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Strain Registration

Strain: F344.OLETF-(D7Mgh16-D7Mgh20)/Tj

Symbol: F344.OLETF-(D7Mgh16-D7Mgh20)/Tj
Strain: F344.OLETF-(D7Mgh16-D7Mgh20)
Substrain: Tj
RGD ID: 1302654
Citation ID: RRID:RGD_1302654
Ontology ID: RS:0001734
Previously known as: F.O-Nidd1/of; NBRP Rat No: 0052; F344.OLETF-(D7Rat18-D7Mit2)/Tj; F.O-Nidd1/of;F344 background OLETF Congenic; F344.OLETF-(D7Mgh16-D7Mgh20)/Tj
Type: congenic
Source: National BioResource Project for the Rat in Japan
Origin: Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.26.6 cM segment of the OLETF genome was transferred.
Inbred Generations: F9
Last Known Status: Cryopreserved Embryo
Research Usage Diabetes Obesity
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,011,396 - 116,294,546RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.07106,995,385 - 126,080,454RGD_MAPPER_PIPELINERnor6.0
Rnor_5.07106,942,155 - 125,794,357RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.47103,612,739 - 123,191,874RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
2. Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat. Kose H, etal., Mamm Genome. 2007 Aug;18(8):609-15. Epub 2007 Aug 21.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D7Rat18)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2798,011,396 - 98,011,544 (+)MAPPER
Rnor_6.07106,995,385 - 106,995,532NCBI
Rnor_5.07106,942,155 - 106,942,302UniSTS
RGSC_v3.47103,612,740 - 103,612,887UniSTS
RGSC_v3.47103,612,739 - 103,612,887RGD
RGSC_v3.17103,646,970 - 103,647,117RGD
Celera794,565,424 - 94,565,579UniSTS
RH 3.4 Map7678.2RGD
RH 3.4 Map7678.2UniSTS
RH 2.0 Map7531.1RGD
FHH x ACI Map746.7299RGD
Cytogenetic Map7q33UniSTS

Flank 2 / 1 (D7Mit2)
Rat AssemblyChrPosition (strand)Source
mRatBN7.27116,294,265 - 116,294,546 (+)MAPPER
Rnor_6.07126,080,176 - 126,080,454NCBI
Rnor_5.07125,794,079 - 125,794,357UniSTS
RGSC_v3.47123,191,595 - 123,191,874RGD
RGSC_v3.47123,191,596 - 123,191,874UniSTS
RGSC_v3.17123,225,737 - 123,226,116RGD
Celera7112,592,399 - 112,592,677UniSTS
RH 3.4 Map7908.3UniSTS
RH 3.4 Map7908.3RGD
RH 2.0 Map7688.5RGD
Cytogenetic Map7 RGD
Strain QTL Data
Symbol Name Trait
Niddm19 Non-insulin dependent diabetes mellitus QTL 19 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Hyperglycemia after glucose challenge in the OGTT assay 625760
strain_reproduction Good breeding performance 625760

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-08 F344.OLETF-(D7Mgh16-D7Mgh20)/Tj    F344.OLETF-(D7Mgh16-D7Mgh20)/Tj    Name updated 68913 APPROVED
2012-05-08 F344.OLETF-(D7Mgh16-D7Mgh20)/Tj    F344.OLETF-(D7Mgh16-D7Mgh20)/Tj    Name updated 68913 APPROVED