Krt8 (keratin 8) - Rat Genome Database

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Gene: Krt8 (keratin 8) Rattus norvegicus
Analyze
Symbol: Krt8
Name: keratin 8
RGD ID: 2984
Description: Predicted to enable scaffold protein binding activity. Involved in response to hydrostatic pressure and sarcomere organization. Located in keratin filament; myofibril; and sarcolemma. Part of dystrophin-associated glycoprotein complex. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT8 (keratin 8); INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CK-8; CYKER; cytokeratin endo A; cytokeratin-8; K8; keratin 8, type II; keratin complex 2, basic, gene 8; keratin, type II cytoskeletal 8; keratin-8; Krt2-8; type-II keratin Kb8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Krt8-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,002,886 - 135,010,339 (-)NCBIGRCr8
mRatBN7.27133,124,203 - 133,131,656 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,124,203 - 133,131,728 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,885,801 - 134,893,230 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,115,319 - 137,122,748 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,093,977 - 137,101,412 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,596,511 - 143,603,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,596,511 - 143,603,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,393,004 - 141,400,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,713,902 - 140,721,199 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,790,339 - 140,797,636 (-)NCBI
Celera7129,561,335 - 129,568,866 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-ephedrine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-aminobenzotriazole  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-acetamidofluorene  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-4-oxoretinol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bucladesine  (ISO)
Butylparaben  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calciol  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciprofibrate  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cumene  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
daunorubicin  (EXP)
DDT  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flavone  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furfural  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (EXP,ISO)
griseofulvin  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
inulin  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lidocaine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
Monobutylphthalate  (ISO)
morphine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
nystatin  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
rac-1,2-dichloropropane  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
SU6656  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Regulation of basal and luminal cell-specific cytokeratin expression in rat accessory sex organs. Evidence for a new class of androgen-repressed genes and insight into their pairwise control. Hsieh JT, etal., J Biol Chem 1992 Feb 5;267(4):2303-10.
4. A disease- and phosphorylation-related nonmechanical function for keratin 8. Ku NO and Omary MB, J Cell Biol. 2006 Jul 3;174(1):115-25. doi: 10.1083/jcb.200602146.
5. Keratin 8 mutations in patients with cryptogenic liver disease. Ku NO, etal., N Engl J Med. 2001 May 24;344(21):1580-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells. Ridge KM, etal., J Biol Chem. 2005 Aug 26;280(34):30400-5. Epub 2005 Jun 22.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Toivola DM, etal., Hepatology. 2004 Aug;40(2):459-66. doi: 10.1002/hep.20277.
15. Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex. Ursitti JA, etal., J Biol Chem. 2004 Oct 1;279(40):41830-8. Epub 2004 Jul 6.
16. Phosphorylation of keratin intermediate filaments by protein kinase C, by calmodulin-dependent protein kinase and by cAMP-dependent protein kinase. Yano T, etal., Eur J Biochem. 1991 Apr 23;197(2):281-90.
Additional References at PubMed
PMID:7525090   PMID:8660345   PMID:10747083   PMID:10852826   PMID:11062258   PMID:12477932   PMID:14576356   PMID:15489334   PMID:15846844   PMID:16128803   PMID:16396499   PMID:16641100  
PMID:17553064   PMID:19188445   PMID:19199708   PMID:19409407   PMID:19487454   PMID:21630459   PMID:22685604   PMID:23266329   PMID:23533145   PMID:24625528   PMID:25002582   PMID:25232867  
PMID:30361391   PMID:36897022  


Genomics

Comparative Map Data
Krt8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,002,886 - 135,010,339 (-)NCBIGRCr8
mRatBN7.27133,124,203 - 133,131,656 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,124,203 - 133,131,728 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,885,801 - 134,893,230 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,115,319 - 137,122,748 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,093,977 - 137,101,412 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,596,511 - 143,603,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,596,511 - 143,603,803 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,393,004 - 141,400,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,713,902 - 140,721,199 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,790,339 - 140,797,636 (-)NCBI
Celera7129,561,335 - 129,568,866 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,897,191 - 52,949,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,897,187 - 52,949,954 (-)EnsemblGRCh38hg38GRCh38
GRCh371253,290,975 - 53,343,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,577,238 - 51,585,127 (-)NCBINCBI36Build 36hg18NCBI36
Build 341251,577,241 - 51,585,089NCBI
Celera1252,937,521 - 52,945,403 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,334,669 - 50,387,466 (-)NCBIHuRef
CHM1_11253,257,746 - 53,310,407 (-)NCBICHM1_1
T2T-CHM13v2.01252,861,778 - 52,914,419 (-)NCBIT2T-CHM13v2.0
Krt8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,905,146 - 101,912,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,905,133 - 101,912,917 (-)EnsemblGRCm39 Ensembl
GRCm3815101,996,711 - 102,004,342 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,996,698 - 102,004,482 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,827,142 - 101,834,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,824,745 - 101,832,317 (-)NCBIMGSCv36mm8
Celera15104,151,508 - 104,159,109 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.2NCBI
Krt8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955458178,954 - 190,310 (-)NCBIChiLan1.0ChiLan1.0
KRT8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,287,911 - 41,295,899 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,284,674 - 41,292,662 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,855,367 - 35,863,248 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,634,582 - 36,642,564 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,634,582 - 36,642,564 (+)Ensemblpanpan1.1panPan2
KRT8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,221,608 - 2,229,343 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,022,937 - 44,030,605 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,222,635 - 2,230,328 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1272,239,283 - 2,246,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,225,535 - 2,233,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,422,008 - 44,429,675 (-)NCBIUU_Cfam_GSD_1.0
Krt8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,910,080 - 62,917,785 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,246,991 - 10,254,827 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,247,049 - 10,254,748 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,167,553 - 18,180,404 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,172,423 - 18,180,277 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,663,339 - 18,671,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,027,879 - 49,051,753 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037197,035,944 - 197,043,662 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624904970,136 - 978,211 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Krt8
111 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:45
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000038480
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
BI284447  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,124,547 - 133,125,318 (+)MAPPERmRatBN7.2
mRatBN7.21163,074,842 - 63,075,045 (+)MAPPERmRatBN7.2
Rnor_6.01165,971,316 - 65,971,518NCBIRnor6.0
Rnor_6.07143,596,856 - 143,597,626NCBIRnor6.0
Rnor_5.01169,063,210 - 69,063,412UniSTSRnor5.0
Rnor_5.07141,393,349 - 141,394,119UniSTSRnor5.0
RGSC_v3.47140,714,247 - 140,715,017UniSTSRGSC3.4
RGSC_v3.41164,864,363 - 64,864,565UniSTSRGSC3.4
Celera1162,571,445 - 62,571,647UniSTS
Celera7129,561,680 - 129,562,450UniSTS
RH 3.4 Map11497.4UniSTS
Cytogenetic Map7q36UniSTS
RH125425  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,126,573 - 133,126,737 (+)MAPPERmRatBN7.2
Rnor_6.07143,598,882 - 143,599,045NCBIRnor6.0
Rnor_5.07141,395,375 - 141,395,538UniSTSRnor5.0
RGSC_v3.47140,716,273 - 140,716,436UniSTSRGSC3.4
Celera7129,563,706 - 129,563,869UniSTS
Cytogenetic Map7q36UniSTS
Krt8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21163,074,397 - 63,074,903 (+)MAPPERmRatBN7.2
Rnor_6.01165,970,871 - 65,971,376NCBIRnor6.0
Rnor_5.01169,062,765 - 69,063,270UniSTSRnor5.0
RGSC_v3.41164,863,918 - 64,864,423UniSTSRGSC3.4
Celera1162,571,000 - 62,571,505UniSTS
Cytogenetic Map7q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000038480   ⟹   ENSRNOP00000029068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,124,203 - 133,131,728 (-)Ensembl
Rnor_6.0 Ensembl7143,596,511 - 143,603,803 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,124,207 - 133,131,728 (-)Ensembl
Rnor_6.0 Ensembl7143,596,514 - 143,597,141 (-)Ensembl
RefSeq Acc Id: NM_199370   ⟹   NP_955402
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,002,886 - 135,010,339 (-)NCBI
mRatBN7.27133,124,203 - 133,131,656 (-)NCBI
Rnor_6.07143,596,511 - 143,603,745 (-)NCBI
Rnor_5.07141,393,004 - 141,400,457 (-)NCBI
RGSC_v3.47140,713,902 - 140,721,199 (-)RGD
Celera7129,561,335 - 129,568,866 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078493   ⟹   XP_038934421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,002,886 - 135,009,446 (-)NCBI
mRatBN7.27133,124,203 - 133,130,800 (-)NCBI
RefSeq Acc Id: NP_955402   ⟸   NM_199370
- UniProtKB: Q5WPB3 (UniProtKB/Swiss-Prot),   Q10758 (UniProtKB/Swiss-Prot),   A6KCS2 (UniProtKB/TrEMBL),   A0A8I6G4D8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000029068   ⟸   ENSRNOT00000038480
RefSeq Acc Id: XP_038934421   ⟸   XM_039078493
- Peptide Label: isoform X1
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q10758-F1-model_v2 AlphaFold Q10758 1-483 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695687
Promoter ID:EPDNEW_R6210
Type:multiple initiation site
Name:Krt8_1
Description:keratin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,603,820 - 143,603,880EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2984 AgrOrtholog
BioCyc Gene G2FUF-31954 BioCyc
Ensembl Genes ENSRNOG00000009779 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038480 ENTREZGENE
  ENSRNOT00000038480.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7381703 IMAGE-MGC_LOAD
  IMAGE:7462062 IMAGE-MGC_LOAD
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
  Keratin_II UniProtKB/Swiss-Prot
KEGG Report rno:25626 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108522 IMAGE-MGC_LOAD
  MGC:114571 IMAGE-MGC_LOAD
NCBI Gene 25626 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  KERATIN, TYPE II CYTOSKELETAL 8 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
PhenoGen Krt8 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009779 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
TIGR TC204073
UniProt A0A8I6G4D8 ENTREZGENE, UniProtKB/TrEMBL
  A6KCS2 ENTREZGENE, UniProtKB/TrEMBL
  K2C8_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5WPB3 ENTREZGENE
UniProt Secondary Q5WPB3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Krt8  keratin 8  Krt8  keratin 8, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt8  keratin 8, type II  Krt8  keratin 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Krt8  keratin 8  Krt2-8  keratin complex 2, basic, gene 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Krt2-8  keratin complex 2, basic, gene 8  Krt8  keratin 8  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-06-10 Krt8  Keratin 8      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is negatively regulated by androgen in prostate tissue 633141