PVALB (parvalbumin) - Rat Genome Database

Name: PVALB
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: PVALB (parvalbumin) Chlorocebus sabaeus

Analyze

Symbol:

PVALB

Name:

parvalbumin

RGD ID:

18417875

Description:

ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cochlea development (ortholog); excitatory chemical synaptic transmission (ortholog); gene expression (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); bipolar disorder (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); FOUND IN axon (ortholog); cuticular plate (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

parvalbumin alpha

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PVALB (parvalbumin)	NCBI	Ortholog
Mus musculus (house mouse):	Pvalb (parvalbumin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Pvalb (parvalbumin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pvalb (parvalbumin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PVALB (parvalbumin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PVALB (parvalbumin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pvalb (parvalbumin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PVALB (parvalbumin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pvalb (parvalbumin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	19,501,100 - 19,520,031 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	19,501,293 - 19,517,340 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	106,347,684 - 106,364,427 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

bipolar disorder (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

genetic disease (ISO)

myoclonic dystonia 26 (ISO)

neurodegeneration with brain iron accumulation 2A (ISO)

oxyphilic adenoma (ISO)

psychotic disorder (ISO)

renal cell carcinoma (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cochlea development (ISO)

excitatory chemical synaptic transmission (ISO)

gene expression (ISO)

inhibitory chemical synaptic transmission (ISO)

Cellular Component

axon (ISO)

cuticular plate (ISO)

cytoplasm (IEA)

neuronal cell body (ISO)

protein-containing complex (ISO)

stereocilium (ISO)

Molecular Function

calcium ion binding (IEA,ISO)

identical protein binding (ISO)

metal ion binding (IEA)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calcium-mediated signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PVALB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	19,501,100 - 19,520,031 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	19,501,293 - 19,517,340 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	106,347,684 - 106,364,427 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PVALB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	36,800,703 - 36,819,499 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	36,800,684 - 36,819,479 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	37,196,747 - 37,215,543 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	35,526,691 - 35,545,463 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	35,521,245 - 35,540,017	NCBI
Celera	22	20,994,687 - 21,013,451 (-)	NCBI		Celera
Cytogenetic Map	22	q12.3	NCBI
HuRef	22	20,158,898 - 20,177,656 (-)	NCBI		HuRef
CHM1_1	22	37,150,960 - 37,169,738 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	37,256,575 - 37,275,349 (-)	NCBI		T2T-CHM13v2.0

Pvalb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	78,075,312 - 78,090,600 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	78,075,314 - 78,090,600 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	78,191,112 - 78,206,400 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	78,191,114 - 78,206,400 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	78,021,547 - 78,036,781 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	78,018,372 - 78,033,606 (-)	NCBI		MGSCv36	mm8
Celera	15	79,652,042 - 79,667,286 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	36.93	NCBI

Pvalb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,653,820 - 111,668,469 (-)	NCBI		GRCr8
mRatBN7.2	7	109,772,939 - 109,787,954 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	109,772,593 - 109,784,561 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	111,523,240 - 111,535,619 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	113,746,801 - 113,759,182 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	113,714,959 - 113,727,413 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	119,428,657 - 119,443,674 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	119,429,019 - 119,441,487 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	119,420,581 - 119,435,235 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	116,115,034 - 116,127,508 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	116,148,899 - 116,163,894 (-)	NCBI
Celera	7	106,113,144 - 106,125,613 (-)	NCBI		Celera
RH 3.4 Map	7	812.5	RGD
Cytogenetic Map	7	q34	NCBI

Pvalb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	23,329,467 - 23,345,487 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	23,329,467 - 23,345,487 (-)	NCBI	ChiLan1.0	ChiLan1.0

PVALB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	46,654,830 - 46,671,318 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	49,346,087 - 49,362,595 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	17,715,109 - 17,731,587 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	35,551,448 - 35,568,316 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	35,551,448 - 35,568,316 (-)	Ensembl	panpan1.1		panPan2

PVALB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	27,655,896 - 27,674,309 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	27,655,905 - 27,707,332 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	27,610,209 - 27,628,586 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	28,447,846 - 28,466,434 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	28,447,871 - 28,466,433 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	28,169,344 - 28,187,929 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	28,477,867 - 28,496,446 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	28,656,677 - 28,675,084 (+)	NCBI		UU_Cfam_GSD_1.0

Pvalb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	11,038,062 - 11,053,610 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	4,048,470 - 4,064,019 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	4,048,459 - 4,064,024 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PVALB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	10,955,491 - 10,973,289 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	10,953,559 - 10,973,300 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	8,553,390 - 8,573,107 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Pvalb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	10,969,757 - 10,986,061 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	10,969,746 - 10,985,437 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	2		18
Low	14	15	34
Below cutoff	17	2	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007975662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007975663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007975665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000005914 ⟹ ENSCSAP00000004129

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	19	19,501,293 - 19,517,340 (-)	Ensembl

RefSeq Acc Id:

XM_007975662 ⟹ XP_007973853

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	19	19,501,100 - 19,518,350 (-)	NCBI
Vero_WHO_p1.0	NW_023666045	106,347,684 - 106,364,427 (+)	NCBI

Sequence:

show sequence

GGCTGCATAAAGATAGACACTGTGACATTTTTCCAGAGGTGAAGTTCAGAGCCCCCACGCCTGC
TTAGATTGTCTACAAAGTGTGGTCTGAAGGTGCTACCCTTCTTCCAAACATATGCGGGGCTTTC
TGGGAGGGACCTTAGCAATTTCAAGCAGCCTCCCCCACCCTACTCTGCCCAAAAAGGTTTATGG
AGGCAGGGGGAGTCTGGTCCCACGATGCCAGGACCCAGGAGACCAGGAAAGCGAGTAGTCAGTA
GAGATCTGAGAAGTGTTCTTTGAAAAATCAAGCCAACAAAAAAATGAAAATGAAATAAATCAGG
TTTTAGAATGTGCATCCCTGGCCAGATGTGGGATGGGGCACCCGAAGTGGGCCCCAGCAGCTAC
TGCTTGTCCCTGTCCCTGTCCCTGCCACCTCCTCCCTGCGTCCGTGGGTCAGGTTTCACGACCT
CAGCGCTCAGATTTTGCAGCATAAATTTGCGTCCAGGAAAGACCAGAGCAGAGGCTGAAGTAGG
AGTGGAGAGAGAAAGAGAGCAGGGCCTAGGGGATCCTGGGGTGCAGGCTGGCCGCTGAGGGTTC
AGGATCTTCCCCCGCGCGACAGGACATCCTCGGAGGTTCCCAGATCTGAGACCCCGCACCTCCT
GCGTGTCCTTGACAGCACGTGGACTTTCCAGACCTGGCTGGTGACTCCAGTGCCCCCTAAATCC
CAGAGGTGGTCCCCTTCCCCTCGTGCCCTAGCCGCAGCCCCTGGGATCCCGCCGATCCCCGGCC
TGGCGGTGCAGGAGCGGTAGCAGGTCCGCGCGCCCTCTTGCCCGCGGCCGGCGCTGCTCAGCCG
CGCGACTGGACTGAGCCGCTCCCGCTGCGCTCAGAGTCCGGGCCCCTGGCGCCATGCCAGGCCC
GGCGGGCGTGCGCCCGGCGCGCAGCACTGCAGCGCTGGTCATATGAGCAGAAATGATGAGAAAA
GCACTTTTTAATCTTTTCGCACTTGCTCTGCCCGCTCAAACAGTTGCAGGATGTCGATGACAGA
CTTGCTCAACGCTGAGGACATCAAGAAGGCGGTGGGAGCCTTTAGCGCTGTTGACTCCTTCGAC
CACAAAAAGTTCTTCCAAATGGTCGGCCTGAAGAAAAAGAGTGCGGACGATGTGAAGAAGGTGT
TTCATATCCTGGACAAGGACAAAAGTGGCTTCATCGAGGAGGATGAGCTGGGATTCATCCTAAA
AGGCTTCTCCCCAGACGCCAGAGACCTGTCTGCTAAAGAAACCAAGACGCTGATGGCTGCTGGA
GACAAAGATGGGGACGGCAAAATTGGGGTTGACGAATTCTCCACTCTGGTGGCTGAAAGCTAAG
AAGCACTGACTGTCCCAGGTCTTCCACCTCTCTGCCCTGAACACTCAATCTCAGCCCCTCTTGC
CACCCTCCTGCGTTTCTGTTCAGTTTGTTTATGTTATTTTTTACTCCCCCCATCCCCTGTGGCC
CTCTAATGACACCATTCTTCTGGAAAATGCTGGAGAAGCAATAAAGATTGTACCAGTCAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007973853	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004129.1

RefSeq Acc Id:	XP_007973853 ⟸ XM_007975662
- UniProtKB:	A0A0D9R690 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000004129 ⟸ ENSCSAT00000005914

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000007866	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000005914.1	UniProtKB/TrEMBL
Gene3D-CATH	EF-hand	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	Parvalbumin	UniProtKB/TrEMBL
KEGG Report	csab:103223256	UniProtKB/TrEMBL
NCBI Gene	PVALB	ENTREZGENE
PANTHER	PARVALBUMIN ALPHA	UniProtKB/TrEMBL
	PTHR11653	UniProtKB/TrEMBL
Pfam	EF-hand_7	UniProtKB/TrEMBL
PRINTS	PARVALBUMIN	UniProtKB/TrEMBL
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
SMART	EFh	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A0A0D9R690	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations