Acr (acrosin) - Rat Genome Database

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Gene: Acr (acrosin) Rattus norvegicus
Analyze
Symbol: Acr
Name: acrosin
RGD ID: 2024
Description: Predicted to enable amidase activity; monosaccharide binding activity; and serine-type endopeptidase activity. Involved in acrosome matrix dispersal; penetration of zona pellucida; and response to steroid hormone. Located in Golgi-associated vesicle and acrosomal vesicle. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human ACR (acrosin); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; flavonoids.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acro; acrosin prepropeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27120,636,581 - 120,644,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,638,321 - 120,644,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,390,433 - 122,396,624 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,616,577 - 124,622,768 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,585,008 - 124,591,223 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,541,320 - 130,548,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,542,202 - 130,548,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,227,661 - 130,233,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,885,399 - 127,891,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,919,648 - 127,925,612 (+)NCBI
Celera7117,109,902 - 117,116,056 (+)NCBICelera
RH 3.4 Map7958.3RGD
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Correlation between male fertility and acrosin-like protease activity in rats treated with Spartium junceum. Chen JS, etal., Zygote. 1993 Nov;1(4):309-13.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Role of acrosomal matrix proteases in sperm-zona pellucida interactions. Honda A, etal., Hum Reprod Update. 2002 Sep-Oct;8(5):405-12.
5. A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats. Isotani A, etal., Biol Reprod. 2017 Jul 1;97(1):61-68. doi: 10.1093/biolre/iox066.
6. Rat sperm acrosin: cDNA sequence, derived primary structure and phylogenetic origin. Klemm U, etal., Biochim Biophys Acta 1991 Oct 8;1090(2):270-2.
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Evidence for a nonlysosomal origin of the acrosome. Martinez-Menarguez JA, etal., J Histochem Cytochem. 1996 Apr;44(4):313-20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Biochemical alterations in the proacrosin-acrosin system during epididymal maturation of the rat spermatozoa. Nagdas SK, etal., J Androl. 1992 Jan-Feb;13(1):36-43.
11. Diploid expression and translational regulation of rat acrosin gene. Nayernia K, etal., Biochem Biophys Res Commun 1994 Jul 15;202(1):88-93.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Endocrine approach to male fertility control by steroid hormone combination in rat Rattus norvegicus L. Rao MV and Shah KD, Indian J Exp Biol. 1998 Aug;36(8):775-9.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
Additional References at PubMed
PMID:1299864   PMID:1802037   PMID:2550339   PMID:2567721   PMID:3162367   PMID:3880736   PMID:6802470   PMID:7521127   PMID:7798216   PMID:7989357   PMID:9041140   PMID:10369396  
PMID:12477932   PMID:12782300   PMID:15051954   PMID:15489334   PMID:15685642   PMID:15950652   PMID:21630459  


Genomics

Comparative Map Data
Acr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27120,636,581 - 120,644,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,638,321 - 120,644,474 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,390,433 - 122,396,624 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,616,577 - 124,622,768 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,585,008 - 124,591,223 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,541,320 - 130,548,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,542,202 - 130,548,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,227,661 - 130,233,848 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,885,399 - 127,891,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,919,648 - 127,925,612 (+)NCBI
Celera7117,109,902 - 117,116,056 (+)NCBICelera
RH 3.4 Map7958.3RGD
Cytogenetic Map7q34NCBI
ACR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,738,204 - 50,745,339 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,738,196 - 50,745,339 (+)EnsemblGRCh38hg38GRCh38
GRCh372251,176,632 - 51,183,767 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,523,518 - 49,530,593 (+)NCBINCBI36Build 36hg18NCBI36
Build 342249,466,790 - 49,473,870NCBI
Celera2235,052,700 - 35,059,775 (+)NCBICelera
Cytogenetic Map22q13.33ENTREZGENE
HuRef2234,069,063 - 34,075,048 (+)NCBIHuRef
CHM1_12251,135,444 - 51,142,475 (+)NCBICHM1_1
T2T-CHM13v2.02251,251,783 - 51,258,912 (+)NCBIT2T-CHM13v2.0
Acr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,452,549 - 89,458,790 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,452,529 - 89,458,788 (+)EnsemblGRCm39 Ensembl
GRCm381589,568,326 - 89,578,853 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,568,326 - 89,574,585 (+)EnsemblGRCm38mm10GRCm38
MGSCv371589,398,757 - 89,405,015 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361589,396,129 - 89,402,195 (+)NCBIMGSCv36mm8
Celera1591,697,705 - 91,703,952 (+)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.96NCBI
Acr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541333,721,984 - 33,728,088 (+)NCBIChiLan1.0ChiLan1.0
ACR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12263,344,652 - 63,352,083 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,978,598 - 30,985,739 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12250,085,719 - 50,092,869 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2250,085,719 - 50,092,869 (+)Ensemblpanpan1.1panPan2
ACR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,607,514 - 16,615,399 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1016,609,915 - 16,615,354 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1016,588,068 - 16,593,422 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,336,704 - 17,342,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,333,872 - 17,342,013 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,061,215 - 17,066,544 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,384,291 - 17,389,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,516,077 - 17,521,431 (-)NCBIUU_Cfam_GSD_1.0
Acr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945104,213 - 109,801 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936629104,301 - 111,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl530,127 - 36,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1530,127 - 36,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap5p15NCBI
ACR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11933,231,521 - 33,236,141 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604592,102,118 - 92,110,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475242,847 - 49,438 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acr
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000045647
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
D7Mgh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map7956.8UniSTS
RH 3.4 Map7956.8RGD
RH 2.0 Map7706.2RGD
Cytogenetic Map7 RGD
D7MGH2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q34-q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 1 23 22 6 19 6 2 3 74 28 30 11 2
Below cutoff 2 20 27 27 27 6 8 7 2 6

Sequence


RefSeq Acc Id: ENSRNOT00000045647   ⟹   ENSRNOP00000046900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,638,321 - 120,644,474 (+)Ensembl
Rnor_6.0 Ensembl7130,542,203 - 130,548,356 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079501   ⟹   ENSRNOP00000072471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7130,542,202 - 130,548,251 (+)Ensembl
RefSeq Acc Id: NM_012490   ⟹   NP_036622
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,638,321 - 120,644,474 (+)NCBI
Rnor_6.07130,542,203 - 130,548,356 (+)NCBI
Rnor_5.07130,227,661 - 130,233,848 (+)NCBI
RGSC_v3.47127,885,399 - 127,891,552 (+)RGD
Celera7117,109,902 - 117,116,056 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242178   ⟹   XP_006242240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,636,586 - 120,643,934 (+)NCBI
Rnor_6.07130,541,320 - 130,547,779 (+)NCBI
Rnor_5.07130,227,661 - 130,233,848 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594655   ⟹   XP_017450144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,638,281 - 120,644,424 (+)NCBI
Rnor_6.07130,542,225 - 130,548,356 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594656   ⟹   XP_017450145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,638,293 - 120,644,424 (+)NCBI
Rnor_6.07130,542,231 - 130,548,356 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078389   ⟹   XP_038934317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,636,592 - 120,644,474 (+)NCBI
RefSeq Acc Id: XM_039078390   ⟹   XP_038934318
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,638,481 - 120,644,424 (+)NCBI
RefSeq Acc Id: XM_039078391   ⟹   XP_038934319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,639,878 - 120,644,424 (+)NCBI
RefSeq Acc Id: XM_039078392   ⟹   XP_038934320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,636,581 - 120,642,970 (+)NCBI
RefSeq Acc Id: NP_036622   ⟸   NM_012490
- Peptide Label: precursor
- UniProtKB: Q4QR89 (UniProtKB/Swiss-Prot),   Q9QWF2 (UniProtKB/Swiss-Prot),   P29293 (UniProtKB/Swiss-Prot),   A6K7N9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242240   ⟸   XM_006242178
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017450144   ⟸   XM_017594655
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017450145   ⟸   XM_017594656
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000072471   ⟸   ENSRNOT00000079501
RefSeq Acc Id: ENSRNOP00000046900   ⟸   ENSRNOT00000045647
RefSeq Acc Id: XP_038934320   ⟸   XM_039078392
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038934317   ⟸   XM_039078389
- Peptide Label: isoform X1
- UniProtKB: Q4QR89 (UniProtKB/Swiss-Prot),   P29293 (UniProtKB/Swiss-Prot),   Q9QWF2 (UniProtKB/Swiss-Prot),   A6K7N9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934318   ⟸   XM_039078390
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934319   ⟸   XM_039078391
- Peptide Label: isoform X4
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29293-F1-model_v2 AlphaFold P29293 1-437 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695592
Promoter ID:EPDNEW_R6117
Type:initiation region
Name:Acr_1
Description:acrosin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07130,542,217 - 130,542,277EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2024 AgrOrtholog
BioCyc Gene G2FUF-32423 BioCyc
Ensembl Genes ENSRNOG00000029762 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055012188 UniProtKB/Swiss-Prot
  ENSRNOG00060022682 UniProtKB/Swiss-Prot
  ENSRNOG00065017336 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045647 ENTREZGENE
  ENSRNOT00000045647.4 UniProtKB/Swiss-Prot
  ENSRNOT00055020727 UniProtKB/Swiss-Prot
  ENSRNOT00060039323 UniProtKB/Swiss-Prot
  ENSRNOT00065028900 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7455117 IMAGE-MGC_LOAD
InterPro Pept_S1A_acrosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24163 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114357 IMAGE-MGC_LOAD
NCBI Gene 24163 ENTREZGENE
PANTHER ACROSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACROSIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acr PhenoGen
PIRSF Acrosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029762 RatGTEx
  ENSRNOG00055012188 RatGTEx
  ENSRNOG00060022682 RatGTEx
  ENSRNOG00065017336 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6K7N9 ENTREZGENE, UniProtKB/TrEMBL
  ACRO_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QR89 ENTREZGENE
  Q9QWF2 ENTREZGENE
UniProt Secondary Q4QR89 UniProtKB/Swiss-Prot
  Q9QWF2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Acr  acrosin  Acr  acrosin prepropeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-02 Acr  acrosin prepropeptide  Acr  acrosin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Acr  acrosin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function serine protease that cleaves at arg- and lys- peptide bonds  
gene_process functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum