Tmprss12 (transmembrane serine protease 12) - Rat Genome Database

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Gene: Tmprss12 (transmembrane serine protease 12) Rattus norvegicus
Analyze
Symbol: Tmprss12
Name: transmembrane serine protease 12
RGD ID: 2323781
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in acrosome assembly and positive regulation of sperm capacitation. Predicted to act upstream of or within binding activity of sperm to zona pellucida and protein processing. Predicted to be located in acrosomal vesicle. Orthologous to human TMPRSS12 (transmembrane serine protease 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; thioacetamide.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100362912; rCG50645-like; RGD1560236; transmembrane (C-terminal) protease, serine 12; transmembrane protease serine 12; transmembrane protease, serine 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,311,839 - 133,324,620 (+)NCBIGRCr8
mRatBN7.27131,433,158 - 131,445,806 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,433,484 - 131,445,791 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.07141,953,336 - 141,966,814 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,953,794 - 141,966,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,763,760 - 139,777,016 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,042,666 - 139,055,345 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7127,910,961 - 127,923,697 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tmprss12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,311,839 - 133,324,620 (+)NCBIGRCr8
mRatBN7.27131,433,158 - 131,445,806 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,433,484 - 131,445,791 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.07141,953,336 - 141,966,814 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7141,953,794 - 141,966,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07139,763,760 - 139,777,016 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47139,042,666 - 139,055,345 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7127,910,961 - 127,923,697 (+)NCBICelera
Cytogenetic Map7q36NCBI
TMPRSS12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381250,842,926 - 50,887,884 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1250,842,920 - 50,887,884 (+)EnsemblGRCh38hg38GRCh38
GRCh371251,236,709 - 51,281,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361249,522,968 - 49,567,934 (+)NCBINCBI36Build 36hg18NCBI36
Celera1250,038,174 - 50,083,137 (+)NCBICelera
Cytogenetic Map12q13.12NCBI
HuRef1248,269,528 - 48,314,535 (+)NCBIHuRef
CHM1_11251,203,138 - 51,247,963 (+)NCBICHM1_1
T2T-CHM13v2.01250,806,068 - 50,851,138 (+)NCBIT2T-CHM13v2.0
Tmprss12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,178,743 - 100,190,943 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,178,718 - 100,190,947 (+)EnsemblGRCm39 Ensembl
GRCm3815100,280,837 - 100,293,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,280,837 - 100,293,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715100,111,268 - 100,123,484 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615100,108,860 - 100,113,701 (+)NCBIMGSCv36mm8
Celera15102,432,167 - 102,444,263 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.24NCBI
Tmprss12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555471,306,129 - 1,332,525 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555471,305,697 - 1,332,131 (+)NCBIChiLan1.0ChiLan1.0
TMPRSS12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21043,298,223 - 43,344,114 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11243,294,985 - 43,340,876 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01237,865,660 - 37,908,657 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11238,768,066 - 38,810,372 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1238,768,072 - 38,810,372 (-)Ensemblpanpan1.1panPan2
TMPRSS12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,877,089 - 3,904,606 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,877,355 - 3,992,904 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2742,352,669 - 42,380,083 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0273,924,683 - 3,952,090 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,924,688 - 3,952,036 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,891,298 - 3,918,685 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,879,011 - 3,906,589 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02742,747,578 - 42,775,039 (+)NCBIUU_Cfam_GSD_1.0
Tmprss12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494564,699,659 - 64,726,207 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365128,438,636 - 8,465,094 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365128,438,636 - 8,465,094 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMPRSS12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl516,698,929 - 16,727,411 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1516,698,794 - 16,727,920 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMPRSS12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,071,798 - 47,115,890 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037198,986,998 - 199,032,132 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmprss12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248161,491,897 - 1,520,365 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248161,499,082 - 1,520,994 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmprss12
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000041938
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
D7Rat116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27131,435,791 - 131,435,949 (+)MAPPERmRatBN7.2
Rnor_6.07141,956,126 - 141,956,283NCBIRnor6.0
Rnor_5.07139,766,922 - 139,767,079UniSTSRnor5.0
RGSC_v3.47139,046,026 - 139,046,183UniSTSRGSC3.4
RGSC_v3.47139,046,025 - 139,046,183RGDRGSC3.4
RGSC_v3.17139,122,463 - 139,122,620RGD
Celera7127,913,716 - 127,913,877UniSTS
RH 3.4 Map71076.7RGD
RH 3.4 Map71076.7UniSTS
RH 2.0 Map7800.7RGD
SHRSP x BN Map786.2099RGD
RH135171  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.07139,768,047 - 139,768,214NCBIRnor5.0
RGSC_v3.47139,047,152 - 139,047,367UniSTSRGSC3.4
Celera7127,914,846 - 127,915,061UniSTS
RH 3.4 Map71077.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 1 42 53 41 16 41 19 27 32 11
Below cutoff 2 1 4 3 6 9 52 8 2 6

Sequence


RefSeq Acc Id: ENSRNOT00000041938   ⟹   ENSRNOP00000047802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7131,433,484 - 131,445,791 (+)Ensembl
Rnor_6.0 Ensembl7141,953,794 - 141,966,522 (+)Ensembl
RefSeq Acc Id: XM_008765860   ⟹   XP_008764082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,311,852 - 133,324,620 (+)NCBI
mRatBN7.27131,433,158 - 131,445,806 (+)NCBI
Rnor_6.07141,953,336 - 141,966,814 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080377   ⟹   XP_038936305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,311,844 - 133,324,620 (+)NCBI
mRatBN7.27131,433,158 - 131,445,806 (+)NCBI
RefSeq Acc Id: XM_039080378   ⟹   XP_038936306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,311,839 - 133,324,620 (+)NCBI
mRatBN7.27131,433,158 - 131,445,806 (+)NCBI
RefSeq Acc Id: XM_039080380   ⟹   XP_038936308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,312,306 - 133,324,620 (+)NCBI
mRatBN7.27131,433,498 - 131,445,806 (+)NCBI
RefSeq Acc Id: XM_039080381   ⟹   XP_038936309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,311,841 - 133,324,620 (+)NCBI
mRatBN7.27131,433,158 - 131,445,429 (+)NCBI
RefSeq Acc Id: XM_063264368   ⟹   XP_063120438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,311,847 - 133,324,620 (+)NCBI
RefSeq Acc Id: XM_063264369   ⟹   XP_063120439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87133,311,841 - 133,321,115 (+)NCBI
RefSeq Acc Id: XP_008764082   ⟸   XM_008765860
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000047802   ⟸   ENSRNOT00000041938
RefSeq Acc Id: XP_038936305   ⟸   XM_039080377
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936306   ⟸   XM_039080378
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038936309   ⟸   XM_039080381
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038936308   ⟸   XM_039080380
- Peptide Label: isoform X6
- UniProtKB: A6KCI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120439   ⟸   XM_063264369
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063120438   ⟸   XM_063264368
- Peptide Label: isoform X4
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M348-F1-model_v2 AlphaFold F1M348 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695655
Promoter ID:EPDNEW_R6178
Type:initiation region
Name:Tmprss12_1
Description:Transmembrane protease serine 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07141,953,801 - 141,953,861EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2323781 AgrOrtholog
BioCyc Gene G2FUF-32032 BioCyc
Ensembl Genes ENSRNOG00000031099 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041938.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene 100362912 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  TRANSMEMBRANE SERINE PROTEASE 12 UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Tmprss12 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031099 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A6KCI5 ENTREZGENE, UniProtKB/TrEMBL
  F1M348_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Tmprss12  transmembrane serine protease 12  Tmprss12  transmembrane protease, serine 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-22 Tmprss12  transmembrane protease, serine 12  Tmprss12  transmembrane (C-terminal) protease, serine 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-30 Tmprss12  transmembrane (C-terminal) protease, serine 12  LOC100362912  rCG50645-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-02 LOC100362912  rCG50645-like  RGD1560236  similar to hypothetical protein MGC57341  Data merged from RGD:1560236 1643240 APPROVED
2010-05-06 LOC100362912  rCG50645-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1560236  similar to hypothetical protein MGC57341   RGD1560236_predicted  similar to hypothetical protein MGC57341 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560236_predicted  similar to hypothetical protein MGC57341 (predicted)  LOC366987  similar to hypothetical protein MGC57341  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366987  similar to hypothetical protein MGC57341      Symbol and Name status set to provisional 70820 PROVISIONAL