Cthrc1 (collagen triple helix repeat containing 1)

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Gene: Cthrc1 (collagen triple helix repeat containing 1) Rattus norvegicus

Analyze

Symbol:

Cthrc1

Name:

collagen triple helix repeat containing 1

RGD ID:

628801

Description:

Predicted to enable Wnt-protein binding activity and frizzled binding activity. Acts upstream of or within cell migration. Located in extracellular matrix. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human CTHRC1 (collagen triple helix repeat containing 1); PARTICIPATES IN Wnt signaling, non-canonical pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

collagen triple helix repeat-containing protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	70,122,474 - 70,132,756 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	70,122,474 - 70,132,756 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	71,996,837 - 72,007,120 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	74,199,413 - 74,209,696 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	74,067,438 - 74,077,719 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	77,966,722 - 77,977,004 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	77,966,722 - 77,977,004 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	78,271,770 - 78,282,052 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	74,630,044 - 74,640,324 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	74,650,773 - 74,661,054 (+)	NCBI
Celera	7	67,178,934 - 67,189,216 (+)	NCBI		Celera
Cytogenetic Map	7	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Barrett's esophagus (ISO)

Cohen syndrome (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

butanal (ISO)

calcitriol (ISO)

calcium dichloride (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

deoxynivalenol (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

gemcitabine (ISO)

genistein (ISO)

glycidol (EXP)

hexane (EXP)

isoprenaline (ISO)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

methimazole (EXP)

milrinone (EXP)

N-nitrosodiethylamine (ISO)

naphthalene (ISO)

oxaliplatin (EXP)

panobinostat (ISO)

paraquat (EXP)

pentane-2,3-dione (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

propanal (ISO)

quercetin (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (EXP)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

trimellitic anhydride (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell migration (IMP)

cochlea morphogenesis (IEA,ISO)

establishment of planar polarity involved in neural tube closure (IEA,ISO)

inner ear receptor cell stereocilium organization (IEA,ISO)

negative regulation of canonical Wnt signaling pathway (IEA,ISO)

ossification involved in bone remodeling (IEA,ISO)

osteoblast differentiation (IEA,ISO)

osteoblast proliferation (IEA,ISO)

positive regulation of osteoblast differentiation (IEA,ISO)

positive regulation of osteoblast proliferation (IEA,ISO)

Wnt signaling pathway, planar cell polarity pathway (IEA,ISO)

Cellular Component

collagen trimer (IEA)

extracellular matrix (IDA)

extracellular space (IEA,ISO)

sarcoplasm (IEA,ISO)

Molecular Function

frizzled binding (IEA,ISO)

protein binding (ISO)

Wnt-protein binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling, non-canonical pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
2.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3.	Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration.	Pyagay P, etal., Circ Res 2005 Feb 4;96(2):261-8. Epub 2004 Dec 23.
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17322174	PMID:18467647	PMID:18606138	PMID:18779865	PMID:23056600	PMID:24006456	PMID:27068509	PMID:28647773	PMID:29357417	PMID:29393342

Genomics

Comparative Map Data

Cthrc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	70,122,474 - 70,132,756 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	70,122,474 - 70,132,756 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	71,996,837 - 72,007,120 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	74,199,413 - 74,209,696 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	74,067,438 - 74,077,719 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	77,966,722 - 77,977,004 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	77,966,722 - 77,977,004 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	78,271,770 - 78,282,052 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	74,630,044 - 74,640,324 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	74,650,773 - 74,661,054 (+)	NCBI
Celera	7	67,178,934 - 67,189,216 (+)	NCBI		Celera
Cytogenetic Map	7	q31	NCBI

CTHRC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	103,371,538 - 103,382,989 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	103,371,538 - 103,382,989 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	104,383,766 - 104,395,217 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	104,452,962 - 104,464,393 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	104,452,961 - 104,464,391	NCBI
Celera	8	100,570,330 - 100,581,762 (+)	NCBI		Celera
Cytogenetic Map	8	q22.3	NCBI
HuRef	8	99,584,145 - 99,595,635 (+)	NCBI		HuRef
CHM1_1	8	104,424,548 - 104,436,037 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	104,499,186 - 104,510,633 (+)	NCBI		T2T-CHM13v2.0

Cthrc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	38,940,327 - 38,950,516 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	38,940,327 - 38,950,516 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	39,076,932 - 39,087,121 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	39,076,932 - 39,087,121 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	38,908,478 - 38,918,665 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	38,906,933 - 38,917,195 (+)	NCBI		MGSCv36	mm8
Celera	15	39,563,883 - 39,573,915 (+)	NCBI		Celera
Cytogenetic Map	15	B3.1	NCBI
cM Map	15	15.35	NCBI

Cthrc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955417	27,520,420 - 27,525,907 (+)	NCBI	ChiLan1.0	ChiLan1.0

CTHRC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	8	96,266,097 - 96,288,939 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	100,027,417 - 100,038,945 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	102,182,944 - 102,194,445 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	102,182,944 - 102,194,445 (+)	Ensembl	panpan1.1		panPan2

CTHRC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	4,801,049 - 4,811,565 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	4,805,577 - 4,811,282 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	4,804,416 - 4,815,108 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	4,964,918 - 4,975,641 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	4,964,661 - 4,975,365 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	4,805,272 - 4,815,967 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	4,923,227 - 4,933,925 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	4,935,964 - 4,946,667 (+)	NCBI		UU_Cfam_GSD_1.0

Cthrc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	32,955,116 - 32,965,990 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	40,377,835 - 40,392,225 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936470	40,381,215 - 40,392,105 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTHRC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	33,759,542 - 33,771,582 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	33,759,541 - 33,771,625 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	36,579,490 - 36,591,565 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTHRC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	98,227,661 - 98,239,984 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	98,227,705 - 98,240,753 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	42,361,868 - 42,374,150 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cthrc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624763	19,917,169 - 19,925,896 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624763	19,917,199 - 19,925,824 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cthrc1
37 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	35
Count of miRNA genes:	34
Interacting mature miRNAs:	34
Transcripts:	ENSRNOT00000006142
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	29409683	74409683	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	29409683	84928080	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	31112832	76112832	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	34293282	79293282	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	34293282	79293282	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	37960569	82960569	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	42787314	87787314	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	43228750	88228750	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	43747099	102228765	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	44867533	89867533	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	46590070	91590070	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	47651439	92651439	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	47651439	92651439	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	47651439	92651439	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	47651439	92651439	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	47651439	92651439	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	47651439	92651439	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	47651439	92651439	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	53612714	103945643	Rat
2317035	Aia16	Adjuvant induced arthritis QTL 16	2.71		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	59238038	104238038	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	61074194	106074194	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	62004452	101773158	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	62004452	101773158	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		25	2	2		2	2	2	37	20	30	3	2
Low	1	17	39	26	13	26	5	8	37	9	9	8	5
Below cutoff	2	1	15	12	6	12	1	1		6	2		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_172333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY136824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220442	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000006142 ⟹ ENSRNOP00000006142

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	70,122,474 - 70,132,756 (+)	Ensembl
Rnor_6.0 Ensembl	7	77,966,722 - 77,977,004 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102466 ⟹ ENSRNOP00000086689

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	70,122,588 - 70,132,756 (+)	Ensembl

RefSeq Acc Id:

NM_001271300 ⟹ NP_001258229

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	70,122,474 - 70,132,756 (+)	NCBI
Rnor_6.0	7	77,966,722 - 77,977,004 (+)	NCBI
Rnor_5.0	7	78,271,770 - 78,282,052 (-)	NCBI
Celera	7	67,178,934 - 67,189,216 (+)	NCBI

Sequence:

show sequence

TCAGTGAAAGGCGCATTGATGCGGCCGGCCGCAGAGCTGGGCCAGACGCTGAGCAGGGCCGGGC
TCTGCCGACCCCTTTGCCTCCTGCTCTGCGCTTCGCAGCTACCGCACACGATGCACCCCCAAGG
CCGCGCCGCCTCCCCACAGCTGCTGCTCGGCCTCTTCCTTGTGCTACTGCTGCTTCTGCAGCTG
TCCGCGCCGTCCAGCGCCTCTGAGAATCCCAAGTATAATGGGATGTGCCTACAAGGACCAGCAG
GAGTTCCTGGTCGCGATGGGAGCCCTGGGGCCAATGGCATTCCTGGCACACCGGGAATCCCAGG
TCGGGATGGATTCAAAGGAGAGAAAGGGGAGTGCTTAAGGGAAAGCTTTGAGGAATCCTGGACC
CCAAACTACAAGCAGTGTTCATGGAGTTCACTTAATTATGGCATAGATCTTGGGAAAATTGCGG
AATGTACATTCACAAAGATGCGATCCAACAGCGCTCTTCGAGTTCTGTTCAGTGGCTCGCTTCG
GCTCAAATGCAGGAATGCTTGCTGTCAACGCTGGTATTTTACCTTTAATGGAGCTGAATGTTCA
GGACCTCTTCCCATTGAAGCTATCATCTATCTGGACCAAGGAAGCCCTGAGTTAAATTCAACTA
TTAATATTCATCGTACTTCCTCCGTGGAAGGACTCTGTGAAGGGATTGGTGCTGGACTGGTAGA
CGTGGCCATCTGGGTCGGCACCTGTTCAGATTACCCCAAAGGAGACGCTTCTACTGGGTGGAAT
TCTGTGTCCCGCATCATCATTGAAGAACTACCAAAATAAAGCCCCTGAAGGTTTCATTCCCTGC
CTCATTTACTTGTTAAATCAAGCCTCTGGATGGGTCATTTAAATGACATTTCAGAAGTCACTTA
TGTGCTCAGCCAAATGAAAAAGCAAAGTTAAATACGTTTACAGACCAAAGTGTGATCTCACACT
TTAAGATCTAGCATTATCCATTTTATTTCAACCAAAGATGGTTTCAGGATTTTATTTCTCATTG
ATTACTTTTTGAGCCTATATACCGGAATGCTGTTATAGTCTTTAATATTTCCTACTGTTGACAT
TTTGAAACATATAAAAGTTATGTCTTTGTAAGAGCTGTATAGAATTATTTTATATGTTAAATAA
AATGCTTCAAACAACCTTA

hide sequence

RefSeq Acc Id:

NM_172333 ⟹ NP_758836

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	70,122,474 - 70,132,756 (+)	NCBI
Rnor_6.0	7	77,966,722 - 77,977,004 (+)	NCBI
Rnor_5.0	7	78,271,770 - 78,282,052 (-)	NCBI
RGSC_v3.4	7	74,630,044 - 74,640,324 (+)	RGD
Celera	7	67,178,934 - 67,189,216 (+)	NCBI

Sequence:

show sequence

TCAGTGAAAGGCGCATTGATGCGGCCGGCCGCAGAGCTGGGCCAGACGCTGAGCAGGGCCGGGC
TCTGCCGACCCCTTTGCCTCCTGCTCTGCGCTTCGCAGCTACCGCACACGATGCACCCCCAAGG
CCGCGCCGCCTCCCCACAGCTGCTGCTCGGCCTCTTCCTTGTGCTACTGCTGCTTCTGCAGCTG
TCCGCGCCGTCCAGCGCCTCTGAGAATCCCAAGGTGAAGCAAAAAGCGCTGATCCGGCAGAGGG
AAGTGGTAGACCTGTATAATGGGATGTGCCTACAAGGACCAGCAGGAGTTCCTGGTCGCGATGG
GAGCCCTGGGGCCAATGGCATTCCTGGCACACCGGGAATCCCAGGTCGGGATGGATTCAAAGGA
GAGAAAGGGGAGTGCTTAAGGGAAAGCTTTGAGGAATCCTGGACCCCAAACTACAAGCAGTGTT
CATGGAGTTCACTTAATTATGGCATAGATCTTGGGAAAATTGCGGAATGTACATTCACAAAGAT
GCGATCCAACAGCGCTCTTCGAGTTCTGTTCAGTGGCTCGCTTCGGCTCAAATGCAGGAATGCT
TGCTGTCAACGCTGGTATTTTACCTTTAATGGAGCTGAATGTTCAGGACCTCTTCCCATTGAAG
CTATCATCTATCTGGACCAAGGAAGCCCTGAGTTAAATTCAACTATTAATATTCATCGTACTTC
CTCCGTGGAAGGACTCTGTGAAGGGATTGGTGCTGGACTGGTAGACGTGGCCATCTGGGTCGGC
ACCTGTTCAGATTACCCCAAAGGAGACGCTTCTACTGGGTGGAATTCTGTGTCCCGCATCATCA
TTGAAGAACTACCAAAATAAAGCCCCTGAAGGTTTCATTCCCTGCCTCATTTACTTGTTAAATC
AAGCCTCTGGATGGGTCATTTAAATGACATTTCAGAAGTCACTTATGTGCTCAGCCAAATGAAA
AAGCAAAGTTAAATACGTTTACAGACCAAAGTGTGATCTCACACTTTAAGATCTAGCATTATCC
ATTTTATTTCAACCAAAGATGGTTTCAGGATTTTATTTCTCATTGATTACTTTTTGAGCCTATA
TACCGGAATGCTGTTATAGTCTTTAATATTTCCTACTGTTGACATTTTGAAACATATAAAAGTT
ATGTCTTTGTAAGAGCTGTATAGAATTATTTTATATGTTAAATAAAATGCTTCAAACAACCTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001258229	(Get FASTA)	NCBI Sequence Viewer
	NP_758836	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAN15748	(Get FASTA)	NCBI Sequence Viewer
	EDM16354	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006142
	ENSRNOP00000006142.3
	ENSRNOP00000086689.1
GenBank Protein	Q8CG08	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_758836 ⟸ NM_172333
- Peptide Label:	isoform 1 precursor
- UniProtKB:	Q8CG08 (UniProtKB/Swiss-Prot), A0A8L2Q207 (UniProtKB/TrEMBL), A6HR68 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHPQGRAASPQLLLGLFLVLLLLLQLSAPSSASENPKVKQKALIRQREVVDLYNGMCLQGPAGV PGRDGSPGANGIPGTPGIPGRDGFKGEKGECLRESFEESWTPNYKQCSWSSLNYGIDLGKIAEC TFTKMRSNSALRVLFSGSLRLKCRNACCQRWYFTFNGAECSGPLPIEAIIYLDQGSPELNSTIN IHRTSSVEGLCEGIGAGLVDVAIWVGTCSDYPKGDASTGWNSVSRIIIEELPK hide sequence

RefSeq Acc Id:	NP_001258229 ⟸ NM_001271300
- Peptide Label:	isoform 2 precursor
- UniProtKB:	A0A8L2Q207 (UniProtKB/TrEMBL), A6HR68 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHPQGRAASPQLLLGLFLVLLLLLQLSAPSSASENPKYNGMCLQGPAGVPGRDGSPGANGIPGT PGIPGRDGFKGEKGECLRESFEESWTPNYKQCSWSSLNYGIDLGKIAECTFTKMRSNSALRVLF SGSLRLKCRNACCQRWYFTFNGAECSGPLPIEAIIYLDQGSPELNSTINIHRTSSVEGLCEGIG AGLVDVAIWVGTCSDYPKGDASTGWNSVSRIIIEELPK hide sequence

RefSeq Acc Id:

ENSRNOP00000006142 ⟸ ENSRNOT00000006142

RefSeq Acc Id:

ENSRNOP00000086689 ⟸ ENSRNOT00000102466

Protein Domains

Collagen-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8CG08-F1-model_v2	AlphaFold	Q8CG08	1-245	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695305

Promoter ID:

EPDNEW_R5830

Type:

initiation region

Name:

Cthrc1_1

Description:

collagen triple helix repeat containing 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	77,966,765 - 77,966,825	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628801	AgrOrtholog
BioCyc Gene	G2FUF-33577	BioCyc
Ensembl Genes	ENSRNOG00000004578	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000006142	ENTREZGENE
	ENSRNOT00000006142.4	UniProtKB/TrEMBL
	ENSRNOT00000102466.1	UniProtKB/TrEMBL
KEGG Report	rno:282836	UniProtKB/Swiss-Prot
NCBI Gene	282836	ENTREZGENE
PANTHER	COLLAGEN TRIPLE HELIX REPEAT-CONTAINING PROTEIN 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROSTAGLANDIN G/H SYNTHASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cthrc1	PhenoGen
RatGTEx	ENSRNOG00000004578	RatGTEx
UniProt	A0A8I6A6B3_RAT	UniProtKB/TrEMBL
	A0A8L2Q207	ENTREZGENE, UniProtKB/TrEMBL
	A6HR68	ENTREZGENE, UniProtKB/TrEMBL
	CTHR1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Cthrc1	collagen triple helix repeat containing 1			Symbol and Name status set to approved	1299863	APPROVED
2003-02-27	Cthrc1	collagen triple helix repeat containing 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)