Mchr1 (melanin-concentrating hormone receptor 1)

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Gene: Mchr1 (melanin-concentrating hormone receptor 1) Rattus norvegicus

Analyze

Symbol:

Mchr1

Name:

melanin-concentrating hormone receptor 1

RGD ID:

619841

Description:

Enables hormone binding activity and melanin-concentrating hormone receptor activity. Involved in cell surface receptor signaling pathway; positive regulation of calcium ion transport; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in ciliary membrane and non-motile cilium. Predicted to be active in neuron projection. Biomarker of obesity. Human ortholog(s) of this gene implicated in morbid obesity. Orthologous to human MCHR1 (melanin concentrating hormone receptor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

G protein-coupled receptor 24; G-protein coupled receptor 24; Gpr24; MCH receptor 1; Mch-1r; MCH-R1; MCH1R; MCHR; MCHR-1; SLC-1; Slc1; somatostatin receptor-like protein

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	112,761,554 - 112,764,746 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	112,761,554 - 112,764,032 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	114,524,098 - 114,526,580 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	116,747,649 - 116,750,131 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	116,717,002 - 116,719,482 (+)	NCBI	Rnor_WKY
Rnor_6.0	7	122,456,846 - 122,459,324 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	122,456,799 - 122,459,960 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	122,432,538 - 122,435,016 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	119,557,141 - 119,559,619 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	119,591,370 - 119,593,849 (+)	NCBI
Celera	7	109,080,262 - 109,082,740 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

genetic disease (ISO)

morbid obesity (ISO)

obesity (IEP)

Rubinstein-Taybi syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-tert-butylhydroquinone (ISO)

3,4-methylenedioxymethamphetamine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

belinostat (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

clothianidin (ISO)

cobalt dichloride (ISO)

dichloroacetic acid (ISO)

dimethylarsinic acid (ISO)

dioxygen (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

fonofos (ISO)

fulvestrant (ISO)

haloperidol (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methylarsonic acid (ISO)

N-Nitrosopyrrolidine (ISO)

O-methyleugenol (ISO)

ozone (ISO)

paracetamol (ISO)

parathion (ISO)

pirinixic acid (ISO)

pyridazines (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

succimer (ISO)

terbufos (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vanadyl sulfate (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway (IMP)

neuropeptide signaling pathway (IBA)

positive regulation of calcium ion transport (IMP)

positive regulation of cytosolic calcium ion concentration (IMP)

Cellular Component

ciliary membrane (ISO)

cilium (ISO)

neuron projection (IBA,ISO)

non-motile cilium (ISO)

plasma membrane (ISO,ISS)

Molecular Function

G protein-coupled receptor activity (IBA)

hormone binding (IDA)

melanin-concentrating hormone receptor activity (IDA)

neuropeptide binding (IBA)

protein binding (IPI)

signaling receptor binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein.	Bachner D, etal., FEBS Lett 2002 Aug 28;526(1-3):124-8.
2.	Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity.	Bell CG, etal., Diabetes. 2005 Oct;54(10):3049-55.
3.	Increases in melanin-concentrating hormone and MCH receptor levels in the hypothalamus of dietary-obese rats.	Elliott JC, etal., Brain Res Mol Brain Res. 2004 Sep 28;128(2):150-9.
4.	Interaction of neurochondrin with the melanin-concentrating hormone receptor 1 interferes with G protein-coupled signal transduction but not agonist-mediated internalization.	Francke F, etal., J Biol Chem. 2006 Oct 27;281(43):32496-507. Epub 2006 Aug 31.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	Cloning of the rat brain cDNA encoding for the SLC-1 G protein-coupled receptor reveals the presence of an intron in the gene.	Lakaye B, etal., Biochim Biophys Acta 1998 Feb 4;1401(2):216-20.
8.	The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor.	Lembo PM, etal., Nat Cell Biol. 1999 Sep;1(5):267-71.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
12.	GOA pipeline	RGD automated data pipeline
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Functional role of N-linked glycosylation on the rat melanin-concentrating hormone receptor 1.	Saito Y, etal., FEBS Lett 2003 Jan 2;533(1-3):29-34.
15.	The basic residues in the membrane-proximal C-terminal tail of the rat melanin-concentrating hormone receptor 1 are required for receptor function.	Tetsuka M, etal., Endocrinology. 2004 Aug;145(8):3712-23. Epub 2004 Apr 29.

Additional References at PubMed

PMID:8977118	PMID:10421368	PMID:12620396	PMID:15476926	PMID:15590649	PMID:15845622	PMID:15950311	PMID:16359819	PMID:18062961	PMID:18334641	PMID:18760349	PMID:18849359
PMID:19428776	PMID:21925200	PMID:21946196	PMID:22139371	PMID:22209364	PMID:23029470	PMID:23351594	PMID:25617691	PMID:26456505	PMID:27579857	PMID:28154160	PMID:32530066
PMID:33197527	PMID:36565982

Genomics

Comparative Map Data

Mchr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	112,761,554 - 112,764,746 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	112,761,554 - 112,764,032 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	114,524,098 - 114,526,580 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	116,747,649 - 116,750,131 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	116,717,002 - 116,719,482 (+)	NCBI	Rnor_WKY
Rnor_6.0	7	122,456,846 - 122,459,324 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	122,456,799 - 122,459,960 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	122,432,538 - 122,435,016 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	119,557,141 - 119,559,619 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	119,591,370 - 119,593,849 (+)	NCBI
Celera	7	109,080,262 - 109,082,740 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

MCHR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	40,679,484 - 40,682,812 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	22	40,679,273 - 40,682,812 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	41,075,488 - 41,078,816 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	39,405,128 - 39,408,764 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	39,399,736 - 39,403,318	NCBI
Celera	22	24,878,864 - 24,882,500 (+)	NCBI		Celera
Cytogenetic Map	22	q13.2	NCBI
HuRef	22	24,037,016 - 24,040,650 (+)	NCBI		HuRef
CHM1_1	22	41,035,201 - 41,038,835 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	41,151,449 - 41,154,777 (+)	NCBI		T2T-CHM13v2.0

Mchr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	81,119,700 - 81,123,165 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	81,119,700 - 81,123,165 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	81,235,499 - 81,238,964 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	81,235,499 - 81,238,964 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	81,065,929 - 81,069,394 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	81,063,029 - 81,065,367 (+)	NCBI		MGSCv36	mm8
Celera	15	83,352,799 - 83,356,252 (+)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI

Mchr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	26,343,759 - 26,347,520 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	26,343,771 - 26,347,374 (+)	NCBI	ChiLan1.0	ChiLan1.0

MCHR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	22	53,212,725 - 53,216,607 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	21,577,190 - 21,581,062 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	39,673,698 - 39,677,517 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	39,673,698 - 39,677,517 (+)	Ensembl	panpan1.1		panPan2

MCHR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	24,526,687 - 24,560,948 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	24,526,693 - 24,559,836 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	24,462,281 - 24,464,655 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	25,276,788 - 25,311,181 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	25,276,794 - 25,280,056 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	24,990,613 - 24,992,985 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	25,312,293 - 25,314,664 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	25,486,758 - 25,489,135 (-)	NCBI		UU_Cfam_GSD_1.0

Mchr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	8,143,469 - 8,147,147 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	1,153,651 - 1,157,142 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936492	1,153,895 - 1,156,980 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCHR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	7,735,825 - 7,738,701 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	7,735,752 - 7,752,006 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	4,916,103 - 4,918,861 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCHR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	23,240,509 - 23,245,553 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	23,241,487 - 23,243,950 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	102,341,335 - 102,346,097 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mchr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	7,801,948 - 7,805,635 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	7,801,867 - 7,805,791 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mchr1
3 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	78
Count of miRNA genes:	65
Interacting mature miRNAs:	67
Transcripts:	ENSRNOT00000025564
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									15
Low			1				3	6	49	4	32	1	3
Below cutoff	2	17	33	22	6	22	5	5	10	27	7	8	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF008650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000186	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U77953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000025564 ⟹ ENSRNOP00000025564

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	112,761,554 - 112,764,032 (+)	Ensembl
Rnor_6.0 Ensembl	7	122,456,799 - 122,459,960 (+)	Ensembl

RefSeq Acc Id:

NM_031758 ⟹ NP_113946

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	112,761,554 - 112,764,032 (+)	NCBI
Rnor_6.0	7	122,456,846 - 122,459,324 (+)	NCBI
Rnor_5.0	7	122,432,538 - 122,435,016 (+)	NCBI
RGSC_v3.4	7	119,557,141 - 119,559,619 (+)	RGD
Celera	7	109,080,262 - 109,082,740 (+)	RGD

Sequence:

show sequence

GCAGGCGACCTGCACCGGCTGCATGGATCTGCAAACCTCGTTGCTGTCCACTGGCCCCAATGCC
AGCAACATCTCCGATGGCCAGGATAATCTCACATTGCCGGGGTCACCTCCTCGCACAGGGAGTG
TCTCCTACATCAACATCATTATGCCTTCCGTGTTTGGTACCATCTGTCTCCTGGGCATCGTGGG
AAACTCCACGGTCATCTTTGCTGTGGTGAAGAAGTCCAAGCTACACTGGTGCAGCAACGTCCCC
GACATCTTCATCATCAACCTCTCTGTGGTGGATCTGCTCTTCCTGCTGGGCATGCCTTTCATGA
TCCACCAGCTCATGGGGAACGGCGTCTGGCACTTTGGGGAAACCATGTGCACCCTCATCACAGC
CATGGACGCCAACAGTCAGTTCACTAGCACCTACATCCTGACTGCCATGACCATTGACCGCTAC
TTGGCCACCGTCCACCCCATCTCCTCCACCAAGTTCCGGAAGCCCTCCATGGCCACCCTGGTGA
TCTGCCTCCTGTGGGCGCTCTCCTTCATCAGTATCACCCCTGTGTGGCTCTACGCCAGGCTCAT
TCCCTTCCCAGGGGGTGCTGTGGGCTGTGGCATCCGCCTGCCAAACCCGGACACTGACCTCTAC
TGGTTCACTCTGTACCAGTTTTTCCTGGCCTTTGCCCTTCCGTTTGTGGTCATTACCGCCGCAT
ACGTGAAAATACTACAGCGCATGACGTCTTCGGTGGCCCCAGCCTCCCAACGCAGCATCCGGCT
TCGGACAAAGAGGGTGACCCGCACGGCCATTGCCATCTGTCTGGTCTTCTTTGTGTGCTGGGCA
CCCTACTATGTGCTGCAGCTGACCCAGCTGTCCATCAGCCGCCCGACCCTCACGTTTGTCTACT
TGTACAACGCGGCCATCAGCTTGGGCTATGCTAACAGCTGCCTGAACCCCTTTGTGTACATAGT
GCTCTGTGAGACCTTTCGAAAACGCTTGGTGTTGTCAGTGAAGCCTGCAGCCCAGGGGCAGCTC
CGCACGGTCAGCAACGCTCAGACAGCTGATGAGGAGAGGACAGAAAGCAAAGGCACCTGACAAT
TCCCCAGTCGCCTCCAAGTCAGGCCACCCCATCAAACCGTGGGGAGAGATACTGAGATTAAACC
CAAGGCTACCCTGGGAGAATGCAGAGGCTGGAGGCTGGGGGCTTGTAGCAACCACATTCCAC

hide sequence

RefSeq Acc Id:

XM_039079955 ⟹ XP_038935883

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	112,761,712 - 112,764,746 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_113946	(Get FASTA)	NCBI Sequence Viewer
	XP_038935883	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC14588	(Get FASTA)	NCBI Sequence Viewer
	AAC27977	(Get FASTA)	NCBI Sequence Viewer
	EDM15736	(Get FASTA)	NCBI Sequence Viewer
	P97639	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_113946 ⟸ NM_031758

- UniProtKB:

A0A140TAD3 (UniProtKB/Swiss-Prot), P97639 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFA
VVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQF
TSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAV
GCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTR
TAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRK
RLVLSVKPAAQGQLRTVSNAQTADEERTESKGT

hide sequence

RefSeq Acc Id:

ENSRNOP00000025564 ⟸ ENSRNOT00000025564

RefSeq Acc Id:	XP_038935883 ⟸ XM_039079955
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P97639-F1-model_v2	AlphaFold	P97639	1-353	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619841	AgrOrtholog
BioCyc Gene	G2FUF-32685	BioCyc
Ensembl Genes	ENSRNOG00000018895	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000025564	ENTREZGENE
	ENSRNOP00000025564.4	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025564	ENTREZGENE
	ENSRNOT00000025564.7	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
	MCH1_rcpt	UniProtKB/Swiss-Prot
	MCH_rcpt	UniProtKB/Swiss-Prot
KEGG Report	rno:83567	UniProtKB/Swiss-Prot
NCBI Gene	83567	ENTREZGENE
PANTHER	NEUROPEPTIDES RECEPTOR	UniProtKB/Swiss-Prot
	PTHR24229:SF91	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PhenoGen	Mchr1	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot
	MCH1RECEPTOR	UniProtKB/Swiss-Prot
	MCHRECEPTOR	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	A0A140TAD3	ENTREZGENE
	MCHR1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A0A140TAD3	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Mchr1	melanin-concentrating hormone receptor 1	Gpr24	G protein-coupled receptor 24	Symbol and Name updated	1299863	APPROVED
2004-12-14	Gpr24	G protein-coupled receptor 24		somatostatin receptor-like protein	Name updated	1299863	APPROVED
2002-08-07	Gpr24	somatostatin receptor-like protein			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_pathway	involves in the Ca2+, cAMP and MAP kinases signaling pathways	628540
gene_protein	all three N-linked glycosylation sites are glycosylated in vivo	628540
gene_regulation	N-glycosylation at Asn23 is important for cell surface expression, ligand binding and signal transduction	628540

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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