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Gene: Pdgfb (platelet derived growth factor subunit B) Rattus norvegicus
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Symbol: Pdgfb
Name: platelet derived growth factor subunit B
Description: Exhibits signaling receptor binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of cell population proliferation; and response to peptide hormone. Localizes to several cellular components, including the basolateral plasma membrane; extracellular space; and neuronal cell body. Used to study asthma; brain infarction; glomerulonephritis; and visual epilepsy. Biomarker of cholestasis; hypertension (multiple); liver cirrhosis; oligohydramnios; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and malignant glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; glioma pathway; INTERACTS WITH (+)-dihydromyricetin; 11-deoxycorticosterone; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: c-sis; pdgf protein; PDGF subunit B; PDGF-2; platelet derived growth factor, B polypeptide; platelet derived growth factor-bb; Platelet-derived growth factor; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor same as Sis (Simian sarcoma viral oncogene homologue c-sis); platelet-derived growth factor subunit B; Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); SIS
Orthologs:
Homo sapiens (human) : PDGFB (platelet derived growth factor subunit B)  HGNC  Alliance
Mus musculus (house mouse) : Pdgfb (platelet derived growth factor, B polypeptide)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfb (platelet derived growth factor subunit B)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFB (platelet derived growth factor subunit B)
Canis lupus familiaris (dog) : PDGFB (platelet derived growth factor subunit B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfb (platelet derived growth factor subunit B)
Sus scrofa (pig) : PDGFB (platelet derived growth factor subunit B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07121,215,458 - 121,233,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07121,205,505 - 121,223,140 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,244,385 - 118,262,021 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17118,279,553 - 118,295,832 (-)NCBI
Celera7107,869,873 - 107,887,412 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pdgfb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3283
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.