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Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Acr | Rat | spermatogenic failure 87 | | ISO | ACR (Homo sapiens) | 7240710 | | OMIM | | |
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Imported Disease Annotations - OMIMObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Acr | Rat | spermatogenic failure 87 | | ISO | ACR (Homo sapiens) | 7240710 | | OMIM | | |
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# | Reference Title | Reference Citation |
1. | Correlation between male fertility and acrosin-like protease activity in rats treated with Spartium junceum. | Chen JS, etal., Zygote. 1993 Nov;1(4):309-13. |
2. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
3. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
4. | Role of acrosomal matrix proteases in sperm-zona pellucida interactions. | Honda A, etal., Hum Reprod Update. 2002 Sep-Oct;8(5):405-12. |
5. | A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats. | Isotani A, etal., Biol Reprod. 2017 Jul 1;97(1):61-68. doi: 10.1093/biolre/iox066. |
6. | Rat sperm acrosin: cDNA sequence, derived primary structure and phylogenetic origin. | Klemm U, etal., Biochim Biophys Acta 1991 Oct 8;1090(2):270-2. |
7. | High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. | Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
8. | Evidence for a nonlysosomal origin of the acrosome. | Martinez-Menarguez JA, etal., J Histochem Cytochem. 1996 Apr;44(4):313-20. |
9. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
10. | Biochemical alterations in the proacrosin-acrosin system during epididymal maturation of the rat spermatozoa. | Nagdas SK, etal., J Androl. 1992 Jan-Feb;13(1):36-43. |
11. | Diploid expression and translational regulation of rat acrosin gene. | Nayernia K, etal., Biochem Biophys Res Commun 1994 Jul 15;202(1):88-93. |
12. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
13. | Endocrine approach to male fertility control by steroid hormone combination in rat Rattus norvegicus L. | Rao MV and Shah KD, Indian J Exp Biol. 1998 Aug;36(8):775-9. |
14. | GOA pipeline | RGD automated data pipeline |
15. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
16. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
17. | Comprehensive gene review and curation | RGD comprehensive gene curation |
18. | Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. | Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34 |
PMID:1299864 | PMID:1802037 | PMID:2550339 | PMID:2567721 | PMID:3162367 | PMID:3880736 | PMID:6802470 | PMID:7521127 | PMID:7798216 | PMID:7989357 | PMID:9041140 | PMID:10369396 |
PMID:12477932 | PMID:12782300 | PMID:15051954 | PMID:15489334 | PMID:15685642 | PMID:15950652 | PMID:21630459 |
Acr (Rattus norvegicus - Norway rat) |
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ACR (Homo sapiens - human) |
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Acr (Mus musculus - house mouse) |
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Acr (Chinchilla lanigera - long-tailed chinchilla) |
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ACR (Pan paniscus - bonobo/pygmy chimpanzee) |
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ACR (Canis lupus familiaris - dog) |
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Acr (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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ACR (Sus scrofa - pig) |
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ACR (Chlorocebus sabaeus - green monkey) |
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Acr (Heterocephalus glaber - naked mole-rat) |
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Variants in Acr
31 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
D7Mgh2 |
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D7MGH2 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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nervous system
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renal system
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reproductive system
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respiratory system
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9 | 11 | 49 | 113 | 79 | 78 | 47 | 25 | 47 | 6 | 205 | 97 | 93 | 44 | 58 | 31 |
Ensembl Acc Id: | ENSRNOT00000045647 ⟹ ENSRNOP00000046900 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000079501 ⟹ ENSRNOP00000072471 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_012490 ⟹ NP_036622 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006242178 ⟹ XP_006242240 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017594655 ⟹ XP_017450144 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017594656 ⟹ XP_017450145 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039078390 ⟹ XP_038934318 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039078391 ⟹ XP_038934319 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063262973 ⟹ XP_063119043 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063262974 ⟹ XP_063119044 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063262975 ⟹ XP_063119045 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_010052941 | ||||||||
Type: | NON-CODING | ||||||||
Position: |
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RefSeq Acc Id: | NP_036622 ⟸ NM_012490 |
- Peptide Label: | precursor |
- UniProtKB: | P29293 (UniProtKB/Swiss-Prot), Q4QR89 (UniProtKB/Swiss-Prot), Q9QWF2 (UniProtKB/Swiss-Prot), A6K7N9 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006242240 ⟸ XM_006242178 |
- Peptide Label: | isoform X3 |
- Sequence: |
RefSeq Acc Id: | XP_017450144 ⟸ XM_017594655 |
- Peptide Label: | isoform X2 |
- Sequence: |
RefSeq Acc Id: | XP_017450145 ⟸ XM_017594656 |
- Peptide Label: | isoform X2 |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000072471 ⟸ ENSRNOT00000079501 |
Ensembl Acc Id: | ENSRNOP00000046900 ⟸ ENSRNOT00000045647 |
RefSeq Acc Id: | XP_038934318 ⟸ XM_039078390 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | XP_038934319 ⟸ XM_039078391 |
- Peptide Label: | isoform X6 |
RefSeq Acc Id: | XP_063119045 ⟸ XM_063262975 |
- Peptide Label: | isoform X5 |
RefSeq Acc Id: | XP_063119044 ⟸ XM_063262974 |
- Peptide Label: | isoform X4 |
RefSeq Acc Id: | XP_063119043 ⟸ XM_063262973 |
- Peptide Label: | isoform X2 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P29293-F1-model_v2 | AlphaFold | P29293 | 1-437 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13695592 | ||||||||
Promoter ID: | EPDNEW_R6117 | ||||||||
Type: | initiation region | ||||||||
Name: | Acr_1 | ||||||||
Description: | acrosin | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:2024 | AgrOrtholog |
BioCyc Gene | G2FUF-32423 | BioCyc |
Ensembl Genes | ENSRNOG00000029762 | Ensembl, UniProtKB/Swiss-Prot |
Ensembl Transcript | ENSRNOT00000045647.4 | UniProtKB/Swiss-Prot |
Gene3D-CATH | 2.40.10.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
IMAGE_CLONE | IMAGE:7455117 | IMAGE-MGC_LOAD |
InterPro | Pept_S1A_acrosin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Peptidase_S1_PA | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Peptidase_S1_PA_chymotrypsin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Peptidase_S1A | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Trypsin_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRYPSIN_HIS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRYPSIN_SER | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:24163 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MGC_CLONE | MGC:114357 | IMAGE-MGC_LOAD |
NCBI Gene | 24163 | ENTREZGENE |
PANTHER | ACROSIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
ACROSIN-RELATED | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Trypsin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Acr | PhenoGen |
PIRSF | Acrosin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PRINTS | CHYMOTRYPSIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PROSITE | TRYPSIN_DOM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
TRYPSIN_HIS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
TRYPSIN_SER | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000029762 | RatGTEx |
ENSRNOG00055012188 | RatGTEx | |
ENSRNOG00060022682 | RatGTEx | |
ENSRNOG00065017336 | RatGTEx | |
SMART | Tryp_SPc | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | SSF50494 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A6K7N9 | ENTREZGENE, UniProtKB/TrEMBL |
ACRO_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
Q4QR89 | ENTREZGENE | |
Q9QWF2 | ENTREZGENE | |
UniProt Secondary | Q4QR89 | UniProtKB/Swiss-Prot |
Q9QWF2 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2008-08-29 | Acr | acrosin | Acr | acrosin prepropeptide | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-07-02 | Acr | acrosin prepropeptide | Acr | acrosin | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-06-10 | Acr | acrosin | Symbol and Name status set to approved | 70586 | APPROVED |
Note Type | Note | Reference |
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gene_function | serine protease that cleaves at arg- and lys- peptide bonds | |
gene_process | functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum |