RGD Reference Report - Expression and role of SNAT3 in the placenta. - Rat Genome Database

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Expression and role of SNAT3 in the placenta.

Authors: Yoshioka, C  Yasuda, S  Kimura, F  Kobayashi, M  Itagaki, S  Hirano, T  Iseki, K 
Citation: Yoshioka C, etal., Placenta. 2009 Dec;30(12):1071-7. doi: 10.1016/j.placenta.2009.09.009. Epub 2009 Nov 5.
RGD ID: 9999228
Pubmed: PMID:19892400   (View Abstract at PubMed)
DOI: DOI:10.1016/j.placenta.2009.09.009   (Journal Full-text)

Glutamine is the most versatile amino acid and its plasma concentration is the highest of all amino acid. Many transporters are therefore involved in glutamine uptake or efflux. Glutamine is actively released from the placenta into fetal circulation. In this study, we examined the alteration of transporters that transport glutamine into fetal circulation as gestation progresses. High expression levels of system A and y(+)L were found in the rat placenta in the late period of pregnancy and the expression levels of these transporters increased as gestation progressed (p<0.05). On the other hand, the expression of SNAT3, the system N transporter, was detected in the early period of pregnancy and its expression level decreased as gestation progressed (p<0.05). SNAT3 was also found to be expressed in isolated human primary cytotrophoblast cells and its expression level was decreased by their differentiation into syncytiotrophoblast cells (p<0.05). Since this regulation is closely related to glutamine synthetase expression, SNAT3 may play a key role in providing glutamine corresponding to glutamine synthetase function in the early period of gestation. This is the first report on the expression of SNAT3 in the placenta in the early stage of pregnancy.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc38a1Ratfemale pregnancy  IEP  RGD 
Slc38a2Ratfemale pregnancy  IEP  RGD 
Slc38a3Ratfemale pregnancy  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc38a1  (solute carrier family 38, member 1)
Slc38a2  (solute carrier family 38, member 2)
Slc38a3  (solute carrier family 38, member 3)


Additional Information