Wnt7b (Wnt family member 7B) - Rat Genome Database
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Gene: Wnt7b (Wnt family member 7B) Rattus norvegicus
Analyze
Symbol: Wnt7b
Name: Wnt family member 7B
RGD ID: 1311441
Description: Predicted to have chemoattractant activity involved in axon guidance; cytokine activity; and frizzled binding activity. Involved in several processes, including activation of JUN kinase activity; regulation of cell projection size; and response to glucocorticoid. Localizes to cytoplasm; extracellular space; and plasma membrane. Orthologous to human WNT7B (Wnt family member 7B); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling, the planar cell polarity pathway; Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC315196; protein Wnt-7b; wingless-related MMTV integration site 7B; wingless-type MMTV integration site family, member 7B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27116,634,817 - 116,679,089 (-)NCBI
Rnor_6.0 Ensembl7126,420,656 - 126,465,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07126,423,418 - 126,465,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07126,136,632 - 126,178,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,533,713 - 123,554,333 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17123,567,943 - 123,588,563 (-)NCBI
Celera7112,932,206 - 112,952,808 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of JUN kinase activity  (IDA)
anatomical structure regression  (ISO)
angiogenesis  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell fate commitment  (IBA)
cell proliferation in forebrain  (ISO)
cellular metabolic process  (ISO)
cellular response to retinoic acid  (ISO)
central nervous system vasculogenesis  (ISO)
chemoattraction of dopaminergic neuron axon  (ISO)
chorio-allantoic fusion  (ISO)
developmental growth involved in morphogenesis  (ISO)
embryonic organ development  (ISO)
embryonic placenta morphogenesis  (ISO)
establishment or maintenance of polarity of embryonic epithelium  (ISO)
fibroblast proliferation  (ISO)
forebrain regionalization  (ISO)
homeostatic process  (ISO)
in utero embryonic development  (ISO)
inner medullary collecting duct development  (ISO)
lobar bronchus development  (ISO)
lung development  (ISO)
lung epithelium development  (ISO)
lung morphogenesis  (ISO)
lung-associated mesenchyme development  (ISO)
mammary gland epithelium development  (ISO)
metanephric collecting duct development  (ISO)
metanephric epithelium development  (ISO)
metanephric loop of Henle development  (ISO)
metanephros morphogenesis  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
neuron differentiation  (IBA,ISO)
neuron projection development  (IMP)
neuron projection morphogenesis  (IDA)
odontogenesis of dentin-containing tooth  (ISO)
outer medullary collecting duct development  (ISO)
oxygen homeostasis  (ISO)
planar cell polarity pathway involved in axon guidance  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of JNK cascade  (IBA,IMP)
positive regulation of osteoblast differentiation  (ISO)
regulation of cell projection size  (IDA)
renal inner medulla development  (ISO)
renal outer medulla development  (ISO)
response to glucocorticoid  (IEP)
smooth muscle cell differentiation  (ISO)
stem cell development  (ISO)
stem cell proliferation  (ISO)
synapse organization  (ISO)
trachea cartilage morphogenesis  (ISO)
vasculature development  (ISO)
Wnt signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8167409   PMID:10781055   PMID:11543617   PMID:12147135   PMID:12239632   PMID:12429992   PMID:12843296   PMID:15164427   PMID:15576404   PMID:16163358   PMID:16818724   PMID:17804636  
PMID:18056042   PMID:18343501   PMID:18367557   PMID:19023080   PMID:19060336   PMID:19129494   PMID:19690384   PMID:19734317   PMID:21106844   PMID:26429533   PMID:28733458   PMID:31001900  


Genomics

Comparative Map Data
Wnt7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27116,634,817 - 116,679,089 (-)NCBI
Rnor_6.0 Ensembl7126,420,656 - 126,465,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07126,423,418 - 126,465,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07126,136,632 - 126,178,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47123,533,713 - 123,554,333 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17123,567,943 - 123,588,563 (-)NCBI
Celera7112,932,206 - 112,952,808 (-)NCBICelera
Cytogenetic Map7q34NCBI
WNT7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2245,920,366 - 45,977,162 (-)EnsemblGRCh38hg38GRCh38
GRCh382245,920,362 - 45,977,162 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372246,316,246 - 46,373,042 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372246,316,246 - 46,373,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,696,316 - 44,751,395 (-)NCBINCBI36hg18NCBI36
Build 342244,638,195 - 44,666,564NCBI
Cytogenetic Map22q13.31NCBI
HuRef2229,261,652 - 29,291,436 (-)NCBIHuRef
CHM1_12246,275,362 - 46,332,075 (-)NCBICHM1_1
Wnt7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,419,638 - 85,466,022 (-)NCBIGRCm39mm39
GRCm381585,535,437 - 85,581,821 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,535,437 - 85,582,473 (-)EnsemblGRCm38mm10GRCm38
MGSCv371585,365,867 - 85,412,251 (-)NCBIGRCm37mm9NCBIm37
MGSCv361585,363,207 - 85,409,348 (-)NCBImm8
Celera1587,665,622 - 87,712,020 (-)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.39NCBI
Wnt7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,144,869 - 30,181,791 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541330,146,185 - 30,185,693 (-)NCBIChiLan1.0ChiLan1.0
WNT7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12244,988,647 - 45,039,601 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2244,988,647 - 45,044,841 (-)Ensemblpanpan1.1panPan2
WNT7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1020,160,206 - 20,243,160 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11020,160,916 - 20,208,786 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Wnt7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366293,869,976 - 3,907,932 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,521,695 - 3,572,314 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.153,521,412 - 3,572,322 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25654,961 - 707,041 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT7B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11928,387,324 - 28,444,019 (-)NCBI
ChlSab1.1 Ensembl1928,385,422 - 28,441,350 (-)Ensembl
Wnt7b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247523,818,073 - 3,856,602 (+)NCBI

Position Markers
D7Rat60  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,438,538 - 126,438,743NCBIRnor6.0
Rnor_5.07126,151,750 - 126,151,955UniSTSRnor5.0
RGSC_v3.47123,548,832 - 123,549,038RGDRGSC3.4
RGSC_v3.47123,548,833 - 123,549,038UniSTSRGSC3.4
RGSC_v3.17123,583,062 - 123,583,268RGD
FHH x ACI Map754.48UniSTS
FHH x ACI Map754.48RGD
Cytogenetic Map7q34UniSTS
D7Rat97  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,463,649 - 126,463,827NCBIRnor6.0
Rnor_5.07126,176,882 - 126,177,060UniSTSRnor5.0
RGSC_v3.47123,574,473 - 123,574,930RGDRGSC3.4
RGSC_v3.47123,574,502 - 123,574,680UniSTSRGSC3.4
RGSC_v3.17123,608,732 - 123,608,910RGD
Celera7112,972,542 - 112,972,733UniSTS
RH 3.4 Map7908.3UniSTS
RH 3.4 Map7908.3RGD
RH 2.0 Map7688.9RGD
SHRSP x BN Map770.2799RGD
FHH x ACI Map754.48RGD
Cytogenetic Map7q34UniSTS
Wnt7b  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,421,533 - 126,422,009NCBIRnor6.0
Rnor_5.07126,134,747 - 126,135,223UniSTSRnor5.0
RGSC_v3.47123,531,828 - 123,532,304UniSTSRGSC3.4
Celera7112,930,321 - 112,930,797UniSTS
Cytogenetic Map7q34UniSTS
Wnt7b  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07126,423,453 - 126,423,837NCBIRnor6.0
Rnor_5.07126,136,667 - 126,137,051UniSTSRnor5.0
RGSC_v3.47123,533,748 - 123,534,132UniSTSRGSC3.4
Celera7112,932,241 - 112,932,625UniSTS
Cytogenetic Map7q34UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)777428105127748511Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)781645773140745067Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)788365265133365265Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)788365265134673427Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)791018361136018361Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)793726906138726906Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)793726906138726906Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)796630946141630946Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7100028953145729302Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)7100160423140335001Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)7100192194145192194Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)7103815550126525386Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)7106564316145729302Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7111519266143965591Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7112429186126525386Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7114825174145729302Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7115922628145729302Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7120746024145692398Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7121654760145729302Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7121986439143965591Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7122421276143965415Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7126463649134098026Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7126463827137325116Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:80
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000021196
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 60 13
Low 2 2 2 2 14 22 32 11
Below cutoff 18 39 30 12 30 3 3 8 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021196   ⟹   ENSRNOP00000021196
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7126,423,418 - 126,465,723 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081032   ⟹   ENSRNOP00000072573
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7126,420,656 - 126,461,658 (-)Ensembl
RefSeq Acc Id: NM_001009695   ⟹   NP_001009695
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27116,636,759 - 116,679,089 (-)NCBI
Rnor_6.07126,423,418 - 126,465,724 (-)NCBI
Rnor_5.07126,136,632 - 126,178,957 (-)NCBI
RGSC_v3.47123,533,713 - 123,554,333 (-)RGD
Celera7112,932,206 - 112,952,808 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079297   ⟹   XP_038935225
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27116,634,817 - 116,675,372 (-)NCBI
RefSeq Acc Id: XM_039079298   ⟹   XP_038935226
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27116,634,817 - 116,657,377 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001009695 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935225 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD83363 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001009695   ⟸   NM_001009695
- UniProtKB: Q5NSW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021196   ⟸   ENSRNOT00000021196
RefSeq Acc Id: ENSRNOP00000072573   ⟸   ENSRNOT00000081032
RefSeq Acc Id: XP_038935225   ⟸   XM_039079297
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935226   ⟸   XM_039079298
- Peptide Label: isoform X2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311441 AgrOrtholog
Ensembl Genes ENSRNOG00000015750 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021196 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072573 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021196 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000081032 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt7 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_grthfactor_CS UniProtKB/TrEMBL
  Wnt_SF UniProtKB/TrEMBL
KEGG Report rno:315196 UniProtKB/TrEMBL
NCBI Gene 315196 ENTREZGENE
PANTHER Wnt UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt7b PhenoGen
PRINTS WNT7PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A0G2K3B7_RAT UniProtKB/TrEMBL
  E9PU66_RAT UniProtKB/TrEMBL
  Q5NSW6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt7b  Wnt family member 7B  Wnt7b  wingless-type MMTV integration site family, member 7B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt7b  wingless-type MMTV integration site family, member 7B  Wnt7b  wingless-related MMTV integration site 7B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Wnt7b  wingless-related MMTV integration site 7B  Wnt7b_predicted  wingless-related MMTV integration site 7B (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Wnt7b_predicted  wingless-related MMTV integration site 7B (predicted)      Symbol and Name status set to approved 70820 APPROVED