Gene: Pvalb (parvalbumin) Rattus norvegicus
Analyze
Symbol:
Pvalb
Name:
parvalbumin
Description:
Exhibits calcium ion binding activity and identical protein binding activity. Involved in cochlea development. Localizes to several cellular components, including cuticular plate; neuronal cell body; and stereocilium. Orthologous to human PVALB (parvalbumin); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 6-propyl-2-thiouracil; acrylamide.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
PALB1; Parvalbumin (calcium binding protein); parvalbumin alpha; Pva
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PVALB (parvalbumin) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):
Pvalb (parvalbumin) HGNC
EggNOG, NCBI, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Pvalb (parvalbumin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PVALB (parvalbumin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PVALB (parvalbumin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pvalb (parvalbumin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PVALB (parvalbumin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PVALB (parvalbumin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Pvalb (parvalbumin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Pvalb (parvalbumin)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Homo sapiens (human):
PVALB (parvalbumin)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
pvalb6 (parvalbumin 6)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
pvalb7 (parvalbumin 7)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Allele / Splice:
Pvalbem1(flpo)Berke
Genetic Models:
LE-Pvalbem1(flpo)Berke /Rrrc
Is Marker For:
Strains:
LE-Tg(Pvalb-icre)2Ottc
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 119,428,657 - 119,443,674 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 119,429,019 - 119,441,487 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 7 119,420,581 - 119,435,235 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 116,115,034 - 116,127,508 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 116,148,899 - 116,163,894 (-) NCBI Celera 7 106,113,144 - 106,125,613 (-) NCBI Celera Cytogenetic Map 7 q34 NCBI RH 3.4 Map 7 812.5 RGD
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-pilocarpine decreases expression EXP 6480464 Pilocarpine results in decreased expression of PVALB protein CTD PMID:12183020 (S)-nicotine decreases expression ISO RGD:11199 6480464 Nicotine results in decreased expression of PVALB mRNA CTD PMID:21955143 1,1-dichloroethene decreases expression ISO RGD:11199 6480464 vinylidene chloride results in decreased expression of PVALB mRNA CTD PMID:26682919 17beta-estradiol decreases expression ISO RGD:11199 6480464 Estradiol results in decreased expression of PVALB mRNA CTD PMID:19484750 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:11199 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:735961 6480464 2 more ... CTD PMID:31173147 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:11199 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:11199 6480464 Tetrachlorodibenzodioxin results in increased expression of PVALB mRNA CTD PMID:19933214 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of PVALB mRNA CTD PMID:24780913 , PMID:30085217 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of PVALB mRNA CTD PMID:28606764 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PVALB mRNA CTD PMID:16483693 amphetamine affects expression EXP 6480464 Amphetamine affects the expression of PVALB protein CTD PMID:12468030 , PMID:15238432 apocynin multiple interactions ISO RGD:11199 6480464 acetovanillone inhibits the reaction [Ketamine results in decreased expression of PVALB protein] CTD PMID:18063801 apomorphine affects expression EXP 6480464 Apomorphine affects the expression of PVALB protein CTD PMID:15238432 benzo[a]pyrene decreases expression ISO RGD:11199 6480464 Benzo(a)pyrene results in decreased expression of PVALB mRNA CTD PMID:22228805 bis(2-ethylhexyl) phthalate increases expression ISO RGD:11199 6480464 Diethylhexyl Phthalate results in increased expression of PVALB mRNA CTD PMID:28085963 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PVALB mRNA CTD PMID:18180321 , PMID:24134786 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PVALB mRNA CTD PMID:25181051 , PMID:30816183 butanal increases expression ISO RGD:735961 6480464 butyraldehyde results in increased expression of PVALB mRNA CTD PMID:26079696 carbon nanotube decreases expression ISO RGD:11199 6480464 Nanotubes, Carbon analog results in decreased expression of PVALB mRNA CTD PMID:25620056 Citreoviridin increases expression ISO RGD:11199 6480464 citreoviridin results in increased expression of PVALB mRNA CTD PMID:30071239 clozapine multiple interactions EXP 6480464 Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 cocaine decreases expression ISO RGD:735961 6480464 Cocaine results in decreased expression of PVALB protein CTD PMID:17075605 cocaine affects expression EXP 6480464 Cocaine affects the expression of PVALB protein CTD PMID:15219666 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of PVALB mRNA CTD PMID:26033743 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of PVALB mRNA CTD PMID:26033743 dexamethasone affects expression ISO RGD:11199 6480464 Dexamethasone affects the expression of PVALB mRNA CTD PMID:22733784 dichloroacetic acid decreases expression ISO RGD:11199 6480464 Dichloroacetic Acid results in decreased expression of PVALB mRNA CTD PMID:28962523 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of PVALB mRNA CTD PMID:17005392 diuron decreases expression EXP 6480464 Diuron results in decreased expression of PVALB mRNA CTD PMID:25152437 domoic acid increases expression ISO RGD:11199 6480464 domoic acid results in increased expression of PVALB protein CTD PMID:26797589 dorsomorphin multiple interactions ISO RGD:735961 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PVALB mRNA CTD PMID:27188386 ethanol increases expression ISO RGD:11199 6480464 Ethanol results in increased expression of PVALB mRNA CTD PMID:21955143 , PMID:30319688 genistein multiple interactions EXP 6480464 [Genistein co-treated with vinclozolin] results in increased expression of PVALB mRNA CTD PMID:23160963 graphite increases expression ISO RGD:11199 6480464 Graphite results in increased expression of PVALB mRNA CTD PMID:27440207 haloperidol multiple interactions EXP 6480464 Haloperidol inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 ketamine multiple interactions ISO RGD:11199 6480464 acetovanillone inhibits the reaction [Ketamine results in decreased expression of PVALB protein] CTD PMID:18063801 ketamine decreases expression ISO RGD:11199 6480464 Ketamine results in decreased expression of PVALB CTD PMID:18063801 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PVALB protein] CTD PMID:31708536 lead diacetate multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in decreased expression of PVALB protein, Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PVALB protein] CTD PMID:31708536 lead(0) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in decreased expression of PVALB protein, Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PVALB protein] CTD PMID:31708536 lead(2+) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in decreased expression of PVALB protein, Ascorbic Acid inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of PVALB protein] CTD PMID:31708536 mancozeb increases expression ISO RGD:11199 6480464 mancozeb results in increased expression of PVALB protein CTD PMID:21375462 manganese atom decreases expression ISO RGD:11199 6480464 Manganese results in decreased expression of PVALB mRNA CTD PMID:23976782 manganese atom increases methylation ISO RGD:11199 6480464 Manganese results in increased methylation of PVALB promoter CTD PMID:23976782 manganese(0) decreases expression ISO RGD:11199 6480464 Manganese results in decreased expression of PVALB mRNA CTD PMID:23976782 manganese(0) increases methylation ISO RGD:11199 6480464 Manganese results in increased methylation of PVALB promoter CTD PMID:23976782 manganese(II) chloride decreases expression ISO RGD:11199 6480464 manganese chloride results in decreased expression of PVALB mRNA, manganese chloride results in decreased expression of PVALB protein CTD PMID:25698507 mercury atom decreases expression ISO RGD:11199 6480464 Mercury analog results in decreased expression of PVALB mRNA CTD PMID:25056781 mercury(0) decreases expression ISO RGD:11199 6480464 Mercury analog results in decreased expression of PVALB mRNA CTD PMID:25056781 methylmercury chloride decreases expression ISO RGD:735961 6480464 methylmercuric chloride results in decreased expression of PVALB mRNA CTD PMID:28001369 morphine decreases expression ISO RGD:11199 6480464 Morphine results in decreased expression of PVALB mRNA CTD PMID:21955143 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PVALB mRNA CTD PMID:28801915 nicotine decreases expression ISO RGD:11199 6480464 Nicotine results in decreased expression of PVALB mRNA CTD PMID:21955143 phencyclidine decreases expression EXP 6480464 Phencyclidine results in decreased expression of PVALB mRNA CTD PMID:12589379 phencyclidine multiple interactions EXP 6480464 Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA], Haloperidol inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 phenylmercury acetate multiple interactions ISO RGD:735961 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PVALB mRNA CTD PMID:27188386 picrotoxin decreases expression EXP 6480464 Picrotoxin results in decreased expression of PVALB protein CTD PMID:15382257 pioglitazone multiple interactions ISO RGD:11199 6480464 [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PVALB mRNA CTD PMID:27935865 propiconazole decreases expression ISO RGD:11199 6480464 propiconazole results in decreased expression of PVALB mRNA CTD PMID:21278054 SB 431542 multiple interactions ISO RGD:735961 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PVALB mRNA CTD PMID:27188386 SKF 38393 affects expression EXP 6480464 2 more ... CTD PMID:15238432 sodium fluoride increases expression ISO RGD:11199 6480464 Sodium Fluoride results in increased expression of PVALB protein CTD PMID:28918527 Soman decreases expression EXP 6480464 Soman results in decreased expression of PVALB mRNA CTD PMID:19281266 testosterone enanthate affects expression ISO RGD:735961 6480464 testosterone enanthate affects the expression of PVALB mRNA CTD PMID:17440010 tetrachloroethene decreases expression ISO RGD:11199 6480464 Tetrachloroethylene results in decreased expression of PVALB mRNA CTD PMID:28973375 tetrodotoxin decreases expression EXP 6480464 Tetrodotoxin results in decreased expression of PVALB mRNA CTD PMID:18775767 valproic acid affects expression ISO RGD:735961 6480464 Valproic Acid affects the expression of PVALB mRNA CTD PMID:25979313 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of PVALB mRNA CTD PMID:31085223 vancomycin increases expression ISO RGD:11199 6480464 Vancomycin results in increased expression of PVALB mRNA CTD PMID:18930951 vinclozolin multiple interactions EXP 6480464 [Genistein co-treated with vinclozolin] results in increased expression of PVALB mRNA CTD PMID:23160963 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of PVALB mRNA CTD PMID:23160963
Gene Ontology Annotations
Molecular Pathway Annotations
634336 Anxrr17 Anxiety related response QTL 17 3.66 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 7 2920071 124838025 Rat 61357 Bp38 Blood pressure QTL 38 1.6 0.052 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 48118835 128611831 Rat 631504 Cm27 Cardiac mass QTL 27 3.45 heart left ventricle mass (VT:0007031) heart left ventricle wet weight (CMO:0000071) 7 50704769 128085642 Rat 1300179 Kidm5 Kidney mass QTL 5 3.51 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 7 51251919 145729302 Rat 2316947 Rf58 Renal function QTL 58 7.8 kidney glomerulus morphology trait (VT:0005325) index of glomerular damage (CMO:0001135) 7 55072862 123602998 Rat 2316952 Pur22 Proteinuria QTL 22 5.2 urine protein amount (VT:0005160) urine protein level (CMO:0000591) 7 55072862 123602998 Rat 2316955 Stl24 Serum triglyceride level QTL 24 7.1 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 7 55072862 123602998 Rat 70173 Niddm19 Non-insulin dependent diabetes mellitus QTL 19 4.33 0.00005 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 7 71448715 145729302 Rat 631540 Bw9 Body weight QTL 9 4.5 body mass (VT:0001259) body weight (CMO:0000012) 7 77428105 127748511 Rat 1357338 Stl17 Serum triglyceride level QTL 17 3.23 blood triglyceride amount (VT:0002644) serum triglyceride level (CMO:0000360) 7 77428234 122421148 Rat 634331 Pia17 Pristane induced arthritis QTL 17 4.7 joint integrity trait (VT:0010548) arthritic paw count (CMO:0001460) 7 81645773 140745067 Rat 7411607 Foco15 Food consumption QTL 15 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 7 85595369 130595369 Rat 7411654 Foco25 Food consumption QTL 25 9.3 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 7 85595369 130595369 Rat 1331746 Kidm9 Kidney mass QTL 9 3.934 kidney mass (VT:0002707) right kidney wet weight (CMO:0000082) 7 88365265 121986709 Rat 1331768 Kidm10 Kidney mass QTL 10 4.62096 kidney mass (VT:0002707) left kidney wet weight (CMO:0000083) 7 88365265 133365265 Rat 1331728 Bp214 Blood pressure QTL 214 2.825 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 88365265 134673427 Rat 2317052 Aia17 Adjuvant induced arthritis QTL 17 2.13 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 7 91018361 136018361 Rat 1358914 Bp266 Blood pressure QTL 266 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 91832949 145158140 Rat 1358891 Bp265 Blood pressure QTL 265 2.21 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 91832949 145158140 Rat 71114 Niddm14 Non-insulin dependent diabetes mellitus QTL 14 4.5 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 7 93726906 138726906 Rat 2298475 Eau6 Experimental allergic uveoretinitis QTL 6 0.0029 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) 7 93726906 138726906 Rat 1558655 Swd4 Spike wave discharge measurement QTL 4 3.68 0.0002 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge severity grade (CMO:0001988) 7 96630946 141630946 Rat 2299163 Iddm34 Insulin dependent diabetes mellitus QTL 34 2.71 blood glucose amount (VT:0000188) age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140) 7 100028953 145729302 Rat 631687 Hcas1 Hepatocarcinoma susceptibility QTL 1 3.9 0.001 liver integrity trait (VT:0010547) volume of liver occupied by tumorous lesions as percentage of total liver volume (CMO:0001081) 7 100160423 140335001 Rat 1549899 Stresp8 Stress response QTL 8 4.37 0.0008 stress-related behavior trait (VT:0010451) defensive burying duration (CMO:0001961) 7 100192194 145192194 Rat 2313102 Bmd79 Bone mineral density QTL 79 2.3 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 7 103815550 126525386 Rat 1357336 Gluco6 Glucose level QTL 6 3.4 blood glucose amount (VT:0000188) serum glucose level (CMO:0000543) 7 103867802 126080176 Rat 731176 Glom5 Glomerulus QTL 5 2.5 0.0035 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) 7 106564316 145729302 Rat 1331731 Bp216 Blood pressure QTL 216 2.851 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 7 111519266 143965591 Rat 70159 Bp61 Blood pressure QTL 61 0.0001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 112429186 126525386 Rat 731174 Uae23 Urinary albumin excretion QTL 23 2.4 0.0042 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 7 114825174 145729302 Rat 2306821 Bp335 Blood pressure QTL 335 0.001 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 115922628 145729302 Rat
The following Strains have been annotated to
Pvalb
Predicted Target Of
Count of predictions: 260 Count of miRNA genes: 163 Interacting mature miRNAs: 186 Transcripts: ENSRNOT00000067635 Prediction methods: Microtar, Miranda, Rnahybrid Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
