Pick1 (protein interacting with PRKCA 1) - Rat Genome Database

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Gene: Pick1 (protein interacting with PRKCA 1) Rattus norvegicus
Analyze
Symbol: Pick1
Name: protein interacting with PRKCA 1
RGD ID: 69437
Description: Enables several functions, including Arp2/3 complex binding activity; SNAP receptor activity; and glutamate receptor binding activity. Involved in several processes, including dendritic spine maintenance; long-term synaptic depression; and regulation of receptor internalization. Located in dendritic spine; perinuclear region of cytoplasm; and postsynaptic density. Part of protein-containing complex. Is active in several cellular components, including glutamatergic synapse; postsynaptic endocytic zone; and synaptic vesicle. Orthologous to human PICK1 (protein interacting with PRKCA 1); PARTICIPATES IN protein kinase C (PKC) signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PRKCA-binding protein; Prkcabp; protein interacting with C kinase 1; protein kinase C alpha binding protein; protein kinase C, alpha binding protein; protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,676,890 - 112,697,275 (+)NCBIGRCr8
mRatBN7.27110,796,623 - 110,816,850 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,797,117 - 110,816,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,545,653 - 112,564,970 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,769,189 - 114,788,506 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,738,549 - 114,757,866 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,465,472 - 120,484,824 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,465,130 - 120,484,840 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,459,118 - 120,478,470 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,213,299 - 117,232,651 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,247,528 - 117,266,879 (+)NCBI
Celera7107,131,151 - 107,150,407 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors. Cao M, etal., J Neurosci. 2007 Nov 21;27(47):12945-56.
2. Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. Chung HJ, etal., J Neurosci. 2000 Oct 1;20(19):7258-67.
3. PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. Dev KK, etal., J Neurosci. 2000 Oct 1;20(19):7252-7.
4. The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits. Dev KK, etal., Neuropharmacology. 1999 May;38(5):635-44.
5. ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1. Deval E, etal., J Biol Chem 2004 May 7;279(19):19531-9. Epub 2004 Feb 19.
6. The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death. Dutta P, etal., J Neurochem. 2014 Aug;130(3):360-73. doi: 10.1111/jnc.12741. Epub 2014 May 19.
7. Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1. El Far O, etal., Eur J Neurosci 2000 Dec;12(12):4215-21.
8. PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 a-appendage and dynamin. Fiuza M, etal., J Cell Biol. 2017 Oct 2;216(10):3323-3338. doi: 10.1083/jcb.201701034. Epub 2017 Aug 30.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Protein interacting with C kinase 1 (PICK1) and GluR2 are associated with presynaptic plasma membrane and vesicles in hippocampal excitatory synapses. Haglerød C, etal., Neuroscience. 2009 Jan 12;158(1):242-52. doi: 10.1016/j.neuroscience.2008.11.029. Epub 2008 Nov 27.
12. NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex. Hanley JG, etal., Neuron 2002 Mar 28;34(1):53-67.
13. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. Hirbec H, etal., J Biol Chem. 2002 May 3;277(18):15221-4. Epub 2002 Mar 12.
14. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Hirbec H, etal., Neuron. 2003 Feb 20;37(4):625-38. doi: 10.1016/s0896-6273(02)01191-1.
15. Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons. Jourdi H, etal., Dev Biol. 2003 Nov 15;263(2):216-30. doi: 10.1016/j.ydbio.2003.07.008.
16. Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering. Karlsen ML, etal., Structure. 2015 Jul 7;23(7):1258-70. doi: 10.1016/j.str.2015.04.020. Epub 2015 Jun 11.
17. Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1. Lin WJ, etal., Biochem J 2001 Mar 15;354(Pt 3):635-43.
18. PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Lu W and Ziff EB, Neuron. 2005 Aug 4;47(3):407-21.
19. Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. Madsen KL, etal., J Biol Chem. 2005 May 27;280(21):20539-48. Epub 2005 Mar 17.
20. Immunolocalization of PICK1 in the ascending auditory pathways of the adult rat. McInvale AC, etal., J Comp Neurol 2002 Sep 2;450(4):382-94.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology. Murk K, etal., J Cell Sci. 2013 Sep 1;126(Pt 17):3873-83. doi: 10.1242/jcs.125146. Epub 2013 Jul 10.
23. PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity. Nakamura Y, etal., EMBO J. 2011 Feb 16;30(4):719-30. doi: 10.1038/emboj.2010.357. Epub 2011 Jan 21.
24. Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes. Pan L, etal., EMBO J. 2007 Oct 31;26(21):4576-87. Epub 2007 Oct 4.
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis. Rocca DL, etal., Nat Cell Biol. 2008 Mar;10(3):259-71. doi: 10.1038/ncb1688. Epub 2008 Feb 24.
28. The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity. Rocca DL, etal., Neuron. 2013 Jul 24;79(2):293-307. doi: 10.1016/j.neuron.2013.05.003.
29. NMDA receptors mediate calcium-dependent, bidirectional changes in dendritic PICK1 clustering. Sossa KG, etal., Mol Cell Neurosci. 2006 Mar;31(3):574-85. Epub 2006 Jan 10.
30. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
31. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Thorsen TS, etal., Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):413-8. doi: 10.1073/pnas.0902225107. Epub 2009 Dec 14.
32. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Torres R, etal., Neuron. 1998 Dec;21(6):1453-63.
33. Protein scaffolds, lipid domains and substrate recognition in protein kinase C function: implications for rational drug design. Walker JW Handb Exp Pharmacol. 2008;(186):185-203.
34. Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Xia J, etal., Neuron 1999 Jan;22(1):179-87.
Additional References at PubMed
PMID:7844141   PMID:9405395   PMID:10567402   PMID:10623590   PMID:11343649   PMID:11375398   PMID:11466413   PMID:12526085   PMID:12826667   PMID:14672991   PMID:15190111   PMID:15458844  
PMID:15895086   PMID:16314870   PMID:17302911   PMID:18184314   PMID:18429931   PMID:18466293   PMID:18492472   PMID:18755154   PMID:19321442   PMID:19644508   PMID:20403402   PMID:21176140  
PMID:21527319   PMID:22129425   PMID:22624977   PMID:22915106   PMID:23697999   PMID:23823934   PMID:23918399   PMID:24069373   PMID:24831007   PMID:25392508   PMID:25475687   PMID:26306493  
PMID:26702130   PMID:26868290   PMID:28057533   PMID:28404816   PMID:28888867   PMID:28951554   PMID:29768204   PMID:30605082  


Genomics

Comparative Map Data
Pick1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87112,676,890 - 112,697,275 (+)NCBIGRCr8
mRatBN7.27110,796,623 - 110,816,850 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7110,797,117 - 110,816,848 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,545,653 - 112,564,970 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07114,769,189 - 114,788,506 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07114,738,549 - 114,757,866 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,465,472 - 120,484,824 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,465,130 - 120,484,840 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,459,118 - 120,478,470 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,213,299 - 117,232,651 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,247,528 - 117,266,879 (+)NCBI
Celera7107,131,151 - 107,150,407 (+)NCBICelera
Cytogenetic Map7q34NCBI
PICK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,057,255 - 38,075,701 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,056,311 - 38,075,701 (+)EnsemblGRCh38hg38GRCh38
GRCh372238,453,262 - 38,471,708 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362236,783,208 - 36,801,654 (+)NCBINCBI36Build 36hg18NCBI36
Build 342236,777,902 - 36,796,207NCBI
Celera2222,255,002 - 22,273,457 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2221,417,897 - 21,436,386 (+)NCBIHuRef
CHM1_12238,411,992 - 38,430,442 (+)NCBICHM1_1
T2T-CHM13v2.02238,518,878 - 38,537,327 (+)NCBIT2T-CHM13v2.0
Pick1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,113,373 - 79,133,666 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,113,373 - 79,133,684 (+)EnsemblGRCm39 Ensembl
GRCm381579,229,140 - 79,249,466 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,229,173 - 79,249,484 (+)EnsemblGRCm38mm10GRCm38
MGSCv371579,059,604 - 79,079,896 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,057,068 - 79,076,715 (+)NCBIMGSCv36mm8
Celera1581,348,804 - 81,369,231 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.7NCBI
Pick1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,383,130 - 24,399,196 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541324,383,130 - 24,399,092 (+)NCBIChiLan1.0ChiLan1.0
POLR2F
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22347,812,190 - 47,900,125 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12250,500,550 - 50,602,004 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02218,868,872 - 18,988,918 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12236,796,053 - 36,814,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2236,796,015 - 36,814,469 (+)Ensemblpanpan1.1panPan2
PICK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,595,301 - 26,614,170 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,595,768 - 26,613,756 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,550,611 - 26,569,400 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,387,103 - 27,406,123 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,387,124 - 27,406,155 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11027,107,123 - 27,126,143 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,418,687 - 27,437,706 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,595,780 - 27,614,797 (-)NCBIUU_Cfam_GSD_1.0
Pick1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494510,087,798 - 10,105,588 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364923,097,629 - 3,116,526 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364923,098,196 - 3,115,921 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PICK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,808,451 - 9,825,539 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,808,444 - 9,829,677 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.257,208,317 - 7,225,652 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PICK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11920,758,199 - 20,778,210 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1920,759,960 - 20,779,514 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045104,992,571 - 105,011,487 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pick1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,880,670 - 9,895,230 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,880,773 - 9,895,270 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pick1
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:68
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000016077
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016077   ⟹   ENSRNOP00000016077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7110,797,117 - 110,816,848 (+)Ensembl
Rnor_6.0 Ensembl7120,465,130 - 120,484,840 (+)Ensembl
RefSeq Acc Id: NM_053460   ⟹   NP_445912
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,677,545 - 112,697,275 (+)NCBI
mRatBN7.27110,797,117 - 110,816,848 (+)NCBI
Rnor_6.07120,465,472 - 120,484,824 (+)NCBI
Rnor_5.07120,459,118 - 120,478,470 (+)NCBI
RGSC_v3.47117,213,299 - 117,232,651 (+)RGD
Celera7107,131,151 - 107,150,407 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079986   ⟹   XP_038935914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,676,890 - 112,697,259 (+)NCBI
mRatBN7.27110,796,657 - 110,816,850 (+)NCBI
RefSeq Acc Id: XM_063264344   ⟹   XP_063120414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87112,687,935 - 112,697,259 (+)NCBI
RefSeq Acc Id: NP_445912   ⟸   NM_053460
- UniProtKB: Q9EP80 (UniProtKB/Swiss-Prot),   Q925D1 (UniProtKB/Swiss-Prot),   Q546X4 (UniProtKB/Swiss-Prot),   Q6GQQ2 (UniProtKB/TrEMBL),   A6HSQ7 (UniProtKB/TrEMBL),   A6HSQ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016077   ⟸   ENSRNOT00000016077
RefSeq Acc Id: XP_038935914   ⟸   XM_039079986
- Peptide Label: isoform X1
- UniProtKB: Q9EP80 (UniProtKB/Swiss-Prot),   Q925D1 (UniProtKB/Swiss-Prot),   Q546X4 (UniProtKB/Swiss-Prot),   Q6GQQ2 (UniProtKB/TrEMBL),   A6HSQ7 (UniProtKB/TrEMBL),   A6HSQ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120414   ⟸   XM_063264344
- Peptide Label: isoform X2
- UniProtKB: A6HSQ8 (UniProtKB/TrEMBL)
Protein Domains
AH   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EP80-F1-model_v2 AlphaFold Q9EP80 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695478
Promoter ID:EPDNEW_R6003
Type:initiation region
Name:Pick1_1
Description:protein interacting with PRKCA 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07120,465,118 - 120,465,178EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69437 AgrOrtholog
BIND 130432
  144347
  144355
BioCyc Gene G2FUF-32768 BioCyc
Ensembl Genes ENSRNOG00000011507 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055031568 UniProtKB/Swiss-Prot
  ENSRNOG00060023479 UniProtKB/Swiss-Prot
  ENSRNOG00065033195 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016077.7 UniProtKB/TrEMBL
  ENSRNOT00055054692 UniProtKB/Swiss-Prot
  ENSRNOT00060040717 UniProtKB/Swiss-Prot
  ENSRNOT00065057081 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105747 IMAGE-MGC_LOAD
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arfaptin_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PICK1_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84591 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91578 IMAGE-MGC_LOAD
NCBI Gene 84591 ENTREZGENE
PANTHER PRKCA-BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arfaptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pick1 PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50870 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011507 RatGTEx
  ENSRNOG00055031568 RatGTEx
  ENSRNOG00060023479 RatGTEx
  ENSRNOG00065033195 RatGTEx
SMART Arfaptin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HSQ5 ENTREZGENE, UniProtKB/TrEMBL
  A6HSQ7 ENTREZGENE, UniProtKB/TrEMBL
  A6HSQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6HSQ9_RAT UniProtKB/TrEMBL
  PICK1_RAT UniProtKB/Swiss-Prot
  Q546X4 ENTREZGENE
  Q6GQQ2 ENTREZGENE
  Q925D1 ENTREZGENE
  Q9EP80 ENTREZGENE
UniProt Secondary Q546X4 UniProtKB/Swiss-Prot
  Q6GQQ2 UniProtKB/TrEMBL
  Q925D1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Pick1  protein interacting with PRKCA 1  Pick1  protein interacting with C kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pick1  protein interacting with C kinase 1  Prkcabp  protein kinase C, alpha binding protein  Symbol and Name updated 1299863 APPROVED
2004-09-10 Prkcabp  protein kinase C, alpha binding protein  Pick1  protein that interacts with C kinase 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Pick1  protein that interacts with C kinase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the dorsal cochlear nucleus, anteroventral cochlear nucleus, posteroventral cochlear nucleus, some divisions of the superior olivary complex, inferior colliculus, medial geniculate body, and primary auditory cortex 1299219
gene_function interacts with the C-terminal tail region of various receptors 1299218
gene_mutations_overexpression mutation in the carboxylate-binding loop in the PDZ domain abolishes its binding to PKC-alpha 68719
gene_mutations_overexpression mutation in the carboxylate-binding loop in the PDZ domain abolishes its binding to PKC-alpha 69384
gene_physical_interaction binds protein kinase C-alpha (Prkca) and B-cell translocation gene 2 (Btg2) through a PDZ domain 68719
gene_physical_interaction binds protein kinase C-alpha (Prkca) and B-cell translocation gene 2 (Btg2) through a PDZ domain 69384
gene_physical_interaction interacts with the C-terminal tail region of mGluR7 1299218
gene_process induces clustering of EphB2 receptor and AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors involved in synaptic transmission 68719
gene_process induces clustering of EphB2 receptor and AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors involved in synaptic transmission 69384
gene_process may act as an intracellular receptor for protein kinase C and modulate Btg2 phosphorylation 68719
gene_process may act as an intracellular receptor for protein kinase C and modulate Btg2 phosphorylation 69384
gene_process may regulate PKCalpha and GluR2 localization in components of the rat auditory system 1299219