Slc38a1 (solute carrier family 38, member 1) - Rat Genome Database

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Gene: Slc38a1 (solute carrier family 38, member 1) Rattus norvegicus
Analyze
Symbol: Slc38a1
Name: solute carrier family 38, member 1
RGD ID: 69645
Description: Enables alanine:sodium symporter activity; glycine:sodium symporter activity; and proline:sodium symporter activity. Involved in several processes, including amino acid transport; glutamine metabolic process; and positive regulation of L-glutamine import across plasma membrane. Located in external side of apical plasma membrane and neuronal cell body. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SLC38A1 (solute carrier family 38 member 1); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; acetamide; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amino acid transporter A1; amino acid transporter system A1; Ata1; GlnT; glutamine transporter; N-system amino acid transporter 2; rATA1; Sat1; sodium-coupled neutral amino acid symporter 1; sodium-coupled neutral amino acid transporter 1; solute carrier family 38 member 1; system A amino acid transporter 1; system A transporter 2; system N amino acid transporter 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27127,733,230 - 127,802,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7127,738,226 - 127,802,218 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7129,539,154 - 129,603,112 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07131,764,672 - 131,828,633 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07131,682,822 - 131,746,754 (-)NCBIRnor_WKY
Rnor_6.07137,970,555 - 138,040,098 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7137,975,549 - 138,039,984 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07137,598,311 - 137,667,871 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47135,252,257 - 135,316,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17135,328,704 - 135,392,693 (-)NCBI
Celera7124,242,806 - 124,306,590 (-)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
calyculin a  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dieldrin  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP)
geldanamycin  (ISO)
graphite  (EXP)
heptachlor  (EXP)
hydrogen chloride  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mirex  (EXP)
N,N-diethyl-m-toluamide  (EXP)
nickel dichloride  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Na+ transport by the neural glutamine transporter ATA1. Albers A, etal., Pflugers Arch. 2001 Oct;443(1):92-101. doi: 10.1007/s004240100663.
2. Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons. Blot A, etal., Neuroscience. 2009 Dec 15;164(3):998-1008. doi: 10.1016/j.neuroscience.2009.09.015. Epub 2009 Sep 12.
3. Glutamine uptake by neurons: interaction of protons with system a transporters. Chaudhry FA, etal., J Neurosci 2002 Jan 1;22(1):62-72.
4. Differential molecular regulation of glutamate in kindling resistant rats. Doi T, etal., Brain Res. 2011 Feb 23;1375:1-6. doi: 10.1016/j.brainres.2010.11.085. Epub 2010 Dec 4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons. Mackenzie B, etal., J Biol Chem 2003 Jun 27;278(26):23720-30. Epub 2003 Apr 8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Park YY, etal., Hepatology. 2016 Jan;63(1):159-72. doi: 10.1002/hep.28223. Epub 2015 Nov 26.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Cloning and functional identification of a neuronal glutamine transporter. Varoqui H, etal., J Biol Chem 2000 Feb 11;275(6):4049-54.
14. Expression and role of SNAT3 in the placenta. Yoshioka C, etal., Placenta. 2009 Dec;30(12):1071-7. doi: 10.1016/j.placenta.2009.09.009. Epub 2009 Nov 5.
Additional References at PubMed
PMID:11325958   PMID:12477932   PMID:15521011   PMID:16023720   PMID:16200463   PMID:17323379   PMID:20458337   PMID:20492358   PMID:20602128   PMID:25957749   PMID:26590355  


Genomics

Comparative Map Data
Slc38a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27127,733,230 - 127,802,541 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7127,738,226 - 127,802,218 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7129,539,154 - 129,603,112 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07131,764,672 - 131,828,633 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07131,682,822 - 131,746,754 (-)NCBIRnor_WKY
Rnor_6.07137,970,555 - 138,040,098 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7137,975,549 - 138,039,984 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07137,598,311 - 137,667,871 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47135,252,257 - 135,316,256 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17135,328,704 - 135,392,693 (-)NCBI
Celera7124,242,806 - 124,306,590 (-)NCBICelera
Cytogenetic Map7q35NCBI
SLC38A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381246,183,063 - 46,269,043 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1246,183,063 - 46,270,017 (-)EnsemblGRCh38hg38GRCh38
GRCh371246,576,846 - 46,662,826 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361244,863,105 - 44,949,475 (-)NCBINCBI36Build 36hg18NCBI36
Build 341244,867,850 - 44,948,816NCBI
Celera1245,374,176 - 45,460,544 (-)NCBICelera
Cytogenetic Map12q13.11NCBI
HuRef1243,608,096 - 43,694,464 (-)NCBIHuRef
CHM1_11246,541,943 - 46,628,310 (-)NCBICHM1_1
T2T-CHM13v2.01246,142,659 - 46,228,603 (-)NCBIT2T-CHM13v2.0
Slc38a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391596,469,299 - 96,541,396 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1596,469,299 - 96,540,794 (-)EnsemblGRCm39 Ensembl
GRCm381596,571,418 - 96,643,438 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1596,571,418 - 96,642,913 (-)EnsemblGRCm38mm10GRCm38
MGSCv371596,401,849 - 96,473,344 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361596,402,709 - 96,452,131 (-)NCBIMGSCv36mm8
Celera1598,716,978 - 98,788,897 (-)NCBICelera
Cytogenetic Map15F1NCBI
Slc38a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555005,398,358 - 5,462,042 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555005,393,211 - 5,468,827 (-)NCBIChiLan1.0ChiLan1.0
SLC38A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11243,333,087 - 43,419,502 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1243,362,597 - 43,413,616 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01242,464,360 - 42,550,324 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SLC38A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,110,327 - 8,179,394 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,130,823 - 8,174,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2738,127,750 - 38,197,361 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,309,904 - 8,379,147 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,309,945 - 8,379,526 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1278,117,874 - 8,187,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0278,156,867 - 8,221,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02738,367,553 - 38,436,859 (-)NCBIUU_Cfam_GSD_1.0
Slc38a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494568,660,514 - 68,726,003 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365124,444,684 - 4,487,165 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365124,438,827 - 4,504,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC38A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl577,009,862 - 77,058,427 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1577,009,840 - 77,076,723 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2579,935,364 - 80,001,646 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC38A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11142,415,986 - 42,502,794 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1142,421,910 - 42,472,838 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037203,924,850 - 204,006,548 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc38a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248165,989,601 - 6,025,987 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248165,988,625 - 6,025,987 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc38a1
586 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:63
Count of miRNA genes:53
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000008138
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
RH130789  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27127,803,358 - 127,803,530 (+)MAPPERmRatBN7.2
Rnor_6.07138,040,771 - 138,040,942NCBIRnor6.0
Rnor_5.07137,668,527 - 137,668,698UniSTSRnor5.0
RGSC_v3.47135,317,397 - 135,317,568UniSTSRGSC3.4
Celera7124,307,731 - 124,307,902UniSTS
RH 3.4 Map71092.0UniSTS
Cytogenetic Map7q35UniSTS
RH131580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27127,737,986 - 127,738,171 (+)MAPPERmRatBN7.2
Rnor_6.07137,975,310 - 137,975,494NCBIRnor6.0
Rnor_5.07137,603,066 - 137,603,250UniSTSRnor5.0
RGSC_v3.47135,252,026 - 135,252,210UniSTSRGSC3.4
Celera7124,242,575 - 124,242,759UniSTS
RH 3.4 Map71092.0UniSTS
Cytogenetic Map7q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 30 14 19 14 1 1 74 23 41 3 1
Low 1 21 21 21 7 10 12 8 7
Below cutoff 6 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008138   ⟹   ENSRNOP00000008138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7127,738,226 - 127,802,218 (-)Ensembl
Rnor_6.0 Ensembl7137,975,549 - 138,039,630 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089806   ⟹   ENSRNOP00000070624
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7137,975,772 - 138,039,984 (-)Ensembl
RefSeq Acc Id: NM_138832   ⟹   NP_620187
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27127,738,218 - 127,802,218 (-)NCBI
Rnor_6.07137,975,541 - 138,039,630 (-)NCBI
Rnor_5.07137,598,311 - 137,667,871 (-)NCBI
RGSC_v3.47135,252,257 - 135,316,256 (-)RGD
Celera7124,242,806 - 124,306,590 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242277   ⟹   XP_006242339
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27127,733,230 - 127,800,819 (-)NCBI
Rnor_6.07137,970,555 - 138,039,326 (-)NCBI
Rnor_5.07137,598,311 - 137,667,871 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242280   ⟹   XP_006242342
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27127,733,230 - 127,802,169 (-)NCBI
Rnor_6.07137,970,555 - 138,039,731 (-)NCBI
Rnor_5.07137,598,311 - 137,667,871 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242281   ⟹   XP_006242343
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27127,733,230 - 127,802,541 (-)NCBI
Rnor_6.07137,970,555 - 138,040,098 (-)NCBI
Rnor_5.07137,598,311 - 137,667,871 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078321   ⟹   XP_038934249
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27127,733,230 - 127,758,622 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_620187   ⟸   NM_138832
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242343   ⟸   XM_006242281
- Peptide Label: isoform X1
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242342   ⟸   XM_006242280
- Peptide Label: isoform X1
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242339   ⟸   XM_006242277
- Peptide Label: isoform X1
- UniProtKB: Q9JM15 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008138   ⟸   ENSRNOT00000008138
RefSeq Acc Id: ENSRNOP00000070624   ⟸   ENSRNOT00000089806
RefSeq Acc Id: XP_038934249   ⟸   XM_039078321
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JM15-F1-model_v2 AlphaFold Q9JM15 1-485 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695608
Promoter ID:EPDNEW_R6133
Type:initiation region
Name:Slc38a1_1
Description:solute carrier family 38, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07138,039,687 - 138,039,747EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69645 AgrOrtholog
BioCyc Gene G2FUF-32246 BioCyc
Ensembl Genes ENSRNOG00000005291 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000008138 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008138 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7444889 IMAGE-MGC_LOAD
InterPro AA_transpt_TM UniProtKB/Swiss-Prot
KEGG Report rno:170567 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114262 IMAGE-MGC_LOAD
NCBI Gene 170567 ENTREZGENE
Pfam Aa_trans UniProtKB/Swiss-Prot
PhenoGen Slc38a1 PhenoGen
TIGR TC232025
UniProt Q9JM15 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Slc38a1  solute carrier family 38, member 1      Symbol and Name status set to approved 70586 APPROVED
2002-02-27 Slc38a1  solute carrier family 38, member 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to somata and proximal dendrites 1299220
gene_function transports glutamine from glutamatergic neurons 68922
gene_process supplies glutamatergic neurons with serine and cysteine 68922
gene_process may have a role in providing metabolic fuel (via alpha-ketoglutarate) or precursors for glutathione synthesis 1299220