Krt8 (keratin 8) - Rat Genome Database

Name: Krt8
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Krt8 (keratin 8) Rattus norvegicus

Analyze

Symbol:

Krt8

Name:

keratin 8

RGD ID:

2984

Description:

Predicted to enable scaffold protein binding activity. Predicted to be a structural constituent of skin epidermis. Involved in response to hydrostatic pressure and sarcomere organization. Located in keratin filament; myofibril; and sarcolemma. Part of dystrophin-associated glycoprotein complex. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT8 (keratin 8); INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

CK-8; CYKER; cytokeratin endo A; cytokeratin-8; K8; keratin 8, type II; keratin complex 2, basic, gene 8; keratin, type II cytoskeletal 8; keratin-8; Krt2-8; type-II keratin Kb8

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KRT8 (keratin 8)	RGD	RGD
Mus musculus (house mouse):	Krt8 (keratin 8)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Krt8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KRT8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KRT8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Krt8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KRT8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KRT8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Krt8 (keratin 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KRT8 (keratin 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Krt8 (keratin 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	krt5 (keratin 5)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	krt4 (keratin 4)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	krt8 (keratin 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:158846	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ifa-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Caenorhabditis elegans (roundworm):	ifa-3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)
Caenorhabditis elegans (roundworm):	ifb-2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder)

Related Pseudogenes:

Krt8-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	133,124,203 - 133,131,656 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	133,124,203 - 133,131,728 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	134,885,801 - 134,893,230 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	137,115,319 - 137,122,748 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	137,093,977 - 137,101,412 (-)	NCBI	Rnor_WKY
Rnor_6.0	7	143,596,511 - 143,603,745 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	143,596,511 - 143,603,803 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	141,393,004 - 141,400,457 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	140,713,902 - 140,721,199 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	140,790,339 - 140,797,636 (-)	NCBI
Celera	7	129,561,335 - 129,568,866 (-)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

adenocarcinoma (ISO)

Breast Neoplasms (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Chronic Hepatitis C (ISO)

Cryptogenic Cirrhosis (ISO)

Experimental Liver Cirrhosis (ISO)

Familial Cirrhosis (ISO)

hepatitis C (ISO)

inflammatory bowel disease (ISO)

liver cirrhosis (ISO)

Liver Injury (ISO)

Liver Neoplasms (ISO)

pre-malignant neoplasm (ISO)

renal cell carcinoma (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP,ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-acetamidofluorene (EXP)

3,5-diethoxycarbonyl-1,4-dihydrocollidine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-azacytidine (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (EXP)

9-cis-retinoic acid (ISO)

acetamide (EXP)

acrolein (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-4-oxoretinoic acid (ISO)

all-trans-4-oxoretinol (ISO)

all-trans-retinoic acid (EXP,ISO)

all-trans-retinol (ISO)

amiodarone (EXP)

arachidonic acid (ISO)

aristolochic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (EXP)

arsenous acid (ISO)

benzbromarone (EXP)

benzo[a]pyrene (EXP,ISO)

beta-carotene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bucladesine (ISO)

Butylparaben (ISO)

C60 fullerene (EXP)

cadmium atom (EXP)

cadmium dichloride (ISO)

calciol (ISO)

cannabidiol (ISO)

captan (ISO)

carbon nanotube (ISO)

carmustine (ISO)

chlordecone (ISO)

chloroform (EXP)

choline (ISO)

chromium(6+) (ISO)

ciprofibrate (ISO)

clofibrate (EXP,ISO)

cobalt dichloride (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

cumene (ISO)

Cuprizon (EXP)

cyclophosphamide (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

daunorubicin (EXP)

DDT (ISO)

dexamethasone (EXP,ISO)

diallyl trisulfide (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP,ISO)

dichloroacetic acid (ISO)

diethylstilbestrol (ISO)

dimethylarsinic acid (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenofibrate (ISO)

fenvalerate (EXP)

fipronil (EXP)

flavone (ISO)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

fulvestrant (ISO)

fumonisin B1 (ISO)

furan (EXP)

gemcitabine (ISO)

genistein (ISO)

griseofulvin (ISO)

hexadecanoic acid (ISO)

hydrazine (EXP)

iron(III) nitrilotriacetate (ISO)

isoflavones (EXP)

ivermectin (ISO)

L-ethionine (EXP)

L-methionine (ISO)

lidocaine (EXP)

medroxyprogesterone acetate (ISO)

megestrol acetate (ISO)

menadione (ISO)

mercury dibromide (ISO)

methapyrilene (EXP)

methidathion (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

methylparaben (ISO)

microcystin-LR (ISO)

Monobutylphthalate (ISO)

morphine (EXP)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-acetyl-L-cysteine (ISO)

N-butyl-N-(4-hydroxybutyl)nitrosamine (ISO)

N-nitrosodiethylamine (EXP,ISO)

N-nitrosodimethylamine (EXP)

N-nitrosomorpholine (EXP)

nefazodone (EXP)

nimesulide (EXP)

nitrofen (EXP)

nystatin (ISO)

omeprazole (EXP)

orphenadrine (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pentachlorophenol (ISO)

perfluorobutyric acid (ISO)

perfluorododecanoic acid (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (EXP,ISO)

phenylmercury acetate (ISO)

phorbol 13-acetate 12-myristate (ISO)

phosgene (ISO)

piperonyl butoxide (ISO)

pirinixic acid (EXP,ISO)

prednisolone (ISO)

pregnenolone 16alpha-carbonitrile (EXP,ISO)

progesterone (ISO)

propiconazole (ISO)

quercetin (EXP,ISO)

rac-1,2-dichloropropane (ISO)

rotenone (EXP)

SB 203580 (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP,ISO)

sodium dichromate (EXP,ISO)

sodium dodecyl sulfate (ISO)

sodium fluoride (ISO)

SU6656 (ISO)

sulforaphane (ISO)

sunitinib (ISO)

T-2 toxin (EXP,ISO)

tamoxifen (EXP,ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (EXP)

thapsigargin (ISO)

theophylline (EXP)

thioacetamide (EXP,ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation involved in embryonic placenta development (ISO)

extrinsic apoptotic signaling pathway (ISO)

hepatocyte apoptotic process (ISO)

intermediate filament organization (IBA)

keratinization (IBA)

response to hydrostatic pressure (IDA)

response to other organism (ISO)

sarcomere organization (IDA)

tumor necrosis factor-mediated signaling pathway (ISO)

Cellular Component

apicolateral plasma membrane (ISO)

cell periphery (ISO)

cell-cell junction (ISO)

costamere (IDA)

cytoplasm (ISO)

dystrophin-associated glycoprotein complex (IDA)

intermediate filament (ISO)

intermediate filament cytoskeleton (ISO)

keratin filament (IBA,IDA,IEA,ISO)

nuclear matrix (IEA)

nucleoplasm (IEA)

sarcolemma (IDA,ISO)

Z disc (IDA,ISO)

Molecular Function

protein binding (IPI,ISO)

protein-containing complex binding (IPI)

scaffold protein binding (ISO)

structural constituent of skin epidermis (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Regulation of basal and luminal cell-specific cytokeratin expression in rat accessory sex organs. Evidence for a new class of androgen-repressed genes and insight into their pairwise control.	Hsieh JT, etal., J Biol Chem 1992 Feb 5;267(4):2303-10.
4.	A disease- and phosphorylation-related nonmechanical function for keratin 8.	Ku NO and Omary MB, J Cell Biol. 2006 Jul 3;174(1):115-25. doi: 10.1083/jcb.200602146.
5.	Keratin 8 mutations in patients with cryptogenic liver disease.	Ku NO, etal., N Engl J Med. 2001 May 24;344(21):1580-7.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells.	Ridge KM, etal., J Biol Chem. 2005 Aug 26;280(34):30400-5. Epub 2005 Jun 22.
13.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14.	Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.	Toivola DM, etal., Hepatology. 2004 Aug;40(2):459-66. doi: 10.1002/hep.20277.
15.	Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex.	Ursitti JA, etal., J Biol Chem. 2004 Oct 1;279(40):41830-8. Epub 2004 Jul 6.
16.	Phosphorylation of keratin intermediate filaments by protein kinase C, by calmodulin-dependent protein kinase and by cAMP-dependent protein kinase.	Yano T, etal., Eur J Biochem. 1991 Apr 23;197(2):281-90.

Additional References at PubMed

PMID:7525090	PMID:8660345	PMID:10747083	PMID:10852826	PMID:11062258	PMID:12477932	PMID:14576356	PMID:15489334	PMID:15846844	PMID:16128803	PMID:16396499	PMID:16641100
PMID:17553064	PMID:19188445	PMID:19199708	PMID:19409407	PMID:19487454	PMID:21630459	PMID:22685604	PMID:23266329	PMID:23533145	PMID:24625528	PMID:25002582	PMID:25232867
PMID:30361391

Genomics

Comparative Map Data

Krt8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	133,124,203 - 133,131,656 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	133,124,203 - 133,131,728 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	134,885,801 - 134,893,230 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	137,115,319 - 137,122,748 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	137,093,977 - 137,101,412 (-)	NCBI	Rnor_WKY
Rnor_6.0	7	143,596,511 - 143,603,745 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	143,596,511 - 143,603,803 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	141,393,004 - 141,400,457 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	140,713,902 - 140,721,199 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	140,790,339 - 140,797,636 (-)	NCBI
Celera	7	129,561,335 - 129,568,866 (-)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

KRT8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	52,897,191 - 52,949,860 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	52,897,187 - 52,949,954 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	53,290,975 - 53,343,644 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	51,577,238 - 51,585,127 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	51,577,241 - 51,585,089	NCBI
Celera	12	52,937,521 - 52,945,403 (-)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	50,334,669 - 50,387,466 (-)	NCBI		HuRef
CHM1_1	12	53,257,746 - 53,310,407 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	52,861,778 - 52,914,419 (-)	NCBI		T2T-CHM13v2.0

Krt8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	101,905,146 - 101,912,777 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	101,905,133 - 101,912,917 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	101,996,711 - 102,004,342 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	101,996,698 - 102,004,482 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	101,827,142 - 101,834,773 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	101,824,745 - 101,832,317 (-)	NCBI		MGSCv36	mm8
Celera	15	104,151,508 - 104,159,109 (-)	NCBI		Celera
Cytogenetic Map	15	F2	NCBI
cM Map	15	57.2	NCBI

Krt8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955458	178,954 - 190,310 (-)	NCBI	ChiLan1.0	ChiLan1.0

KRT8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	36,634,582 - 36,642,564 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	36,634,582 - 36,642,564 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	35,855,367 - 35,863,248 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

KRT8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	2,221,608 - 2,229,343 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	44,022,937 - 44,030,605 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	2,222,635 - 2,230,328 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	27	2,239,283 - 2,246,949 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	2,225,535 - 2,233,175 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	44,422,008 - 44,429,675 (-)	NCBI		UU_Cfam_GSD_1.0

Krt8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	62,910,080 - 62,917,785 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936512	10,247,049 - 10,254,748 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KRT8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	18,167,553 - 18,180,404 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	18,172,423 - 18,180,277 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	18,663,339 - 18,671,193 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KRT8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	49,027,879 - 49,051,753 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	197,035,944 - 197,043,662 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Krt8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624904	970,136 - 978,211 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Krt8
107 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	45
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000038480
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	119513385	135012528	Rat

Markers in Region

BI284447

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	133,124,547 - 133,125,318 (+)	MAPPER	mRatBN7.2
mRatBN7.2	11	63,074,842 - 63,075,045 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	65,971,316 - 65,971,518	NCBI	Rnor6.0
Rnor_6.0	7	143,596,856 - 143,597,626	NCBI	Rnor6.0
Rnor_5.0	11	69,063,210 - 69,063,412	UniSTS	Rnor5.0
Rnor_5.0	7	141,393,349 - 141,394,119	UniSTS	Rnor5.0
RGSC_v3.4	7	140,714,247 - 140,715,017	UniSTS	RGSC3.4
RGSC_v3.4	11	64,864,363 - 64,864,565	UniSTS	RGSC3.4
Celera	11	62,571,445 - 62,571,647	UniSTS
Celera	7	129,561,680 - 129,562,450	UniSTS
RH 3.4 Map	11	497.4	UniSTS
Cytogenetic Map	7	q36	UniSTS

RH125425

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	133,126,573 - 133,126,737 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	143,598,882 - 143,599,045	NCBI	Rnor6.0
Rnor_5.0	7	141,395,375 - 141,395,538	UniSTS	Rnor5.0
RGSC_v3.4	7	140,716,273 - 140,716,436	UniSTS	RGSC3.4
Celera	7	129,563,706 - 129,563,869	UniSTS
Cytogenetic Map	7	q36	UniSTS

Krt8

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	63,074,397 - 63,074,903 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	65,970,871 - 65,971,376	NCBI	Rnor6.0
Rnor_5.0	11	69,062,765 - 69,063,270	UniSTS	Rnor5.0
RGSC_v3.4	11	64,863,918 - 64,864,423	UniSTS	RGSC3.4
Celera	11	62,571,000 - 62,571,505	UniSTS
Cytogenetic Map	7	q36	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High	3
Medium		10	49	41	8	41			4	35	34	11
Low		33	8		11		8	10	68		7		8
Below cutoff								1	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC108351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY464139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M63482	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S76054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U64832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U73961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000038480 ⟹ ENSRNOP00000029068

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	133,124,203 - 133,131,728 (-)	Ensembl
Rnor_6.0 Ensembl	7	143,596,511 - 143,603,803 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000089279

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	133,124,207 - 133,131,728 (-)	Ensembl
Rnor_6.0 Ensembl	7	143,596,514 - 143,597,141 (-)	Ensembl

RefSeq Acc Id:

NM_199370 ⟹ NP_955402

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	133,124,203 - 133,131,656 (-)	NCBI
Rnor_6.0	7	143,596,511 - 143,603,745 (-)	NCBI
Rnor_5.0	7	141,393,004 - 141,400,457 (-)	NCBI
RGSC_v3.4	7	140,713,902 - 140,721,199 (-)	RGD
Celera	7	129,561,335 - 129,568,866 (-)	RGD

Sequence:

show sequence

ATGTCCGTCAGGGTGACTCAGAAATCCTACAAGATGTCCACCTCCGGTCCCCGGGCCTTCAGCA
GCCGCTCGTTCACGAGTGGACCCGGTGCCCGCATCAGCTCTTCCAGCTTTTCCCGGGTGGGCAG
CAGCAGCAGCAGCTTCCGCGGAAGCCTGGGCGGCTTTGGCGGGGCTGGTGTCGGGGGCATCACG
GCGGTCACGGTGAACCAGAGCCTGCTGAACCCCTTGAAGCTGGAGGTGGACCCCAACATCCAGG
CTGTGCGCACTCAGGAGAAAGAGCAGATCAAGACCCTGAACAACAAGTTCGCCTCTTTCATTGA
CAAGGTACGCTTCCTGGAGCAGCAGAACAAGATGCTGGAGACCAAATGGAGCTTGCTGCAACAG
CAGAAGACATCCAGGAGCAACATGGACAACATGTTTGAGAGTTACATCAACAACCTCCGTCGGC
AGCTGGAAGCCCTGGGCCAGGAGAAGCTGAAGCTGGAGGTGGAGCTTGGCAACATGCAGGGCCT
GGTGGAGGACTTCAAGAATAAGTATGAGGATGAGATCAACAAGCGTACAGAGATGGAGAATGAG
TTTGTCCTCATCAAGAAGGATGTGGATGAAGCCTACATGAACAAGGTGGAGCTTGAGTCCCGCC
TGGAAGGACTGACCGACGAGATCAACTTCCTCCGGCAGATCCATGAAGAGGAGATCCGTGAGCT
GCAGTCTCAGATCTCAGACACGTCTGTGGTGCTGTCCATGGACAACAGCCGCTCCCTGGACATG
GACAGCATCATTGCTGAAGTTCGTGCCCAGTATGAGGAGATCGCCAACCGCAGCCGAGCTGAGG
CCGAAACCATGTACCAGATTAAGTATGAGGAATTGCAGACCCTGGCTGGGAAGCACGGGGATGA
TCTACGTCGCTCGAAGACGGAGATCTCTGAGATGAACCGTAACATCAGCCGCCTGCAGGCGGAG
ATTGACGCCCTCAAAGGCCAGAGGGCAACCCTGGAGGCGGCCATTGCTGATGCAGAGCAGCGTG
GGGAACTGGCCGTGAAGGATGCCAATGCCAAGCTGGAGGATCTGAAGAATGCCCTGCAGAAGGC
CAAGCAGGACATGGCCCGGCAGCTGCGCGAGTACCAGGAGCTGATGAACGTCAAGCTGGCGCTT
GACATCGAGATCGCCACCTACCGCAAGCTGCTGGAGGGCGAGGAGAGCAGGCTGGAGTCTGGGA
TGCAGAACATGAGCATCCACACGAAGACCACCAGTGGCTACGCAGGAGGACTGAGTTCATCCTA
CGGGGGACTCACTAGCCCCGGCTTCAGCTATGGAATGAGCTCTTTCCAGCCCGGCTTCGGTTCT
GTTGGGGGATCCAGCACTTATAGCCGCACCAAGGCTGTGGTCGTGAAGAAGATTGAAACCCGAG
ATGGGAAACTGGTGTCTGAGTCTTCTGACATCATGTCCAAGTGAATGGCCACTGAAGTCATTGC
CAGCCTGAGGTCCTGCAGCTGCTCAGGGGTCAAGGGGAGACAGCTGTATGGCAGAGTGCAGGGA
ACTAGGGACCAGCCAGAGTACCAGCCCTAAACCTCTGGCCAACCTTGGGAGGAATTTCCTATCT
GGGATATGCCAATGCCCAACTCAATTGTATTTTCCAAAATAAAGCCTCAGCTGGCTGTATCAAC
TAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039078493 ⟹ XP_038934421

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	133,124,203 - 133,130,800 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_955402	(Get FASTA)	NCBI Sequence Viewer
	XP_038934421	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA19667	(Get FASTA)	NCBI Sequence Viewer
	AAA19668	(Get FASTA)	NCBI Sequence Viewer
	AAB18254	(Get FASTA)	NCBI Sequence Viewer
	AAH91106	(Get FASTA)	NCBI Sequence Viewer
	AAH97497	(Get FASTA)	NCBI Sequence Viewer
	AAP31862	(Get FASTA)	NCBI Sequence Viewer
	AAR36875	(Get FASTA)	NCBI Sequence Viewer
	EDL86869	(Get FASTA)	NCBI Sequence Viewer
	EDL86870	(Get FASTA)	NCBI Sequence Viewer
	Q10758	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_955402 ⟸ NM_199370

- UniProtKB:

Q5WPB3 (UniProtKB/Swiss-Prot), Q10758 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSVRVTQKSYKMSTSGPRAFSSRSFTSGPGARISSSSFSRVGSSSSSFRGSLGGFGGAGVGGIT
AVTVNQSLLNPLKLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQ
QKTSRSNMDNMFESYINNLRRQLEALGQEKLKLEVELGNMQGLVEDFKNKYEDEINKRTEMENE
FVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQIHEEEIRELQSQISDTSVVLSMDNSRSLDM
DSIIAEVRAQYEEIANRSRAEAETMYQIKYEELQTLAGKHGDDLRRSKTEISEMNRNISRLQAE
IDALKGQRATLEAAIADAEQRGELAVKDANAKLEDLKNALQKAKQDMARQLREYQELMNVKLAL
DIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSSYGGLTSPGFSYGMSSFQPGFGS
VGGSSTYSRTKAVVVKKIETRDGKLVSESSDIMSK

hide sequence

RefSeq Acc Id:

ENSRNOP00000029068 ⟸ ENSRNOT00000038480

RefSeq Acc Id:	XP_038934421 ⟸ XM_039078493
- Peptide Label:	isoform X1

Protein Domains

IF rod

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q10758-F1-model_v2	AlphaFold	Q10758	1-483	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695687

Promoter ID:

EPDNEW_R6210

Type:

multiple initiation site

Name:

Krt8_1

Description:

keratin 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	143,603,820 - 143,603,880	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2984	AgrOrtholog
BioCyc Gene	G2FUF-31954	BioCyc
Ensembl Genes	ENSRNOG00000009779	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000029068	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000080317.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000038480	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000089279.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7381703	IMAGE-MGC_LOAD
	IMAGE:7462062	IMAGE-MGC_LOAD
InterPro	IF_conserved	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IF_rod_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Keratin_2_head	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Keratin_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25626	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108522	IMAGE-MGC_LOAD
	MGC:114571	IMAGE-MGC_LOAD
NCBI Gene	25626	ENTREZGENE
Pfam	Filament	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Keratin_2_head	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Krt8	PhenoGen
PRINTS	TYPE2KERATIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	IF_ROD_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IF_ROD_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Filament	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC204073
UniProt	A0A8I6G4D8_RAT	UniProtKB/TrEMBL
	K2C8_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5WPB3	ENTREZGENE
UniProt Secondary	Q5WPB3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-16	Krt8	keratin 8	Krt8	keratin 8, type II	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-28	Krt8	keratin 8, type II	Krt8	keratin 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-15	Krt8	keratin 8	Krt2-8	keratin complex 2, basic, gene 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-11	Krt2-8	keratin complex 2, basic, gene 8	Krt8	keratin 8	Symbol and Name updated to reflect Human and Mouse nomenclature	625702	APPROVED
2002-06-10	Krt8	Keratin 8			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	expression is negatively regulated by androgen in prostate tissue	633141

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD