Trhr (thyrotropin releasing hormone receptor) - Rat Genome Database

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Gene: Trhr (thyrotropin releasing hormone receptor) Mus musculus
Analyze
Symbol: Trhr
Name: thyrotropin releasing hormone receptor
RGD ID: 11453
MGI Page MGI
Description: Predicted to enable identical protein binding activity and thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of protein-containing complex assembly. Predicted to act upstream of or within signal transduction. Predicted to be located in cell surface. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and skeleton. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; dibutyl phthalate; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC124380; MGC124381; thyroliberin receptor; thyrotropin-releasing hormone receptor; TRH-; TRH-R; TRH-R1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391544,059,314 - 44,099,308 (+)NCBIGRCm39mm39
GRCm39 Ensembl1544,059,531 - 44,099,308 (+)Ensembl
GRCm381544,195,924 - 44,235,912 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1544,196,135 - 44,235,912 (+)EnsemblGRCm38mm10GRCm38
MGSCv371544,027,681 - 44,067,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv361544,026,307 - 44,065,986 (+)NCBImm8
Celera1544,658,539 - 44,700,386 (+)NCBICelera
Cytogenetic Map15B3.2NCBI
cM Map1516.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1324930   PMID:2175902   PMID:7903570   PMID:8243797   PMID:8297470   PMID:8592728   PMID:8858346   PMID:9013814   PMID:9141550   PMID:9156522   PMID:10066258   PMID:10349636  
PMID:10673341   PMID:11042159   PMID:11076861   PMID:11181534   PMID:11217851   PMID:11285235   PMID:11852232   PMID:12477932   PMID:12593718   PMID:14630711   PMID:14681479   PMID:14988432  
PMID:15181539   PMID:15245428   PMID:15709754   PMID:16141072   PMID:16141073   PMID:16183993   PMID:16602821   PMID:17666589   PMID:17849455   PMID:17979196   PMID:18799693   PMID:19357273  
PMID:20702572   PMID:21677750   PMID:21873635   PMID:22593547   PMID:23143598   PMID:23303050   PMID:24952961   PMID:25490146   PMID:28883467   PMID:31375626   PMID:33084572  


Genomics

Comparative Map Data
Trhr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391544,059,314 - 44,099,308 (+)NCBIGRCm39mm39
GRCm39 Ensembl1544,059,531 - 44,099,308 (+)Ensembl
GRCm381544,195,924 - 44,235,912 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1544,196,135 - 44,235,912 (+)EnsemblGRCm38mm10GRCm38
MGSCv371544,027,681 - 44,067,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv361544,026,307 - 44,065,986 (+)NCBImm8
Celera1544,658,539 - 44,700,386 (+)NCBICelera
Cytogenetic Map15B3.2NCBI
cM Map1516.82NCBI
TRHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8109,086,585 - 109,121,565 (+)EnsemblGRCh38hg38GRCh38
GRCh388109,086,585 - 109,121,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378110,098,814 - 110,133,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368110,168,900 - 110,200,989 (+)NCBINCBI36hg18NCBI36
Build 348110,168,901 - 110,200,989NCBI
Celera8106,287,347 - 106,319,484 (+)NCBI
Cytogenetic Map8q23.1NCBI
HuRef8105,421,383 - 105,453,868 (+)NCBIHuRef
CHM1_18110,139,931 - 110,172,069 (+)NCBICHM1_1
Trhr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2775,348,672 - 75,393,310 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl775,348,672 - 75,393,309 (+)Ensembl
Rnor_6.0783,113,641 - 83,153,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl783,113,672 - 83,153,519 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0783,121,134 - 83,161,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4780,050,671 - 80,095,991 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1780,071,435 - 80,116,717 (+)NCBI
Celera772,334,405 - 72,378,742 (+)NCBICelera
Cytogenetic Map7q31NCBI
Trhr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541716,529,293 - 16,565,359 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541716,529,293 - 16,565,359 (+)NCBIChiLan1.0ChiLan1.0
TRHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18107,886,593 - 107,918,825 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8107,886,593 - 107,918,825 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08105,739,651 - 105,780,470 (+)NCBIMhudiblu_PPA_v0panPan3
TRHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1139,642,565 - 9,681,778 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl139,642,387 - 9,674,831 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha139,626,666 - 9,666,386 (+)NCBI
ROS_Cfam_1.0139,923,346 - 9,963,040 (+)NCBI
UMICH_Zoey_3.1139,666,106 - 9,705,368 (+)NCBI
UNSW_CanFamBas_1.0139,782,697 - 9,821,730 (+)NCBI
UU_Cfam_GSD_1.0139,871,822 - 9,911,555 (+)NCBI
Trhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530328,375,898 - 28,418,063 (-)NCBI
SpeTri2.0NW_00493647035,808,569 - 35,844,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl428,436,758 - 28,482,893 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1428,480,637 - 28,482,031 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2430,819,213 - 31,155,972 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18103,798,423 - 103,835,284 (+)NCBI
ChlSab1.1 Ensembl8103,800,175 - 103,831,628 (+)Ensembl
Vero_WHO_p1.0NW_02366603936,743,423 - 36,777,184 (-)NCBI
Trhr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247638,191,550 - 8,255,274 (+)NCBI

Position Markers
M94384  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381544,234,571 - 44,234,764UniSTSGRCm38
MGSCv371544,066,117 - 44,066,310UniSTSGRCm37
Celera1544,699,045 - 44,699,238UniSTS
Cytogenetic Map15B3.2UniSTS
Whitehead_YAC15 UniSTS
Trhr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371544,028,826 - 44,029,126UniSTSGRCm37
Celera1544,659,676 - 44,659,976UniSTS
Cytogenetic Map15B3.2UniSTS
cM Map1524.7UniSTS
Trhr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381544,197,280 - 44,197,580UniSTSGRCm38
MGSCv371544,028,826 - 44,029,126UniSTSGRCm37
Celera1544,659,676 - 44,659,976UniSTS
Cytogenetic Map15B3.2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15344490771325689Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined346021278717086Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined346021278717086Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined346021278717086Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15346021278717086Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15346021278717086Mouse
26884384Skwq12_mskull length QTL 12, 16 week (mouse)15610000050900000Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15610000068400000Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15610000071600000Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15610000072600000Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15610000076000000Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15610000076500000Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15610000078800000Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
26884429Zlq6_mzygomatic length QTL 6, 10 week (mouse)15680000045100000Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15690000076000000Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15690000076000000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15720000055400000Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15760000055400000Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15760000059400000Mouse
26884439Sklq11_mskull length QTL 11, 10 week (mouse)15810000047800000Mouse
4141192Ssrq2_mstress response QTL 2 (mouse)Not determined927293656323454Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927293679590561Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
1302165Yv_myellow value (mouse)Not determined151384686047847002Mouse
1301020Pheo_mpheomelanin (mouse)Not determined151384686047847002Mouse
1301951Eila3_methanol induced locomotor activity 3 (mouse)Not determined151492744148927610Mouse
4141423Nstr2_mnerve sheath tumor resistance QTL 2 (mouse)Not determined1492744148927610Mouse
1302007Bbaa14_mB.burgdorferi-associated arthritis 14 (mouse)Not determined151492744148927610Mouse
1301499Bdln2_mbody length 2 (mouse)Not determined151564519749645324Mouse
12859288Criq1_mCitrobacter rodentium infection QTL 1 (mouse)151603380850033808Mouse
26884423Zlq10_mzygomatic length QTL 10, 16 week (mouse)152060000050900000Mouse
14928313Manh78_mmandible shape 78 (mouse)152148439755484397Mouse
12859289Criq3_mCitrobacter rodentium infection QTL 3 (mouse)152273036956730369Mouse
4142160Femwf10_mfemur work to failure 10 (mouse)Not determined2302961857029764Mouse
1301557Bbaa22_mB.burgdorferi-associated arthritis 22 (mouse)Not determined152459917658599409Mouse
1300967Bdt6_mbone density traits 6 (mouse)Not determined152543241059432532Mouse
4141409Radsvq1_mradiation sensitivity QTL 1 (mouse)Not determined2562158259621582Mouse
1301345Bgeq14_mbody growth early QTL 14 (mouse)Not determined152644838460448484Mouse
1300772Bglq16_mbody growth late QTL 16 (mouse)Not determined152644838460448484Mouse
1357514Mbis3_mMycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)Not determined162644838460448484Mouse
1301406Egrd2_mearly growth rate (mouse)Not determined152644838460448484Mouse
27226800Scvln20_msacral vertebrae length 2, 16 week (mouse)152660000066500000Mouse
1301450Bpq6_mblood pressure QTL 6 (mouse)Not determined152841925062419343Mouse
1357512Bsbob5_mBSB obesity 5 (mouse)Not determined152841925062419343Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930000076200000Mouse
26884452Sklq17_mskull length QTL 17, 16 week (mouse)153020000058100000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
1300578Cd8ts3_mCD8 T cell subset 3 (mouse)Not determined153414129868141408Mouse
1301324Cdif_mcolor difference (mouse)Not determined153611251070112623Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800000086800000Mouse
1301580Hrq2_mheart rate quantitative locus 2 (mouse)Not determined153923699973237197Mouse
1300949Lore5_mloss of righting induced by ethanol 5 (mouse)Not determined154015604558158901Mouse
4142459Lfnq3_mlung function QTL 3 (mouse)Not determined4031362672500731Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154230000095600000Mouse
1300644Fob3_mF-line obesity QTL 3 (mouse)11.3Not determined154414443889377036Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:771
Count of miRNA genes:400
Interacting mature miRNAs:467
Transcripts:ENSMUST00000038856, ENSMUST00000110289
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000038856   ⟹   ENSMUSP00000036320
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1544,059,531 - 44,098,940 (+)Ensembl
GRCm38.p6 Ensembl1544,196,135 - 44,235,544 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110289   ⟹   ENSMUSP00000105918
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1544,059,629 - 44,097,559 (+)Ensembl
GRCm38.p6 Ensembl1544,196,233 - 44,234,163 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226626   ⟹   ENSMUSP00000154650
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1544,059,629 - 44,099,308 (+)Ensembl
GRCm38.p6 Ensembl1544,196,233 - 44,235,912 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227505   ⟹   ENSMUSP00000154140
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1544,060,363 - 44,092,597 (+)Ensembl
GRCm38.p6 Ensembl1544,196,967 - 44,229,201 (+)Ensembl
RefSeq Acc Id: NM_013696   ⟹   NP_038724
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391544,059,531 - 44,099,308 (+)NCBI
GRCm381544,196,135 - 44,235,912 (+)NCBI
MGSCv371544,027,681 - 44,067,458 (+)RGD
Celera1544,658,539 - 44,700,386 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520748   ⟹   XP_006520811
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391544,059,314 - 44,064,333 (+)NCBI
GRCm381544,195,924 - 44,200,937 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038724   ⟸   NM_013696
- UniProtKB: P21761 (UniProtKB/Swiss-Prot),   Q32MS1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520811   ⟸   XM_006520748
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000105918   ⟸   ENSMUST00000110289
RefSeq Acc Id: ENSMUSP00000154140   ⟸   ENSMUST00000227505
RefSeq Acc Id: ENSMUSP00000154650   ⟸   ENSMUST00000226626
RefSeq Acc Id: ENSMUSP00000036320   ⟸   ENSMUST00000038856
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:8683688
Promoter ID:EPDNEW_M19874
Type:multiple initiation site
Name:Trhr_1
Description:Mus musculus thyrotropin releasing hormone receptor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381544,196,189 - 44,196,249EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98824 AgrOrtholog
Ensembl Genes ENSMUSG00000038760 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000036320 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105918 UniProtKB/Swiss-Prot
  ENSMUSP00000154140 UniProtKB/TrEMBL
  ENSMUSP00000154650 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038856 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000110289 UniProtKB/Swiss-Prot
  ENSMUST00000226626 UniProtKB/Swiss-Prot
  ENSMUST00000227505 UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRH_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22045 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98824 ENTREZGENE
NCBI Gene 22045 ENTREZGENE
PANTHER PTHR46061 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trhr PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROLIBRINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRHRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BQM9_MOUSE UniProtKB/TrEMBL
  P21761 ENTREZGENE
  Q32MS1 ENTREZGENE, UniProtKB/TrEMBL
  Q3UYL6_MOUSE UniProtKB/TrEMBL
  TRFR_MOUSE UniProtKB/Swiss-Prot