Rrm2b (ribonucleotide reductase regulatory TP53 inducible subunit M2B) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Rrm2b (ribonucleotide reductase regulatory TP53 inducible subunit M2B) Rattus norvegicus
Analyze
Symbol: Rrm2b
Name: ribonucleotide reductase regulatory TP53 inducible subunit M2B
RGD ID: 1306045
Description: Predicted to enable identical protein binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in response to amine. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; gemcitabine pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299976; ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2769,077,024 - 69,108,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,078,291 - 69,108,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx770,964,402 - 70,992,039 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0773,166,927 - 73,194,570 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0773,034,966 - 73,062,605 (-)NCBIRnor_WKY
Rnor_6.0776,750,045 - 76,780,817 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl776,750,050 - 76,780,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0776,865,854 - 76,898,097 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4773,432,161 - 73,459,541 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1773,452,888 - 73,480,282 (-)NCBI
Celera766,144,175 - 66,172,166 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloramphenicol  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dicrotophos  (ISO)
diethanolamine  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (EXP)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
hydroxyurea  (ISO)
ifosfamide  (ISO)
isobutyraldehyde  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
ochratoxin A  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
toluene 2,4-diisocyanate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zebularine  (ISO)
zidovudine  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Strong induction of p73 protein in vivo coincides with the onset of apoptosis in rat liver after treatment with the hepatocarcinogen N-nitrosomorpholine (NNM). Tudzarova-Trajkovska S and Wesierska-Gadek J, J Cell Biochem. 2003 Nov 1;90(4):837-55.
Additional References at PubMed
PMID:11517226   PMID:12858174   PMID:17486094   PMID:23376485   PMID:25416956   PMID:25502805   PMID:31515488  


Genomics

Comparative Map Data
Rrm2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2769,077,024 - 69,108,742 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl769,078,291 - 69,108,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx770,964,402 - 70,992,039 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0773,166,927 - 73,194,570 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0773,034,966 - 73,062,605 (-)NCBIRnor_WKY
Rnor_6.0776,750,045 - 76,780,817 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl776,750,050 - 76,780,817 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0776,865,854 - 76,898,097 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4773,432,161 - 73,459,541 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1773,452,888 - 73,480,282 (-)NCBI
Celera766,144,175 - 66,172,166 (-)NCBICelera
Cytogenetic Map7q22NCBI
RRM2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388102,204,501 - 102,238,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl8102,204,502 - 102,238,961 (-)EnsemblGRCh38hg38GRCh38
GRCh378103,216,729 - 103,251,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368103,285,907 - 103,320,522 (-)NCBINCBI36Build 36hg18NCBI36
Build 348103,285,907 - 103,320,522NCBI
Celera899,401,627 - 99,436,245 (-)NCBICelera
Cytogenetic Map8q22.3NCBI
HuRef898,415,432 - 98,450,050 (-)NCBIHuRef
CHM1_18103,257,019 - 103,291,637 (-)NCBICHM1_1
T2T-CHM13v2.08103,330,401 - 103,364,861 (-)NCBIT2T-CHM13v2.0
Rrm2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391537,924,196 - 37,961,363 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1537,924,196 - 37,961,562 (-)EnsemblGRCm39 Ensembl
GRCm381537,923,952 - 37,961,119 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1537,923,952 - 37,961,318 (-)EnsemblGRCm38mm10GRCm38
MGSCv371537,853,707 - 37,890,810 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361537,868,541 - 37,905,644 (-)NCBIMGSCv36mm8
Celera1538,542,769 - 38,579,866 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
Rrm2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541726,949,686 - 26,976,726 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541726,949,686 - 26,976,976 (-)NCBIChiLan1.0ChiLan1.0
RRM2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18101,016,069 - 101,052,235 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8101,019,699 - 101,052,056 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0898,854,101 - 98,890,365 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RRM2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1133,774,725 - 3,838,576 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl133,799,025 - 3,837,934 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha133,776,853 - 3,840,752 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0133,934,984 - 3,998,893 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl133,956,962 - 3,998,249 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1133,777,888 - 3,841,775 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0133,890,675 - 3,954,582 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0133,907,686 - 3,971,792 (-)NCBIUU_Cfam_GSD_1.0
Rrm2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530333,928,024 - 33,975,215 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647041,354,287 - 41,401,317 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647041,354,387 - 41,401,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRM2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl434,823,758 - 34,859,778 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1434,823,869 - 34,859,777 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2437,679,202 - 37,715,064 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RRM2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1897,055,111 - 97,091,980 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603943,559,489 - 43,596,372 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rrm2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476319,362,663 - 19,391,443 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476319,362,793 - 19,391,401 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rrm2b
174 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:120
Interacting mature miRNAs:129
Transcripts:ENSRNOT00000033704
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat

Markers in Region
D7Rat110  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,089,957 - 69,090,184 (+)MAPPERmRatBN7.2
Rnor_6.0776,759,399 - 76,759,625NCBIRnor6.0
Rnor_5.0776,875,208 - 76,875,434UniSTSRnor5.0
RGSC_v3.4773,441,514 - 73,441,741RGDRGSC3.4
RGSC_v3.4773,441,515 - 73,441,741UniSTSRGSC3.4
RGSC_v3.1773,462,169 - 73,462,477RGD
Celera766,153,529 - 66,153,755UniSTS
SHRSP x BN Map744.42RGD
SHRSP x BN Map744.42UniSTS
Cytogenetic Map7q22UniSTS
BF387246  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2769,110,281 - 69,110,469 (+)MAPPERmRatBN7.2
Rnor_6.0776,782,636 - 76,782,823NCBIRnor6.0
Rnor_5.0776,899,916 - 76,900,103UniSTSRnor5.0
RGSC_v3.4773,461,202 - 73,461,389UniSTSRGSC3.4
Celera766,173,827 - 66,174,014UniSTS
RH 3.4 Map7638.0UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 14 22 6 19 6 8 10 54 29 20 11 8
Low 1 29 35 35 35 1 20 6 21
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033704   ⟹   ENSRNOP00000038047
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,078,547 - 69,108,586 (-)Ensembl
Rnor_6.0 Ensembl776,750,050 - 76,780,817 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107052   ⟹   ENSRNOP00000090940
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,078,547 - 69,108,633 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114573   ⟹   ENSRNOP00000077843
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl769,078,291 - 69,108,490 (-)Ensembl
RefSeq Acc Id: NM_001130543   ⟹   NP_001124015
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2769,080,604 - 69,108,621 (-)NCBI
Rnor_6.0776,750,045 - 76,780,817 (-)NCBI
Rnor_5.0776,865,854 - 76,898,097 (-)NCBI
RGSC_v3.4773,432,161 - 73,459,541 (-)RGD
Celera766,144,175 - 66,172,166 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078800   ⟹   XP_038934728
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2769,077,024 - 69,108,738 (-)NCBI
RefSeq Acc Id: XM_039078801   ⟹   XP_038934729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2769,077,024 - 69,108,742 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001124015 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934728 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934729 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16371 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001124015   ⟸   NM_001130543
- UniProtKB: D4ADQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038047   ⟸   ENSRNOT00000033704
RefSeq Acc Id: XP_038934729   ⟸   XM_039078801
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ACU7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934728   ⟸   XM_039078800
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000090940   ⟸   ENSRNOT00000107052
RefSeq Acc Id: ENSRNOP00000077843   ⟸   ENSRNOT00000114573

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADQ1-F1-model_v2 AlphaFold D4ADQ1 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695298
Promoter ID:EPDNEW_R5823
Type:initiation region
Name:Rrm2b_1
Description:ribonucleotide reductase regulatory TP53 inducible subunit M2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0776,780,744 - 76,780,804EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306045 AgrOrtholog
BioCyc Gene G2FUF-33616 BioCyc
BioCyc Pathway PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP] BioCyc
  PWY-7226 [guanosine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7227 [adenosine deoxyribonucleotides de novo biosynthesis I] BioCyc
Ensembl Genes ENSRNOG00000025454 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000038047 ENTREZGENE
  ENSRNOP00000038047.6 UniProtKB/TrEMBL
  ENSRNOP00000077843.1 UniProtKB/TrEMBL
  ENSRNOP00000090940 ENTREZGENE
  ENSRNOP00000090940.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033704 ENTREZGENE
  ENSRNOT00000033704.7 UniProtKB/TrEMBL
  ENSRNOT00000107052 ENTREZGENE
  ENSRNOT00000107052.1 UniProtKB/TrEMBL
  ENSRNOT00000114573.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.620.20 UniProtKB/TrEMBL
InterPro Ferritin-like_SF UniProtKB/TrEMBL
  RNR-like UniProtKB/TrEMBL
  RNR_small UniProtKB/TrEMBL
  RNR_small UniProtKB/TrEMBL
  RNR_small_AS UniProtKB/TrEMBL
KEGG Report rno:299976 UniProtKB/TrEMBL
NCBI Gene 299976 ENTREZGENE
PANTHER PTHR23409 UniProtKB/TrEMBL
Pfam Ribonuc_red_sm UniProtKB/TrEMBL
PhenoGen Rrm2b PhenoGen
PIRSF NrdB UniProtKB/TrEMBL
PROSITE RIBORED_SMALL UniProtKB/TrEMBL
Superfamily-SCOP SSF47240 UniProtKB/TrEMBL
UniProt A0A8I5YCI9_RAT UniProtKB/TrEMBL
  A0A8I6ACU7 ENTREZGENE, UniProtKB/TrEMBL
  D4ADQ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Rrm2b  ribonucleotide reductase regulatory TP53 inducible subunit M2B  Rrm2b  ribonucleotide reductase M2 B (TP53 inducible)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rrm2b  ribonucleotide reductase M2 B (TP53 inducible)   Rrm2b_predicted  ribonucleotide reductase M2 B (TP53 inducible) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rrm2b_predicted  ribonucleotide reductase M2 B (TP53 inducible) (predicted)      Symbol and Name status set to approved 70820 APPROVED