxin B2 results in increased methylation of SHANK3 intron CTD PMID:30157460 antirheumatic drug increases expression ISO RGD:732251 6480464 Antirheumatic Agents results in increased expression of SHANK3 mRNA CTD PMID:24449571 arsane affects methylation ISO RGD:732251 6480464 Arsenic affects the methylation of SHANK3 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:732251 6480464 Arsenic affects the methylation of SHANK3 gene CTD PMID:25304211 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of SHANK3 mRNA CTD PMID:21839799 benzo[e]pyrene increases methylation ISO RGD:732251 6480464 benzo(e)pyrene results in increased methylation of SHANK3 intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SHANK3 promoter CTD PMID:23359474 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SHANK3 promoter, [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SHANK3 mRNA CTD PMID:23359474 , PMID:25607892 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SHANK3 gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SHANK3 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:732252 6480464 bisphenol F results in increased expression of SHANK3 mRNA CTD PMID:30951980 Butylparaben multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SHANK3 mRNA CTD PMID:25607892 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of SHANK3 mRNA CTD PMID:19167457 carbendazim multiple interactions EXP 6480464 [carbendazim co-treated with 2, 5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 chloroacetaldehyde affects expression ISO RGD:732251 6480464 chloroacetaldehyde affects the expression of SHANK3 mRNA CTD PMID:25596134 cidofovir anhydrous affects expression ISO RGD:732251 6480464 Cidofovir affects the expression of SHANK3 mRNA CTD PMID:25596134 clodronic acid decreases expression ISO RGD:732251 6480464 Clodronic Acid results in decreased expression of SHANK3 mRNA CTD PMID:25596134 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of SHANK3 mRNA CTD PMID:24386269 cocaine multiple interactions ISO RGD:732252 6480464 [Cocaine co-treated with FOS protein mutant form] results in decreased expression of SHANK3 mRNA CTD PMID:18355967 copper atom multiple interactions EXP 6480464 Copper inhibits the reaction [Potassium results in increased expression of SHANK3 protein], Copper inhibits the reaction [zinc chloride results in increased expression of SHANK3 protein] CTD PMID:25007851 copper atom decreases expression ISO RGD:732252 6480464 Copper results in decreased expression of SHANK3 protein CTD PMID:25007851 copper(0) multiple interactions EXP 6480464 Copper inhibits the reaction [Potassium results in increased expression of SHANK3 protein], Copper inhibits the reaction [zinc chloride results in increased expression of SHANK3 protein] CTD PMID:25007851 copper(0) decreases expression ISO RGD:732252 6480464 Copper results in decreased expression of SHANK3 protein CTD PMID:25007851 copper(II) chloride multiple interactions EXP 6480464 [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK3 protein CTD PMID:25007851 crocidolite asbestos decreases methylation ISO RGD:732251 6480464 Asbestos, Crocidolite results in decreased methylation of SHANK3 3' UTR CTD PMID:29523930 cyclosporin A decreases expression ISO RGD:732251 6480464 Cyclosporine results in decreased expression of SHANK3 mRNA CTD PMID:25562108 dibutyl phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SHANK3 promoter CTD PMID:23359474 dicrotophos increases expression ISO RGD:732251 6480464 dicrotophos results in increased expression of SHANK3 mRNA CTD PMID:28302478 dioxygen increases expression ISO RGD:732251 6480464 Oxygen deficiency results in increased expression of SHANK3 mRNA CTD PMID:25596134 dorsomorphin multiple interactions ISO RGD:732251 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin affects methylation EXP 6480464 Doxorubicin affects the methylation of SHANK3 gene CTD PMID:28962528 doxorubicin decreases expression ISO RGD:732251 6480464 Doxorubicin results in decreased expression of SHANK3 mRNA CTD PMID:29803840 enzacamene multiple interactions EXP 6480464 [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of SHANK3 mRNA CTD PMID:25607892 ethanol decreases expression ISO RGD:732252 6480464 Ethanol results in decreased expression of SHANK3 mRNA CTD PMID:29018328 ethanol increases expression ISO RGD:732252 6480464 Ethanol results in increased expression of SHANK3 mRNA CTD PMID:30319688 ethanol affects splicing ISO RGD:732252 6480464 Ethanol affects the splicing of SHANK3 mRNA CTD PMID:30319688 furan decreases expression EXP 6480464 furan results in decreased expression of SHANK3 mRNA CTD PMID:25539665 , PMID:26194646 glyphosate increases methylation EXP 6480464 glyphosate results in increased methylation of SHANK3 gene CTD PMID:31011160 L-methionine decreases expression EXP 6480464 Methionine results in decreased expression of SHANK3 mRNA, Methionine results in decreased expression of SHANK3 protein CTD PMID:17419801 lipopolysaccharide multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of SHANK3 mRNA CTD PMID:16415329 methapyrilene increases methylation ISO RGD:732251 6480464 Methapyrilene results in increased methylation of SHANK3 intron CTD PMID:30157460 methoxychlor increases methylation EXP 6480464 Methoxychlor results in increased methylation of SHANK3 gene CTD PMID:23303685 Methylazoxymethanol acetate decreases expression EXP 6480464 Methylazoxymethanol Acetate results in decreased expression of SHANK3 mRNA CTD PMID:28349193 N-methyl-4-phenylpyridinium increases expression ISO RGD:732251 6480464 1-Methyl-4-phenylpyridinium results in increased expression of SHANK3 mRNA CTD PMID:24810058 N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of SHANK3 mRNA CTD PMID:16415329 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of SHANK3 mRNA CTD PMID:23665939 phenylmercury acetate decreases expression ISO RGD:732251 6480464 Phenylmercuric Acetate results in decreased expression of SHANK3 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:732251 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHANK3 mRNA CTD PMID:27188386 phosgene affects expression ISO RGD:732252 6480464 Phosgene affects the expression of SHANK3 mRNA CTD PMID:16300373 potassium atom multiple interactions EXP 6480464 Copper inhibits the reaction [Potassium results in increased expression of SHANK3 protein] CTD PMID:25007851 potassium atom increases expression EXP 6480464 Potassium results in increased expression of SHANK3 protein CTD PMID:25007851 potassium dichromate decreases expression ISO RGD:732252 6480464 Potassium Dichromate results in decreased expression of SHANK3 mRNA CTD PMID:23608068 ranitidine multiple interactions EXP 6480464 [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of SHANK3 mRNA CTD PMID:16415329 S-butyl-DL-homocysteine (S,R)-sulfoximine decreases expression ISO RGD:732252 6480464 Buthionine Sulfoximine results in decreased expression of SHANK3 mRNA CTD PMID:15878706 SB 431542 multiple interactions ISO RGD:732251 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serpentine asbestos increases methylation ISO RGD:732251 6480464 Asbestos, Serpentine results in increased methylation of SHANK3 5' UTR CTD PMID:29523930 valproic acid affects expression ISO RGD:732251 6480464 Valproic Acid affects the expression of SHANK3 mRNA CTD PMID:25979313 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of SHANK3 mRNA CTD PMID:29427782 valproic acid multiple interactions ISO RGD:732251 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SHANK3 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:732251 6480464 Valproic Acid results in decreased expression of SHANK3 mRNA CTD PMID:23179753 , PMID:26272509 vorinostat decreases expression ISO RGD:732251 6480464 vorinostat results in decreased expression of SHANK3 mRNA CTD PMID:27188386 zinc atom affects binding EXP 6480464 Zinc binds to SHANK3 protein CTD PMID:16793273 zinc atom affects folding EXP 6480464 Zinc affects the folding of SHANK3 protein CTD PMID:16793273 zinc dichloride increases expression EXP 6480464 zinc chloride results in increased expression of SHANK3 protein CTD PMID:25007851 zinc dichloride multiple interactions EXP 6480464 [COMMD1 protein co-treated with zinc chloride co-treated with cupric chloride] results in increased expression of SHANK3 protein, Copper inhibits the reaction [zinc chloride results in increased expression of SHANK3 protein] CTD PMID:25007851 zinc(0) affects binding EXP 6480464 Zinc binds to SHANK3 protein CTD PMID:16793273 zinc(0) affects folding EXP 6480464 Zinc affects the folding of SHANK3 protein CTD PMID:16793273
Biological Process adult behavior ISO RGD:732251 1624291 (PMID:17173049), (PMID:21378602) RGD PMID:17173049 , PMID:21378602 AMPA glutamate receptor clustering ISO RGD:732252 1624291 (MGI:MGI:5013997 more ... RGD MGI:MGI:5013997 more ... AMPA glutamate receptor clustering ISS UniProtKB:Q4ACU6 7349315 PMID:21795692 BHF-UCL brain morphogenesis ISO RGD:732252 1624291 (MGI:MGI:4948759, PMID:21423165) RGD MGI:MGI:4948759 , PMID:21423165 brain morphogenesis IBA MGI:MGI:1930016 more ... 13792537 PMID:21873635 GO_Central brain morphogenesis ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 dendritic spine morphogenesis ISO RGD:732252 1624291 MGI:MGI:5056336 (MGI:MGI:4948759 more ... RGD MGI:MGI:4948759 more ... dendritic spine morphogenesis IBA MGI:MGI:1930016 more ... 13792537 PMID:21873635 GO_Central dendritic spine morphogenesis ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 embryonic epithelial tube formation ISO RGD:732252 1624291 MGI:MGI:97902 (MGI:MGI:3513229 , PMID:15569713) RGD MGI:MGI:3513229 , PMID:15569713 exploration behavior ISO RGD:732252 1624291 (MGI:MGI:5013997, PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 guanylate kinase-associated protein clustering ISO RGD:732252 1624291 (MGI:MGI:5013997, PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 guanylate kinase-associated protein clustering ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 learning ISO RGD:732252 1624291 (MGI:MGI:5013997, PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 learning ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 learning ISO RGD:732251 1624291 (PMID:17173049), (PMID:21378602) RGD PMID:17173049 , PMID:21378602 learning or memory ISO RGD:732252 1624291 MGI:MGI:5056336 (MGI:MGI:5013997 , PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 locomotion ISO RGD:732252 1624291 (MGI:MGI:5013997, PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 locomotory behavior ISO RGD:732252 1624291 MGI:MGI:5056336 (MGI:MGI:5013997 , PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 locomotory exploration behavior ISO RGD:732252 1624291 (MGI:MGI:4948759 more ... RGD MGI:MGI:4948759 more ... locomotory exploration behavior ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 long-term synaptic depression ISO RGD:732252 1624291 (MGI:MGI:5320264, PMID:21795692) RGD MGI:MGI:5320264 , PMID:21795692 long-term synaptic potentiation ISO RGD:732252 1624291 (MGI:MGI:5013997, PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 long-term synaptic potentiation IBA MGI:MGI:1930016 more ... 13792537 PMID:21873635 GO_Central maintenance of postsynaptic density structure IC GO:0014069, GO:0030160 1600115 GO_REF:0000036 SynGO GO_REF:0000036 MAPK cascade ISO RGD:732252 1624291 MGI:MGI:95805 more ... RGD MGI:MGI:3513229 , PMID:15569713 MAPK cascade ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 memory ISO RGD:732252 1624291 (MGI:MGI:5013997, PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 memory ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of actin filament bundle assembly ISO RGD:732252 1624291 (MGI:MGI:3846509, PMID:19208628) RGD MGI:MGI:3846509 , PMID:19208628 negative regulation of actin filament bundle assembly ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 negative regulation of cell volume ISO RGD:732252 1624291 (MGI:MGI:4948759, PMID:21423165) RGD MGI:MGI:4948759 , PMID:21423165 negative regulation of cell volume ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 neuromuscular process controlling balance ISO RGD:732252 1624291 (MGI:MGI:5013997, PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 neuromuscular process controlling balance ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 NMDA glutamate receptor clustering ISO RGD:732252 1624291 (MGI:MGI:5013997, PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 NMDA glutamate receptor clustering ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of AMPA receptor activity ISO RGD:732252 1624291 (MGI:MGI:4948759, PMID:21423165) RGD MGI:MGI:4948759 , PMID:21423165 positive regulation of AMPA receptor activity ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of dendritic spine development ISO RGD:732252 1624291 (MGI:MGI:5320264, PMID:21795692) RGD MGI:MGI:5320264 , PMID:21795692 positive regulation of dendritic spine development IBA MGI:MGI:1930016 more ... 13792537 PMID:21873635 GO_Central positive regulation of dendritic spine development ISS UniProtKB:Q4ACU6 7349315 PMID:21795692 BHF-UCL positive regulation of excitatory postsynaptic potential ISO RGD:732252 1624291 (MGI:MGI:4948759 more ... RGD MGI:MGI:4948759 more ... positive regulation of excitatory postsynaptic potential IBA MGI:MGI:1930016 more ... 13792537 PMID:21873635 GO_Central positive regulation of excitatory postsynaptic potential ISS UniProtKB:Q4ACU6 7349315 PMID:21795692 BHF-UCL positive regulation of excitatory postsynaptic potential ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of glutamate receptor signaling pathway IMP 7349315 RGD positive regulation of glutamate receptor signaling pathway ISS UniProtKB:Q4ACU6 7349315 PMID:21795692 BHF-UCL positive regulation of glutamate receptor signaling pathway ISO RGD:732252 1624291 (MGI:MGI:5320264, PMID:21795692) RGD MGI:MGI:5320264 , PMID:21795692 positive regulation of long-term neuronal synaptic plasticity ISO RGD:732252 1624291 (MGI:MGI:5285139, PMID:21167025) RGD MGI:MGI:5285139 , PMID:21167025 positive regulation of long-term neuronal synaptic plasticity ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of long-term synaptic potentiation ISO RGD:732252 1624291 (MGI:MGI:5285139, PMID:21167025) RGD MGI:MGI:5285139 , PMID:21167025 positive regulation of long-term synaptic potentiation ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of synapse structural plasticity ISO RGD:732252 1624291 (MGI:MGI:5285139, PMID:21167025) RGD MGI:MGI:5285139 , PMID:21167025 positive regulation of synapse structural plasticity ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of synaptic transmission, glutamatergic ISO RGD:732252 1624291 (MGI:MGI:4948759 more ... RGD MGI:MGI:4948759 more ... positive regulation of synaptic transmission, glutamatergic IBA MGI:MGI:1930016 more ... 13792537 PMID:21873635 GO_Central positive regulation of synaptic transmission, glutamatergic ISS UniProtKB:Q4ACU6 7349315 PMID:21795692 BHF-UCL positive regulation of synaptic transmission, glutamatergic ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 postsynaptic density assembly ISO RGD:732252 1624291 (MGI:MGI:4948759, PMID:21423165) RGD MGI:MGI:4948759 , PMID:21423165 postsynaptic density assembly IBA MGI:MGI:1930016 , PANTHER:PTN001191880 13792537 PMID:21873635 GO_Central postsynaptic density assembly ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 regulation of AMPA glutamate receptor clustering ISO RGD:732252 1624291 MGI:MGI:5056336 (MGI:MGI:5013997 , PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 regulation of AMPA receptor activity IBA MGI:MGI:1930016 more ... 13792537 PMID:21873635 GO_Central regulation of behavioral fear response ISO RGD:732252 1624291 (MGI:MGI:4948759, PMID:21423165) RGD MGI:MGI:4948759 , PMID:21423165 regulation of behavioral fear response ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 regulation of dendritic spine morphogenesis ISO RGD:732252 1624291 (MGI:MGI:5320264, PMID:21795692) RGD MGI:MGI:5320264 , PMID:21795692 regulation of dendritic spine morphogenesis ISS UniProtKB:Q4ACU6 7349315 PMID:21795692 BHF-UCL regulation of grooming behavior ISO RGD:732252 1624291 (MGI:MGI:4948759 more ... RGD MGI:MGI:4948759 more ... regulation of grooming behavior ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 regulation of long-term synaptic depression ISO RGD:732252 1624291 (MGI:MGI:5320264, PMID:21795692) RGD MGI:MGI:5320264 , PMID:21795692 regulation of long-term synaptic depression ISS UniProtKB:Q4ACU6 7349315 PMID:21795692 BHF-UCL regulation of long-term synaptic potentiation ISO RGD:732252 1624291 (MGI:MGI:5013997, PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 regulation of long-term synaptic potentiation ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 regulation of synapse organization IDA 13702145 PMID:21217644 SynGO regulation of synapse organization IMP 13702145 PMID:21217644 SynGO regulation of synaptic plasticity ISO RGD:732252 1624291 MGI:MGI:5056336 (MGI:MGI:5013997 , PMID:21558424) RGD MGI:MGI:5013997 , PMID:21558424 social behavior ISO RGD:732252 1624291 MGI:MGI:5056336 (MGI:MGI:4948759 more ... RGD MGI:MGI:4948759 more ... social behavior ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 social behavior ISO RGD:732251 1624291 (PMID:17173049), (PMID:21378602) RGD PMID:17173049 , PMID:21378602 striatal medium spiny neuron differentiation ISO RGD:732252 1624291 (MGI:MGI:4948759, PMID:21423165) RGD MGI:MGI:4948759 , PMID:21423165 striatal medium spiny neuron differentiation ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 synapse assembly ISO RGD:732252 1624291 (MGI:MGI:4948759, PMID:21423165) RGD MGI:MGI:4948759 , PMID:21423165 synapse assembly IBA FB:FBgn0040752 more ... 13792537 PMID:21873635 GO_Central synapse assembly ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 synaptic growth at neuromuscular junction IBA FB:FBgn0040752 , PANTHER:PTN001191880 13792537 PMID:21873635 GO_Central vocal learning ISO RGD:732251 1624291 (PMID:17173049), (PMID:21378602) RGD PMID:17173049 , PMID:21378602 vocalization behavior ISO RGD:732251 1624291 (PMID:17173049), (PMID:21378602) RGD PMID:17173049 , PMID:21378602 vocalization behavior ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 vocalization behavior ISO RGD:732252 1624291 MGI:MGI:5056336 (MGI:MGI:5013997 more ... RGD MGI:MGI:5013997 more ... Cellular Component ciliary membrane IDA 8554451 PMID:18596612 BHF-UCL cytoplasm IEA UniProtKB-SubCell:SL-0086 1600115 GO_REF:0000044 UniProt GO_REF:0000044 dendrite IBA MGI:MGI:2671987 more ... 13792537 PMID:21873635 GO_Central dendritic spine IBA MGI:MGI:2671987 more ... 13792537 PMID:21873635 GO_Central extrinsic component of cytoplasmic side of plasma membrane ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 extrinsic component of cytoplasmic side of plasma membrane ISO RGD:732252 1624291 (MGI:MGI:3624607, PMID:16606358) RGD MGI:MGI:3624607 , PMID:16606358 glutamatergic synapse IDA 8554380 PMID:10433269 SynGO glutamatergic synapse IMP 12050098 PMID:23719161 SynGO glutamatergic synapse ISO RGD:732252 1624291 (MGI:MGI:5800303, PMID:27161151) RGD MGI:MGI:5800303 , PMID:27161151 glutamatergic synapse IDA 12050098 PMID:23719161 SynGO glutamatergic synapse IMP 13702145 PMID:21217644 SynGO glutamatergic synapse IDA 13702145 PMID:21217644 SynGO glutamatergic synapse IDA 12050114 PMID:15894489 SynGO ionotropic glutamate receptor complex colocalizes_with IBA MGI:MGI:2671987 more ... 13792537 PMID:21873635 GO_Central neuron projection ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 neuron projection ISO RGD:732252 1624291 (MGI:MGI:5320264, PMID:21795692) RGD MGI:MGI:5320264 , PMID:21795692 neuron projection IBA FB:FBgn0040752 more ... 13792537 PMID:21873635 GO_Central neuron spine ISO RGD:732252 1624291 (MGI:MGI:3624607, PMID:16606358) RGD MGI:MGI:3624607 , PMID:16606358 neuron spine IBA MGI:MGI:1930016 more ... 13792537 PMID:21873635 GO_Central neuron spine ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 postsynaptic density IDA 1599732 ; 1599734 RGD postsynaptic density IMP 12050098 PMID:23719161 SynGO postsynaptic density IBA FB:FBgn0040752 more ... 13792537 PMID:21873635 GO_Central postsynaptic density IDA 8553782 PMID:16522626 UniProt postsynaptic density IDA 12050098 PMID:23719161 SynGO postsynaptic density IDA 12050114 PMID:15894489 SynGO postsynaptic density IDA 8554380 PMID:10433269 BHF-UCL postsynaptic density, intracellular component IDA 12050114 PMID:15894489 SynGO postsynaptic membrane colocalizes_with IBA MGI:MGI:2671987 more ... 13792537 PMID:21873635 GO_Central synapse IDA 628460 RGD Molecular Function actin binding IEA UniProtKB-KW:KW-0009 1600115 GO_REF:0000043 UniProt GO_REF:0000043 identical protein binding IPI UniProtKB:Q9JLU4 68848 PMID:10433268 IntAct ionotropic glutamate receptor binding ISO RGD:732252 1624291 UniProtKB:P23818 more ... RGD MGI:MGI:3624607 more ... ionotropic glutamate receptor binding IBA MGI:MGI:1930016 more ... 13792537 PMID:21873635 GO_Central ionotropic glutamate receptor binding ISS UniProtKB:Q4ACU6 1600115 GO_REF:0000024 BHF-UCL GO_REF:0000024 protein binding IPI RGD:621714 628460 RGD protein binding ISO RGD:732251 1624291 UniProtKB:P16333 more ... RGD PMID:17474147 more ... protein binding ISO RGD:732252 1624291 PR:P35546-2 more ... RGD MGI:MGI:3513229 more ... protein binding IPI UniProtKB:Q9ES28-2 8553890 PMID:12626503 IntAct protein binding IPI RGD:619814 11576289 RGD protein binding IPI UniProtKB:Q9QZM5 8553800 PMID:17304222 IntAct protein binding IPI UniProtKB:Q8K1Q4 8553782 PMID:16522626 UniProt protein C-terminus binding IPI RGD:620768 633972 RGD protein C-terminus binding IPI UniProtKB:P97838 8554380 PMID:10433269 BHF-UCL protein C-terminus binding ISO RGD:732252 1624291 UniProtKB:P23818 (MGI:MGI:3624607 , PMID:16606358) RGD MGI:MGI:3624607 , PMID:16606358 protein self-association IDA 1599732 RGD protein-containing complex binding IDA 1599732 oligomerization RGD scaffold protein binding ISO RGD:732252 1624291 UniProtKB:Q62108 (MGI:MGI:3624607 , PMID:16606358) RGD MGI:MGI:3624607 , PMID:16606358 scaffold protein binding IPI UniProtKB:Q9Z214 8554380 PMID:10433269 BHF-UCL scaffold protein binding IPI UniProtKB:P97838 8554380 PMID:10433269 BHF-UCL SH3 domain binding IPI RGD:70941 1599734 RGD signaling receptor complex adaptor activity IBA MGI:MGI:3613677 more ... 13792537 PMID:21873635 GO_Central structural constituent of postsynaptic density IC GO:0014069, GO:0030160 1600115 GO_REF:0000036 SynGO GO_REF:0000036 structural constituent of postsynaptic density ISO RGD:732252 1624291 (MGI:MGI:5800303, PMID:27161151) RGD MGI:MGI:5800303 , PMID:27161151 structural constituent of postsynaptic density IMP 13702145 PMID:21217644 SynGO structural constituent of postsynaptic density IDA 13702145 PMID:21217644 SynGO structural constituent of postsynaptic density IDA 8554380 PMID:10433269 SynGO synaptic receptor adaptor activity IDA 8554380 PMID:10433269 BHF-UCL synaptic receptor adaptor activity IBA MGI:MGI:3613677 more ... 13792537 PMID:21873635 GO_Central zinc ion binding IDA 1599732 RGD
Gene-Chemical Interaction Annotations
