Twf1 (twinfilin actin-binding protein 1)

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Gene: Twf1 (twinfilin actin-binding protein 1) Rattus norvegicus

Analyze

Symbol:

Twf1

Name:

twinfilin actin-binding protein 1

RGD ID:

1311872

Description:

Predicted to enable actin binding activity; anion binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including actin filament depolymerization; regulation of actin cytoskeleton organization; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in several cellular components, including cell-cell junction; filopodium; and perinuclear region of cytoplasm. Predicted to be active in actin filament and myofibril. Predicted to colocalize with ruffle membrane. Orthologous to human TWF1 (twinfilin actin binding protein 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC315265; MGC105817; protein tyrosine kinase 9; Ptk9; twinfilin, actin-binding protein, homolog 1; twinfilin, actin-binding protein, homolog 1 (Drosophila); twinfilin-1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TWF1 (twinfilin actin binding protein 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Twf1 (twinfilin actin binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Twf1 (twinfilin actin binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TWF1 (twinfilin actin binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TWF1 (twinfilin actin binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Twf1 (twinfilin actin binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TWF1 (twinfilin actin binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TWF1 (twinfilin actin binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Twf1 (twinfilin actin binding protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TWF2 (twinfilin actin binding protein 2)	HGNC	OrthoDB
Homo sapiens (human):	TSSC4 (tumor suppressing subtransferable candidate 4)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TWF1 (twinfilin actin binding protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Twf1 (twinfilin actin binding protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	twf1a (twinfilin actin-binding protein 1a)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	twf1b (twinfilin actin-binding protein 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TWF1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	twf	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	twf-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	twf1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Related Pseudogenes:

Twf1-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	125,715,938 - 125,727,834 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	125,716,015 - 125,727,894 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	127,501,266 - 127,513,176 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	129,727,164 - 129,739,074 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	129,628,398 - 129,640,309 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	135,838,647 - 135,850,542 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	135,838,648 - 135,850,542 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	135,495,109 - 135,507,004 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	133,089,255 - 133,101,150 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	133,165,692 - 133,177,587 (-)	NCBI
Celera	7	122,105,689 - 122,117,583 (-)	NCBI		Celera
Cytogenetic Map	7	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

lymphoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

amphetamine (EXP)

ampicillin (EXP)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-carotene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

caffeine (ISO)

camptothecin (ISO)

carbon nanotube (ISO)

choline (ISO)

cobalt dichloride (ISO)

decabromodiphenyl ether (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

glafenine (EXP)

ivermectin (ISO)

kojic acid (ISO)

L-methionine (ISO)

methidathion (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

metronidazole (EXP)

microcystin-LR (ISO)

neomycin (EXP)

nickel atom (ISO)

ochratoxin A (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

quercetin (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

tetrachloromethane (EXP)

thapsigargin (EXP)

thioacetamide (EXP)

torcetrapib (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vancomycin (EXP)

vinclozolin (EXP)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament depolymerization (IBA)

barbed-end actin filament capping (IBA,ISO)

negative regulation of actin filament polymerization (IEA,ISO)

positive regulation of cardiac muscle hypertrophy (ISO)

positive regulation of neuron projection development (IBA)

regulation of actin phosphorylation (ISO)

regulation of lamellipodium assembly (IBA)

sequestering of actin monomers (IBA,ISO)

Cellular Component

actin cytoskeleton (ISO)

actin filament (IBA)

cell-cell junction (ISO)

cytoplasm (IBA)

cytoskeleton (IEA)

cytosol (ISO)

filopodium (ISO)

myofibril (IBA,ISO)

perinuclear region of cytoplasm (ISO)

ruffle membrane (ISO)

Molecular Function

actin binding (IEA,ISO,ISS)

actin filament binding (IBA)

actin monomer binding (IBA,ISO)

ATP binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (ISO)

protein binding (ISO)

protein tyrosine kinase activity (ISO)

protein-containing complex binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9249064	PMID:10406962	PMID:10669753	PMID:11604420	PMID:12477932	PMID:12807912	PMID:15489334	PMID:18837697	PMID:20571053	PMID:21423176	PMID:25468996	PMID:28493397
PMID:33450132	PMID:33963280

Genomics

Comparative Map Data

Twf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	125,715,938 - 125,727,834 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	125,716,015 - 125,727,894 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	127,501,266 - 127,513,176 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	129,727,164 - 129,739,074 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	129,628,398 - 129,640,309 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	135,838,647 - 135,850,542 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	135,838,648 - 135,850,542 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	135,495,109 - 135,507,004 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	133,089,255 - 133,101,150 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	133,165,692 - 133,177,587 (-)	NCBI
Celera	7	122,105,689 - 122,117,583 (-)	NCBI		Celera
Cytogenetic Map	7	q35	NCBI

TWF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	43,793,723 - 43,806,317 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	43,793,723 - 43,806,328 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	44,187,526 - 44,200,120 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	42,473,793 - 42,486,445 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	42,989,914 - 43,003,516 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI
HuRef	12	41,215,942 - 41,228,787 (-)	NCBI		HuRef
CHM1_1	12	44,152,507 - 44,165,159 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	43,752,448 - 43,765,042 (-)	NCBI		T2T-CHM13v2.0

Twf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	94,475,829 - 94,487,727 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	94,475,832 - 94,487,770 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	94,577,948 - 94,589,884 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	94,577,951 - 94,589,889 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	94,408,379 - 94,420,255 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	94,406,128 - 94,418,004 (-)	NCBI		MGSCv36	mm8
Celera	15	96,725,758 - 96,737,654 (-)	NCBI		Celera
Cytogenetic Map	15	E3	NCBI
cM Map	15	48.59	NCBI

Twf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955500	3,050,028 - 3,070,799 (-)	NCBI	ChiLan1.0	ChiLan1.0

TWF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	50,361,874 - 50,377,135 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	44,925,701 - 44,938,344 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	45,794,763 - 45,807,404 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	45,794,763 - 45,807,404 (+)	Ensembl	panpan1.1		panPan2

TWF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	10,281,249 - 10,295,550 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	10,246,746 - 10,293,543 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	36,012,669 - 36,026,965 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	10,470,479 - 10,484,783 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	10,470,517 - 10,484,924 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	10,281,754 - 10,296,048 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	10,316,285 - 10,330,591 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	36,254,132 - 36,268,471 (-)	NCBI		UU_Cfam_GSD_1.0

Twf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	70,871,699 - 70,884,564 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	2,280,064 - 2,293,117 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936512	2,280,266 - 2,293,101 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TWF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	74,868,585 - 74,893,698 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	74,868,586 - 74,881,220 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	77,681,086 - 77,694,013 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TWF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	40,000,458 - 40,019,490 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	39,999,926 - 40,019,502 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	206,491,729 - 206,504,658 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Twf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	8,765,922 - 8,778,396 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624816	8,765,937 - 8,780,301 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Twf1
51 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	408
Count of miRNA genes:	238
Interacting mature miRNAs:	292
Transcripts:	ENSRNOT00000038032
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	119513385	135012528	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
631201	Panci1	Pancreas inflammation QTL 1	0	0.001	pancreas integrity trait (VT:0010560)	percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)	7	116677189	127103496	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat

Markers in Region

RH128344

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	125,716,164 - 125,716,351 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	135,838,874 - 135,839,060	NCBI	Rnor6.0
Rnor_5.0	7	135,495,336 - 135,495,522	UniSTS	Rnor5.0
RGSC_v3.4	7	133,089,482 - 133,089,668	UniSTS	RGSC3.4
Celera	7	122,105,916 - 122,106,102	UniSTS
Cytogenetic Map	7	q35	UniSTS

RH142801

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	125,725,733 - 125,725,836 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	135,848,442 - 135,848,544	NCBI	Rnor6.0
Rnor_5.0	7	135,504,904 - 135,505,006	UniSTS	Rnor5.0
RGSC_v3.4	7	133,099,050 - 133,099,152	UniSTS	RGSC3.4
Celera	7	122,115,483 - 122,115,585	UniSTS
RH 3.4 Map	7	1022.0	UniSTS
Cytogenetic Map	7	q35	UniSTS

RH143291

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	135,069,070 - 135,069,177 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	140,486,160 - 140,486,266	NCBI	Rnor6.0
Rnor_5.0	5	144,276,897 - 144,277,003	UniSTS	Rnor5.0
RGSC_v3.4	5	142,100,959 - 142,101,065	UniSTS	RGSC3.4
Celera	5	133,607,813 - 133,607,919	UniSTS
RH 3.4 Map	5	890.1	UniSTS
Cytogenetic Map	5	q36	UniSTS
Cytogenetic Map	7	q35	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	32	57	41	19	41	3	3	74	35	41	11	3
Low		11					5	8					5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000038032 ⟹ ENSRNOP00000030138

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	125,716,015 - 125,727,894 (-)	Ensembl
Rnor_6.0 Ensembl	7	135,838,648 - 135,850,542 (-)	Ensembl

RefSeq Acc Id:

NM_001008521 ⟹ NP_001008521

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	125,715,938 - 125,727,834 (-)	NCBI
Rnor_6.0	7	135,838,647 - 135,850,542 (-)	NCBI
Rnor_5.0	7	135,495,109 - 135,507,004 (-)	NCBI
RGSC_v3.4	7	133,089,255 - 133,101,150 (-)	RGD
Celera	7	122,105,689 - 122,117,583 (-)	RGD

Sequence:

show sequence

TCGCCATGTCCCACCAGACCGGCATCCAAGCAAGTGAAGACGTCAAAGAGATCTTTGCCAGAGC
CAGAAATGGGAAATACCGACTTCTAAAAATATCGATTGAAAATGAGCAACTGGTGGTCGGGTCC
TGTAGTCCGCCTTCAGATTCCTGGGAACAGGATTACGATCCCTTTGTCTTGCCCCTGCTGGAGG
ACAAGCAACCGTGCTATGTGTTATTCAGGTTAGATTCTCAGAATGCCCAGGGATATGAGTGGAT
ATTCATTGCATGGTCTCCAGATCATTCTCATGTTCGTCAAAAAATGCTGTATGCGGCAACAAGA
GCAACTCTGAAAAAAGAATTTGGAGGTGGCCACATTAAAGATGAAGTGTTTGGAACAGTAAAGG
AGGACGTATCACTACATGGATATAGAAAGTATCTTCTCTCCCAGTCTTCTCCTGCCCCTCTGAC
TGCAGCAGAGGAAGAATTAAGGCAGATTAAAATCAGTGAGGTACAAACTGACGTGAGTGTGGAC
ACAAAGCATCAGACACTACAAGGAGTAGCATTTCCTATTTCTCGAGATGCCTTCCAGGCTTTGG
AAAAACTGAGTAAGAGACAGCTCAACTATGTGCAGTTGGAAATAGATATAAAAAATGAAACAAT
AATTTTGGCCAACACAGAAAATACAGAACTAAAAGATTTGCCAAAGAGGATTCCCAAGGATTCA
GCACGCTACCATTTCTTTCTGTATAAGCATTCCCACGAAGGAGACTACTTAGAGTCCATAGTTT
TTATTTATTCAATGCCCGGATACACATGCAGCATAAGAGAGCGGATGCTGTATTCCAGCTGCAA
GAGCCCTCTGTTAGATATTGTAGAAAGACAACTGCAGATGGATGTGATCAGAAAGATTGAGATA
GACAATGGGGATGAACTGACCGCAGATTTCCTGTACGATGAAGTCCATCCCAAGCAGCATGCAC
ATAAGCAGAGTTTTGCTAAACCAAAGGGTCCTGCGGGAAAGAGAGGGATTAGAAGATTGATTAG
GGGTCCAGCGGAAGCAGAAGCCACTACTGATTAAAATTGTCTTATTAAATGTTGCAATATAGTT
TTGTAAGATTTCCAGCTTTTAGTACAAGGAGAACTGAAATCATTCCATGTTGATATAGTTGGGA
GGAAAATTGTACTTTTTGAAAAATAGCACTTTTCACTTCTATGTATTTTTTAAATTAATGCTAT
AGAAGACTCATGGTTTTTATTTTTTAGTTAAAGCTAGACAAGGTTTCAACATAGTAATGTTTGG
TTTTGTCACACTGTTTTCATAGCGTGTTGATTCCACACTTTCACATAATCTTCAACGAAAGCGT
AAGGACTTGCTTTTTAGAACTCTGTAGTGAGTTCTGTTTGCCTATAAGGGAAGTGGAACAACCG
AGACACTCGCACTTCTTTCGAGTGTTAAGGAGCCTGGGAGGAGCAGGCAGCCGCTTGCTTTGAG
CATGCTCAGGTGGGGCTGTCCGCCGCTGTGGGGAAGGCACCCTGCAGCAGGGCTTCCTGCCCCA
CCTCTCCATTGTAGTAGTGTCCAGATCTCAGAAACGCAGCTTGAACCCAGCTTCAAAGGTACCA
GATGCCTCAGGCTTTCTCATGGCGCTGGAAGACTGCAGTCTTGTAAGGTCTTTGCAGAGCTCTC
AGTTGACGATTTCCAAAGGGATTGTGAAAAGACTGTGAAGCCAGATGTTCACCTTCAGATGGAG
ATTCAAGTGTCATTAAAGAGAAACAACTAAAGGAAGTGTCTGACCTTTCAAGGTTTTTTGGTTT
TTCTTTTTCTTTTCTTTTTTTTTTTGTATTTTTTTCTTCTCTTTGAAACCATGTGTCTTAAAGG
AGATTGTCATATTGCTTGGGAGCAAGTTTTCAGACCTAAAATTATTGATTTCTAATACTTAGTA
GGCTAGCACAGAGAATACGTAGCCTAAGGCTCTTTTGTCAATTAATAATGCCTCGGAACACGGG
CTTTCTGAAGCTTGGTTACTTTCAGTTAAAACCTAAAGAGTTTGAGCCTCAAGAGTTCATTGTT
ACTTGAAATAGAGGGAGTTAGAACACTTGGTATTTAATCTGCTAAACCTGCTGCAGAGCCATAA
CTCAGAAGTTTGGAAGCGGACTGACGTGTCCGGGATTTGGAAGACCTTGACCTGAACCTCATGC
TGCCTGAGATGGTGTCAGTAACGTACATTTCATGGAATGAACTATGAAGCACCCATTGCAGAGC
CTTATTACCTAAGGTAATACATGCGCCTTTCAGAAATTCAGTGTGGACTCACCTAGATCACAGA
GGAATTACGAGCTGATGGAAGTTTTTAAAAATAGATTTGTGTGTTTTGTTTGTTTACAAATACG
TAGACTTTACTACTTAAATATGCAGGAGAGTTGACAGTAATGTTGCTCTTGTTTACGAGAGGTA
AACTTTTTAGTCGTGCGTGTGTACACGTCATCACACGTGCCCATAGAGTGCTGCAGCGAGAGAC
CTGGAGCTGTGACGCAGACCTTCCAGAGCTGCCGTTTCAAGCAGAGGGGGTGCTTTGCGTCCTG
GGTCCAGACCCGGTGGGGACTGTTCTGAAGCAGTGTGTGCAATGATGCGCTGAAGCCTGTCACA
CTACAGCGGTCACTGACATTCCACAGAGATGTGACCTTGTAACCTACTAATAATCAAACCAATG
ATTGCTGAGAATCACGTATGCATTTGTCTTAGGGAATAACCCATTGTTTACAGTATGTTTTAGG
TGACAATAGATGTGAATAACATTCCCAATAAATTTATATAGCAGTGAAAAATGACATGTCTTCT
GTGGACATTTTATAAGTGCATTTTATATCAATAAAATTTTTCTCTTTGAGTTGTGTAAAAAAAA
AAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001008521	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86536	(Get FASTA)	NCBI Sequence Viewer
	EDL76645	(Get FASTA)	NCBI Sequence Viewer
	Q5RJR2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008521 ⟸ NM_001008521

- UniProtKB:

Q5RJR2 (UniProtKB/Swiss-Prot), A6K7V2 (UniProtKB/TrEMBL), A0A8L2QHU7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVVGSCSPPSDSWEQDYDPFVLPLLEDK
QPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKED
VSLHGYRKYLLSQSSPAPLTAAEEELRQIKISEVQTDVSVDTKHQTLQGVAFPISRDAFQALEK
LSKRQLNYVQLEIDIKNETIILANTENTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESIVFI
YSMPGYTCSIRERMLYSSCKSPLLDIVERQLQMDVIRKIEIDNGDELTADFLYDEVHPKQHAHK
QSFAKPKGPAGKRGIRRLIRGPAEAEATTD

hide sequence

RefSeq Acc Id:

ENSRNOP00000030138 ⟸ ENSRNOT00000038032

Protein Domains

ADF-H

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5RJR2-F1-model_v2	AlphaFold	Q5RJR2	1-350	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311872	AgrOrtholog
BioCyc Gene	G2FUF-32299	BioCyc
Ensembl Genes	ENSRNOG00000022507	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000030138	ENTREZGENE
	ENSRNOP00000030138.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000038032	ENTREZGENE
	ENSRNOT00000038032.4	UniProtKB/TrEMBL
Gene3D-CATH	3.40.20.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7106678	IMAGE-MGC_LOAD
InterPro	ADF-H	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADF-H/Gelsolin-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Twinfilin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:315265	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105817	IMAGE-MGC_LOAD
NCBI Gene	315265	ENTREZGENE
PANTHER	PTHR13759	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TWINFILIN-1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Cofilin_ADF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Twf1	PhenoGen
PROSITE	ADF_H	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	ADF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Actin depolymerizing proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2QHU7	ENTREZGENE, UniProtKB/TrEMBL
	A6K7V2	ENTREZGENE, UniProtKB/TrEMBL
	Q5RJR2	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-05-01	Twf1	twinfilin actin-binding protein 1	Twf1	twinfilin, actin-binding protein, homolog 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Twf1	twinfilin, actin-binding protein, homolog 1 (Drosophila)	Ptk9	protein tyrosine kinase 9	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Ptk9	protein tyrosine kinase 9	Ptk9_predicted	protein tyrosine kinase 9 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ptk9_predicted	protein tyrosine kinase 9 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD