Cacng2 (calcium voltage-gated channel auxiliary subunit gamma 2) - Rat Genome Database
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Gene: Cacng2 (calcium voltage-gated channel auxiliary subunit gamma 2) Rattus norvegicus
Analyze
Symbol: Cacng2
Name: calcium voltage-gated channel auxiliary subunit gamma 2
RGD ID: 71095
Description: Exhibits ionotropic glutamate receptor binding activity. Involved in several processes, including eye blink reflex; positive regulation of AMPA receptor activity; and positive regulation of protein localization to basolateral plasma membrane. Localizes to several cellular components, including AMPA glutamate receptor complex; cerebellar mossy fiber; and postsynaptic density membrane. Biomarker of childhood absence epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: calcium channel, voltage-dependent, gamma subunit 2; Ipr328; neuronal voltage-gated calcium channel gamma-2 subunit; stargazin; TARP gamma-2; transmembrane AMPAR regulatory protein gamma-2; voltage-dependent calcium channel gamma-2 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27109,572,838 - 109,698,516 (-)NCBI
Rnor_6.0 Ensembl7119,228,102 - 119,352,605 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07119,228,112 - 119,353,332 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07119,221,311 - 119,344,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,913,440 - 116,037,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17115,947,669 - 116,072,121 (-)NCBI
Celera7105,915,114 - 106,037,137 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
1. Bedoukian MA, etal., J Biol Chem. 2008 Jan 18;283(3):1597-600. doi: 10.1074/jbc.M708141200. Epub 2007 Nov 6.
2. Chu PJ, etal., Gene 2001 Dec 12;280(1-2):37-48.
3. Ferrario CR, etal., Neuropharmacology. 2011 Dec;61(7):1141-51. doi: 10.1016/j.neuropharm.2011.01.021. Epub 2011 Jan 27.
4. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. GOA data from the GO Consortium
6. Hamdan FF, etal., Am J Hum Genet. 2011 Mar 11;88(3):306-16. doi: 10.1016/j.ajhg.2011.02.001. Epub 2011 Mar 3.
7. Inamura M, etal., Neurosci Res. 2006 May;55(1):45-53. Epub 2006 Mar 3.
8. Itakura M, etal., FEBS J. 2014 Mar;281(5):1366-78. doi: 10.1111/febs.12708. Epub 2014 Jan 27.
9. Joiner ML, etal., EMBO J. 2010 Jan 20;29(2):482-95. Epub 2009 Nov 26.
10. Kang MG, etal., Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3549-54. doi: 10.1073/pnas.0812861106. Epub 2009 Feb 10.
11. Kato AS, etal., Neuron. 2008 Sep 25;59(6):986-96. doi: 10.1016/j.neuron.2008.07.034.
12. Kennard JT, etal., Neurobiol Dis. 2011 Apr;42(1):48-54. doi: 10.1016/j.nbd.2011.01.003. Epub 2011 Jan 8.
13. Kim S and Thompson RF, Behav Neurosci. 2011 Feb;125(1):117-23. doi: 10.1037/a0022328.
14. Larsson M, etal., Neuroscience. 2013 Sep 17;248:180-93. doi: 10.1016/j.neuroscience.2013.05.060. Epub 2013 Jun 7.
15. Lisman J, etal., Nat Rev Neurosci. 2012 Feb 15;13(3):169-82. doi: 10.1038/nrn3192.
16. Martinez-Turrillas R, etal., Biochem Biophys Res Commun. 2007 Feb 16;353(3):750-5. Epub 2006 Dec 19.
17. MGD Curation, June 12, 2002
18. MGD data from the GO Consortium
19. Milstein AD, etal., Neuron. 2007 Sep 20;55(6):905-18.
20. NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline
22. Pipeline to import KEGG annotations from KEGG into RGD
23. Powell KL, etal., Neurobiol Dis. 2008 Aug;31(2):261-5. doi: 10.1016/j.nbd.2008.04.012. Epub 2008 May 10.
24. Rademacher N, etal., Sci Rep. 2016 Oct 19;6:35283. doi: 10.1038/srep35283.
25. RGD automated data pipeline
26. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. RGD automated import pipeline for gene-chemical interactions
28. Schnell E, etal., Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13902-7. Epub 2002 Oct 1.
29. Schwenk J, etal., Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.
30. Selvakumar B, etal., Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16440-5. doi: 10.1073/pnas.0908949106. Epub 2009 Sep 10.
31. Shi Y, etal., Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16315-9. doi: 10.1073/pnas.1011706107. Epub 2010 Aug 30.
32. Soto D, etal., Nat Neurosci. 2009 Mar;12(3):277-85. doi: 10.1038/nn.2266. Epub 2009 Feb 22.
33. Tomita S, etal., J Cell Biol. 2003 May 26;161(4):805-16. doi: 10.1083/jcb.200212116.
34. Tomita S, etal., Science 2004 Mar 5;303(5663):1508-11.
35. Turetsky D, etal., J Neurosci. 2005 Aug 10;25(32):7438-48. doi: 10.1523/JNEUROSCI.1108-05.2005.
36. Yu L, etal., Neuroscience. 2011 Mar 31;178:13-20. doi: 10.1016/j.neuroscience.2011.01.026. Epub 2011 Jan 20.
Additional References at PubMed
PMID:9065835   PMID:9293489   PMID:11140673   PMID:12151514   PMID:15136571   PMID:15664178   PMID:15677329   PMID:15758178   PMID:16485113   PMID:17320843   PMID:17329211   PMID:18341993  
PMID:18753375   PMID:22632720   PMID:24035918   PMID:24217640   PMID:26742808   PMID:27076426   PMID:27368053   PMID:28823560   PMID:29476059  


Genomics

Comparative Map Data
Cacng2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27109,572,838 - 109,698,516 (-)NCBI
Rnor_6.0 Ensembl7119,228,102 - 119,352,605 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07119,228,112 - 119,353,332 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07119,221,311 - 119,344,620 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,913,440 - 116,037,891 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17115,947,669 - 116,072,121 (-)NCBI
Celera7105,915,114 - 106,037,137 (-)NCBICelera
Cytogenetic Map7q34NCBI
CACNG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2236,560,857 - 36,703,752 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2236,563,921 - 36,703,558 (-)EnsemblGRCh38hg38GRCh38
GRCh382236,560,857 - 36,703,752 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372236,956,916 - 37,098,690 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372236,956,904 - 37,099,797 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,290,050 - 35,428,849 (-)NCBINCBI36hg18NCBI36
Build 342235,284,603 - 35,423,403NCBI
Celera2220,762,236 - 20,901,711 (-)NCBI
Cytogenetic Map22q12.3NCBI
HuRef2219,924,851 - 20,065,866 (-)NCBIHuRef
CHM1_12236,915,848 - 37,057,863 (-)NCBICHM1_1
Cacng2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391577,876,119 - 78,004,420 (-)NCBIGRCm39mm39
GRCm381577,991,919 - 78,120,220 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,991,748 - 78,120,028 (-)EnsemblGRCm38mm10GRCm38
MGSCv371577,824,053 - 77,949,710 (-)NCBIGRCm37mm9NCBIm37
MGSCv361577,822,211 - 77,946,535 (-)NCBImm8
Celera1579,452,871 - 79,580,282 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1536.92NCBI
Cacng2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,132,896 - 23,248,231 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,136,369 - 23,248,231 (-)NCBIChiLan1.0ChiLan1.0
CACNG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12235,313,679 - 35,454,844 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,317,121 - 35,454,850 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02217,475,693 - 17,618,299 (-)NCBIMhudiblu_PPA_v0panPan3
CACNG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1027,750,935 - 27,862,885 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11027,750,314 - 27,862,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cacng2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364924,125,182 - 4,232,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl511,067,692 - 11,185,505 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1511,067,016 - 11,185,480 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,846,099 - 8,866,357 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNG2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,263,950 - 19,406,952 (-)NCBI
ChlSab1.1 Ensembl1919,267,426 - 19,406,883 (-)Ensembl
Cacng2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475211,062,059 - 11,172,357 (+)NCBI

Position Markers
BF388004  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera7105,941,940 - 105,942,125UniSTS
RH 3.4 Map7814.9UniSTS
Cytogenetic Map7q33-q34UniSTS
BF416002  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.07119,333,365 - 119,333,604NCBIRnor6.0
Rnor_5.07119,326,942 - 119,327,181UniSTSRnor5.0
RGSC_v3.47116,020,983 - 116,021,222UniSTSRGSC3.4
Celera7106,020,366 - 106,020,605UniSTS
RH 3.4 Map7815.0UniSTS
Cytogenetic Map7q33-q34UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)748118835128611831Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)750704769128085642Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)751251919145729302Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)755072862123602998Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)755072862123602998Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)755072862123602998Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)771448715145729302Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)777428105127748511Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)777428234122421148Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)781645773140745067Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)785595369130595369Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)788365265119318087Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)788365265121986709Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)788365265133365265Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)788365265134673427Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)791018361136018361Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)791832949145158140Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)793726906138726906Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)793726906138726906Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)796630946141630946Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7100028953145729302Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)7100160423140335001Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)7100192194145192194Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)7103815550126525386Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)7103867802126080176Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)7106564316145729302Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7111519266143965591Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7112429186126525386Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7114825174145729302Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7115922628145729302Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:50
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000008414
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 52
Low 20 5 1
Below cutoff 2 2 9 4 8 4 2 4 2 2 23 8 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008414   ⟹   ENSRNOP00000008414
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7119,228,102 - 119,352,605 (-)Ensembl
RefSeq Acc Id: NM_053351   ⟹   NP_445803
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,574,426 - 109,697,227 (-)NCBI
Rnor_6.07119,229,268 - 119,352,033 (-)NCBI
Rnor_5.07119,221,311 - 119,344,620 (-)NCBI
RGSC_v3.47115,913,440 - 116,037,891 (-)RGD
Celera7105,915,114 - 106,037,137 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595134   ⟹   XP_017450623
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07119,228,112 - 119,353,332 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595135   ⟹   XP_017450624
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27109,572,838 - 109,698,516 (-)NCBI
Rnor_6.07119,228,112 - 119,352,645 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_445803 (Get FASTA)   NCBI Sequence Viewer  
  XP_017450624 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK08653 (Get FASTA)   NCBI Sequence Viewer  
  AAL50034 (Get FASTA)   NCBI Sequence Viewer  
  EDM15892 (Get FASTA)   NCBI Sequence Viewer  
  Q71RJ2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_445803   ⟸   NM_053351
- Sequence:
RefSeq Acc Id: XP_017450623   ⟸   XM_017595134
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450624   ⟸   XM_017595135
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000008414   ⟸   ENSRNOT00000008414

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695455
Promoter ID:EPDNEW_R5980
Type:single initiation site
Name:Cacng2_1
Description:calcium voltage-gated channel auxiliary subunit gamma 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07119,352,672 - 119,352,732EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71095 AgrOrtholog
Ensembl Genes ENSRNOG00000006226 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000008414 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008414 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_g2su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_gsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84347 UniProtKB/TrEMBL
NCBI Gene 84347 ENTREZGENE
PANTHER PTHR12107:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacng2 PhenoGen
PRINTS VDCCGAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCCGAMMA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CCG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q99PR9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacng2  calcium voltage-gated channel auxiliary subunit gamma 2  Cacng2  calcium channel, voltage-dependent, gamma subunit 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cacng2  calcium channel, voltage-dependent, gamma subunit 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_evolution may have evolved from a common ancestral gamma subunit via gene duplication 70681