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Gene: Aco2 (aconitase 2, mitochondrial) Mus musculus
Symbol: Aco2
Name: aconitase 2, mitochondrial
Description: Exhibits aconitate hydratase activity. Predicted to be involved in citrate metabolic process; isocitrate metabolic process; and tricarboxylic acid cycle. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human ACO2 (aconitase 2); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrabromodibenzodioxine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Aco-2; Aco3; aconitate hydratase, mitochondrial; citrate hydro-lyase; D10Wsu183e
Homo sapiens (human) : ACO2 (aconitase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aco2 (aconitase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aco2 (aconitase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACO2 (aconitase 2)
Canis lupus familiaris (dog) : ACO2 (aconitase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aco2 (aconitase 2)
Sus scrofa (pig) : ACO2 (aconitase 2)
more info ...
Related Pseudogenes: Gm18398   Gm5421  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381581,872,463 - 81,915,137 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371581,702,893 - 81,745,567 (+)NCBIGRCm37mm9NCBIm37
MGSCv361581,699,718 - 81,742,392 (+)NCBImm8
Celera1583,991,539 - 84,036,379 (+)NCBICelera
Cytogenetic Map15 E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Aco2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332293
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.