Cacng2 (calcium voltage-gated channel auxiliary subunit gamma 2) - Rat Genome Database

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Gene: Cacng2 (calcium voltage-gated channel auxiliary subunit gamma 2) Rattus norvegicus
Analyze
Symbol: Cacng2
Name: calcium voltage-gated channel auxiliary subunit gamma 2
RGD ID: 71095
Description: Enables ionotropic glutamate receptor binding activity. Involved in several processes, including eye blink reflex; positive regulation of AMPA receptor activity; and positive regulation of protein localization to basolateral plasma membrane. Located in several cellular components, including cell surface; cerebellar mossy fiber; and postsynaptic density membrane. Part of AMPA glutamate receptor complex. Biomarker of childhood absence epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium channel, voltage-dependent, gamma subunit 2; Ipr328; neuronal voltage-gated calcium channel gamma-2 subunit; stargazin; TARP gamma-2; transmembrane AMPAR regulatory protein gamma-2; voltage-dependent calcium channel gamma-2 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27109,572,838 - 109,698,516 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7109,574,459 - 109,697,227 (-)Ensembl
Rnor_6.07119,228,112 - 119,353,332 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,228,102 - 119,352,605 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,221,311 - 119,344,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,913,440 - 116,037,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17115,947,669 - 116,072,121 (-)NCBI
Celera7105,915,114 - 106,037,137 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The stargazin C terminus encodes an intrinsic and transferable membrane sorting signal. Bedoukian MA, etal., J Biol Chem. 2008 Jan 18;283(3):1597-600. doi: 10.1074/jbc.M708141200. Epub 2007 Nov 6.
2. Calcium channel gamma subunits provide insights into the evolution of this gene family. Chu PJ, etal., Gene 2001 Dec 12;280(1-2):37-48.
3. Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²¿-permeable AMPA receptors during the incubation of cocaine craving. Ferrario CR, etal., Neuropharmacology. 2011 Dec;61(7):1141-51. doi: 10.1016/j.neuropharm.2011.01.021. Epub 2011 Jan 27.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Hamdan FF, etal., Am J Hum Genet. 2011 Mar 11;88(3):306-16. doi: 10.1016/j.ajhg.2011.02.001. Epub 2011 Mar 3.
7. Differential localization and regulation of stargazin-like protein, gamma-8 and stargazin in the plasma membrane of hippocampal and cortical neurons. Inamura M, etal., Neurosci Res. 2006 May;55(1):45-53. Epub 2006 Mar 3.
8. Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein gamma-8 with calcineurin. Itakura M, etal., FEBS J. 2014 Mar;281(5):1366-78. doi: 10.1111/febs.12708. Epub 2014 Jan 27.
9. Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling. Joiner ML, etal., EMBO J. 2010 Jan 20;29(2):482-95. Epub 2009 Nov 26.
10. AMPA receptor and GEF-H1/Lfc complex regulates dendritic spine development through RhoA signaling cascade. Kang MG, etal., Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3549-54. doi: 10.1073/pnas.0812861106. Epub 2009 Feb 10.
11. AMPA receptor subunit-specific regulation by a distinct family of type II TARPs. Kato AS, etal., Neuron. 2008 Sep 25;59(6):986-96. doi: 10.1016/j.neuron.2008.07.034.
12. Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg. Kennard JT, etal., Neurobiol Dis. 2011 Apr;42(1):48-54. doi: 10.1016/j.nbd.2011.01.003. Epub 2011 Jan 8.
13. c-Fos, Arc, and stargazin expression in rat eyeblink conditioning. Kim S and Thompson RF, Behav Neurosci. 2011 Feb;125(1):117-23. doi: 10.1037/a0022328.
14. Distribution of transmembrane AMPA receptor regulatory protein (TARP) isoforms in the rat spinal cord. Larsson M, etal., Neuroscience. 2013 Sep 17;248:180-93. doi: 10.1016/j.neuroscience.2013.05.060. Epub 2013 Jun 7.
15. Mechanisms of CaMKII action in long-term potentiation. Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192.
16. Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs. Martinez-Turrillas R, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):750-5. Epub 2006 Dec 19.
17. Gene Data Set MGD Curation, June 12, 2002
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating. Milstein AD, etal., Neuron. 2007 Sep 20;55(6):905-18.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin. Powell KL, etal., Neurobiol Dis. 2008 Aug;31(2):261-5. doi: 10.1016/j.nbd.2008.04.012. Epub 2008 May 10.
24. MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Rademacher N, etal., Sci Rep. 2016 Oct 19;6:35283. doi: 10.1038/srep35283.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Schnell E, etal., Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13902-7. Epub 2002 Oct 1.
29. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Schwenk J, etal., Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.
30. S-nitrosylation of stargazin regulates surface expression of AMPA-glutamate neurotransmitter receptors. Selvakumar B, etal., Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16440-5. doi: 10.1073/pnas.0908949106. Epub 2009 Sep 10.
31. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. Shi Y, etal., Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16315-9. doi: 10.1073/pnas.1011706107. Epub 2010 Aug 30.
32. Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Soto D, etal., Nat Neurosci. 2009 Mar;12(3):277-85. doi: 10.1038/nn.2266. Epub 2009 Feb 22.
33. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. Tomita S, etal., J Cell Biol. 2003 May 26;161(4):805-16. doi: 10.1083/jcb.200212116.
34. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Tomita S, etal., Science 2004 Mar 5;303(5663):1508-11.
35. Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms. Turetsky D, etal., J Neurosci. 2005 Aug 10;25(32):7438-48. doi: 10.1523/JNEUROSCI.1108-05.2005.
36. Calpain-mediated regulation of stargazin in adult rat brain. Yu L, etal., Neuroscience. 2011 Mar 31;178:13-20. doi: 10.1016/j.neuroscience.2011.01.026. Epub 2011 Jan 20.
Additional References at PubMed
PMID:9065835   PMID:9293489   PMID:11140673   PMID:12151514   PMID:15136571   PMID:15664178   PMID:15677329   PMID:15758178   PMID:16485113   PMID:17320843   PMID:17329211   PMID:18341993  
PMID:18753375   PMID:22632720   PMID:24035918   PMID:24217640   PMID:26742808   PMID:27076426   PMID:27368053   PMID:28823560   PMID:29476059  


Genomics

Comparative Map Data
Cacng2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27109,572,838 - 109,698,516 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7109,574,459 - 109,697,227 (-)Ensembl
Rnor_6.07119,228,112 - 119,353,332 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,228,102 - 119,352,605 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,221,311 - 119,344,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,913,440 - 116,037,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17115,947,669 - 116,072,121 (-)NCBI
Celera7105,915,114 - 106,037,137 (-)NCBICelera
Cytogenetic Map7q34NCBI
CACNG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,560,857 - 36,703,752 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2236,560,857 - 36,703,752 (-)EnsemblGRCh38hg38GRCh38
GRCh372236,956,904 - 37,099,797 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,290,050 - 35,428,849 (-)NCBINCBI36hg18NCBI36
Build 342235,284,603 - 35,423,403NCBI
Celera2220,762,236 - 20,901,711 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2219,924,851 - 20,065,866 (-)NCBIHuRef
CHM1_12236,915,848 - 37,057,863 (-)NCBICHM1_1
T2T-CHM13v2.02237,021,025 - 37,164,438 (-)NCBI
Cacng2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391577,876,119 - 78,004,420 (-)NCBIGRCm39mm39
GRCm39 Ensembl1577,875,948 - 78,004,228 (-)Ensembl
GRCm381577,991,919 - 78,120,220 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,991,748 - 78,120,028 (-)EnsemblGRCm38mm10GRCm38
MGSCv371577,824,053 - 77,949,710 (-)NCBIGRCm37mm9NCBIm37
MGSCv361577,822,211 - 77,946,535 (-)NCBImm8
Celera1579,452,871 - 79,580,282 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1536.92NCBI
Cacng2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,132,896 - 23,248,231 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,136,369 - 23,248,231 (-)NCBIChiLan1.0ChiLan1.0
CACNG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12235,313,679 - 35,454,844 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,317,121 - 35,454,850 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02217,475,693 - 17,618,299 (-)NCBIMhudiblu_PPA_v0panPan3
CACNG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,750,314 - 27,862,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,750,935 - 27,862,885 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,704,742 - 27,816,319 (+)NCBI
ROS_Cfam_1.01028,542,976 - 28,647,844 (+)NCBI
ROS_Cfam_1.0 Ensembl1028,543,246 - 28,649,561 (+)Ensembl
UMICH_Zoey_3.11028,264,819 - 28,376,310 (+)NCBI
UNSW_CanFamBas_1.01028,572,787 - 28,684,331 (+)NCBI
UU_Cfam_GSD_1.01028,751,224 - 28,862,860 (+)NCBI
Cacng2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,115,362 - 11,221,857 (+)NCBI
SpeTri2.0NW_0049364924,125,182 - 4,232,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl511,067,692 - 11,185,480 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1511,067,016 - 11,185,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,846,099 - 8,866,357 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,263,950 - 19,406,952 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,267,426 - 19,406,883 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045106,459,860 - 106,604,857 (+)NCBIVero_WHO_p1.0
Cacng2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475211,062,002 - 11,170,406 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475211,062,059 - 11,172,357 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
BF388004  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera7105,941,940 - 105,942,125UniSTS
RH 3.4 Map7814.9UniSTS
Cytogenetic Map7q33-q34UniSTS
BF416002  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27109,679,894 - 109,680,134 (+)MAPPERmRatBN7.2
Rnor_6.07119,333,365 - 119,333,604NCBIRnor6.0
Rnor_5.07119,326,942 - 119,327,181UniSTSRnor5.0
RGSC_v3.47116,020,983 - 116,021,222UniSTSRGSC3.4
Celera7106,020,366 - 106,020,605UniSTS
RH 3.4 Map7815.0UniSTS
Cytogenetic Map7q33-q34UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:50
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000008414
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 52
Low 20 5 1
Below cutoff 2 2 9 4 8 4 2 4 2 2 23 8 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008414   ⟹   ENSRNOP00000008414
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7119,228,102 - 119,352,605 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106728   ⟹   ENSRNOP00000085982
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7109,574,459 - 109,697,227 (-)Ensembl
RefSeq Acc Id: NM_053351   ⟹   NP_445803
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,574,426 - 109,697,227 (-)NCBI
Rnor_6.07119,229,268 - 119,352,033 (-)NCBI
Rnor_5.07119,221,311 - 119,344,620 (-)NCBI
RGSC_v3.47115,913,440 - 116,037,891 (-)RGD
Celera7105,915,114 - 106,037,137 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595135   ⟹   XP_017450624
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,572,838 - 109,698,516 (-)NCBI
Rnor_6.07119,228,112 - 119,352,645 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_445803 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450624 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK08653 (Get FASTA)   NCBI Sequence Viewer  
  AAL50034 (Get FASTA)   NCBI Sequence Viewer  
  EDM15892 (Get FASTA)   NCBI Sequence Viewer  
  Q71RJ2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_445803   ⟸   NM_053351
- Sequence:
RefSeq Acc Id: XP_017450624   ⟸   XM_017595135
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000008414   ⟸   ENSRNOT00000008414
RefSeq Acc Id: ENSRNOP00000085982   ⟸   ENSRNOT00000106728

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q71RJ2-F1-model_v2 AlphaFold Q71RJ2 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695455
Promoter ID:EPDNEW_R5980
Type:single initiation site
Name:Cacng2_1
Description:calcium voltage-gated channel auxiliary subunit gamma 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07119,352,672 - 119,352,732EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71095 AgrOrtholog
BioCyc Gene G2FUF-32845 BioCyc
Ensembl Genes ENSRNOG00000006226 Ensembl
  ENSRNOG00000065511 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000085982 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000106728 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_g2su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_gsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84347 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 84347 ENTREZGENE
PANTHER PTHR12107:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacng2 PhenoGen
PRINTS VDCCGAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCCGAMMA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CCG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q99PR9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacng2  calcium voltage-gated channel auxiliary subunit gamma 2  Cacng2  calcium channel, voltage-dependent, gamma subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cacng2  calcium channel, voltage-dependent, gamma subunit 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_evolution may have evolved from a common ancestral gamma subunit via gene duplication 70681