Twf1 (twinfilin actin-binding protein 1) - Rat Genome Database

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Gene: Twf1 (twinfilin actin-binding protein 1) Rattus norvegicus
Analyze
Symbol: Twf1
Name: twinfilin actin-binding protein 1
RGD ID: 1311872
Description: Predicted to enable actin binding activity; anion binding activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including actin filament depolymerization; regulation of actin cytoskeleton organization; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in several cellular components, including filopodium; nucleolus; and perinuclear region of cytoplasm. Predicted to be active in actin filament and myofibril. Predicted to colocalize with ruffle membrane. Orthologous to human TWF1 (twinfilin actin binding protein 1); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC315265; MGC105817; protein tyrosine kinase 9; Ptk9; twinfilin, actin-binding protein, homolog 1; twinfilin, actin-binding protein, homolog 1 (Drosophila); twinfilin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Twf1-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27125,715,938 - 125,727,834 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7125,716,015 - 125,727,894 (-)Ensembl
Rnor_6.07135,838,647 - 135,850,542 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7135,838,648 - 135,850,542 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07135,495,109 - 135,507,004 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47133,089,255 - 133,101,150 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17133,165,692 - 133,177,587 (-)NCBI
Celera7122,105,689 - 122,117,583 (-)NCBICelera
Cytogenetic Map7q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
lymphoma  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9249064   PMID:10406962   PMID:10669753   PMID:11604420   PMID:12477932   PMID:12807912   PMID:15489334   PMID:18837697   PMID:20571053   PMID:21423176   PMID:25468996   PMID:28493397  
PMID:33450132   PMID:33963280  


Genomics

Comparative Map Data
Twf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27125,715,938 - 125,727,834 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7125,716,015 - 125,727,894 (-)Ensembl
Rnor_6.07135,838,647 - 135,850,542 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7135,838,648 - 135,850,542 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07135,495,109 - 135,507,004 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47133,089,255 - 133,101,150 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17133,165,692 - 133,177,587 (-)NCBI
Celera7122,105,689 - 122,117,583 (-)NCBICelera
Cytogenetic Map7q35NCBI
TWF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381243,793,723 - 43,806,317 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1243,793,723 - 43,806,328 (-)EnsemblGRCh38hg38GRCh38
GRCh371244,187,526 - 44,200,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361242,473,793 - 42,486,445 (-)NCBINCBI36hg18NCBI36
Celera1242,989,914 - 43,003,516 (-)NCBI
Cytogenetic Map12q12NCBI
HuRef1241,215,942 - 41,228,787 (-)NCBIHuRef
CHM1_11244,152,507 - 44,165,159 (-)NCBICHM1_1
T2T-CHM13v2.01243,752,448 - 43,765,042 (-)NCBI
Twf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391594,475,829 - 94,487,870 (-)NCBIGRCm39mm39
GRCm39 Ensembl1594,475,832 - 94,487,770 (-)Ensembl
GRCm381594,577,948 - 94,589,884 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1594,577,951 - 94,589,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv371594,408,379 - 94,420,255 (-)NCBIGRCm37mm9NCBIm37
MGSCv361594,406,128 - 94,418,004 (-)NCBImm8
Celera1596,725,758 - 96,737,654 (-)NCBICelera
Cytogenetic Map15E3NCBI
Twf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555003,050,028 - 3,070,799 (-)NCBIChiLan1.0ChiLan1.0
TWF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11245,794,763 - 45,807,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1245,794,763 - 45,807,404 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01244,925,701 - 44,938,344 (+)NCBIMhudiblu_PPA_v0panPan3
TWF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12710,281,249 - 10,295,550 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2710,246,746 - 10,293,543 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2736,012,669 - 36,026,965 (-)NCBI
ROS_Cfam_1.02710,470,479 - 10,484,783 (+)NCBI
ROS_Cfam_1.0 Ensembl2710,470,517 - 10,484,924 (+)Ensembl
UMICH_Zoey_3.12710,281,754 - 10,296,048 (+)NCBI
UNSW_CanFamBas_1.02710,316,285 - 10,330,591 (+)NCBI
UU_Cfam_GSD_1.02736,254,132 - 36,268,471 (-)NCBI
Twf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494570,871,699 - 70,884,564 (+)NCBI
SpeTri2.0NW_0049365122,280,266 - 2,293,101 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl574,868,585 - 74,893,698 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1574,868,586 - 74,881,220 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2577,681,086 - 77,694,013 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11140,000,458 - 40,019,490 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1139,999,926 - 40,019,502 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037206,491,729 - 206,504,658 (+)NCBIVero_WHO_p1.0
Twf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248168,765,922 - 8,778,396 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248168,765,937 - 8,780,301 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH128344  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27125,716,164 - 125,716,351 (+)MAPPERmRatBN7.2
Rnor_6.07135,838,874 - 135,839,060NCBIRnor6.0
Rnor_5.07135,495,336 - 135,495,522UniSTSRnor5.0
RGSC_v3.47133,089,482 - 133,089,668UniSTSRGSC3.4
Celera7122,105,916 - 122,106,102UniSTS
Cytogenetic Map7q35UniSTS
RH142801  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27125,725,733 - 125,725,836 (+)MAPPERmRatBN7.2
Rnor_6.07135,848,442 - 135,848,544NCBIRnor6.0
Rnor_5.07135,504,904 - 135,505,006UniSTSRnor5.0
RGSC_v3.47133,099,050 - 133,099,152UniSTSRGSC3.4
Celera7122,115,483 - 122,115,585UniSTS
RH 3.4 Map71022.0UniSTS
Cytogenetic Map7q35UniSTS
RH143291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25135,069,070 - 135,069,177 (+)MAPPERmRatBN7.2
Rnor_6.05140,486,160 - 140,486,266NCBIRnor6.0
Rnor_5.05144,276,897 - 144,277,003UniSTSRnor5.0
RGSC_v3.45142,100,959 - 142,101,065UniSTSRGSC3.4
Celera5133,607,813 - 133,607,919UniSTS
RH 3.4 Map5890.1UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map7q35UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:408
Count of miRNA genes:238
Interacting mature miRNAs:292
Transcripts:ENSRNOT00000038032
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 57 41 19 41 3 3 74 35 41 11 3
Low 11 5 8 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000038032   ⟹   ENSRNOP00000030138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7125,716,015 - 125,727,894 (-)Ensembl
Rnor_6.0 Ensembl7135,838,648 - 135,850,542 (-)Ensembl
RefSeq Acc Id: NM_001008521   ⟹   NP_001008521
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27125,715,938 - 125,727,834 (-)NCBI
Rnor_6.07135,838,647 - 135,850,542 (-)NCBI
Rnor_5.07135,495,109 - 135,507,004 (-)NCBI
RGSC_v3.47133,089,255 - 133,101,150 (-)RGD
Celera7122,105,689 - 122,117,583 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008521 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86536 (Get FASTA)   NCBI Sequence Viewer  
  EDL76645 (Get FASTA)   NCBI Sequence Viewer  
  Q5RJR2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001008521   ⟸   NM_001008521
- UniProtKB: Q5RJR2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030138   ⟸   ENSRNOT00000038032
Protein Domains
ADF-H

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5RJR2-F1-model_v2 AlphaFold Q5RJR2 1-350 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695604
Promoter ID:EPDNEW_R6129
Type:initiation region
Name:Twf1_1
Description:twinfilin actin-binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07135,850,607 - 135,850,667EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 135840481 135840482 C T snv FHH/EurMcwi (MCW)
7 135847180 135847181 A C snv ACI/N (MCW), Buf/N (MCW), F344/NRrrc (MCW), M520/N (MCW), CDR, WN/N (MCW)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 135496943 135496944 C T snv FHH/EurMcwi (MCW)
7 135503642 135503643 A C snv NIG-III/Hok (KyushuU), HTX/Kyo (KyushuU), BUF/MNa (KyushuU), LE/Stm (KyushuU)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 133091089 133091090 C T snv FHH/EurMcwi (MCW)
7 133097788 133097789 A C snv FHL/EurMcwi (MCW), SR/JrHsd (MCW), SHRSP/Gcrc (MDC), ACI/N (KNAW), F344/NRrrc (KNAW), LE/Stm (KNAW), M520/N (KNAW), WN/N (KNAW), ACI/EurMcwi (MCW), BUF/N (KNAW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311872 AgrOrtholog
BioCyc Gene G2FUF-32299 BioCyc
Ensembl Genes ENSRNOG00000022507 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000030138 ENTREZGENE
  ENSRNOP00000030138.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038032 ENTREZGENE
  ENSRNOT00000038032.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106678 IMAGE-MGC_LOAD
InterPro ADF-H UniProtKB/Swiss-Prot
  ADF-H/Gelsolin-like_dom_sf UniProtKB/Swiss-Prot
  Twinfilin UniProtKB/Swiss-Prot
KEGG Report rno:315265 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105817 IMAGE-MGC_LOAD
NCBI Gene 315265 ENTREZGENE
PANTHER PTHR13759 UniProtKB/Swiss-Prot
Pfam Cofilin_ADF UniProtKB/Swiss-Prot
PhenoGen Twf1 PhenoGen
PROSITE ADF_H UniProtKB/Swiss-Prot
SMART ADF UniProtKB/Swiss-Prot
UniProt A0A8L2QHU7_RAT UniProtKB/TrEMBL
  Q5RJR2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-01 Twf1  twinfilin actin-binding protein 1  Twf1  twinfilin, actin-binding protein, homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Twf1  twinfilin, actin-binding protein, homolog 1 (Drosophila)  Ptk9  protein tyrosine kinase 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ptk9  protein tyrosine kinase 9  Ptk9_predicted  protein tyrosine kinase 9 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ptk9_predicted  protein tyrosine kinase 9 (predicted)      Symbol and Name status set to approved 70820 APPROVED