Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cyth4 | Rat | 1,1-dichloroethene | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of CYTH4 mRNA | CTD | PMID:26682919 | Cyth4 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Cyth4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of CYTH4 mRNA | CTD | PMID:22206623 | Cyth4 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of CYTH4 mRNA | CTD | PMID:22206623 | Cyth4 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CYTH4 mRNA | CTD | PMID:32741896 | Cyth4 | Rat | 17beta-estradiol | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Estradiol results in increased expression of CYTH4 mRNA | CTD | PMID:31614463 | Cyth4 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CYTH4 mRNA | CTD | PMID:32741896 | Cyth4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cyth4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CYTH4 mRNA | CTD | PMID:28922406 | Cyth4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CYTH4 mRNA | CTD | PMID:33387578 and PMID:34747641 | Cyth4 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Cyth4 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38648751 | Cyth4 | Rat | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | tetrabromobisphenol A results in increased expression of CYTH4 mRNA | CTD | PMID:25172293 | Cyth4 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | bisphenol S results in increased expression of CYTH4 mRNA | CTD | PMID:30951980 | Cyth4 | Rat | 4-hydroxynon-2-enal | decreases expression | ISO | Cyth4 (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of CYTH4 mRNA | CTD | PMID:19191707 | Cyth4 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of CYTH4 mRNA | CTD | PMID:31881176 | Cyth4 | Rat | aflatoxin B1 | increases methylation | ISO | CYTH4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of CYTH4 intron | CTD | PMID:30157460 | Cyth4 | Rat | aflatoxin B1 | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of CYTH4 mRNA | CTD | PMID:32234424 | Cyth4 | Rat | all-trans-retinoic acid | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of CYTH4 mRNA | CTD | PMID:33167477 | Cyth4 | Rat | amphotericin B | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Amphotericin B analog results in increased expression of CYTH4 mRNA | CTD | PMID:28534445 | Cyth4 | Rat | antirheumatic drug | decreases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of CYTH4 mRNA | CTD | PMID:24449571 | Cyth4 | Rat | aristolochic acid A | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of CYTH4 mRNA | CTD | PMID:33212167 | Cyth4 | Rat | arsane | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Arsenic results in increased expression of CYTH4 mRNA | CTD | PMID:36861143 | Cyth4 | Rat | arsenic atom | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Arsenic results in increased expression of CYTH4 mRNA | CTD | PMID:36861143 | Cyth4 | Rat | benzo[a]pyrene | decreases expression | ISO | Cyth4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of CYTH4 mRNA | CTD | PMID:17942131 and PMID:22228805 | Cyth4 | Rat | benzo[a]pyrene | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of CYTH4 mRNA | CTD | PMID:32234424 | Cyth4 | Rat | benzo[a]pyrene | decreases methylation | ISO | CYTH4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of CYTH4 promoter | CTD | PMID:27901495 | Cyth4 | Rat | benzo[a]pyrene | affects methylation | ISO | CYTH4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CYTH4 intron | CTD | PMID:30157460 | Cyth4 | Rat | benzo[a]pyrene | increases methylation | ISO | CYTH4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CYTH4 3' UTR | CTD | PMID:27901495 | Cyth4 | Rat | benzo[e]pyrene | increases methylation | ISO | CYTH4 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of CYTH4 intron | CTD | PMID:30157460 | Cyth4 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CYTH4 mRNA | CTD | PMID:25181051 and PMID:34947998 | Cyth4 | Rat | bisphenol A | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of CYTH4 mRNA | CTD | PMID:32156529 and PMID:38701888 | Cyth4 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CYTH4 mRNA | CTD | PMID:30816183 and PMID:32528016 | Cyth4 | Rat | bisphenol F | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | bisphenol F results in increased expression of CYTH4 mRNA | CTD | PMID:30951980 | Cyth4 | Rat | butanal | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of CYTH4 mRNA | CTD | PMID:26079696 | Cyth4 | Rat | cadmium dichloride | decreases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of CYTH4 mRNA | CTD | PMID:38382870 | Cyth4 | Rat | cadmium dichloride | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of CYTH4 mRNA | CTD | PMID:38568856 | Cyth4 | Rat | cannabidiol | multiple interactions | EXP | | 6480464 | Cannabidiol inhibits the reaction [Ketamine results in decreased expression of CYTH4 mRNA] | CTD | PMID:31823199 | Cyth4 | Rat | carbon nanotube | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:27106021 | Cyth4 | Rat | CGP 52608 | multiple interactions | ISO | CYTH4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to CYTH4 gene] | CTD | PMID:28238834 | Cyth4 | Rat | chloroprene | decreases expression | ISO | Cyth4 (Mus musculus) | 6480464 | Chloroprene results in decreased expression of CYTH4 mRNA | CTD | PMID:23125180 | Cyth4 | Rat | choline | multiple interactions | ISO | Cyth4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYTH4 mRNA | CTD | PMID:20938992 | Cyth4 | Rat | cisplatin | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of CYTH4 mRNA | CTD | PMID:27594783 | Cyth4 | Rat | clothianidin | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | clothianidin results in increased expression of CYTH4 mRNA | CTD | PMID:31626844 | Cyth4 | Rat | curcumin | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Curcumin results in increased expression of CYTH4 mRNA | CTD | PMID:17198877 | Cyth4 | Rat | cyclosporin A | decreases expression | ISO | Cyth4 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of CYTH4 mRNA | CTD | PMID:17942131 | Cyth4 | Rat | diquat | decreases expression | ISO | Cyth4 (Mus musculus) | 6480464 | Diquat results in decreased expression of CYTH4 mRNA | CTD | PMID:36851058 | Cyth4 | Rat | ethanol | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | Ethanol results in increased expression of CYTH4 mRNA | CTD | PMID:30319688 | Cyth4 | Rat | fenthion | decreases expression | ISO | Cyth4 (Mus musculus) | 6480464 | Fenthion results in decreased expression of CYTH4 mRNA | CTD | PMID:34813904 | Cyth4 | Rat | folic acid | multiple interactions | ISO | Cyth4 (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | Cyth4 | Rat | glycidyl methacrylate | decreases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | glycidyl methacrylate results in decreased expression of CYTH4 protein | CTD | PMID:36641056 | Cyth4 | Rat | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of CYTH4 mRNA | CTD | PMID:31823199 | Cyth4 | Rat | ketamine | multiple interactions | EXP | | 6480464 | Cannabidiol inhibits the reaction [Ketamine results in decreased expression of CYTH4 mRNA] | CTD | PMID:31823199 | Cyth4 | Rat | L-methionine | multiple interactions | ISO | Cyth4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CYTH4 mRNA | CTD | PMID:20938992 | Cyth4 | Rat | methapyrilene | increases methylation | ISO | CYTH4 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of CYTH4 intron | CTD | PMID:30157460 | Cyth4 | Rat | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of CYTH4 mRNA | CTD | PMID:31378766 | Cyth4 | Rat | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | decreases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | N more ... | CTD | PMID:12756304 | Cyth4 | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of CYTH4 gene | CTD | PMID:33148267 | Cyth4 | Rat | N-Nitrosopyrrolidine | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in increased expression of CYTH4 mRNA | CTD | PMID:32234424 | Cyth4 | Rat | nickel atom | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Nickel results in increased expression of CYTH4 mRNA | CTD | PMID:24768652 | Cyth4 | Rat | ozone | multiple interactions | ISO | Cyth4 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in increased expression of CYTH4 mRNA | CTD | PMID:34911549 | Cyth4 | Rat | paracetamol | decreases expression | ISO | Cyth4 (Mus musculus) | 6480464 | Acetaminophen results in decreased expression of CYTH4 mRNA | CTD | PMID:17942131 | Cyth4 | Rat | paracetamol | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of CYTH4 mRNA | CTD | PMID:26690555 | Cyth4 | Rat | PCB138 | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | Cyth4 | Rat | pentanal | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | pentanal results in increased expression of CYTH4 mRNA | CTD | PMID:26079696 | Cyth4 | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of CYTH4 gene | CTD | PMID:33148267 | Cyth4 | Rat | propanal | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of CYTH4 mRNA | CTD | PMID:26079696 | Cyth4 | Rat | silicon dioxide | increases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of CYTH4 mRNA | CTD | PMID:25895662 | Cyth4 | Rat | silicon dioxide | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of CYTH4 mRNA | CTD | PMID:29341224 | Cyth4 | Rat | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide results in increased expression of CYTH4 mRNA | CTD | PMID:32721576 | Cyth4 | Rat | temozolomide | decreases expression | ISO | CYTH4 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of CYTH4 mRNA | CTD | PMID:31758290 | Cyth4 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CYTH4 mRNA | CTD | PMID:32741896 | Cyth4 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CYTH4 mRNA | CTD | PMID:31150632 | Cyth4 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of CYTH4 mRNA | CTD | PMID:34492290 | Cyth4 | Rat | Tributyltin oxide | decreases expression | ISO | Cyth4 (Mus musculus) | 6480464 | bis(tri-n-butyltin)oxide results in decreased expression of CYTH4 mRNA | CTD | PMID:17942131 | Cyth4 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of CYTH4 mRNA | CTD | PMID:33387578 | Cyth4 | Rat | triphenyl phosphate | affects expression | ISO | CYTH4 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of CYTH4 mRNA | CTD | PMID:37042841 | Cyth4 | Rat | triptonide | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | triptonide results in increased expression of CYTH4 mRNA | CTD | PMID:33045310 | Cyth4 | Rat | trovafloxacin | increases expression | ISO | Cyth4 (Mus musculus) | 6480464 | trovafloxacin results in increased expression of CYTH4 mRNA | CTD | PMID:35537566 | |