Tmprss12 (transmembrane serine protease 12)

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Gene: Tmprss12 (transmembrane serine protease 12) Rattus norvegicus

Analyze

Symbol:

Tmprss12

Name:

transmembrane serine protease 12

RGD ID:

2323781

Description:

Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within binding activity of sperm to zona pellucida and protein processing. Predicted to be located in acrosomal vesicle. Orthologous to human TMPRSS12 (transmembrane serine protease 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; thioacetamide.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC100362912; rCG50645-like; RGD1560236; transmembrane (C-terminal) protease, serine 12; transmembrane protease serine 12; transmembrane protease, serine 12

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMPRSS12 (transmembrane serine protease 12)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tmprss12 (transmembrane (C-terminal) protease, serine 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmprss12 (transmembrane serine protease 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMPRSS12 (transmembrane serine protease 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMPRSS12 (transmembrane serine protease 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmprss12 (transmembrane serine protease 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMPRSS12 (transmembrane serine protease 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMPRSS12 (transmembrane serine protease 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmprss12 (transmembrane serine protease 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TMPRSS12 (transmembrane serine protease 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmprss12 (transmembrane (C-terminal) protease, serine 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch73-182e20.4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkeyp-93a5.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	tmprss12	Alliance	DIOPT (OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	tmprss12	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	mettl7a	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	mettl7a.2	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	131,433,158 - 131,445,806 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	131,433,484 - 131,445,791 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	7	141,953,336 - 141,966,814 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	141,953,794 - 141,966,522 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	139,763,760 - 139,777,016 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	139,042,666 - 139,055,345 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	127,910,961 - 127,923,697 (+)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

pirinixic acid (ISO)

sevoflurane (ISO)

thioacetamide (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

binding of sperm to zona pellucida (ISO)

protein processing (ISO)

Cellular Component

acrosomal vesicle (ISO)

Molecular Function

serine-type endopeptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Tmprss12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	131,433,158 - 131,445,806 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	131,433,484 - 131,445,791 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	7	141,953,336 - 141,966,814 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	141,953,794 - 141,966,522 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	139,763,760 - 139,777,016 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	139,042,666 - 139,055,345 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	127,910,961 - 127,923,697 (+)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

TMPRSS12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	50,842,926 - 50,887,884 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	50,842,920 - 50,887,884 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	51,236,709 - 51,281,667 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	49,522,968 - 49,567,934 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	50,038,174 - 50,083,137 (+)	NCBI		Celera
Cytogenetic Map	12	q13.12	NCBI
HuRef	12	48,269,528 - 48,314,535 (+)	NCBI		HuRef
CHM1_1	12	51,203,138 - 51,247,963 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	50,806,068 - 50,851,138 (+)	NCBI		T2T-CHM13v2.0

Tmprss12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	100,178,743 - 100,190,943 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	100,178,718 - 100,190,947 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	100,280,837 - 100,293,056 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	100,280,837 - 100,293,066 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	100,111,268 - 100,123,484 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	100,108,860 - 100,113,701 (+)	NCBI		MGSCv36	mm8
Celera	15	102,432,167 - 102,444,263 (+)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI

Tmprss12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955547	1,306,129 - 1,332,525 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955547	1,305,697 - 1,332,131 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMPRSS12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	12	43,294,985 - 43,340,876 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	37,865,660 - 37,908,657 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	38,768,066 - 38,810,372 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	38,768,072 - 38,810,372 (-)	Ensembl	panpan1.1		panPan2

TMPRSS12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	3,877,089 - 3,904,606 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	3,877,355 - 3,992,904 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	42,352,669 - 42,380,083 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	3,924,683 - 3,952,090 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	3,924,688 - 3,952,036 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	3,891,298 - 3,918,685 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	3,879,011 - 3,906,589 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	42,747,578 - 42,775,039 (+)	NCBI		UU_Cfam_GSD_1.0

Tmprss12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	64,699,659 - 64,726,207 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	8,438,636 - 8,465,094 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936512	8,438,636 - 8,465,094 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMPRSS12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	16,698,929 - 16,727,411 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	16,698,794 - 16,727,920 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TMPRSS12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	47,071,798 - 47,115,890 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	198,986,998 - 199,032,132 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmprss12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	1,491,897 - 1,520,365 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624816	1,499,082 - 1,520,994 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmprss12
56 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	50
Count of miRNA genes:	49
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000041938
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	119513385	135012528	Rat

Markers in Region

D7Rat116

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	131,435,791 - 131,435,949 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	141,956,126 - 141,956,283	NCBI	Rnor6.0
Rnor_5.0	7	139,766,922 - 139,767,079	UniSTS	Rnor5.0
RGSC_v3.4	7	139,046,026 - 139,046,183	UniSTS	RGSC3.4
RGSC_v3.4	7	139,046,025 - 139,046,183	RGD	RGSC3.4
RGSC_v3.1	7	139,122,463 - 139,122,620	RGD
Celera	7	127,913,716 - 127,913,877	UniSTS
RH 3.4 Map	7	1076.7	RGD
RH 3.4 Map	7	1076.7	UniSTS
RH 2.0 Map	7	800.7	RGD
SHRSP x BN Map	7	86.2099	RGD

RH135171

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	7	139,768,047 - 139,768,214	NCBI	Rnor5.0
RGSC_v3.4	7	139,047,152 - 139,047,367	UniSTS	RGSC3.4
Celera	7	127,914,846 - 127,915,061	UniSTS
RH 3.4 Map	7	1077.3	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium											7
Low	1	42	53	41	16	41			19	27	32	11
Below cutoff	2	1	4		3		6	9	52	8	2		6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003754362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008765860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080381	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005487418	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000041938 ⟹ ENSRNOP00000047802

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	131,433,484 - 131,445,791 (+)	Ensembl
Rnor_6.0 Ensembl	7	141,953,794 - 141,966,522 (+)	Ensembl

RefSeq Acc Id:

XM_008765860 ⟹ XP_008764082

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	131,433,158 - 131,445,806 (+)	NCBI
Rnor_6.0	7	141,953,336 - 141,966,814 (+)	NCBI

Sequence:

show sequence

CCCGAGTGCTGGGATTAGAGGCAGTTTTTTCCTTAGGAAATATTTACTTGTTATTGTGGGCATC
CCTGGGTGTATGACGTGTGGGAGCATGAATGGACAAGCTATGGTGCCTGTTAGGTGAGAGGATG
TCTTCTGCAGCCGGCTCCTTCCAAACCTGTTGAGCATGCTCGCGAGGCGAGGGCTTCGACCTGA
CCATGGCGAGCCCTCCCTTCCCCTCTCACGCCTACTCTGAGGTGCTGGAGGCAAACCTTTTCAA
TCCGGGCCCACAGCCCCGCGGTGTGGAGAGACCTTCCTTCCCGTGCCCAATGGCGTCCAGAGTC
GGCGGCCTTCCGGAAGTCCTCTGCTGGGCGACAGGCCCGGAGCGGCCTCACCAGTCGAGCGAAG
GCGGGAAGCGGTGGAGGACCAGCAGGCACCGCGCGGACCTCCCCGCAGCCGCCATCTTGGGGCC
TGCGGCCGCCATGGGGTCATGGGCGCTGAGCGCCGCACTGCTGTGTTTGGGCGGAGCCCTTGCG
TACGGCAAGCTGCACTCGCTGACCCTCAGGGAGGGCTCCAGCCCGGCGCAGGGACAGGCTGCCA
TGCCAGGGCCGCCGGAAGAGGAGCAGCCGGTCACGAAGGGCTGTGGAATAGCACCACTCAGAGG
TGCACTGGAAGGGTCTCGGATTATAGGAGGTATGCAAGCCAACGCTGGAGCCTGGCCATGGCAA
GTTAGCCTGCAGGTTCAAGATGGCAATTTTCTTGTGCACGTATGTGGTGGTGCCCTAGTGAGAG
ACAGGNGGGTCCTCACAGCTGTCACTGCCACTAAAGAGGCTAGCGATCCTCTCAAGTGGAGGGC
GGTGATCGGGACCACCGACCTCACCCGGAGCCACTCCCACAGCAGGAGTGTACGCGTGTCAGAC
ATCGTCATCCAGCCAGATTTCATTCTGGAAACGTTCGTAAATGATATCGCACTGTTCCATTTAA
AGAAGGCCGTGAGGTATAATGACCATATTCAGCCCATTTGCCTCCCTTTTGGTGTTTTCCAAAA
ACTGGACCAAAACACAACGTGTTTTGTAAGTGGCTGGGGAAGAACCCAAGAAGAAGGCAACGGC
ACAACCATTTTACAAGAGGCGAAAGTCCACTTCATCTCTCGAGAGATCTGTAACTCTGACAGAA
GCTACGGAGGAGTGATTCCTAACACTTCCTTCTGTGCAGGTCATGAAAATGGGACCTTTGACAC
GTGCAGGGGTGACAGCGGTGGACCCCTAATGTGCTACCTAACAGAACACAAAAGATACTTTGTG
ATGGGAGTTACCAGTTACGGACACGGCTGCGGACGGAGGCATTTTCCCGGTGTCTACAGCAGCC
CGTCCTTCTTCCAGCAGTGGCTGACGGCTTACCTGTCCCAGGGAAACACCAAGCACCTGTTTGA
CATGGACATGATGCTTGGCCAGGTCCTCATGGCCCTAGGTTCCATCATCCTTCTGGGGGCAACA
TAAGGAGCCTCCGCAGGCTGGGGCGTCACGGGCGTCACTCTGCCCCTGCTGCGTCTACACGGCT
CCCTTTAGCGCTTCCACACCAACATTGGCTTGTTTTCATTTTTGTGTTTTTGAATGAAAAAGAT
TGTGACAGATACATAGTTGTGAATTCTGGCTCCAAATCACATACTTCATTAGAACCTGATTCAC
AATTCTGTATTTGGAATACTTTCCTAGGGTTTGTATAAAATATTCAGTTCACTATGTATGTACT
TTATGTGTATAAAGGCCAATAAACAGTTTATAATTTAAC

hide sequence

RefSeq Acc Id:

XM_039080377 ⟹ XP_038936305

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	131,433,158 - 131,445,806 (+)	NCBI

RefSeq Acc Id:

XM_039080378 ⟹ XP_038936306

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	131,433,158 - 131,445,806 (+)	NCBI

RefSeq Acc Id:

XM_039080379 ⟹ XP_038936307

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	131,433,158 - 131,445,392 (+)	NCBI

RefSeq Acc Id:

XM_039080380 ⟹ XP_038936308

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	131,433,498 - 131,445,806 (+)	NCBI

RefSeq Acc Id:

XM_039080381 ⟹ XP_038936309

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	131,433,158 - 131,445,429 (+)	NCBI

RefSeq Acc Id:

XR_005487418

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	131,433,158 - 131,445,396 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008764082	(Get FASTA)	NCBI Sequence Viewer
	XP_038936305	(Get FASTA)	NCBI Sequence Viewer
	XP_038936306	(Get FASTA)	NCBI Sequence Viewer
	XP_038936307	(Get FASTA)	NCBI Sequence Viewer
	XP_038936308	(Get FASTA)	NCBI Sequence Viewer
	XP_038936309	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_008764082 ⟸ XM_008765860

- Peptide Label:

isoform X2

- Sequence:

show sequence

MASPPFPSHAYSEVLEANLFNPGPQPRGVERPSFPCPMASRVGGLPEVLCWATGPERPHQSSEG
GKRWRTSRHRADLPAAAILGPAAAMGSWALSAALLCLGGALAYGKLHSLTLREGSSPAQGQAAM
PGPPEEEQPVTKGCGIAPLRGALEGSRIIGGMQANAGAWPWQVSLQVQDGNFLVHVCGGALVRD
RXVLTAVTATKEASDPLKWRAVIGTTDLTRSHSHSRSVRVSDIVIQPDFILETFVNDIALFHLK
KAVRYNDHIQPICLPFGVFQKLDQNTTCFVSGWGRTQEEGNGTTILQEAKVHFISREICNSDRS
YGGVIPNTSFCAGHENGTFDTCRGDSGGPLMCYLTEHKRYFVMGVTSYGHGCGRRHFPGVYSSP
SFFQQWLTAYLSQGNTKHLFDMDMMLGQVLMALGSIILLGAT

hide sequence

RefSeq Acc Id:

ENSRNOP00000047802 ⟸ ENSRNOT00000041938

RefSeq Acc Id:	XP_038936305 ⟸ XM_039080377
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038936306 ⟸ XM_039080378
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038936309 ⟸ XM_039080381
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_038936307 ⟸ XM_039080379
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038936308 ⟸ XM_039080380
- Peptide Label:	isoform X5

Protein Domains

Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M348-F1-model_v2	AlphaFold	F1M348	1-337	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695655

Promoter ID:

EPDNEW_R6178

Type:

initiation region

Name:

Tmprss12_1

Description:

Transmembrane protease serine 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	141,953,801 - 141,953,861	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2323781	AgrOrtholog
BioCyc Gene	G2FUF-32032	BioCyc
Ensembl Genes	ENSRNOG00000031099	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000047802.6	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000041938.6	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
NCBI Gene	100362912	ENTREZGENE
PANTHER	ACROSIN	UniProtKB/TrEMBL
	ACROSIN-RELATED	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PhenoGen	Tmprss12	PhenoGen
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	F1M348_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-26	Tmprss12	transmembrane serine protease 12	Tmprss12	transmembrane protease, serine 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-22	Tmprss12	transmembrane protease, serine 12	Tmprss12	transmembrane (C-terminal) protease, serine 12	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-08-30	Tmprss12	transmembrane (C-terminal) protease, serine 12	LOC100362912	rCG50645-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-07-02	LOC100362912	rCG50645-like	RGD1560236	similar to hypothetical protein MGC57341	Data Merged	1643240	APPROVED
2010-05-06	LOC100362912	rCG50645-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-04-30	RGD1560236	similar to hypothetical protein MGC57341	RGD1560236_predicted	similar to hypothetical protein MGC57341 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1560236_predicted	similar to hypothetical protein MGC57341 (predicted)	LOC366987	similar to hypothetical protein MGC57341	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC366987	similar to hypothetical protein MGC57341			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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