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Gene: Krt8 (keratin 8) Rattus norvegicus
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Symbol: Krt8
Name: keratin 8
Description: Predicted to have scaffold protein binding activity. Involved in response to hydrostatic pressure and sarcomere organization. Localizes to several cellular components, including the keratin filament; myofibril; and sarcolemma. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT8 (keratin 8); INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CK-8; CYKER; cytokeratin endo A; cytokeratin-8; K8; keratin 8, type II; keratin complex 2, basic, gene 8; keratin, type II cytoskeletal 8; keratin-8; Krt2-8; type-II keratin Kb8
Orthologs:
Homo sapiens (human) : KRT8 (keratin 8)  HGNC  Alliance
Mus musculus (house mouse) : Krt8 (keratin 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Krt8 (keratin 8)
Pan paniscus (bonobo/pygmy chimpanzee) : KRT8 (keratin 8)
Canis lupus familiaris (dog) : KRT8 (keratin 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Krt8 (keratin 8)
Sus scrofa (pig) : KRT8 (keratin 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07143,596,511 - 143,603,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07141,393,004 - 141,400,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,713,902 - 140,721,199 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17140,790,339 - 140,797,636 (-)NCBI
Celera7129,561,335 - 129,568,866 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Krt8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2984
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.