Pycr3 (pyrroline-5-carboxylate reductase 3)

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Gene: Pycr3 (pyrroline-5-carboxylate reductase 3) Rattus norvegicus

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Symbol:

Pycr3

Name:

pyrroline-5-carboxylate reductase 3

RGD ID:

1309115

Description:

Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Predicted to be part of eukaryotic translation elongation factor 1 complex. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3); PARTICIPATES IN arginine and proline metabolic pathway; INTERACTS WITH (+)-schisandrin B; 3-chloropropane-1,2-diol; astemizole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC300035; P5C reductase 3; P5CR 3; Pycrl; pyrroline-5-carboxylate reductase-like; pyrroline-5-carboxylate reductase-like protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PYCR3 (pyrroline-5-carboxylate reductase 3)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Pycr3 (pyrroline-5-carboxylate reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pycr3 (pyrroline-5-carboxylate reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PYCR3 (pyrroline-5-carboxylate reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PYCR3 (pyrroline-5-carboxylate reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pycr3 (pyrroline-5-carboxylate reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PYCR3 (pyrroline-5-carboxylate reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PYCR3 (pyrroline-5-carboxylate reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pycr3 (pyrroline-5-carboxylate reductase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PYCR3 (pyrroline-5-carboxylate reductase 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pycr3 (pyrroline-5-carboxylate reductase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PRO3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	M153.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	P5cr-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	pycr3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	109,484,263 - 109,489,554 (-)	NCBI		GRCr8
mRatBN7.2	7	107,603,543 - 107,608,831 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	107,581,930 - 107,608,799 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	109,343,046 - 109,348,315 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	111,566,724 - 111,571,993 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	111,512,657 - 111,517,925 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	116,949,882 - 116,955,150 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	116,949,879 - 116,955,148 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	116,842,453 - 116,847,953 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	113,895,788 - 113,926,200 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	113,930,019 - 113,960,430 (-)	NCBI
Celera	7	103,960,547 - 103,965,815 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brown-Vialetto-Van Laere syndrome 2 (ISO)

epidermolysis bullosa simplex with muscular dystrophy (ISO)

holoprosencephaly (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

aristolochic acid A (ISO)

astemizole (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

copper atom (ISO)

copper(0) (ISO)

cylindrospermopsin (ISO)

DDE (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dioxygen (ISO)

elemental selenium (ISO)

esketamine (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

finasteride (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

hydralazine (ISO)

inulin (ISO)

iron dichloride (ISO)

ivermectin (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thiram (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to ionizing radiation (IEA)

L-proline biosynthetic process (IBA,IEA,ISO,ISS)

translational elongation (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO,ISS)

endoplasmic reticulum (IEA)

eukaryotic translation elongation factor 1 complex (IEA)

fibrillar center (IEA)

intercellular bridge (ISO)

mitotic spindle (ISO)

nucleoplasm (IEA)

Molecular Function

protein binding (ISO)

pyrroline-5-carboxylate reductase activity (IBA,IEA,ISO,ISS)

translation elongation factor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

arginine and proline metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2722838	PMID:11591653	PMID:12477932	PMID:23024808

Genomics

Comparative Map Data

Pycr3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	109,484,263 - 109,489,554 (-)	NCBI		GRCr8
mRatBN7.2	7	107,603,543 - 107,608,831 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	107,581,930 - 107,608,799 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	109,343,046 - 109,348,315 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	111,566,724 - 111,571,993 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	111,512,657 - 111,517,925 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	116,949,882 - 116,955,150 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	116,949,879 - 116,955,148 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	116,842,453 - 116,847,953 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	113,895,788 - 113,926,200 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	113,930,019 - 113,960,430 (-)	NCBI
Celera	7	103,960,547 - 103,965,815 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

PYCR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	143,603,210 - 143,609,575 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	143,603,210 - 143,609,773 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	144,685,380 - 144,691,745 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	144,757,532 - 144,762,887 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	144,757,531 - 144,762,887	NCBI
Celera	8	140,996,326 - 141,002,023 (-)	NCBI		Celera
Cytogenetic Map	8	q24.3	NCBI
HuRef	8	139,937,358 - 139,943,055 (-)	NCBI		HuRef
CHM1_1	8	144,726,322 - 144,732,023 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	144,752,622 - 144,758,991 (-)	NCBI		T2T-CHM13v2.0

Pycr3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	75,788,319 - 75,793,369 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	75,788,326 - 75,793,409 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	75,916,463 - 75,921,560 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	75,916,477 - 75,921,560 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	75,746,893 - 75,751,990 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	75,743,732 - 75,748,815 (-)	NCBI		MGSCv36	mm8
Celera	15	77,417,474 - 77,422,576 (-)	NCBI		Celera
Cytogenetic Map	15	D3	NCBI
cM Map	15	35.09	NCBI

Pycr3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955454	2,305,485 - 2,311,280 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955454	2,305,485 - 2,311,280 (-)	NCBI	ChiLan1.0	ChiLan1.0

PYCR3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	161,087,677 - 161,093,061 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	136,604,352 - 136,610,747 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	140,356,586 - 140,362,972 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	143,372,465 - 143,378,032 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	143,371,748 - 143,378,032 (-)	Ensembl	panpan1.1		panPan2

PYCR3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	37,259,139 - 37,264,337 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	37,259,139 - 37,264,337 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	37,215,627 - 37,220,822 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	37,730,959 - 37,736,154 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	37,730,962 - 37,736,140 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	37,405,229 - 37,410,424 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	37,522,197 - 37,527,386 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	38,003,432 - 38,008,627 (-)	NCBI		UU_Cfam_GSD_1.0

Pycr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	1,101,848 - 1,105,689 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	8,528,103 - 8,531,569 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	8,527,896 - 8,531,788 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PYCR3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	959,710 - 964,192 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	959,709 - 964,195 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	1,012,808 - 1,014,006 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PYCR3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	137,823,685 - 137,830,630 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	137,826,293 - 137,830,546 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	2,062,896 - 2,068,829 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pycr3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624735	13,136,287 - 13,142,051 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pycr3
16 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
631529	Tls2	T-lymphoma susceptibility QTL 2	0	0.001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	7	80221299	109401111	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	80221299	112308525	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Markers in Region

RH134115

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	107,603,551 - 107,603,743 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	116,949,885 - 116,950,076	NCBI	Rnor6.0
Rnor_5.0	7	116,842,456 - 116,842,647	UniSTS	Rnor5.0
RGSC_v3.4	7	113,895,791 - 113,895,982	UniSTS	RGSC3.4
Celera	7	103,960,550 - 103,960,741	UniSTS
RH 3.4 Map	7	785.1	UniSTS
Cytogenetic Map	7	q34	UniSTS

AI169002

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	107,603,830 - 107,604,010 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	116,950,164 - 116,950,343	NCBI	Rnor6.0
Rnor_5.0	7	116,842,735 - 116,842,914	UniSTS	Rnor5.0
RGSC_v3.4	7	113,896,070 - 113,896,249	UniSTS	RGSC3.4
Celera	7	103,960,829 - 103,961,008	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000087328 ⟹ ENSRNOP00000071183

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	116,949,879 - 116,955,148 (-)	Ensembl

RefSeq Acc Id:

NM_001011993 ⟹ NP_001011993

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	109,484,263 - 109,489,531 (-)	NCBI
mRatBN7.2	7	107,603,549 - 107,608,817 (-)	NCBI
Rnor_6.0	7	116,949,882 - 116,955,150 (-)	NCBI
Rnor_5.0	7	116,842,453 - 116,847,953 (-)	NCBI
RGSC_v3.4	7	113,895,788 - 113,926,200 (-)	RGD
Celera	7	103,960,547 - 103,965,815 (-)	RGD

Sequence:

show sequence

AATGCAGCTCTAGTGGGCGGGGCCCGCTGCAGCAAGGACGAGAGAAGGCCAGCTCGGAACCGGA
TGGCGGATGAGATGTCTGAACCTCGGCGTGTGGGCTTCGTAGGTGCTGGTCGCATGGCGGAAGC
CATTGCCCAAGGCCTCATCCGAGCAGGCAAAGTAGAAGCAAAGCAAGTGCTGGCCAGTGCACCA
ACAGACAAGAACCTCTGCCACTTCAGGGCTCTGGGTTGCCAGACTACTCACTCCAACCACGAGG
TGCTGCAAAACTGCCCACTCGTCATCTTTGCCACCAAACCCCAAGTCCTGCCAGCTGTTCTGGC
AGAAGTGGCCCCTGTAGTCACCACTGAGCACATCATTGTATCCGTGGCTGCTGGGATCTCTCTG
AGCTCTATGGAGGAGCTGTTACCCCCGAAAACACGAGTACTGCGAGTCTCTCCCAATCTACCCT
GCGTAGTTCAGGAGGGAGCTATGGTTATGACACGGGGCCACCATGCTGGGAATGAAGACGCCAA
GCTCCTACAGAACTTGCTGGAAGCCTGTGGGCAGTGCATAGAGGTTCCTGAGTCCTACGTCGAT
ATCCACACTGGCCTCAGCGGCAGTGGTGTGGCCTTTGTGTGTACATTTTCGGAGGCCCTGGCTG
AAGGCGCCATCAAGATGGGCATGCCCAGTGACCTGGCCCACCGCATTGCCGCTCAGACCCTGCT
GGGGACAGCCAAAATGCTGCAGCAGGAAGGGAAGCACCCAGCCCAGCTGCGGACGGATGTGCTC
ACACCAGCTGGAACCACCATCCACGGGCTTCATGCCCTAGAGCAGGGCGGTTTTCGAGCAGCTG
CCATGAGTGCTGTGGAAGCAGCTACCTGCCGGGCTAAAGAGCTCAGCAAGAAGTAAGGCAAGGC
CTCAGACGAGACTACAGGCTCCTTGCCCATCTGCAGGCTCTGTGGTGAGGATAGCCCTGCGTGG
GTGTTGTATTGGGCGGTCCTCTGAGCTTAACGGCCATAGTCTTCATCCGAGAAGCTGTGACTAC
CCGTAAGATACCATCAAGAGGGGTTGGGGATTTAGCTCAGCGGTAGAGCGCTTGCCTAGCGAGC
ACAAGGCCCTGGGTTCGGTCCCCAACTCCGAAAAAAATTAAAAAAAAAAAAGATACCATCAAGA
GTCAAGATGGGGTGTGTTGACTGTGACGTTCAGTCAAGGATTCAAGGAAGGAAAAGGGAGGGTC
ACTCAATCCTTCTCTGAGATTTCAGATCCTCCTTCTGCACCTCCCAGCCAGTTACAGTTGTGTC
CTCATTGTGCAGGGCCTCATGGTCTCAGGAGGGGGTAGAATGTGTAGCCTGTGAAGGTGGTAGA
CATCATCCCCCATGCTGGCGTGAGACGTTTTGATGGTTGTGGCTGCTTTGTGATCACCCACACT
CCCGTAAGCAACACCCCGTTCATATTCTCTAAGCCCAATAAACTCATTTGTTCCCTAAAAAAAA
AAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039078820 ⟹ XP_038934748

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	109,484,263 - 109,489,554 (-)	NCBI
mRatBN7.2	7	107,603,543 - 107,608,831 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001011993	(Get FASTA)	NCBI Sequence Viewer
	XP_038934748	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87166	(Get FASTA)	NCBI Sequence Viewer
	EDM16035	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000034828.5
	ENSRNOP00000071183.2
	ENSRNOP00000076544.1
	ENSRNOP00000081329.1
	ENSRNOP00000084037.1
	ENSRNOP00000087171.1
	ENSRNOP00000092090.1
	ENSRNOP00000096307.1
	ENSRNOP00000097149.1
GenBank Protein	Q5PQJ6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001011993 ⟸ NM_001011993

- UniProtKB:

Q5PQJ6 (UniProtKB/Swiss-Prot), A6HS37 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADEMSEPRRVGFVGAGRMAEAIAQGLIRAGKVEAKQVLASAPTDKNLCHFRALGCQTTHSNHE
VLQNCPLVIFATKPQVLPAVLAEVAPVVTTEHIIVSVAAGISLSSMEELLPPKTRVLRVSPNLP
CVVQEGAMVMTRGHHAGNEDAKLLQNLLEACGQCIEVPESYVDIHTGLSGSGVAFVCTFSEALA
EGAIKMGMPSDLAHRIAAQTLLGTAKMLQQEGKHPAQLRTDVLTPAGTTIHGLHALEQGGFRAA
AMSAVEAATCRAKELSKK

hide sequence

Ensembl Acc Id:

ENSRNOP00000071183 ⟸ ENSRNOT00000087328

RefSeq Acc Id:	XP_038934748 ⟸ XM_039078820
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2UQA6 (UniProtKB/TrEMBL)

Protein Domains

Elongation factor 1 beta central acidic region Pyrroline-5-carboxylate reductase catalytic N- Pyrroline-5-carboxylate reductase dimerisation Translation elongation factor EF1B beta/delta

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PQJ6-F1-model_v2	AlphaFold	Q5PQJ6	1-274	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695395

Promoter ID:

EPDNEW_R5919

Type:

initiation region

Name:

Pycr3_1

Description:

pyrroline-5-carboxylate reductase 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	116,955,111 - 116,955,171	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309115	AgrOrtholog
BioCyc Gene	G2FUF-32974	BioCyc
BioCyc Pathway	ARG-PRO-PWY [L-arginine degradation VI (arginase 2 pathway)]	BioCyc
BioCyc Pathway Image	ARG-PRO-PWY	BioCyc
Ensembl Genes	ENSRNOG00000021638	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000054724	Ensembl
Ensembl Transcript	ENSRNOT00000029456.6	UniProtKB/TrEMBL
	ENSRNOT00000087328.2	UniProtKB/TrEMBL
	ENSRNOT00000094330.1	UniProtKB/TrEMBL
	ENSRNOT00000098616.1	UniProtKB/TrEMBL
	ENSRNOT00000106771.1	UniProtKB/TrEMBL
	ENSRNOT00000110570.1	UniProtKB/TrEMBL
	ENSRNOT00000111979.1	UniProtKB/TrEMBL
	ENSRNOT00000112184.1	UniProtKB/TrEMBL
	ENSRNOT00000117537.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.60	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ProC C-terminal domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7135468	IMAGE-MGC_LOAD
InterPro	6-PGluconate_DH-like_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	eEF-1beta-like_sf	UniProtKB/TrEMBL
	EF-1_beta_acid_region_euk	UniProtKB/TrEMBL
	EF1B_bsu/dsu	UniProtKB/TrEMBL
	EF1B_bsu/dsu_GNE	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P5C_Rdtase_cat_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pyrroline-COOH_reductase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transl_elong_EF1B/ribosomal_S6	UniProtKB/TrEMBL
	Transl_elong_EF1B_B/D_CS	UniProtKB/TrEMBL
KEGG Report	rno:300035	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:95331	IMAGE-MGC_LOAD
NCBI Gene	300035	ENTREZGENE
PANTHER	EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER	UniProtKB/TrEMBL
	ELONGATION FACTOR 1-DELTA	UniProtKB/TrEMBL
	PTHR11645	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PYRROLINE-5-CARBOXYLATE REDUCTASE 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	EF-1_beta_acid	UniProtKB/TrEMBL
	EF1_GNE	UniProtKB/TrEMBL
	F420_oxidored	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P5CR_dimer	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pycr3	PhenoGen
PIRSF	Pyrrol-5-carb_rd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	EF1BD_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000021638	RatGTEx
	ENSRNOG00000054724	RatGTEx
SMART	EF-1_beta_acid	UniProtKB/TrEMBL
	EF1_GNE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48179	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54984	UniProtKB/TrEMBL
UniProt	A0A8I5Y6S6_RAT	UniProtKB/TrEMBL
	A0A8I5ZUU1_RAT	UniProtKB/TrEMBL
	A0A8I5ZWY7_RAT	UniProtKB/TrEMBL
	A0A8I6AQM3_RAT	UniProtKB/TrEMBL
	A0A8I6ARB5_RAT	UniProtKB/TrEMBL
	A0A8I6GFR4_RAT	UniProtKB/TrEMBL
	A0A8I6GJH3_RAT	UniProtKB/TrEMBL
	A0A8L2QI22_RAT	UniProtKB/TrEMBL
	A0A8L2UQA6	ENTREZGENE, UniProtKB/TrEMBL
	A6HS37	ENTREZGENE, UniProtKB/TrEMBL
	P5CR3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-29	Pycr3	pyrroline-5-carboxylate reductase 3	Pycrl	pyrroline-5-carboxylate reductase-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Pycrl	pyrroline-5-carboxylate reductase-like	Pycrl_predicted	pyrroline-5-carboxylate reductase-like (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Pycrl_predicted	pyrroline-5-carboxylate reductase-like (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

BioCyc Pathways