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Gene: Aco2 (aconitase 2) Rattus norvegicus
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Symbol: Aco2
Name: aconitase 2
Description: Exhibits 3 iron, 4 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and aconitate hydratase activity. Involved in several processes, including response to isolation stress; tricarboxylic acid cycle; and tricarboxylic acid metabolic process. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy. Orthologous to human ACO2 (aconitase 2); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; INTERACTS WITH (R)-adrenaline; 1,3-dinitrobenzene; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: aconitase 2, mitochondrial; aconitate hydratase, mitochondrial; citrate hydro-lyase; mitochondrial aconitase (nuclear aco2 gene)
Orthologs:
Homo sapiens (human) : ACO2 (aconitase 2)  HGNC  Alliance
Mus musculus (house mouse) : Aco2 (aconitase 2, mitochondrial)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aco2 (aconitase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACO2 (aconitase 2)
Canis lupus familiaris (dog) : ACO2 (aconitase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aco2 (aconitase 2)
Sus scrofa (pig) : ACO2 (aconitase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07123,102,493 - 123,145,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,102,468 - 123,145,635 (+)Ensembl
Rnor_5.07123,077,888 - 123,121,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,223,788 - 120,266,944 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17120,258,017 - 120,301,166 (+)NCBI
Celera7109,704,354 - 109,747,462 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Aco2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621360
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.