Miox (myo-inositol oxygenase) - Rat Genome Database

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Gene: Miox (myo-inositol oxygenase) Rattus norvegicus
Analyze
Symbol: Miox
Name: myo-inositol oxygenase
RGD ID: 628739
Description: Enables NADP binding activity. Predicted to be involved in inositol catabolic process. Predicted to be located in cytoplasm and inclusion body. Orthologous to human MIOX (myo-inositol oxygenase); PARTICIPATES IN inositol metabolic pathway; ascorbate and aldarate metabolic pathway; inositol phosphate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: aldehyde reductase (aldose reductase) like 6; aldehyde reductase-like 6; Aldrl6; inositol oxygenase; kidney-specific protein 32; MI oxygenase; renal-specific oxido-reductase; renal-specific oxidoreductase; RSOR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27120,405,031 - 120,407,529 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,405,031 - 120,407,537 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,155,669 - 122,158,167 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07124,381,826 - 124,384,324 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07124,344,535 - 124,347,033 (+)NCBIRnor_WKY
Rnor_6.07130,308,707 - 130,311,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,308,532 - 130,313,727 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07129,994,009 - 129,996,507 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,632,433 - 127,634,931 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,666,662 - 127,669,160 (+)NCBI
Celera7116,878,837 - 116,881,335 (+)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
inositol catabolic process  (IBA,IEA,ISO,ISS)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
inclusion body  (ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Identification of a renal-specific oxido-reductase in newborn diabetic mice. Yang Q, etal., Proc Natl Acad Sci U S A 2000 Aug 29;97(18):9896-901.
Additional References at PubMed
PMID:11716759   PMID:12477932   PMID:15489334   PMID:15504367   PMID:18364358   PMID:19053028   PMID:23376485   PMID:26578517  


Genomics

Comparative Map Data
Miox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27120,405,031 - 120,407,529 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,405,031 - 120,407,537 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,155,669 - 122,158,167 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.07124,381,826 - 124,384,324 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.07124,344,535 - 124,347,033 (+)NCBIRnor_WKY
Rnor_6.07130,308,707 - 130,311,205 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,308,532 - 130,313,727 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07129,994,009 - 129,996,507 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,632,433 - 127,634,931 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,666,662 - 127,669,160 (+)NCBI
Celera7116,878,837 - 116,881,335 (+)NCBICelera
Cytogenetic Map7q34NCBI
MIOX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,486,859 - 50,490,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2250,486,784 - 50,490,648 (+)EnsemblGRCh38hg38GRCh38
GRCh372250,925,288 - 50,929,077 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,272,079 - 49,275,616 (+)NCBINCBI36Build 36hg18NCBI36
Build 342249,215,356 - 49,218,894NCBI
Celera2234,801,247 - 34,804,784 (+)NCBICelera
Cytogenetic Map22q13.33NCBI
HuRef2233,815,598 - 33,819,135 (+)NCBIHuRef
CHM1_12250,883,973 - 50,887,497 (+)NCBICHM1_1
T2T-CHM13v2.02250,996,041 - 50,999,830 (+)NCBIT2T-CHM13v2.0
Miox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,218,676 - 89,221,210 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,218,601 - 89,221,218 (+)EnsemblGRCm39 Ensembl
GRCm381589,334,473 - 89,337,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,334,398 - 89,337,015 (+)EnsemblGRCm38mm10GRCm38
MGSCv371589,164,904 - 89,167,438 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361589,162,240 - 89,164,774 (+)NCBIMGSCv36mm8
Celera1591,463,588 - 91,466,122 (+)NCBICelera
Cytogenetic Map15E3NCBI
Miox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541333,476,033 - 33,478,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541333,476,097 - 33,478,539 (+)NCBIChiLan1.0ChiLan1.0
MIOX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12249,720,339 - 49,724,370 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2249,720,339 - 49,724,370 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02230,735,206 - 30,738,738 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MIOX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,813,532 - 16,815,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1016,813,545 - 16,818,015 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1016,790,954 - 16,795,346 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,539,689 - 17,542,009 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,539,608 - 17,544,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,263,991 - 17,268,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,587,203 - 17,591,592 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,719,250 - 17,723,642 (-)NCBIUU_Cfam_GSD_1.0
Miox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945355,356 - 357,742 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936629355,517 - 357,678 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIOX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5248,235 - 251,553 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15249,312 - 251,547 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25110,529,984 - 110,532,905 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIOX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11932,953,268 - 32,960,123 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1932,957,256 - 32,961,023 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604592,380,757 - 92,383,861 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Miox
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000011941
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat

Markers in Region
AW108536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,406,767 - 120,406,979 (+)MAPPERmRatBN7.2
Rnor_6.07130,310,444 - 130,310,655NCBIRnor6.0
Rnor_5.07129,995,746 - 129,995,957UniSTSRnor5.0
RGSC_v3.47127,634,170 - 127,634,381UniSTSRGSC3.4
Celera7116,880,574 - 116,880,785UniSTS
Cytogenetic Map7q34UniSTS
RH131425  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 3
Medium 17 17 17 24
Low 3 9 40 24 19 24 8 8 9 4 19 10 8
Below cutoff 6 3 4 2 14 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011941   ⟹   ENSRNOP00000011941
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,405,031 - 120,407,528 (+)Ensembl
Rnor_6.0 Ensembl7130,308,532 - 130,313,727 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119874   ⟹   ENSRNOP00000087792
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,405,507 - 120,407,537 (+)Ensembl
RefSeq Acc Id: NM_145771   ⟹   NP_665714
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.27120,405,031 - 120,407,529 (+)NCBI
Rnor_6.07130,308,707 - 130,311,205 (+)NCBI
Rnor_5.07129,994,009 - 129,996,507 (+)NCBI
RGSC_v3.47127,632,433 - 127,634,931 (+)RGD
Celera7116,878,837 - 116,881,335 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_665714   ⟸   NM_145771
- UniProtKB: Q99PN7 (UniProtKB/Swiss-Prot),   Q9QXN4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011941   ⟸   ENSRNOT00000011941
RefSeq Acc Id: ENSRNOP00000087792   ⟸   ENSRNOT00000119874

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXN4-F1-model_v2 AlphaFold Q9QXN4 1-285 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695582
Promoter ID:EPDNEW_R6107
Type:multiple initiation site
Name:Miox_1
Description:myo-inositol oxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6108  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07130,308,556 - 130,308,616EPDNEW
RGD ID:13695583
Promoter ID:EPDNEW_R6108
Type:multiple initiation site
Name:Miox_2
Description:myo-inositol oxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6107  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07130,308,688 - 130,308,748EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628739 AgrOrtholog
BioCyc Gene G2FUF-32444 BioCyc
Ensembl Genes ENSRNOG00000008694 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011941 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000087792.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011941 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000119874.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110224 IMAGE-MGC_LOAD
InterPro Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Inositol_oxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:252899 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93474 IMAGE-MGC_LOAD
NCBI Gene 252899 ENTREZGENE
PANTHER PTHR12588 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Miox PhenoGen
PROSITE ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHH0_RAT UniProtKB/TrEMBL
  A0A8I6GFH1_RAT UniProtKB/TrEMBL
  MIOX_RAT UniProtKB/Swiss-Prot
  Q99PN7 ENTREZGENE
  Q9QXN4 ENTREZGENE
UniProt Secondary Q5S8C8 UniProtKB/Swiss-Prot
  Q68G06 UniProtKB/Swiss-Prot
  Q99PN7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-11 Miox  myo-inositol oxygenase  Aldrl6  aldehyde reductase (aldose reductase) like 6  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-12-14 Aldrl6  aldehyde reductase (aldose reductase) like 6      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Aldrl6  aldehyde reductase (aldose reductase) like 6      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in renal proximal tubules 631888
gene_product member of the aldo-keto reductase family 631888