TMPRSS12 (transmembrane serine protease 12)

Gene: TMPRSS12 (transmembrane serine protease 12) Pan paniscus

Analyze

Symbol:

TMPRSS12

Name:

transmembrane serine protease 12

RGD ID:

11968808

Description:

ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein processing (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN acrosomal vesicle (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transmembrane protease serine 12; transmembrane protease, serine 12

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	43,298,223 - 43,344,114 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	43,294,985 - 43,340,876 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	37,865,660 - 37,908,657 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	38,768,066 - 38,810,372 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	38,768,072 - 38,810,372 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acrosome assembly (IEA)

binding of sperm to zona pellucida (IEA,ISO)

positive regulation of sperm capacitation (IEA)

protein processing (IEA,ISO)

proteolysis (IEA)

spermatogenesis (IEA)

Cellular Component

acrosomal vesicle (IEA)

membrane (IEA)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA)

serine-type endopeptidase activity (IEA)

serine-type peptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

TMPRSS12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	43,298,223 - 43,344,114 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	43,294,985 - 43,340,876 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	37,865,660 - 37,908,657 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	38,768,066 - 38,810,372 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	38,768,072 - 38,810,372 (-)	Ensembl	panpan1.1		panPan2

TMPRSS12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	50,842,926 - 50,887,884 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	50,842,920 - 50,887,884 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	51,236,709 - 51,281,667 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	49,522,968 - 49,567,934 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	50,038,174 - 50,083,137 (+)	NCBI		Celera
Cytogenetic Map	12	q13.12	NCBI
HuRef	12	48,269,528 - 48,314,535 (+)	NCBI		HuRef
CHM1_1	12	51,203,138 - 51,247,963 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	50,806,068 - 50,851,138 (+)	NCBI		T2T-CHM13v2.0

Tmprss12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	100,178,743 - 100,190,943 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	100,178,718 - 100,190,947 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	100,280,837 - 100,293,056 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	100,280,837 - 100,293,066 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	100,111,268 - 100,123,484 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	100,108,860 - 100,113,701 (+)	NCBI		MGSCv36	mm8
Celera	15	102,432,167 - 102,444,263 (+)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI
cM Map	15	56.24	NCBI

Tmprss12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	133,311,839 - 133,324,620 (+)	NCBI		GRCr8
mRatBN7.2	7	131,433,158 - 131,445,806 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	131,433,484 - 131,445,791 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	7	141,953,336 - 141,966,814 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	141,953,794 - 141,966,522 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	139,763,760 - 139,777,016 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	139,042,666 - 139,055,345 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	127,910,961 - 127,923,697 (+)	NCBI		Celera
Cytogenetic Map	7	q36	NCBI

Tmprss12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955547	1,306,129 - 1,332,525 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955547	1,305,697 - 1,332,131 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMPRSS12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	3,877,089 - 3,904,606 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	3,877,355 - 3,992,904 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	42,352,669 - 42,380,083 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	3,924,683 - 3,952,090 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	3,924,688 - 3,952,036 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	3,891,298 - 3,918,685 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	3,879,011 - 3,906,589 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	42,747,578 - 42,775,039 (+)	NCBI		UU_Cfam_GSD_1.0

Tmprss12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	64,699,659 - 64,726,207 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	8,438,636 - 8,465,094 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	8,438,636 - 8,465,094 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMPRSS12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	16,698,929 - 16,727,411 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	16,698,794 - 16,727,920 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TMPRSS12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	47,071,798 - 47,115,890 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	198,986,998 - 199,032,132 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmprss12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	1,491,897 - 1,520,365 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624816	1,499,082 - 1,520,994 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003825868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000055123 ⟹ ENSPPAP00000032257

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	38,768,072 - 38,810,372 (-)	Ensembl

RefSeq Acc Id:

XM_003825868 ⟹ XP_003825916

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	43,298,223 - 43,344,114 (-)	NCBI
NHGRI_mPanPan1	12	43,294,985 - 43,340,876 (-)	NCBI
Mhudiblu_PPA_v0	12	37,865,660 - 37,908,657 (-)	NCBI
PanPan1.1	12	38,768,066 - 38,810,372 (-)	NCBI

Sequence:

show sequence

GTGGGAAGTACCTGCCGCCATCTTGCTCACCAGCCTCCAAAATGCGGCTGGGGCTCCTGAGCGT
GGCGCTGTTGTTTGTGGGGAGCTCTCACTCATACTCAGACCACTACTCGCCCTCTGGAAGGCAC
AGGCTCGGCCCCTCGCCGGAACCGGCGGCTAGTTCCCAGCAGGCTGAGGCCGTCCGCAAGAGGC
TCGGGCGGCGGAGGGAGGGAGGGGCGCATGCAAAGGATTGTGGAACAGCACCGCTTAAGGATGT
GTTGCAAGGGTCTCGGATTATAGGGGGCACCGAAGCACAAGCTGGCGCATGGCCGTGGGTGGTG
AGCCTGCAGATTAAATATGGCCGTGTTCTTGTTCATGTATGTGGGGGAGCCCTAGTGAGAGAAA
GGTGGGTCCTCACAGCTGCCCACTGCACTAAAGACGCTAGCGATCCTTTAATGTGGACAGCTGT
GATTGGAACTAATAATATACATGGACGCTATCCTCATACCAAGAAGATAAAAATTAAAGCAATC
ATTATTCATCCAAACTTCATTTTGGAATCTTATGTAAATGATATTGCACTTTTTCACTTAAAAA
AAGCAGTGAGGTATAATGACTATATTCAGCCTATTTGCCTACCTTTTGATGTTTTCCAAATCCT
GGACGGAAACACAAAGTGTTTTATAAGTGGCTGGGGAAGAACAAAAGAAGAAGGTAATGCTACA
AATATTTTACAAGACGCAGAAGTGCATTATATTTCTCGAGAGATGTGTAATTCTGAGAGGAGTT
ATGGGGGAATAATTCCCAACACTTCATTTTGTGCAGGTGATGAAGATGGAGCTTTTGATACTTG
CAGGGGTGACAGTGGGGGACCATTAATGTGCTACTTACCAGAATATAAAAGATTTTTTGTAATG
GGAATTACCAGTTACGGACATGGCTGTGGCCGAAGAGGTTTTCCTGGTGTCTATATTGGGCCAT
CCTTCTACCAAAAGTGGCTGACAGAGCATTTCTTCCATGCAAGCACTCAAGGCATACTTACTAT
AAATATTTTACGTGGCCAGATCCTCATAGCTTTATGTTTTGTCATCTTACTAGCAACAACATAA
AGAAATTCTGAAGGCTTTCATATCTTTATTTTGCATTGTGTCCCTTTCTCTGTTCTATATAATG
AACATCATTTATTCTTCTAGCAATTAATTGCCTACATTAGAGATTTCATGTGAACATTTTATGG
GCTATAAGTATTGTGACAGATATAGAATTGTAATTTTGGCACTGAATCACATGTCTCCTTGAAA
TATCTTGATTGTTTTATTTTATAATCATAATTCTGTATCTGGAATACTCAGAGTTTGTACAAAA
TATTCAGTTAAACATATATTTTATGTGTATAAATGCCAAATAATAGTTTATAATTAAAATGAAA
GCTGTTATTTGGTTAAATTAATAAAAATTCTTCCTTAGATTTTATTCTAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003825916	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000032257
	ENSPPAP00000032257.1

RefSeq Acc Id:

XP_003825916 ⟸ XM_003825868

- UniProtKB:

A0A2R9BRF6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRLGLLSVALLFVGSSHSYSDHYSPSGRHRLGPSPEPAASSQQAEAVRKRLGRRREGGAHAKDC
GTAPLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGALVRERWVLTAAHCTKDAS
DPLMWTAVIGTNNIHGRYPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICL
PFDVFQILDGNTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNSERSYGGIIPNTSFCAGD
EDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWLTEHFFHA
STQGILTINILRGQILIALCFVILLATT

hide sequence

RefSeq Acc Id:

ENSPPAP00000032257 ⟸ ENSPPAT00000055123

Protein Domains

Peptidase S1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000039011	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000055123.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
InterPro	Peptidase_S1_PA	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Trypsin_dom	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	pps:100984038	UniProtKB/TrEMBL
NCBI Gene	TMPRSS12	ENTREZGENE
PANTHER	ACROSIN-RELATED	UniProtKB/TrEMBL
	TRANSMEMBRANE SERINE PROTEASE 12	UniProtKB/TrEMBL
Pfam	Trypsin	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
SMART	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50494	UniProtKB/TrEMBL
UniProt	A0A2R9BRF6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-23	TMPRSS12	transmembrane serine protease 12		transmembrane protease, serine 12	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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