Pdgfb (platelet derived growth factor subunit B) - Rat Genome Database

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Gene: Pdgfb (platelet derived growth factor subunit B) Rattus norvegicus
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Symbol: Pdgfb
Name: platelet derived growth factor subunit B
RGD ID: 3283
Description: Enables signaling receptor binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of nucleobase-containing compound metabolic process; and response to peptide hormone. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study asthma; brain infarction; glomerulonephritis; and visual epilepsy. Biomarker of cholestasis; hypertension (multiple); liver cirrhosis; oligohydramnios; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; glioma pathway; INTERACTS WITH (+)-dihydromyricetin; (S)-nicotine; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: c-sis; pdgf protein; PDGF subunit B; PDGF-2; platelet derived growth factor, B polypeptide; platelet derived growth factor-bb; Platelet-derived growth factor; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor same as Sis (Simian sarcoma viral oncogene homologue c-sis); platelet-derived growth factor subunit B; Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); SIS
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,419,882 - 113,438,343 (-)NCBIGRCr8
mRatBN7.27111,539,444 - 111,557,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,540,345 - 111,557,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,288,390 - 113,306,033 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,511,934 - 115,529,580 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,481,281 - 115,498,926 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,215,458 - 121,233,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,214,628 - 121,232,741 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,205,505 - 121,223,140 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,244,385 - 118,262,021 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,279,553 - 118,295,832 (-)NCBI
Celera7107,869,873 - 107,887,412 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenylosuccinase lyase deficiency  (ISO)
AIDS Dementia Complex  (ISO)
Alzheimer's disease  (ISO)
asthma  (IMP,ISO)
background diabetic retinopathy  (ISO)
basal ganglia disease  (ISO)
Brain Hypoxia-Ischemia  (IEP)
brain infarction  (IMP)
Brain Injuries  (IEP)
calcinosis  (ISO)
cholestasis  (IEP)
choriocarcinoma  (ISO)
Chronic Allograft Nephropathy  (IEP)
clear cell renal cell carcinoma  (ISO)
COVID-19  (ISO)
dermatofibrosarcoma protuberans  (ISO)
Diabetic Nephropathies  (ISO)
essential thrombocythemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
familial meningioma  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
genetic disease  (ISO)
Gingival Hyperplasia  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (IMP)
graft-versus-host disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
high grade glioma  (ISO)
Hyperoxic Lung Injury  (IEP)
hypertension  (IEP)
Idiopathic Basal Ganglia Calcification 1  (ISO)
Idiopathic Basal Ganglia Calcification 5  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Kidney Reperfusion Injury  (IEP)
Kuhnt-Junius degeneration  (ISO)
leiomyoma  (ISO)
Leydig cell tumor  (ISO)
liver cirrhosis  (IEP)
Liver Injury  (IEP)
Lymphatic Metastasis  (ISO)
meningioma  (ISO)
Neointima  (IEP)
Neoplasm Metastasis  (ISO)
oligohydramnios  (IEP)
Optic Nerve Injuries  (IEP)
pancreatitis  (ISO)
Penetrating Head Injuries  (IEP)
Periapical Diseases  (IEP)
proliferative diabetic retinopathy  (ISO)
prostate carcinoma  (ISO)
prostatic hypertrophy  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IEP,ISO)
retinal disease  (ISO)
rheumatoid arthritis  (ISO)
sinusitis  (ISO)
Spinal Cord Injuries  (ISO)
Tibial Fractures  (ISO)
ureteral obstruction  (IEP)
visual epilepsy  (IMP)
Wounds and Injuries  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dihydromyricetin  (EXP)
(+)-taxifolin  (ISO)
(S)-nicotine  (EXP,ISO)
11-deoxycorticosterone  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6,7-dimethoxy-2-phenylquinoxaline  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
ADP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
anagrelide  (ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
BAPTA  (EXP)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bivalirudin  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clopidogrel  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP)
cyanidin cation  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
desferrioxamine B  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl malate  (ISO)
dihydrolipoic acid  (EXP)
dimethyl fumarate  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylparaben  (ISO)
fenhexamid  (ISO)
ferroheme b  (ISO)
folic acid  (ISO)
gadolinium trichloride  (EXP)
genistein  (ISO)
Glutathione ethyl ester  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
heme b  (ISO)
hemin  (ISO)
heparin  (EXP)
hydrogen peroxide  (EXP)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lipoxin A4  (ISO)
losartan  (EXP)
luteolin  (EXP)
LY294002  (EXP,ISO)
mabuterol  (EXP)
malvidin  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mevalonic acid  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodimethylamine  (EXP)
nebivolol  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nicotine  (EXP,ISO)
nitrofen  (EXP)
oleic acid  (ISO)
ozone  (ISO)
palbociclib  (ISO)
Panaxynol  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
peonidin  (ISO)
peonidin chloride  (ISO)
perindopril  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
ramipril  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salvianolic acid A  (EXP)
salvianolic acid B  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vildagliptin  (ISO)
Vitisin A  (EXP)
warfarin  (EXP)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
blood vessel development  (ISO)
blood vessel morphogenesis  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
cell chemotaxis  (ISO,ISS)
cell migration  (ISO)
cell projection assembly  (ISO)
cellular response to angiotensin  (IEP)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to mycophenolic acid  (IDA)
cellular response to platelet-derived growth factor stimulus  (ISO,ISS)
embryonic placenta development  (ISO,ISS)
endothelial cell proliferation  (ISO)
epithelial cell proliferation involved in salivary gland morphogenesis  (ISO)
eye photoreceptor cell development  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
fibroblast migration  (ISO)
gene expression  (IEA,ISO)
glial cell development  (ISO)
heart development  (ISO,ISS)
hemopoiesis  (ISO,ISS)
interleukin-18-mediated signaling pathway  (IEA,ISO)
male gonad development  (IEP)
metanephric glomerular endothelium development  (ISO)
metanephric glomerular mesangial cell development  (ISO,ISS)
metanephric glomerular mesangial cell proliferation involved in metanephros development  (ISO)
monocyte chemotaxis  (IEA,ISO,ISS)
myoblast proliferation  (IEP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (IEA,ISO,ISS)
negative regulation of miRNA transcription  (IEA,ISO)
negative regulation of phosphatidylinositol biosynthetic process  (IEA,ISO,ISS)
negative regulation of platelet activation  (IEA,ISO,ISS)
negative regulation of vascular associated smooth muscle cell differentiation  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
neuron remodeling  (ISO)
paracrine signaling  (ISO,ISS)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
platelet-derived growth factor receptor signaling pathway  (IBA,IMP,ISO,NAS)
positive chemotaxis  (IEA)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO,ISS)
positive regulation of calcium ion import  (IEA,ISO,ISS)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (IBA,ISO)
positive regulation of cell population proliferation  (IBA,ISO,ISS)
positive regulation of cell-substrate adhesion  (IEA,ISO)
positive regulation of chemotaxis  (IEA,ISO,ISS)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of DNA biosynthetic process  (IEA,ISO,ISS)
positive regulation of DNA replication  (IMP)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of endothelial cell proliferation  (IEA,ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (IBA,IEA,ISO,ISS)
positive regulation of fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of fibroblast proliferation  (IEA,ISO,ISS)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of glomerular filtration  (ISO,ISS)
positive regulation of glomerular mesangial cell proliferation  (IEA,ISO,ISS)
positive regulation of hepatic stellate cell activation  (IMP)
positive regulation of hepatic stellate cell proliferation  (IMP)
positive regulation of hyaluronan biosynthetic process  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of metanephric mesenchymal cell migration  (IDA,ISO)
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  (IEA,ISO,ISS)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of mitotic cell cycle, embryonic  (ISO)
positive regulation of mitotic nuclear division  (IEA,ISO,ISS)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO,ISS)
positive regulation of protein autophosphorylation  (IBA,IEA,ISO,ISS)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO,ISS)
positive regulation of smooth muscle cell migration  (IMP,ISO)
positive regulation of smooth muscle cell proliferation  (IMP,ISO,ISS)
positive regulation of vascular associated smooth muscle cell dedifferentiation  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell migration  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (IEA,ISO)
protein kinase C signaling  (IEA,ISO)
reactive oxygen species metabolic process  (IEA,ISO,ISS)
regulation of cell population proliferation  (IEP)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
response to axon injury  (IEP)
response to estradiol  (IEP)
response to estrogen  (IEP)
response to human chorionic gonadotropin  (IEP)
response to hypoxia  (IEP)
response to insulin  (IEP)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to wounding  (IEA,ISO,ISS)
response to xenobiotic stimulus  (IEP)
retina development in camera-type eye  (ISO)
retina vasculature development in camera-type eye  (ISO)
substrate-dependent cell migration  (ISO)
synapse assembly  (ISO)
vascular associated smooth muscle cell migration  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Expression of platelet-derived growth factor-A (PDGF-A), PDGF-B, and PDGF receptor-alpha and -beta during human testicular development and disease. Basciani S, etal., J Clin Endocrinol Metab. 2002 May;87(5):2310-9.
2. HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1. Bethel-Brown C, etal., J Immunol. 2011 Apr 1;186(7):4119-29. Epub 2011 Mar 2.
3. Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease. Bjorkqvist M, etal., PLoS One. 2012;7(1):e29868. doi: 10.1371/journal.pone.0029868. Epub 2012 Jan 18.
4. Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis. Borkham-Kamphorst E, etal., Biochem Biophys Res Commun. 2004 Aug 20;321(2):413-23.
5. Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC). Breitkopf K, etal., Cytokine. 2005 Sep 7;31(5):349-57.
6. Oligohydramnios decreases platelet-derived growth factor expression in fetal rat lungs. Chen CM, etal., Neonatology. 2007;92(3):187-93. Epub 2007 May 21.
7. Platelet-derived growth factor-BB accelerates prostate cancer growth by promoting the proliferation of mesenchymal stem cells. Cheng J, etal., J Cell Biochem. 2013 Jul;114(7):1510-8. doi: 10.1002/jcb.24492.
8. Temporal changes in gene expression following cryogenic rat brain injury. Cook JL, etal., Brain Res Mol Brain Res. 1998 Mar 30;55(1):9-19.
9. Sources of PDGF expression in murine retina and the effect of short-term diabetes. Cox OT, etal., Mol Vis. 2003 Dec 10;9:665-72.
10. Angiotensin II stimulates platelet-derived growth factor-B chain expression in newborn rat vascular smooth muscle cells and neointimal cells through Ras, extracellular signal-regulated protein kinase, and c-Jun N-terminal protein kinase mechanisms. Deguchi J, etal., Circ Res. 1999 Oct 1;85(7):565-74.
11. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Distler JH, etal., Arthritis Rheum. 2007 Jan;56(1):311-22.
12. Diabetes-induced impairment of macrophage cytokine release in a rat model: potential role of serum lipids. Doxey DL, etal., Life Sci. 1998;63(13):1127-36.
13. The PDGF B-chain is involved in the ontogenic susceptibility of the developing rat brain to NMDA toxicity. Egawa-Tsuzuki T, etal., Exp Neurol. 2004 Mar;186(1):89-98.
14. Hypoxia regulates PDGF-B interactions between glomerular capillary endothelial and mesangial cells. Eng E, etal., Kidney Int. 2005 Aug;68(2):695-703.
15. Soluble angiogenic factors in patients with acute pancreatitis. Espinosa L, etal., J Clin Gastroenterol. 2011 Aug;45(7):630-7.
16. Increased expression of PDGF-B (c-sis) mRNA in rat lung precedes DNA synthesis and tissue repair during chronic hyperoxia. Fabisiak JP, etal., Am J Respir Cell Mol Biol. 1989 Sep;1(3):181-9.
17. Innate immunity, through late complement components activation, contributes to the development of early vascular inflammation and morphologic alterations in experimental diabetes. Fischetti F, etal., Atherosclerosis. 2011 May;216(1):83-9. Epub 2011 Mar 1.
18. Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor. Fretto LJ, etal., J Biol Chem. 1993 Feb 15;268(5):3625-31.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Dermatofibrosarcoma protuberans of the vulva and groin: detection of COL1A1-PDGFB fusion transcripts by RT-PCR. Gokden N, etal., J Cutan Pathol. 2003 Mar;30(3):190-5.
22. Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats. Grappone C, etal., J Hepatol. 1999 Jul;31(1):100-9.
23. Determination of cytokine mRNA-expression in term human placenta of patients with gestational hypertension, intrauterine growth retardation and gestational diabetes mellitus using polymerase chain reaction. Heinig J, etal., Zentralbl Gynakol. 2000;122(8):413-8.
24. Conservation in sequence and affinity of human and rodent PDGF ligands and receptors. Herren B, etal., Biochim Biophys Acta 1993 Jun 25;1173(3):294-302.
25. In vivo role of platelet-derived growth factor-BB in airway smooth muscle proliferation in mouse lung. Hirota JA, etal., Am J Respir Cell Mol Biol. 2011 Sep;45(3):566-72. Epub 2011 Jan 7.
26. Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-BB and an injectable beta-tricalcium phosphate/collagen matrix. Hollinger JO, etal., J Orthop Res. 2008 Jan;26(1):83-90.
27. Successive activation of the platelet-derived growth factor beta receptor and platelet-derived growth factor B genes correlates with the genesis of human choriocarcinoma. Holmgren L, etal., Cancer Res. 1993 Jun 15;53(12):2927-31.
28. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
29. [Effects of quercetin and enalapril on amount of PDGF-B and VEGF-1 in kidney of diabetic rats] Huang H, etal., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005 Aug;22(4):791-4.
30. Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migration. Ishizawa K, etal., J Endocrinol. 2009 Aug;202(2):309-16. doi: 10.1677/JOE-08-0469. Epub 2009 May 21.
31. PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation. Jiang Y, etal., Neoplasia. 2011 Jun;13(6):492-503.
32. Increased expression of PDGF A- and B-chain genes in rat lungs with hypoxic pulmonary hypertension. Katayose D, etal., Am J Physiol. 1993 Feb;264(2 Pt 1):L100-6.
33. Crosstalk between platelet-derived growth factor-induced Nox4 activation and MUC8 gene overexpression in human airway epithelial cells. Kim HJ, etal., Free Radic Biol Med. 2011 May 1;50(9):1039-52. Epub 2011 Jan 19.
34. Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease. Kumagai S, etal., Tohoku J Exp Med. 2001 Sep;195(1):21-33.
35. Differential expression of protooncogenes related to transformation and cancer progression in rat myoblasts. Leibovitch SA, etal., Cancer Res. 1986 Aug;46(8):4097-103.
36. Expression and functional analysis of platelet-derived growth factor in uterine leiomyomata. Liang M, etal., Cancer Biol Ther. 2006 Jan;5(1):28-33. Epub 2006 Jan 12.
37. Role of basic fibroblast growth factor and platelet-derived growth factor (B-chain) in neointima formation after arterial injury. Lindner V Z Kardiol. 1995;84 Suppl 4:137-44.
38. A subpopulation of smooth muscle cells in injured rat arteries expresses platelet-derived growth factor-B chain mRNA. Lindner V, etal., Circ Res 1995 Jun;76(6):951-7.
39. Antisense oligonucleotides for PDGF-B and its receptor inhibit mechanical strain-induced fetal lung cell growth. Liu M, etal., Am J Physiol. 1995 Aug;269(2 Pt 1):L178-84.
40. Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis. Liu X, etal., Mult Scler. 2005 Aug;11(4):381-9.
41. Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells. Lo HM, etal., Biochem Pharmacol. 2007 Jun 30;74(1):54-63. Epub 2007 Mar 24.
42. Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis. Lo Re S, etal., Am J Respir Crit Care Med. 2011 Dec 1;184(11):1270-81. Epub 2011 Aug 25.
43. Combined VEGF and PDGF treatment reduces secondary degeneration after spinal cord injury. Lutton C, etal., J Neurotrauma. 2012 Mar 20;29(5):957-70. Epub 2011 Aug 9.
44. Inhibition of matrix metalloproteinases during chronic allograft nephropathy in rats. Lutz J, etal., Transplantation. 2005 Mar 27;79(6):655-61.
45. Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of unique intercellular carbon structures that bridge alveolar macrophages in situ. Mangum JB, etal., Part Fibre Toxicol. 2006 Nov 29;3:15.
46. Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis. Maurer B, etal., Ann Rheum Dis. 2012 Apr 20.
47. Platelet-derived growth factor B-chain expression in the rat retina and optic nerve: distribution and changes after transection of the optic nerve. Mekada A, etal., Vision Res. 1998 Oct;38(20):3031-9.
48. Hypoxia-inducible factor-1 alpha/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling. Mermis J, etal., Respir Res. 2011 Aug 5;12:103.
49. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
50. Simultaneous changes in high-fat and high-cholesterol diet-induced steatohepatitis and severe fibrosis and those underlying molecular mechanisms in novel SHRSP5/Dmcr rat. Moriya T, etal., Environ Health Prev Med. 2012 Mar 11.
51. Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer. Najy AJ, etal., Mol Cancer Res. 2012 Aug;10(8):1087-97. doi: 10.1158/1541-7786.MCR-12-0071. Epub 2012 Jun 11.
52. Immunohistochemical characterization of glomerular PDGF B-chain and PDGF beta-receptor expression in diabetic rats. Nakagawa H, etal., Diabetes Res Clin Pract. 2000 May;48(2):87-98.
53. Role of PDGF B-chain and PDGF receptors in rat tubular regeneration after acute injury. Nakagawa T, etal., Am J Pathol. 1999 Nov;155(5):1689-99.
54. mRNA expression of growth factors in glomeruli from diabetic rats. Nakamura T, etal., Diabetes. 1993 Mar;42(3):450-6.
55. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
56. Novel regulation of adrenomedullin receptor by PDGF: role of receptor activity modifying protein-3. Nowak W, etal., Am J Physiol Cell Physiol 2002 Jun;282(6):C1322-31.
57. Expression of platelet-derived growth factor B-chain and beta-receptor in hypoxic/ischemic encephalopathy of neonatal rats. Ohno M, etal., Neuroscience. 1999 May;90(2):643-51.
58. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
59. Specific antagonism of PDGF prevents renal scarring in experimental glomerulonephritis. Ostendorf T, etal., J Am Soc Nephrol. 2001 May;12(5):909-18.
60. In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodimeric proteins. Pierce GF, etal., J Exp Med. 1988 Mar 1;167(3):974-87.
61. Expression of platelet-derived growth factor in a model of acute liver injury. Pinzani M, etal., Hepatology. 1994 Mar;19(3):701-7.
62. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
63. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
64. Gene expression profile of cytokines in patients with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation with reduced conditioning. Poloni A, etal., Cytokine. 2011 Mar;53(3):376-83. Epub 2011 Jan 5.
65. Vitreous and serum levels of vascular endothelial growth factor and platelet-derived growth factor and their correlation in patients with non-proliferative diabetic retinopathy and clinically significant macula oedema. Praidou A, etal., Acta Ophthalmol. 2011 May;89(3):248-54. doi: 10.1111/j.1755-3768.2009.01661.x.
66. Low differentiated microvascular density and low expression of platelet-derived growth factor-BB (PDGF-BB) predict distant metastasis and poor prognosis in clear cell renal cell carcinoma. Qi L, etal., BJU Int. 2013 Aug;112(4):E415-23. doi: 10.1111/bju.12191.
67. von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter. Rafty LA and Khachigian LM, J Cell Biochem 2002;85(3):490-5.
68. Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1. Remmers EF, etal., J Rheumatol. 1991 Jan;18(1):7-13.
69. GOA pipeline RGD automated data pipeline
70. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
71. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
72. Mycophenolic acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells. Sabuda-Widemann D, etal., Nephrol Dial Transplant. 2009 Jan;24(1):52-61. doi: 10.1093/ndt/gfn462. Epub 2008 Aug 22.
73. Platelet-derived growth factor B-chain comprises the major part of enhanced released mitogen from aortic endothelial cells of stroke-prone spontaneously hypertensive rats. Sasahara M, etal., Clin Exp Pharmacol Physiol Suppl. 1995 Dec;22(1):S123-5.
74. The effect of acute rejection and cyclosporin A-treatment on induction of platelet-derived growth factor and its receptors during the development of chronic rat renal allograft rejection. Savikko J, etal., Transplantation. 2002 Feb 27;73(4):506-11.
75. Estrogen regulates insulin-like growth factor 1, platelet-derived growth factor A and B, and their receptors in the vascular wall. Savolainen-Peltonen H, etal., Transplantation. 2004 Jan 15;77(1):35-42.
76. Increased expression of platelet-derived growth factor associated protein-1 is associated with PDGF-B mediated glioma progression. Sharma VK, etal., Int J Biochem Cell Biol. 2016 Sep;78:194-205. doi: 10.1016/j.biocel.2016.07.016. Epub 2016 Jul 19.
77. Platelet-derived growth factors and receptors in the rat corpus luteum: localization and identification of an effect on luteogenesis. Sleer LS and Taylor CC, Biol Reprod. 2007 Mar;76(3):391-400. Epub 2006 Nov 15.
78. Time course of cytokine mRNA expression in kidneys of rats with unilateral ureteral obstruction. Sommer M, etal., Nephron. 2000 Jan;84(1):49-57.
79. Platelet-derived growth factor B-chain-like immunoreactivity in injured rat brain. Takayama S, etal., Brain Res. 1994 Aug 8;653(1-2):131-40.
80. Activation of Src kinase in platelet-derived growth factor-B-dependent tubular regeneration after acute ischemic renal injury. Takikita-Suzuki M, etal., Am J Pathol. 2003 Jul;163(1):277-86.
81. Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. Tang WW, etal., Am J Pathol. 1996 Apr;148(4):1169-80.
82. Persistent roles of signal transduction of platelet-derived growth factor B in genesis, growth, and anaplastic transformation of gliomas in an in-vivo serial transplantation model. Torisu R, etal., Brain Tumor Pathol. 2011 Feb;28(1):33-42. Epub 2011 Jan 6.
83. Glomerular expression of platelet-derived growth factor (PDGF)-A, -B chain and PDGF receptor-alpha, -beta in human diabetic nephropathy. Uehara G, etal., Clin Exp Nephrol. 2004 Mar;8(1):36-42.
84. Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. Usui S, etal., J Biol Chem 2004 Mar 26;279(13):12300-11. Epub 2004 Jan 07.
85. Inhibition of platelet-derived growth factor actions in the embryonic testis influences normal cord development and morphology. Uzumcu M, etal., Biol Reprod. 2002 Mar;66(3):745-53.
86. Comparison of molecular determinants of angiogenesis and lymphangiogenesis in lymph node metastases and in primary tumours of patients with breast cancer. Van den Eynden GG, etal., J Pathol. 2007 Sep;213(1):56-64.
87. [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing] Wang HJ, etal., Fa Yi Xue Za Zhi. 2001 Nov;17(4):198-201, 204.
88. Correlation between platelet-derived growth factor B chain and bone resorption in rat periapical lesions. Wang L and Peng B, J Endod. 2007 Jun;33(6):709-11. Epub 2007 Apr 17.
89. Effect of platelet-derived growth factor-B on renal cell carcinoma growth and progression. Wang W, etal., Urol Oncol. 2015 Apr;33(4):168.e17-27. doi: 10.1016/j.urolonc.2014.12.015. Epub 2015 Mar 9.
90. Decreased immunoreactivity of platelet-derived growth factor B chain-like peptide after axotomy in the dorsal motor nucleus of the vagus nerve. Yamada E and Hazama F, Brain Res. 1994 Jul 18;651(1-2):108-14.
91. The angiotensin I-converting enzyme inhibitor, cilazapril inhibits the platelet-derived growth factor B chain expression in glomeruli of spontaneously hypertensive rats. Yamauchi T, etal., Ren Physiol Biochem. 1995 Sep-Oct;18(5):237-45.
92. Hepatic Stimulator Substance Alleviates Toxin-Induced and Immune-Mediated Liver Injury and Fibrosis in Rats. Yi X, etal., Dig Dis Sci. 2012 Apr 27.
93. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Yokota T, etal., Diabetes. 2003 Mar;52(3):838-45.
94. A role for platelet-derived growth factor-BB in rat postpneumonectomy compensatory lung growth. Yuan S, etal., Pediatr Res. 2002 Jul;52(1):25-33.
95. Systemic upregulation of PDGF-B in patients with neovascular AMD. Zehetner C, etal., Invest Ophthalmol Vis Sci. 2014 Jan 20;55(1):337-44. doi: 10.1167/iovs.13-12978.
96. Glioma-Derived Platelet-Derived Growth Factor-BB Recruits Oligodendrocyte Progenitor Cells via Platelet-Derived Growth Factor Receptor-a and Remodels Cancer Stroma. Zheng Y, etal., Am J Pathol. 2016 May;186(5):1081-91. doi: 10.1016/j.ajpath.2015.12.020. Epub 2016 Mar 3.
97. Possible predictive markers related to micro-metastasis in breast cancer patients. Zhu L, etal., Oncol Rep. 2006 May;15(5):1217-23.
Additional References at PubMed
PMID:291037   PMID:1396586   PMID:2439522   PMID:2536956   PMID:2538439   PMID:2836953   PMID:7073684   PMID:8889548   PMID:8900172   PMID:9409235   PMID:9685360   PMID:9693135  
PMID:10375497   PMID:10644978   PMID:10734101   PMID:11264163   PMID:11788434   PMID:11903042   PMID:11940581   PMID:12070119   PMID:12171932   PMID:12176888   PMID:12753322   PMID:14751865  
PMID:15021824   PMID:15084468   PMID:15183724   PMID:15681847   PMID:15919073   PMID:16019429   PMID:16368696   PMID:16456542   PMID:16530387   PMID:16644864   PMID:16893901   PMID:16971352  
PMID:16990553   PMID:17324121   PMID:17442164   PMID:17533428   PMID:17654489   PMID:17893914   PMID:17942966   PMID:17991872   PMID:18180311   PMID:18483410   PMID:18559345   PMID:18775895  
PMID:18827006   PMID:19019919   PMID:19088079   PMID:19133316   PMID:19426591   PMID:19442606   PMID:19691150   PMID:19880494   PMID:20307544   PMID:20452974   PMID:20718713   PMID:20860549  
PMID:21092652   PMID:21158157   PMID:21245329   PMID:21245381   PMID:21321938   PMID:21351537   PMID:21435466   PMID:21451101   PMID:21792920   PMID:21803557   PMID:22488213   PMID:22619279  
PMID:23103565   PMID:23139410   PMID:23179587   PMID:23298764   PMID:23460471   PMID:23554459   PMID:23979707   PMID:24008408   PMID:24100802   PMID:24248537   PMID:24397990   PMID:24472833  
PMID:24591339   PMID:25089138   PMID:25224828   PMID:25684702   PMID:25899145   PMID:26262503   PMID:26311435   PMID:26493107   PMID:28738389   PMID:28791754   PMID:29786113   PMID:30257103  
PMID:32647179   PMID:33520084  


Genomics

Comparative Map Data
Pdgfb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,419,882 - 113,438,343 (-)NCBIGRCr8
mRatBN7.27111,539,444 - 111,557,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,540,345 - 111,557,984 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,288,390 - 113,306,033 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,511,934 - 115,529,580 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,481,281 - 115,498,926 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,215,458 - 121,233,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,214,628 - 121,232,741 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,205,505 - 121,223,140 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,244,385 - 118,262,021 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,279,553 - 118,295,832 (-)NCBI
Celera7107,869,873 - 107,887,412 (-)NCBICelera
Cytogenetic Map7q34NCBI
PDGFB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,223,359 - 39,244,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,223,359 - 39,244,982 (-)EnsemblGRCh38hg38GRCh38
GRCh372239,619,364 - 39,640,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,949,665 - 37,970,936 (-)NCBINCBI36Build 36hg18NCBI36
Build 342237,944,218 - 37,961,419NCBI
Celera2223,421,845 - 23,443,115 (-)NCBICelera
Cytogenetic Map22q13.1ENTREZGENE
HuRef2222,586,719 - 22,607,974 (-)NCBIHuRef
CHM1_12239,578,202 - 39,599,467 (-)NCBICHM1_1
T2T-CHM13v2.02239,694,033 - 39,715,652 (-)NCBIT2T-CHM13v2.0
Pdgfb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,880,066 - 79,899,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,880,075 - 79,899,178 (-)EnsemblGRCm39 Ensembl
GRCm381579,995,865 - 80,024,614 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,995,874 - 80,014,977 (-)EnsemblGRCm38mm10GRCm38
MGSCv371579,826,304 - 79,845,238 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,823,129 - 79,842,063 (-)NCBIMGSCv36mm8
Celera1582,118,153 - 82,136,874 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Pdgfb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,148,062 - 25,166,987 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,150,702 - 25,166,987 (-)NCBIChiLan1.0ChiLan1.0
PDGFB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,068,209 - 49,089,303 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,759,600 - 51,779,759 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,127,223 - 20,148,407 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,944,018 - 37,964,883 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,944,018 - 37,964,883 (-)Ensemblpanpan1.1panPan2
PDGFB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,798,877 - 25,819,422 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,798,938 - 25,817,746 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,734,794 - 25,753,108 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,550,122 - 26,571,489 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,551,117 - 26,571,479 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,264,832 - 26,283,141 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,584,490 - 26,602,860 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,760,558 - 26,778,890 (+)NCBIUU_Cfam_GSD_1.0
Pdgfb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,343,420 - 9,358,195 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,353,841 - 2,368,573 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,353,840 - 2,368,573 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,986,462 - 9,007,435 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,330,898 - 6,333,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDGFB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,865,792 - 21,888,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,863,768 - 21,886,395 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045103,877,990 - 103,890,183 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdgfb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,072,512 - 9,088,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,072,471 - 9,088,289 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdgfb
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:170
Interacting mature miRNAs:194
Transcripts:ENSRNOT00000023196
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 3 1 4 50 29 18 11 1
Low 3 20 50 34 16 34 7 7 24 6 23 7
Below cutoff 7 7 7

Sequence


RefSeq Acc Id: ENSRNOT00000023196   ⟹   ENSRNOP00000023196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,540,345 - 111,557,984 (-)Ensembl
Rnor_6.0 Ensembl7121,214,628 - 121,232,741 (-)Ensembl
RefSeq Acc Id: NM_031524   ⟹   NP_113712
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,420,709 - 113,438,343 (-)NCBI
mRatBN7.27111,540,344 - 111,557,984 (-)NCBI
Rnor_6.07121,215,458 - 121,233,092 (-)NCBI
Rnor_5.07121,205,505 - 121,223,140 (-)NCBI
RGSC_v3.47118,244,385 - 118,262,021 (-)RGD
Celera7107,869,873 - 107,887,412 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078420   ⟹   XP_038934348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,419,882 - 113,429,633 (-)NCBI
mRatBN7.27111,539,444 - 111,549,272 (-)NCBI
RefSeq Acc Id: XM_063262996   ⟹   XP_063119066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,419,882 - 113,433,911 (-)NCBI
RefSeq Acc Id: NP_113712   ⟸   NM_031524
- Peptide Label: precursor
- UniProtKB: G3V882 (UniProtKB/TrEMBL),   A0A221LG85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023196   ⟸   ENSRNOT00000023196
RefSeq Acc Id: XP_038934348   ⟸   XM_039078420
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119066   ⟸   XM_063262996
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05028-F1-model_v2 AlphaFold Q05028 1-225 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3283 AgrOrtholog
BioCyc Gene G2FUF-32726 BioCyc
Ensembl Genes ENSRNOG00000017197 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023196 ENTREZGENE
  ENSRNOT00000023196.6 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PD_growth_factor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF/VEGF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24628 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24628 ENTREZGENE
PANTHER PLATELET-DERIVED GROWTH FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11633:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdgfb PhenoGen
PROSITE PDGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017197 RatGTEx
SMART PDGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A221LG85 ENTREZGENE, UniProtKB/TrEMBL
  G3V882 ENTREZGENE, UniProtKB/TrEMBL
  PDGFB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-25 Pdgfb  platelet derived growth factor subunit B  Pdgfb  platelet-derived growth factor beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Pdgfb  platelet-derived growth factor beta polypeptide  Pdgfb  platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Pdgfb  platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)  Pdgfb  platelet derived growth factor, B polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pdgfb  Platelet-derived growth factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process increases the expression and mRNA stability of Ramp3 631307