Trhr (thyrotropin releasing hormone receptor)

Gene: Trhr (thyrotropin releasing hormone receptor) Rattus norvegicus

Analyze

Symbol:

Trhr

Name:

thyrotropin releasing hormone receptor

RGD ID:

3904

Description:

Enables identical protein binding activity and thyrotropin-releasing hormone receptor activity. Involved in positive regulation of cytosolic calcium ion concentration and positive regulation of protein-containing complex assembly. Located in cell surface. Used to study hypertension. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,2',4,4',5,5'-hexachlorobiphenyl; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

thyroliberin receptor; thyrotropin-releasing hormone receptor; TRH-R

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TRHR (thyrotropin releasing hormone receptor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Trhr (thyrotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Trhr (thyrotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TRHR (thyrotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TRHR (thyrotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Trhr (thyrotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TRHR (thyrotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TRHR (thyrotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Trhr (thyrotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RASGRP4 (RAS guanyl releasing protein 4)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Trhr (thyrotropin releasing hormone receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TRHR (thyrotropin releasing hormone receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	trhra (thyrotropin-releasing hormone receptor a)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	trhrb (thyrotropin-releasing hormone receptor b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ETHR	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	trhr-1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	trhr	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	agtr1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)

Is Marker For:

Strains: SS.LEW-(D7Rat73-D7Rat128)/Ayd LEW.SS-(D7Rat73-D7Rat128)/Ayd

Candidate Gene For:

Ept7

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	77,233,175 - 77,277,988 (+)	NCBI		GRCr8
mRatBN7.2	7	75,348,672 - 75,393,310 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	75,348,672 - 75,393,309 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	77,174,030 - 77,218,735 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	79,376,541 - 79,421,226 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	79,269,664 - 79,314,345 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	83,113,641 - 83,153,520 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	83,113,672 - 83,153,519 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	83,121,134 - 83,161,215 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	80,050,671 - 80,095,991 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	80,071,435 - 80,116,717 (+)	NCBI
Celera	7	72,334,405 - 72,378,742 (+)	NCBI		Celera
Cytogenetic Map	7	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital hypothyroidism (ISS)

congenital nongoitrous hypothyroidism 7 (ISO)

genetic disease (ISO)

hypertension (IDA)

hypothyroidism (ISO)

thyroid hormone resistance syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

adinazolam (EXP)

aflatoxin B1 (ISO)

alprazolam (EXP)

ammonium chloride (EXP)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (EXP)

carbonyl sulfide (EXP)

CGP 52608 (ISO)

chlordiazepoxide (EXP)

corticosterone (EXP)

DDE (EXP)

decabromodiphenyl ether (EXP)

diazepam (EXP)

dibutyl phthalate (ISO)

estazolam (EXP)

fenvalerate (EXP)

flurazepam (EXP)

folic acid (ISO)

genistein (ISO)

glyphosate (ISO)

kainic acid (EXP)

lead diacetate (EXP)

melatonin (ISO)

midazolam (EXP)

morphine (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (EXP)

picrotoxin (EXP)

potassium dichromate (ISO)

tetrachloromethane (EXP)

triazolam (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IBA)

positive regulation of cytosolic calcium ion concentration (IDA)

positive regulation of protein-containing complex assembly (IDA)

Cellular Component

cell surface (IDA)

plasma membrane (IEA)

Molecular Function

identical protein binding (IPI)

protein binding (ISO)

thyrotropin-releasing hormone receptor activity (IBA,IDA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calcium-mediated signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Cloning and expression of the thyrotropin-releasing hormone receptor from GH3 rat anterior pituitary cells.	de la Pena P, etal., Biochem J 1992 Jun 15;284 ( Pt 3):891-9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Estradiol transcriptionally and posttranscriptionally up-regulates thyrotropin-releasing hormone receptor messenger ribonucleic acid in rat pituitary cells.	Kimura N, etal., Endocrinology 1994 Jan;134(1):432-40.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	A truncated isoform of the thyrotropin-releasing hormone receptor is expressed in the rat central nervous system as well as in the pituitary gland.	Satoh T, etal., Brain Res Mol Brain Res 1993 Dec;20(4):353-6.
12.	Functional expression and molecular characterization of the thyrotrophin-releasing hormone receptor from the rat anterior pituitary gland.	Sellar RE, etal., J Mol Endocrinol 1993 Apr;10(2):199-206.
13.	Antisense to thyrotropin releasing hormone receptor reduces arterial blood pressure in spontaneously hypertensive rats.	Suzuki S, etal., Circ Res. 1995 Oct;77(4):679-83.
14.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15.	Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.	Zhu CC, etal., J Biol Chem 2002 Aug 2;277(31):28228-37.

Additional References at PubMed

PMID:1317787	PMID:1334485	PMID:1338727	PMID:1373613	PMID:8889548	PMID:11278883	PMID:12393857	PMID:15879366	PMID:15905217	PMID:15944919	PMID:16257458	PMID:18795335
PMID:20691166

Genomics

Comparative Map Data

Trhr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	77,233,175 - 77,277,988 (+)	NCBI		GRCr8
mRatBN7.2	7	75,348,672 - 75,393,310 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	75,348,672 - 75,393,309 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	77,174,030 - 77,218,735 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	79,376,541 - 79,421,226 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	79,269,664 - 79,314,345 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	83,113,641 - 83,153,520 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	83,113,672 - 83,153,519 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	83,121,134 - 83,161,215 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	80,050,671 - 80,095,991 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	80,071,435 - 80,116,717 (+)	NCBI
Celera	7	72,334,405 - 72,378,742 (+)	NCBI		Celera
Cytogenetic Map	7	q31	NCBI

TRHR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	109,086,585 - 109,121,565 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	109,086,585 - 109,121,565 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	110,098,814 - 110,133,794 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	110,168,900 - 110,200,989 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	110,168,901 - 110,200,989	NCBI
Celera	8	106,287,347 - 106,319,484 (+)	NCBI		Celera
Cytogenetic Map	8	q23.1	NCBI
HuRef	8	105,421,383 - 105,453,868 (+)	NCBI		HuRef
CHM1_1	8	110,139,931 - 110,172,069 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	110,215,119 - 110,250,098 (+)	NCBI		T2T-CHM13v2.0

Trhr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	44,059,314 - 44,099,308 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	44,059,531 - 44,099,308 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	44,195,924 - 44,235,912 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	44,196,135 - 44,235,912 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	44,027,681 - 44,067,458 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	44,026,307 - 44,065,986 (+)	NCBI		MGSCv36	mm8
Celera	15	44,658,539 - 44,700,386 (+)	NCBI		Celera
Cytogenetic Map	15	B3.2	NCBI
cM Map	15	16.82	NCBI

Trhr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	16,529,293 - 16,565,359 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	16,529,293 - 16,565,359 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRHR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	126,461,619 - 126,504,116 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	101,984,988 - 102,020,610 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	105,739,651 - 105,780,470 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	107,886,593 - 107,918,825 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	107,886,593 - 107,918,825 (+)	Ensembl	panpan1.1		panPan2

TRHR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	9,642,565 - 9,681,778 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	9,642,387 - 9,674,831 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	9,626,666 - 9,666,386 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	9,923,346 - 9,963,040 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	9,923,867 - 9,956,094 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	9,666,106 - 9,705,368 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	9,782,697 - 9,821,730 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	9,871,822 - 9,911,555 (+)	NCBI		UU_Cfam_GSD_1.0

Trhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	28,375,898 - 28,418,063 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	35,806,397 - 35,844,267 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	35,808,569 - 35,844,062 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRHR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	28,436,758 - 28,482,893 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	28,480,637 - 28,482,031 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	30,819,213 - 31,155,972 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRHR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	103,798,423 - 103,835,284 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	103,800,175 - 103,831,628 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	36,743,423 - 36,777,184 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trhr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624763	8,192,356 - 8,258,958 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624763	8,191,550 - 8,255,274 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Trhr
376 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	227
Count of miRNA genes:	144
Interacting mature miRNAs:	180
Transcripts:	ENSRNOT00000006783
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	47651439	92651439	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	43228750	88228750	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	59238038	104238038	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	29409683	84928080	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	47651439	92651439	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	37960569	82960569	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	47651439	92651439	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	31112832	76112832	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	42787314	87787314	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	47651439	92651439	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	34293282	79293282	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	53612714	103945643	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	62004452	101773158	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	46590070	91590070	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	43747099	102228765	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	34293282	79293282	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	47651439	92651439	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	47651439	92651439	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	47651439	92651439	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	61074194	106074194	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	44867533	89867533	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	62004452	101773158	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat

Markers in Region

RH144005

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	75,392,973 - 75,393,255 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	83,153,184 - 83,153,465	NCBI	Rnor6.0
Rnor_5.0	7	83,160,879 - 83,161,160	UniSTS	Rnor5.0
RGSC_v3.4	7	80,095,655 - 80,095,936	UniSTS	RGSC3.4
Celera	7	72,378,406 - 72,378,687	UniSTS
RH 3.4 Map	7	516.6	UniSTS
Cytogenetic Map	7	q31	UniSTS

Related Rat Strains

The following Strains have been annotated to Trhr

LEW.SS-(D7Rat73-D7Rat128)/Ayd SS.LEW-(D7Rat73-D7Rat128)/Ayd

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low		6		6				46	10	4
Below cutoff	1	14	8	3	8	2	2	22	9	22	6	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594675	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594676	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063263031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AW522207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M90308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S69160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S69161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X64630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X66726	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006783 ⟹ ENSRNOP00000006783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	75,348,672 - 75,393,309 (+)	Ensembl
Rnor_6.0 Ensembl	7	83,113,672 - 83,153,519 (+)	Ensembl

RefSeq Acc Id:

NM_013047 ⟹ NP_037179

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	77,233,354 - 77,277,988 (+)	NCBI
mRatBN7.2	7	75,348,672 - 75,393,310 (+)	NCBI
Rnor_6.0	7	83,113,672 - 83,153,520 (+)	NCBI
Rnor_5.0	7	83,121,134 - 83,161,215 (+)	NCBI
RGSC_v3.4	7	80,050,671 - 80,095,991 (+)	RGD
Celera	7	72,334,405 - 72,378,742 (+)	RGD

Sequence:

show sequence

CTATGGTTTGACAGCCTCTGTGCTGCTCCTGCTGCTTCTGTTACTGCGGCTGTGTGGTCTGTCA
TGAGTTGAGACGGGATGTGAGGGTTTAGAGAAACTGCCGCTCTGAAGCCTGAGCCTCTGCTCAG
TGATCTTCCTGCCAGAGGGACTGGACAAGATTTCTTCTGCATGATTGGAAACTTGGACCTATTA
GCACGTCATCTACCCAGAGAAGCAGGCAGCGTGACAGAGTGAAGAGGGGAAGGAACTACTGCAG
AAACAAGCAAACAGCACAAAAGGTGGAGGCTGGAAAGATGTTTTAGAAAGTCTCTGTGTCAGAG
AAGCTTCAAGCCACTGAAGATGGAGAATGAAACCGTCAGTGAACTGAACCAAACCGAGCTCCCG
CCGCAAGTAGCCGTGGCCCTCGAGTACCAGGTGGTCACCATCTTACTTGTGGTGGTTATCTGTG
GACTGGGCATTGTGGGCAACATCATGGTAGTCCTGGTGGTCATGAGAACGAAGCACATGAGAAC
CGCTACAAACTGCTACCTGGTGAGTCTGGCTGTGGCGGATCTCATGGTCCTGGTGGCTGCAGGC
CTCCCCAACATCACCGACAGCATCTATGGTTCCTGGGTCTATGGCTATGTTGGCTGCCTCTGCA
TCACGTATCTCCAGTACTTAGGAATTAACGCATCTTCATGCTCAATAACAGCCTTTACCATTGA
GAGGTACATAGCAATCTGCCACCCCATCAAAGCCCAGTTTCTGTGCACATTTTCCAGAGCCAAA
AAAATCATTATCTTTGTCTGGGCCTTTACATCCATTTACTGTATGCTGTGGTTCTTCCTTCTGG
ATCTCAATATCAGCACCTACAAAGATGCTATTGTGATATCCTGTGGCTACAAGATCTCCCGCAA
CTACTACTCACCTATTTACCTAATGGACTTTGGCGTCTTTTATGTCATGCCAATGATCCTGGCC
ACTGTGCTTTACGGGTTTATAGCTAGAATCCTCTTCTTAAACCCCATTCCTTCAGACCCTAAAG
AAAACTCTAAGACGTGGAAAAATGACTCAACCCATCAGAACAAGAATATGAATTTAAACACCAC
CAACAGATGTTTCAACAGCACCGTTTCTTCCAGGAAGCAGGTCACCAAGATGCTTGCAGTGGTT
GTAATTCTGTTTGCCCTTTTATGGATGCCCTACAGGACTCTTGTGGTTGTCAACTCATTTCTCT
CCAGCCCTTTCCAGGAAAATTGGTTCTTGCTCTTTTGCAGAATTTGCATTTATCTCAACAGTGC
CATCAACCCGGTGATTTACAACCTCATGTCTCAGAAGTTTCGTGCAGCCTTCAGGAAGCTCTGC
AATTGCAAGCAGAAGCCCACTGAGAAAGCTGCTAACTACAGTGTGGCCCTAAATTACAGTGTCA
TCAAGGAGTCAGACCGCTTTAGCACAGAGCTAGATGACATCACCGTCACTGACACGTATGTGTC
AACCACAAAAGTATCATTTGATGACACCTGCTTGGCCTCCGAGAAGAATGGACCCAGTTCTTGT
ACATATGGATATTCTTTGACTGCCAAACAGGAGAAAATATGAACTTCCTCAAGAATACCTTGGG
CTGGTATTAATAAAGGAAATCTTTCAAAAAATTCAATGTGACTCAAAAAGATCCAACTGATCGA
AGGTCTTCATTCAGAAGTCAGTAAGAACATCGTGATACTTAAATGGTACAGGGTGGCACAATAA
GGAAGCAAACATCTAATCCCTAGCCATGAGGACAAGCCACTCCTGTTTTGATATATATATATAC
AAATTACTGGCATGCTTTTCCTTAATGTGTCTCTCTTTCTCAAAATAACTGTTATTTGCCAGAT
GACTCTGAACACATCCTGGAAACCAATTTGTTCTGAGCCTCCACATATGTCCTTCAATACCCTT
GAATACCAAATAATTCTGAATAGGCAAGTTAAACAGAAAATCCCATGGAGGACAAGTTCATTTC
ATGTTTGTCTCCAAGAAATTGAACTAAGATGCTGAGCTCAACATTGACTTTCTCTTGAATGAAT
GAACGAACGAACGAAAGAATGAATGAACATGAATAAGTAAATTTATGAATCTCCAACTAAGAAA
TATAACGTAAAATCTTCATGATGCCTGATTTCCTCATAGATTTGTTCACAAATATAAAACTTGT
TTGCCTTTTGTTTTTATCATCTTAAACCATTCTCTTGGCTTATTAAAATGTACTATATTTTGTC
AGATCATGGTCACCACCATCTCTGTGTATATATTATGAATACAAAGTTCAATAGTACTCTCAAA
TCTCTCACCTAATTTAATAATGATCAAGATTATTACATGTATGTTCAGAGAATAACAACATACT
ATCACTGACATGTGAATAAAATTAAATGTGCAGAGTACATGGTAGGAAGAGAAGTTATATGATT
TCAGATTACAAACCTTAGAATTCCTCATTGGGAAAAGAATATCAGGGGGGTGCTAGAGTAATTA
GAACAACCTCATAGGAAAGCTTGAATTTCTTATAAGAATAGACTTGGCTTAGATAGGAAAAGAC
AAGTGATGTAAGGAAAGAGAGGTGAGTAAGGGTAGGAGGAAAAGAAACAAACTCTAGGTGTAAT
GGATAATGTGTCCAGTTAAGTGTGACTCATTGGGGATTGATCAAGGCAAGCAACTAGAAGAAAG
GAAAGAAGGGAAATAAAGTATTTCCTGATTATTGTATTTGTTGAGGAAATAGTCAGCCAGACAG
GTGGTAGATGTGTATATTAGTAAGCTGTCATGTATTTTCTAAACATTGTAAATTTCACTTATTA
TCTATAAAAATGTAGTATGCTATTTGTCTCCTAAGTGTTATAATTCTGTAAGTATCCTAAAGTC
ATAATTTCCAGGTAAAAACTAATTGTATATGTGTATATCTTTTCTATATTGCACTGTTATCATA
TATGGGATATATTTATTTATGTATATATGATTCAGAGGTCCTTAACAGCCATGAAGTTATCCAG
TTATGCTCACCGTAGAGATCCAAGCTAGCTCATAGGCCCTTCATATGCCTAAGCATCCATATTA
AATGAGAAACTGATAAGCAGTGACAAGCTTCTAATGCCCTCACCCTGTTGACTTGCATGCTGCT
TATATCGTGCTCCTGAATGCTTGGTTTCTTACAACATGCCTCTGAATGTTTTGGTTTCCTTTTA
CCATTTGTAGAGAGCTGTATACTCACTCATCTCATTGCTTGGAGATCAATCATTGTGTCCGTGT
GGAAAAATAATCTCCTTTAAGAAAGTGCAGTATTATGTGTTCTCTCTGCAATGGGAAACTATTA
CTGTATGTGTATGCATGCACAATAAAGTATCAAACTGAAAGATCCAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063263031 ⟹ XP_063119101

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	77,233,175 - 77,277,982 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_037179	(Get FASTA)	NCBI Sequence Viewer
	XP_063119101	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA42277	(Get FASTA)	NCBI Sequence Viewer
	AAB29945	(Get FASTA)	NCBI Sequence Viewer
	AAB29946	(Get FASTA)	NCBI Sequence Viewer
	CAA45913	(Get FASTA)	NCBI Sequence Viewer
	CAA47263	(Get FASTA)	NCBI Sequence Viewer
	EDM16314	(Get FASTA)	NCBI Sequence Viewer
	EDM16315	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006783.4
GenBank Protein	Q01717	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037179 ⟸ NM_013047

- UniProtKB:

Q63948 (UniProtKB/Swiss-Prot), Q63949 (UniProtKB/Swiss-Prot), Q01717 (UniProtKB/Swiss-Prot), A6HRA7 (UniProtKB/TrEMBL), G3V6M9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYL
VSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAIC
HPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIY
LMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNS
TVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIY
NLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSF
DDTCLASEKNGPSSCTYGYSLTAKQEKI

hide sequence

Ensembl Acc Id:

ENSRNOP00000006783 ⟸ ENSRNOT00000006783

RefSeq Acc Id:	XP_063119101 ⟸ XM_063263031
- Peptide Label:	isoform X1
- UniProtKB:	A6HRA7 (UniProtKB/TrEMBL), G3V6M9 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q01717-F1-model_v2	AlphaFold	Q01717	1-412	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3904	AgrOrtholog
BioCyc Gene	G2FUF-33484	BioCyc
Ensembl Genes	ENSRNOG00000005048	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000006783.6	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRH_rcpt_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25570	UniProtKB/Swiss-Prot
NCBI Gene	25570	ENTREZGENE
PANTHER	PTHR46061	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	THYROTROPIN-RELEASING HORMONE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Trhr	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	THYROLIBRINR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRHRFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005048	RatGTEx
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC218150
UniProt	A6HRA7	ENTREZGENE, UniProtKB/TrEMBL
	A6HRA8_RAT	UniProtKB/TrEMBL
	G3V6M9	ENTREZGENE, UniProtKB/TrEMBL
	Q01717	ENTREZGENE
	Q63948	ENTREZGENE
	Q63949	ENTREZGENE
	TRFR_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q63948	UniProtKB/Swiss-Prot
	Q63949	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Trhr	Thyrotropin releasing hormone receptor			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_protein	forms monomers and dimers	730055
gene_regulation	receptor dimerization and phosphorylation increases in the presence of thyrotropin-releasing hormone	730055

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)